KEGG ORTHOLOGY: K13760

ORTHOLOGY: K13760

Entry

K13760                      KO

Symbol

PDE6H

Name

retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Pathway

map00230

Purine metabolism

map01100

Metabolic pathways

Reaction

R01234

guanosine 3',5'-cyclic phosphate 5'-nucleotidohydrolase

Disease

H00481

Cone-rod dystrophy and cone dystrophy

H00971

Achromatopsia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K13760  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Genes

HSA:	5149(PDE6H)

PTR:	742049(PDE6H)

PPS:	100979826(PDE6H)

GGO:	101137656(PDE6H)

PON:	112135805(PDE6H)

PPYG:

129010404(PDE6H)

NLE:	100600699(PDE6H)

HMH:	116472727(PDE6H)

MCC:	700447(PDE6H)

MCF:	102138604(PDE6H)

MTHB:

126931361

MNI:	105481707(PDE6H)

CSAB:

103218686(PDE6H)

CATY:

105585110(PDE6H)

PANU:

101018967(PDE6H)

TGE:	112634894(PDE6H)

MLEU:

105547284(PDE6H)

RRO:	104666392(PDE6H)

RBB:	108530285(PDE6H)

TFN:	117090457(PDE6H)

PTEH:

111552105(PDE6H)

CANG:

105521469(PDE6H)

CJC:	100409873(PDE6H)

SBQ:	101044097(PDE6H)

CIMI:

108304393(PDE6H)

ANAN:

105713884(PDE6H)

CSYR:

103273761(PDE6H)

MMUR:

105865294(PDE6H)

LCAT:

123640693(PDE6H)

PCOQ:

105816686(PDE6H)

OGA:	100942735(PDE6H)

MMU:	78600(Pde6h)

MCAL:

110296932(Pde6h)

MPAH:

110317179(Pde6h)

RNO:	114248(Pde6h)

MCOC:

116099730(Pde6h)

ANU:	117715318(Pde6h)

ASYL:

127677727(Pde6h)

MUN:	110552747(Pde6h)

CGE:	100753606(Pde6h)

MAUA:

101829341(Pde6h)

PROB:

127212943(Pde6h)

PLEU:

114695057(Pde6h)

MORG:

121442982(Pde6h)

MFOT:

126497286

AAMP:

119808205(Pde6h)

NGI:	103752312(Pde6h)

HGL:	101717519(Pde6h)

CPOC:

100735374(Pde6h)

CCAN:

109689039(Pde6h)

DORD:

105992277(Pde6h)

DSP:	122101017(Pde6h)

PLOP:

125345185(Pde6h)

NCAR:

124984021

MMMA:

107152795(Pde6h)

ITI:	101975706(Pde6h)

OCU:

100345162

OPI:	101525936(PDE6H)

TUP:	102489661(PDE6H)

GVR:	103605867(PDE6H)

CFA:	611031(PDE6H)

CLUD:

112665439(PDE6H)

VVP:	112917256(PDE6H)

VLG:	121480413(PDE6H)

NPO:	129505584(PDE6H)

AML:	100481382(PDE6H)

UMR:	103677781(PDE6H)

UAH:	113257848(PDE6H)

UAR:	123781744(PDE6H)

ELK:

111142046

LLV:

125107127

MPUF:

101676711(PDE6H)

MNP:	132019515(PDE6H)

MLK:	131839003(PDE6H)

NVS:	122891345(PDE6H)

ORO:	101379642(PDE6H)

EJU:	114221609(PDE6H)

ZCA:	113922877(PDE6H)

MLX:	118025626(PDE6H)

NSU:	110581006(PDE6H)

LWW:	102727605(PDE6H)

FCA:	101097496(PDE6H)

PYU:	121038882(PDE6H)

PCOO:

112867331(PDE6H)

PBG:	122473183(PDE6H)

PVIV:

125170859(PDE6H)

LRUF:

124502634

LGF:	123591540(PDE6H)

AJU:

106965672

PTG:	102962054(PDE6H)

PPAD:

109268659(PDE6H)

PUC:

125920397

PLEZ:

122225580(PDE6H)

HHV:	120236904(PDE6H)

BTA:	281978(PDE6H)

BOM:	102287072(PDE6H)

BIU:	109558806(PDE6H)

BBUB:

102414830(PDE6H)

BBIS:

105002199(PDE6H)

CHX:	108636136(PDE6H)

OAS:	101105813(PDE6H)

BTAX:

128048825(PDE6H)

CSUM:

138079203(PDE6H)

ODA:	120858896(PDE6H)

CCAD:

122423670(PDE6H) 122444140 122444141

MREE:

136159619(PDE6H)

OVR:	110133569(PDE6H)

MBEZ:

129536641(PDE6H)

SSC:	100156675(PDE6H)

CFR:	102514355(PDE6H)

CBAI:

105062259(PDE6H)

CDK:	105096509(PDE6H)

VPC:	102539948(PDE6H)

BACU:

103018198(PDE6H)

BMUS:

118902340(PDE6H)

LVE:	103078753(PDE6H)

OOR:	101282014(PDE6H)

LALB:

132529318(PDE6H)

DLE:	111176525(PDE6H)

PCAD:

102982317(PDE6H)

PSIU:

116760911(PDE6H)

NASI:

112391916(PDE6H)

ECB:	100629178(PDE6H)

EPZ:	139083353(PDE6H)

EAI:	106826719(PDE6H)

MYB:	102245018(PDE6H)

MYD:	102762681(PDE6H)

MMYO:

118650239(PDE6H)

MLF:	102438472(PDE6H)

MDT:	132226053(PDE6H)

MYUM:

139005636(PDE6H)

PKL:	118729231(PDE6H)

EFUS:

103285120(PDE6H)

MNA:	107525351(PDE6H)

DRO:	112318540(PDE6H)

SHON:

118978467(PDE6H)

AJM:	119042833(PDE6H)

PDIC:

114514139(PDE6H)

PHAS:

123812875(PDE6H)

MMF:	118624327(PDE6H)

PPAM:

129084717(PDE6H)

HAI:	109383125(PDE6H)

RFQ:	117029096(PDE6H)

PALE:

102885670(PDE6H)

PGIG:

120613755(PDE6H)

PVP:	105300637(PDE6H)

RAY:	107508619(PDE6H)

MJV:	108403145(PDE6H)

TOD:	119247676(PDE6H)

SARA:

101541091(PDE6H)

SFUM:

130042464(PDE6H)

SETR:

126022724(PDE6H)

LAV:	100654385(PDE6H)

TMU:

101342955

ETF:	101641046(PDE6H)

MDO:	100011684(PDE6H)

GAS:	123249510(PDE6H)

SHR:	100926066(PDE6H)

AFZ:

127564301

PCW:	110213859(PDE6H)

TVP:	118852067(PDE6H)

PBRV:

138175575(PDE6H)

OAA:	103166085 114805687

GGA:	378929(PDE6H)

PCOC:

116233242(PDE6H)

MGP:	100538611(PDE6H)

CJO:	107312277(PDE6H)

TPAI:

128074058(PDE6H)

LMUT:

125690767(PDE6H)

NMEL:

110407478(PDE6H)

APLA:

101804524(PDE6H)

ACYG:

106045732(PDE6H)

CATA:

118250538(PDE6H)

AFUL:

116501279(PDE6H)

TGU:	100226307(PDE6H)

LSR:	110483093(PDE6H)

SCAN:

103813370(PDE6H)

PMOA:

120499866(PDE6H)

OTC:	121335984(PDE6H)

PRUF:

121357222(PDE6H)

ATRC:

139588153(PDE6H)

GFR:	102041341(PDE6H)

FAB:	101805910(PDE6H)

OMA:	130266378(PDE6H)

PHI:	102106100(PDE6H)

PMAJ:

107204262(PDE6H)

CCAE:

111930500(PDE6H)

CCW:	104696408(PDE6H)

CBRC:

103618163(PDE6H)

ACOE:

138104692(PDE6H)

ETL:	114058435(PDE6H)

ZAB:	102072761(PDE6H)

ZLE:	135457249(PDE6H)

ACHL:

103804259

SVG:	106863076(PDE6H)

MMEA:

130585678(PDE6H)

HRT:	120751813(PDE6H)

SATI:

136361449(PDE6H)

CCIC:

134043256(PDE6H)

FPG:	101922659(PDE6H)

FCH:	102058501(PDE6H)

CCRI:

104168719(PDE6H)

NNT:	104409210(PDE6H)

SHAB:

115605295(PDE6H)

ACUN:

113491117(PDE6H)

TALA:

104364949(PDE6H)

ACHC:

115336302(PDE6H)

HALD:

104312757(PDE6H)

HLE:	104832818(PDE6H)

AGEN:

126034510

HHAR:

128135628(PDE6H)

GCL:

127029317

CSTI:

104551279(PDE6H)

LDI:	104345534(PDE6H)

MNB:	103768228(PDE6H)

DPUB:

104298430(PDE6H)

PPUS:

135181533(PDE6H)

AVIT:

104269800(PDE6H)

BRHI:

104490664(PDE6H)

EGZ:	104132307(PDE6H)

NNI:	104011673(PDE6H)

PCRI:

104031064(PDE6H)

PCAO:

104051797(PDE6H)

PADL:

103915588(PDE6H)

AFOR:

103907839(PDE6H)

FGA:	104078327(PDE6H)

GSTE:

104258646(PDE6H)

CLV:	102096582(PDE6H)

MUI:	104537509(PDE6H)

PGUU:

104460793(PDE6H)

PLET:

104621558(PDE6H)

EHS:	104509141(PDE6H)

CMAC:

104476326(PDE6H)

CUCA:

104068650(PDE6H)

TEO:

104376692

BREG:

104637966(PDE6H)

OHA:	104334493(PDE6H)

ACAR:

104530449

CPEA:

104389958(PDE6H)

CVF:	104294743(PDE6H)

RTD:	128911058(PDE6H)

CRID:

134509979(PDE6H)

AAM:	106488530(PDE6H)

AROW:

112971076(PDE6H)

NPD:	112959501(PDE6H)

TGT:	104566140(PDE6H)

DNE:	112993425(PDE6H)

SCAM:

104145823(PDE6H)

ASN:	102369046(PDE6H)

AMJ:	102566928(PDE6H)

CPOO:

109316821(PDE6H)

GGN:	109295864(PDE6H)

PSS:	102464001(PDE6H)

CMY:	102931166(PDE6H)

CCAY:

125630021(PDE6H)

DCC:	119843216(PDE6H)

CPIC:

101952796(PDE6H)

TST:	117879072(PDE6H)

CABI:

116827259(PDE6H)

MRV:	120374249(PDE6H)

ACS:	100553314(pde6h)

ASAO:

132776040(PDE6H)

PVT:	110091372(PDE6H)

SUND:

121931309(PDE6H)

PBI:	103057564(PDE6H)

PMUR:

107286150(PDE6H)

CTIG:

120312820(PDE6H)

TSR:	106537932(PDE6H)

PGUT:

117655644(PDE6H)

APRI:

131202659(PDE6H)

PTEX:

113437087(PDE6H)

NSS:	113430744(PDE6H)

VKO:	123036258(PDE6H)

PMUA:

114605752(PDE6H)

PRAF:

128422344(PDE6H)

ZVI:	118090731(PDE6H)

HCG:	128326274(PDE6H)

GJA:	107118917(PDE6H)

STOW:

125435087(PDE6H)

EMC:	129335313(PDE6H)

XLA:	444661(pde6h.L) 444662 447555(pde6h.S)

XTR:	549499(pde6h)

NPR:	108793451(PDE6H)

RTEM:

120944916(PDE6H)

BBUF:

120978843(PDE6H)

BGAR:

122943785 122943850

PWL:	138292487(PDE6H)

DRE:	393810(pde6hb)

SRX:	107724721 107733865 107737993 107751601

SANH:

107656947(pde6h) 107666691 107685924 107690252 107698069

SGH:	107569883 107572348 107574614 107590586

CCAR:

109058359 109074488 109075997 109095158 109096922

CAUA:

113041735 113047642 113067477 113084490 113090100 113095148

CGIB:

127952222 127956512 128015308

PTET:

122333339 122341498(pde6hb) 122341796

LROH:

127156432(pde6hb) 127160103 127166402

OMC:	131536582(pde6hb) 131536930

PPRM:

120489441

RKG:	130090693 130105965(pde6hb)

MAMB:

125248562(pde6hb) 125275772

CIDE:

127508216

CERY:

137008229(pde6hb) 137011241

MASI:

127446216 127450069 127451211

TROS:

130550571(pde6hb) 130561899

TDW:	130426668(pde6hb)

MANU:

129436188 129436887(pde6hb) 129450684

PDAB:

135720808 135758999 135769125(pde6hb) 135783356

IPU:	108272934 108273052

IFU:	128615631 128615848

PHYP:

113538318

SMEO:

124381911

TFD:	113634513 113640138

TVC:	132842555 132844037

CGAR:

128516016 128526932

NGRA:

132870569 132884298

TRN:

134334771

AMEX:

103022544 103033145(pde6hb)

CMAO:

118805093(pde6hb) 118821320

EEE:

113589373

CHAR:

105898575 105902979 105910162 116219862

SPIL:

134076122 134079879 134095311 134095312 134095313

TRU:	101070191 101074909 115252061

TFS:	130514481 130520427 130527847

TNG:	GSTEN00011509G001

LCO:	104937546 104937730 104938485 109137891

TBEN:

117480022 117481614 117481615 117481616

CGOB:

115012516 115012590 115027235

PGEO:

117451583 117455168

GACU:

117538033 117551375

EMAC:

134865288 134878362

ELY:	117251769 117255386 117255974 117257462 117268128

EFO:	125879929 125885656 125885657 125905622 125905639

PLEP:

121942583 121942627 121945173 121957123(pde6hb)

SLUC:

116040414 116040585 116065474 116067245

ECRA:

117935019 117957845

ESP:	116698065 116703562 116706588

PFLV:

114546936 114547565 114560400 114569691

GAT:	120825017(pde6hb) 120828464

PPUG:

119220540

AFB:	129096122 129099005 129109025

CLUM:

117735029

PSWI:

130189887

CANA:

137787000 137794914 137795303

CVE:	137878407(pde6hb) 137885042 137885059 137886327 137886328

MSAM:

119884030 119890440

SCHU:

122869395 122872840 122872842

CUD:	121503800 121508968 121528685 121528769

SPUL:

138586115 138586131 138594894 138595168 138604369(pde6hb)

LMIX:

132954723 132980174 132995551

ALAT:

119014159 119018308 119018325 119022883 119023081 119023087 119024344 119024539

ASTR:

137597540 137600508 137600547 137610336(pde6hb)

MZE:	101467268 101472679 101484651

ONL:	100690909 100691394 100696010

OAU:	116321359 116327151 116329703

OLA:	101158417 101158770 101159081

OML:	112144878 112145902(pde6hb) 112157556

CSAI:

133418498 133419496 133421659(pde6hb)

XMA:	102218990 102220713 106699947

XCO:	114143698 114143699 114159505

XHE:	116718924 116718925 116730971 116730972 116734997

PRET:

103463000 103463001 103468412(pde6h)

PFOR:

103143662 103151136 103151138

PLAI:

106963377 106963964 106963965

PMEI:

106925398 106925399 106931391

GAF:	122822130 122824301 122824307

PPRL:

129352166 129352167 129356081 129356082 129363425(pde6hb)

CVG:	107095969 107097718

CTUL:

119775707 119788854

GMU:	124862531 124864573 124866763 124867309

NFU:	107376293(pde6h) 107381234 107382209

KMR:	108236166(pde6hb) 108243989

ALIM:

106523883 106533555 106534187

NWH:	119422143(pde6hb)

AOCE:

111568803 111574501 111574509 111581810

EJA:	138197686(pde6hb)

BFRE:

138622353(pde6hb)

MCEP:

124998467(pde6hb) 125003893 125003894 125005243

CSEM:

103383788 103384609 103393384

POV:	109627457 109627458 109647267

SSEN:

122770630 122770654 122772638 122777135 122785584(pde6hb)

SSOE:

131459880 131466988 131466989 131468582 131475395(pde6hb)

HHIP:

117752640 117766294(pde6hb) 117768188 117768195

HSP:	118101685 118115549 118115558 118123189

PPLT:

128437104 128437186 128445527

SMAU:

118288836 118302267 118312526 118312527

LCF:	108875876 108875877 108877587 108894331 108894332 108894333 108894404 108894405

SDU:	111223775 111224497 111224752 111231536 111231541

SLAL:

111644311 111644330 111662511 111664496 111664502

XGL:	120788087 120792389 120795663 120800503 120800557

HCQ:	109516454 109529188 109529209

SSCV:

125984193

SBIA:

133497988 133506671 133514665

PEE:	133403767 133415461

PTAO:

133466349 133477086(pde6hb)

BPEC:

110162419 110172661 110173399 110173431

ENY:	140357738(pde6hb)

MALB:

109974670

BSPL:

114858358 114860328(pde6hb)

SJO:	128367084 128369057 128379029

SSCO:

133978769 133978815 133997646 133999898

GMH:	115541114 115541115 115558707

SASA:

106601202(CNRG) 106607098

STRU:

115171344 115200495

OTW:	112258847(pde6hb)

OMY:	110487544 110538323

OGO:	123998753 124016103

ONE:	115103637 115110464

OKI:	109892262 109898627

OKE:

118364755

OMM:	135554968(pde6hb)

OCLA:

139421359 139423972

SALP:

111980306 111980344

SNH:	120038178 120045560

CCLU:

121551378(pde6hb)

ELS:

105013455

OEP:	134008579 134008764 134014970

SFM:	108926051 108940000(pde6h)

PKI:	111833576(pde6h) 111853256

AANG:

118217126 118219900

AROT:

135243815 135248895

CCOG:

133115258 133121288

LOC:	102691894(pde6h)

ARUT:

PSEX:

CPLA:

HOC:

PMRN:

LRJ:

Reference

PMID:8786098

Authors

Shimizu-Matsumoto A, Itoh K, Inazawa J, Nishida K, Matsumoto Y, Kinoshita S, Matsubara K, Okubo K

Title

Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H).

Journal

Genomics 32:121-4 (1996)
DOI:10.1006/geno.1996.0085

Sequence

[hsa:5149]

Reference

PMID:17307970

Authors

Omori K, Kotera J

Title

Overview of PDEs and their regulation.

Journal

Circ Res 100:309-27 (2007)
DOI:10.1161/01.RES.0000256354.95791.f1

Reference

PMID:16102838

Authors

Lugnier C

Title

Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.

Journal

Pharmacol Ther 109:366-98 (2006)
DOI:10.1016/j.pharmthera.2005.07.003

LinkDB

DBGET integrated database retrieval system