KEGG   ORTHOLOGY: K14040
Entry
K14040            Tight     KO                                     
Symbol
CYP720B, PTAO
Name
abieta-7,13-dien-18-ol hydroxylase [EC:1.14.14.145]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06354  abietinol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating)
R10077  
R10078  
R12123  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K14040  CYP720B, PTAO; abieta-7,13-dien-18-ol hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K14040  CYP720B, PTAO; abieta-7,13-dien-18-ol hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.145  abieta-7,13-dien-18-ol hydroxylase
     K14040  CYP720B, PTAO; abieta-7,13-dien-18-ol hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP720 family
   K14040  CYP720B, PTAO; abieta-7,13-dien-18-ol hydroxylase
Other DBs
GO: 0036204
Genes
AG: AAX07431(CYP720B1) ADR78276(CYP720B4)
Reference
PMID:15911762 (CYP720B1)
  Authors
Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J
  Title
Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase.
  Journal
Proc Natl Acad Sci U S A 102:8060-5 (2005)
DOI:10.1073/pnas.0500825102
  Sequence
[ag:AAX07431]
Reference
PMID:16497345
  Authors
Ro DK, Bohlmann J
  Title
Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1).
  Journal
Phytochemistry 67:1572-8 (2006)
DOI:10.1016/j.phytochem.2006.01.011
Reference
PMID:21994349 (CYP720B4)
  Authors
Hamberger B, Ohnishi T, Hamberger B, Seguin A, Bohlmann J
  Title
Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects.
  Journal
Plant Physiol 157:1677-95 (2011)
DOI:10.1104/pp.111.185843
  Sequence
[ag:ADR78276]
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