KEGG   ORTHOLOGY: K14047
Entry
K14047            Tight     KO                                     
Symbol
PADC4
Name
fusicocca-2,10(14)-diene synthase [EC:4.2.3.43]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09123  geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K14047  PADC4; fusicocca-2,10(14)-diene synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.43  fusicocca-2,10(14)-diene synthase
     K14047  PADC4; fusicocca-2,10(14)-diene synthase
Genes
AG: BAF45924(PADC4)
Reference
PMID:17360612
  Authors
Toyomasu T, Tsukahara M, Kaneko A, Niida R, Mitsuhashi W, Dairi T, Kato N, Sassa T
  Title
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi.
  Journal
Proc Natl Acad Sci U S A 104:3084-8 (2007)
DOI:10.1073/pnas.0608426104
  Sequence
[ag:BAF45924]
LinkDB

KEGG   ENZYME: 4.2.3.43
Entry
EC 4.2.3.43                 Enzyme                                 
Name
fusicocca-2,10(14)-diene synthase;
fusicoccadiene synthase;
PaFS;
PaDC4
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate [RN:R09123]
Reaction(KEGG)
R09123
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
fusicocca-2,10(14)-diene [CPD:C18229];
diphosphate [CPD:C00013]
Comment
A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity.
History
EC 4.2.3.43 created 2009
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14047  fusicocca-2,10(14)-diene synthase
Reference
1  [PMID:17360612]
  Authors
Toyomasu T, Tsukahara M, Kaneko A, Niida R, Mitsuhashi W, Dairi T, Kato N, Sassa T
  Title
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi.
  Journal
Proc Natl Acad Sci U S A 104:3084-8 (2007)
DOI:10.1073/pnas.0608426104
  Sequence
[ag:BAF45924]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.43
IUBMB Enzyme Nomenclature: 4.2.3.43
ExPASy - ENZYME nomenclature database: 4.2.3.43
BRENDA, the Enzyme Database: 4.2.3.43
LinkDB

KEGG   REACTION: R09123
Entry
R09123                      Reaction                               
Name
geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming)
Definition
Geranylgeranyl diphosphate <=> Fusicocca-2,10(14)-diene + Diphosphate
Equation
C00353 <=> C18229 + C00013
Reaction class
RC02781  C00353_C18229
Enzyme
4.2.3.43
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.43
     R09123  Geranylgeranyl diphosphate <=> Fusicocca-2,10(14)-diene + Diphosphate
Orthology
K14047  fusicocca-2,10(14)-diene synthase [EC:4.2.3.43]
Other DBs
RHEA: 26248
LinkDB

DBGET integrated database retrieval system