KEGG ORTHOLOGY: K14584

ORTHOLOGY: K14584

Entry

K14584                      KO

Symbol

nahD

Name

2-hydroxychromene-2-carboxylate isomerase [EC:5.99.1.4]

Pathway

map00626

Naphthalene degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Module

M00534

Naphthalene degradation, naphthalene => salicylate

Reaction

R05137

2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K14584  nahD; 2-hydroxychromene-2-carboxylate isomerase
Enzymes [BR:ko01000]
5. Isomerases
  5.99  Other isomerases
   5.99.1  Sole sub-subclass for isomerases that do not belong in the other subclasses
    5.99.1.4  2-hydroxychromene-2-carboxylate isomerase
     K14584  nahD; 2-hydroxychromene-2-carboxylate isomerase
Dioxygenases [br01602.html]
Dioxygenases in aromatic ring cleavage
  K14584

Other DBs

GO:

0018845

Genes

PAEU:

BN889_06506

PSC:	A458_06695

PSTU:

UIB01_22655

ALT:	ambt_17880

CYQ:	Q91_2218(dsbA2)

CZA:	CYCME_2536

RMN:	TK49_07985

BMK:	DM80_1450(doxJ)

BUQ:	AC233_10855 AC233_11015 AC233_11145

BFN:	OI25_3056(nahD)

PNA:

Pnap_2478

DEL:	DelCs14_1745

MASW:

AM586_27545

RBU:	PG1C_04270

NPM:	QEO92_31585

MAAD:

AZF01_18320

CID:

P73_0352

CON:	TQ29_19105

SAGZ:

QNI11_26360

PGV:	SL003B_4081 SL003B_4106

NAR:

Saro_3869

NPP:	PP1Y_AT15569

NPN:	JI59_24555

SPHY:

CHN51_06890

SAND:

H3309_09115

CNA:	AB433_10405 AB433_18205

ERY:	CP97_14145

NCH:	A0U93_15775

AG:	AAA66358(nahD) AAD45416(nsaD)

» show all

Reference

PMID:8002605

Authors

Eaton RW

Title

Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid.

Journal

J Bacteriol 176:7757-62 (1994)
DOI:10.1128/JB.176.24.7757-7762.1994

Sequence

[ag:AAA66358]

Reference

PMID:18662317

Authors

Peng RH, Xiong AS, Xue Y, Fu XY, Gao F, Zhao W, Tian YS, Yao QH

Title

Microbial biodegradation of polyaromatic hydrocarbons.

Journal

FEMS Microbiol Rev 32:927-55 (2008)
DOI:10.1111/j.1574-6976.2008.00127.x

LinkDB

ENZYME: 5.99.1.4

Entry

EC 5.99.1.4                 Enzyme

Name

2-hydroxychromene-2-carboxylate isomerase;
HCCA isomerase;
2HC2CA isomerase;
2-hydroxychromene-2-carboxylic acid isomerase

Class

Isomerases;
Other isomerases;
Sole sub-subclass for isomerases that do not belong in the other subclasses

Sysname

2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase

Reaction(IUBMB)

2-hydroxy-2H-chromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate [RN:R05137]

Reaction(KEGG)

R05137

Substrate

2-hydroxy-2H-chromene-2-carboxylate [CPD:C06204]

Product

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate [CPD:C06203]

Comment

This enzyme is involved in naphthalene degradation.

History

EC 5.99.1.4 created 2010

Pathway

ec00626

Naphthalene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14584

2-hydroxychromene-2-carboxylate isomerase

Genes

PAEU:

BN889_06506

PSC:	A458_06695

PSTU:

UIB01_22655

ALT:	ambt_17880

CYQ:	Q91_2218(dsbA2)

CZA:	CYCME_2536

RMN:	TK49_07985

BMK:	DM80_1450(doxJ)

BUQ:	AC233_10855 AC233_11015 AC233_11145

BFN:	OI25_3056(nahD)

PNA:

Pnap_2478

DEL:	DelCs14_1745

MASW:

AM586_27545

RBU:	PG1C_04270

NPM:	QEO92_31585

MAAD:

AZF01_18320

CID:

P73_0352

CON:	TQ29_19105

SAGZ:

QNI11_26360

PGV:	SL003B_4081 SL003B_4106

NAR:

Saro_3869

NPP:	PP1Y_AT15569

NPN:	JI59_24555

SPHY:

CHN51_06890

SAND:

H3309_09115

CNA:	AB433_10405 AB433_18205

ERY:	CP97_14145

NCH:	A0U93_15775

» show all

Reference

1 [PMID:9722670]

Authors

Ohmoto T, Kinoshita T, Moriyoshi K, Sakai K, Hamada N, Ohe T

Title

Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2.

Journal

J Biochem 124:591-7 (1998)
DOI:10.1093/oxfordjournals.jbchem.a022152

Reference

2 [PMID:16804169]

Authors

Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J

Title

Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6.

Journal

Microbiology 152:1929-40 (2006)
DOI:10.1099/mic.0.28783-0

Sequence

[ag:AAD45416]

Reference

3 [PMID:8002605]

Authors

Eaton RW

Title

Journal

J Bacteriol 176:7757-62 (1994)
DOI:10.1128/JB.176.24.7757-7762.1994

Sequence

[ag:AAA66358]

Reference

4 [PMID:17508726]

Authors

Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN

Title

2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida.

Journal

Biochemistry 46:6710-22 (2007)
DOI:10.1021/bi700356u

Sequence

[ag:AAA66358]

Other DBs

ExplorEnz - The Enzyme Database:

5.99.1.4

IUBMB Enzyme Nomenclature:

5.99.1.4

ExPASy - ENZYME nomenclature database:

5.99.1.4

UM-BBD (Biocatalysis/Biodegradation Database):

5.99.1.4

BRENDA, the Enzyme Database:

5.99.1.4

LinkDB

REACTION: R05137

Entry

R05137                      Reaction

Name

2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase

Definition

trans-o-Hydroxybenzylidenepyruvate <=> 2-Hydroxychromene-2-carboxylate

Equation

C06203 <=> C06204

Reaction class

RC03084

C06203_C06204

Enzyme

5.99.1.4

Pathway

rn00626

Naphthalene degradation

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01220

Degradation of aromatic compounds

Module

M00534

Naphthalene degradation, naphthalene => salicylate

Brite

Enzymatic reactions [BR:br08201]
5. Isomerase reactions
  5.99  Other isomerases
   5.99.1  Sole sub-subclass for isomerases that do not belong in the other subclasses
    5.99.1.4
     R05137  trans-o-Hydroxybenzylidenepyruvate <=> 2-Hydroxychromene-2-carboxylate

Orthology

K14584

2-hydroxychromene-2-carboxylate isomerase [EC:5.99.1.4]

Other DBs

RHEA:

27404

LinkDB

DBGET integrated database retrieval system