KEGG ORTHOLOGY: K15314

ORTHOLOGY: K15314

Entry

K15314                      KO

Symbol

sgcE, mdpE, ncsE, kedE, calE8, pksE

Name

enediyne polyketide synthase

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

M00825

10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core

Reaction

R11435

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
  Iterative type I PKS
   Bacterial type
    K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase

Other DBs

COG:	COG0331 COG3321 COG1028

Genes

LANH:

TAMN:

MCA:

METU:

MMEO:

MAH:	MEALZ_1605

MBUR:

EQU24_12390

MEIN:

methR_P2299

TIG:

THII_0012

REV:	HUE57_15315

POX:	MB84_31255

ECOM:

QTN59_00795

DOV:	DSCO28_52900

DWD:	DSCW_50130

DALK:

DSCA_31660

ADE:

Adeh_3899

ACP:	A2cp1_4041

ANK:	AnaeK_4000

HOH:

Hoch_0693

LFB:	C1X05_03380

NBR:	O3I_023120

NTP:	CRH09_15810

NOZ:	DMB37_04400 DMB37_37225

NAH:	F5544_22905

RER:

RER_03770

REY:

O5Y_01845

REB:	XU06_02050

RQI:	C1M55_02140

SGR:	SGR_609(pksE)

SGB:

SANL:

STRM:

SCLF:

SGS:	AVL59_07295 AVL59_19230

SPLU:

LK06_002505

STIR:

DDW44_31470

SGZ:	C0216_12050

SSPB:

CP982_03205

SGK:	PET44_34885

SFIY:

F0344_34710

SLAI:

P8A22_37555

RIA:	C7V51_07095

AIL:	FLP10_09560

THAO:

NI17_008395

NGV:	CDO52_11635

NEX:	NE857_19710

NCG:	KGD84_11505

SNAH:

OUQ99_16590

ACTW:

F7P10_19165

ACIR:

OG979_40600

SPIQ:

OHA34_00410 OHA34_03970

SRO:	Sros_6999 Sros_8249

NGN:	LCN96_24415

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30260

AMYC:

CU254_17290

AMYB:

BKN51_01415

AAB:	A4R43_37300

AMYY:

YIM_40785(ppsA6)

AORI:

APRT:

AROO:

APRE:

AMI:

SESP:

BN6_39290(pks6-2)

SSYI:

EKG83_13185 EKG83_27920

KPHY:

AOZ06_31050

ACTI:

UA75_19075

ACAD:

UA74_18585

AHG:	AHOG_16585(ppsA)

ALO:

CRK57498

ACTU:

Actkin_05268(ppsA_10)

UME:	RM788_41540

STP:	Strop_0598 Strop_2697

SAQ:	Sare_0551 Sare_2179

MAU:	Micau_2514

MIL:

MICB:

MICH:

MTEM:

MCAB:

VMA:	VAB18032_18450

MCRA:

MENO:

MCHL:

MPRN:

ACTN:

L083_3210(pks1C)

AIH:	Aiant_18150

PLAB:

C6361_26110

PLAT:

C6W10_12740

PFLA:

Pflav_005000

PSUU:

Psuf_058040 Psuf_070000

PRY:	Prubr_36670

CCAZ:

COUCH_16280

CAI:

Caci_6351

WNA:	KA717_09025

CHON:

NIES4102_18920 NIES4102_18930

MAR:

MAE_12840

MPK:

VL20_1920

MIQ:	B5D77_13875

MVZ:	myaer102_46860

CYJ:	Cyan7822_0309 Cyan7822_5840 Cyan7822_5841

GML:	ISF26_08925

NOP:	Nos7524_5243

NED:	HUN01_33010

RSIN:

B6N60_00268

NCN:	BZZ01_17185

HAU:

Haur_0866

UAM:	UABAM_02751

CSAC:

SIO70_14460

AG:	AAM78012(ncsE) AAM94794(calE8) AAQ17110(mdpE) AFV52145(kedE)

» show all

Reference

PMID:20534556

Authors

Horsman GP, Chen Y, Thorson JS, Shen B

Title

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.

Journal

Proc Natl Acad Sci U S A 107:11331-5 (2010)
DOI:10.1073/pnas.1003442107

Reference

PMID:19362637

Authors

Horsman GP, Van Lanen SG, Shen B

Title

Iterative type I polyketide synthases for enediyne core biosynthesis.

Journal

Methods Enzymol 459:97-112 (2009)
DOI:10.1016/S0076-6879(09)04605-9

Reference

PMID:12183628 (sgcE)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33990]

Reference

PMID:17918933 (mdpE)

Authors

Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B

Title

Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.

Journal

J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o

Sequence

[ag:AAQ17110]

Reference

PMID:15797213 (ncsE)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78012]

Reference

PMID:23360970 (kedE)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52145]

Reference

PMID:12183629 (calE8)

Authors

Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS

Title

The calicheamicin gene cluster and its iterative type I enediyne PKS.

Journal

Science 297:1173-6 (2002)
DOI:10.1126/science.1072105

Sequence

[ag:AAM94794]

LinkDB

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