KEGG   ORTHOLOGY: K15373
Entry
K15373                      KO                                     
Symbol
isfD
Name
sulfoacetaldehyde reductase [EC:1.1.1.313]
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Reaction
R02600  isethionate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K15373  isfD; sulfoacetaldehyde reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.313  sulfoacetaldehyde reductase (NADPH)
     K15373  isfD; sulfoacetaldehyde reductase
Genes
ENR: H650_21530
ENF: AKI40_3718
KPN: KPN_00576
KPU: KP1_1516
KPM: KPHS_14060
KPP: A79E_3668
KPH: KPNIH24_21755
KPZ: KPNIH27_06510
KPV: KPNIH29_07210
KPW: KPNIH30_07240
KPY: KPNIH31_07125
KPG: KPNIH32_07345
KPC: KPNIH10_07035
KPQ: KPR0928_06945
KPT: VK055_1961(sdh)
KPO: KPN2242_05720
KPR: KPR_3984
KPJ: N559_3751
KPI: D364_02995
KPA: KPNJ1_04010
KPX: PMK1_02903(isfD)
KPB: FH42_23905
KPNE: KU54_019415
KPNU: LI86_19240
KPNK: BN49_1630
KVA: Kvar_3797
KPE: KPK_4008
KPK: A593_17310
KVD: KR75_14770
KVQ: SP68_21400
KOX: KOX_13770
KOE: A225_1573
KOY: J415_23770
KOM: HR38_12515
KOK: KONIH1_07720
KOC: AB185_28375
KQU: AVR78_11510
KLL: BJF97_08105
KLW: DA718_20615
KAR: LGL98_18440
KGR: JJJ10_20430
KPAS: LUW96_14500
KLC: K7H21_20455
KLM: BWI76_07595
REE: electrica_03726(isfD)
ROR: RORB6_12190
RON: TE10_08740
RPLN: B1209_19890
RAO: DSD31_18740
RTG: NCTC13098_05468(sdh)
PGE: LG71_22100
KSA: C813_08935
KOR: AWR26_18435
KRD: A3780_05845
KPSE: IP581_05955
KOO: O9K67_18310
KOU: C0557_06255
KGO: CEW81_17995
KIE: NCTC12125_02387(sdh)
KAS: KATP_32820
KLU: K7B04_11875
KCY: RIN60_16890
KIN: AB182_18395
PDZ: HHA33_20875
METY: MRY16398_41760
PVJ: LMA04_06695
SUPE: P0H77_06935
EBC: C2U52_29615
EBU: CUC76_08560
SERA: Ser39006_001610
SERQ: CWC46_01610
DAQ: DAQ1742_04400
DLC: O1Q98_12030
DDA: Dd703_0033
BGJ: AWC36_18995
BRB: EH207_00165
BNG: EH206_00325
PROD: PCO85_00670
LBQ: CKQ53_05475
LPOP: I6N93_00125
VNA: PN96_16100
VEJ: VEJY3_24206
VBR: A6E01_10135
VCC: FAZ90_18230
VAS: GT360_16430
VZI: G5S32_21200
VOS: KNV97_10020
VCRA: IS519_17345
PGB: H744_1c1567
PPSE: BN5_0584
PFV: Psefu_4080
PRH: LT40_19355
PSES: PSCI_0298
PALL: UYA_03345
PSEJ: HNQ25_20830
PKH: JLK41_03575
PTY: JWV26_14350
PPHN: HU825_04595
PCHE: QYM18_11210
PSLP: BHQ29_18710
PSA: PST_4121
PSZ: PSTAB_4103
PSR: PSTAA_4273
PSC: A458_00540
PSJ: PSJM300_18885
PSH: Psest_0101
PSTT: CH92_10795
PSTU: UIB01_00490
PSED: DM292_19735
PCHL: LLJ08_00490
PBM: CL52_20375
PKG: LW136_00495
SDEG: GOM96_10015
PZD: KQ248_07990
AVN: Avin_16870 Avin_30890
AVL: AvCA_16870 AvCA_30890
AVD: AvCA6_16870 AvCA6_30890
ACX: Achr_17360 Achr_26200
EMO: DM558_08540
EAZ: JHT90_10540
ENTO: MTZ49_15490
HPEG: EAO82_01580
HAES: LO767_00655
HARR: HV822_10695
PBAU: OS670_13085
MSR: AU15_02960
TZO: THMIRHAT_10700
SSAL: SPISAL_03475
CSA: Csal_0161 Csal_2684
CCAG: SR908_04100 SR908_07265
HCS: FF32_03330
HAK: KO116_00630
HAM: HALO0642
HSI: BOX17_12380
HALO: BWR19_05090 BWR19_11015
HHH: CLM76_08275
HPRO: LMS44_20250
HQD: K1Y77_15710
HALF: QEN58_17610
HHAO: QWG60_09720
HASO: B2G49_15610
HASH: HXW73_16000
HAMS: NF683_03725
HAAH: HALA3H3_490001(isfD)
HAXH: J4377_15725
HALK: CUU95_08810
HVN: EI420_17320
HOL: HORIV_63670
HSR: HSBAA_60050
HPIZ: GYM47_15200
HNP: SR894_18565
HTT: HZS52_07980
HTX: EKK97_11325
ZPL: ZBT109_2532
HAA: A5892_16765
KUS: B9G99_08575
KMA: B9H00_06270
KUY: FY550_02415 FY550_11870
SAJS: QO259_04000
CDIZ: CEDIAZO_03401(isfD)
BOJ: CBF45_06055
ODI: ODI_R0192
KGY: EHF36_06485
HGR: DW355_05040
MMYR: MXMO3_02929
AUA: M673_19980
EBLA: JGUZn3_01220(isfD)
 » show all
Reference
PMID:20133363
  Authors
Krejcik Z, Hollemeyer K, Smits TH, Cook AM
  Title
Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase.
  Journal
Microbiology 156:1547-55 (2010)
DOI:10.1099/mic.0.036699-0
  Sequence
[csa:Csal_2684 Csal_0161]
LinkDB

KEGG   ENZYME: 1.1.1.313
Entry
EC 1.1.1.313                Enzyme                                 
Name
sulfoacetaldehyde reductase (NADPH);
isfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
isethionate:NADP+ oxidoreductase
Reaction(IUBMB)
isethionate + NADP+ = 2-sulfoacetaldehyde + NADPH + H+ [RN:R02600]
Reaction(KEGG)
R02600
Substrate
isethionate [CPD:C05123];
NADP+ [CPD:C00006]
Product
2-sulfoacetaldehyde [CPD:C00593];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells. cf. EC 1.1.1.433, sulfoacetaldehyde reductase (NADH).
History
EC 1.1.1.313 created 2011, modified 2022
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K15373  sulfoacetaldehyde reductase
Genes
ENR: H650_21530
ENF: AKI40_3718
KPN: KPN_00576
KPU: KP1_1516
KPM: KPHS_14060
KPP: A79E_3668
KPH: KPNIH24_21755
KPZ: KPNIH27_06510
KPV: KPNIH29_07210
KPW: KPNIH30_07240
KPY: KPNIH31_07125
KPG: KPNIH32_07345
KPC: KPNIH10_07035
KPQ: KPR0928_06945
KPT: VK055_1961(sdh)
KPO: KPN2242_05720
KPR: KPR_3984
KPJ: N559_3751
KPI: D364_02995
KPA: KPNJ1_04010
KPX: PMK1_02903(isfD)
KPB: FH42_23905
KPNE: KU54_019415
KPNU: LI86_19240
KPNK: BN49_1630
KVA: Kvar_3797
KPE: KPK_4008
KPK: A593_17310
KVD: KR75_14770
KVQ: SP68_21400
KOX: KOX_13770
KOE: A225_1573
KOY: J415_23770
KOM: HR38_12515
KOK: KONIH1_07720
KOC: AB185_28375
KQU: AVR78_11510
KLL: BJF97_08105
KLW: DA718_20615
KAR: LGL98_18440
KGR: JJJ10_20430
KPAS: LUW96_14500
KLC: K7H21_20455
KLM: BWI76_07595
REE: electrica_03726(isfD)
ROR: RORB6_12190
RON: TE10_08740
RPLN: B1209_19890
RAO: DSD31_18740
RTG: NCTC13098_05468(sdh)
PGE: LG71_22100
KSA: C813_08935
KOR: AWR26_18435
KRD: A3780_05845
KPSE: IP581_05955
KOO: O9K67_18310
KOU: C0557_06255
KGO: CEW81_17995
KIE: NCTC12125_02387(sdh)
KAS: KATP_32820
KLU: K7B04_11875
KCY: RIN60_16890
KIN: AB182_18395
PDZ: HHA33_20875
METY: MRY16398_41760
PVJ: LMA04_06695
SUPE: P0H77_06935
EBC: C2U52_29615
EBU: CUC76_08560
SERA: Ser39006_001610
SERQ: CWC46_01610
DAQ: DAQ1742_04400
DLC: O1Q98_12030
DDA: Dd703_0033
BGJ: AWC36_18995
BRB: EH207_00165
BNG: EH206_00325
PROD: PCO85_00670
LBQ: CKQ53_05475
LPOP: I6N93_00125
VNA: PN96_16100
VEJ: VEJY3_24206
VBR: A6E01_10135
VCC: FAZ90_18230
VAS: GT360_16430
VZI: G5S32_21200
VOS: KNV97_10020
VCRA: IS519_17345
PGB: H744_1c1567
PPSE: BN5_0584
PFV: Psefu_4080
PRH: LT40_19355
PSES: PSCI_0298
PALL: UYA_03345
PSEJ: HNQ25_20830
PKH: JLK41_03575
PTY: JWV26_14350
PPHN: HU825_04595
PCHE: QYM18_11210
PSLP: BHQ29_18710
PSA: PST_4121
PSZ: PSTAB_4103
PSR: PSTAA_4273
PSC: A458_00540
PSJ: PSJM300_18885
PSH: Psest_0101
PSTT: CH92_10795
PSTU: UIB01_00490
PSED: DM292_19735
PCHL: LLJ08_00490
PBM: CL52_20375
PKG: LW136_00495
SDEG: GOM96_10015
PZD: KQ248_07990
AVN: Avin_16870 Avin_30890
AVL: AvCA_16870 AvCA_30890
AVD: AvCA6_16870 AvCA6_30890
ACX: Achr_17360 Achr_26200
EMO: DM558_08540
EAZ: JHT90_10540
ENTO: MTZ49_15490
HPEG: EAO82_01580
HAES: LO767_00655
HARR: HV822_10695
PBAU: OS670_13085
MSR: AU15_02960
TZO: THMIRHAT_10700
SSAL: SPISAL_03475
CSA: Csal_0161 Csal_2684
CCAG: SR908_04100 SR908_07265
HCS: FF32_03330
HAK: KO116_00630
HAM: HALO0642
HSI: BOX17_12380
HALO: BWR19_05090 BWR19_11015
HHH: CLM76_08275
HPRO: LMS44_20250
HQD: K1Y77_15710
HALF: QEN58_17610
HHAO: QWG60_09720
HASO: B2G49_15610
HASH: HXW73_16000
HAMS: NF683_03725
HAAH: HALA3H3_490001(isfD)
HAXH: J4377_15725
HALK: CUU95_08810
HVN: EI420_17320
HOL: HORIV_63670
HSR: HSBAA_60050
HPIZ: GYM47_15200
HNP: SR894_18565
HTT: HZS52_07980
HTX: EKK97_11325
ZPL: ZBT109_2532
HAA: A5892_16765
KUS: B9G99_08575
KMA: B9H00_06270
KUY: FY550_02415 FY550_11870
SAJS: QO259_04000
CDIZ: CEDIAZO_03401(isfD)
BOJ: CBF45_06055
ODI: ODI_R0192
KGY: EHF36_06485
HGR: DW355_05040
MMYR: MXMO3_02929
AUA: M673_19980
EBLA: JGUZn3_01220(isfD)
 » show all
Reference
1  [PMID:20133363]
  Authors
Krejcik Z, Hollemeyer K, Smits TH, Cook AM
  Title
Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase.
  Journal
Microbiology 156:1547-55 (2010)
DOI:10.1099/mic.0.036699-0
  Sequence
[csa:Csal_2684 Csal_0161]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.313
IUBMB Enzyme Nomenclature: 1.1.1.313
ExPASy - ENZYME nomenclature database: 1.1.1.313
BRENDA, the Enzyme Database: 1.1.1.313
LinkDB

KEGG   REACTION: R02600
Entry
R02600                      Reaction                               
Name
isethionate:NADP+ oxidoreductase
Definition
Sulfoacetaldehyde + NADPH + H+ <=> 2-Hydroxyethanesulfonate + NADP+
Equation
C00593 + C00005 + C00080 <=> C05123 + C00006
Reaction class
RC00001  C00005_C00006
RC00087  C00593_C05123
Enzyme
1.1.1.313
Pathway
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.313
     R02600  Sulfoacetaldehyde + NADPH + H+ <=> 2-Hydroxyethanesulfonate + NADP+
Orthology
K15373  sulfoacetaldehyde reductase [EC:1.1.1.313]
Other DBs
RHEA: 29594
LinkDB

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