KEGG ORTHOLOGY: K15500

ORTHOLOGY: K15500

Entry

K15500                      KO

Symbol

PPP6R2, SAPS2

Name

serine/threonine-protein phosphatase 6 regulatory subunit 2

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K15500  PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K15500  PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-6
    Regulatory subunits
     K15500  PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   Other DSBR factors
    Protein phosphatase 6
     K15500  PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2

Genes

HSA:	9701(PPP6R2)

PTR:	458987(PPP6R2)

PPS:	100971975(PPP6R2)

GGO:	101135918(PPP6R2)

PON:	100441303(PPP6R2)

NLE:	100581471(PPP6R2)

HMH:	116458993(PPP6R2)

MCC:	720657(PPP6R2)

MCF:	102129280(PPP6R2)

MTHB:

126929426

MNI:	105489750(PPP6R2)

CSAB:

103223559(PPP6R2)

CATY:

105586870(PPP6R2)

PANU:

101004127(PPP6R2)

TGE:	112632684(PPP6R2)

MLEU:

105543601(PPP6R2)

RRO:	104655406(PPP6R2)

RBB:	108539412(PPP6R2)

TFN:	117096263(PPP6R2)

PTEH:

111548881(PPP6R2)

CANG:

105512010(PPP6R2)

CJC:	100399506(PPP6R2)

SBQ:	101041442(PPP6R2)

CIMI:

108286827(PPP6R2)

CSYR:

103251159(PPP6R2)

MMUR:

105885012(PPP6R2)

LCAT:

123640761(PPP6R2)

PCOQ:

105813948(PPP6R2)

OGA:	100964105(PPP6R2)

MMU:	71474(Ppp6r2)

MCAL:

110310191(Ppp6r2)

MPAH:

110334802(Ppp6r2)

RNO:	300146(Ppp6r2)

MCOC:

116077877(Ppp6r2)

ANU:	117718513(Ppp6r2)

MUN:	110549679(Ppp6r2)

CGE:	100755203(Ppp6r2)

MAUA:

101826857(Ppp6r2)

PROB:

127225946(Ppp6r2)

PLEU:

114693024(Ppp6r2)

MORG:

121461207(Ppp6r2)

MFOT:

126493414

AAMP:

119822977(Ppp6r2)

NGI:	103735478(Ppp6r2)

HGL:	101701944(Ppp6r2)

CPOC:

100720382(Ppp6r2)

CCAN:

109697569(Ppp6r2)

DORD:

105992744(Ppp6r2)

DSP:	122123633(Ppp6r2)

PLOP:

125356928(Ppp6r2)

NCAR:

124981935

MMMA:

107160242(Ppp6r2)

OCU:

100352630

OPI:	101528238(PPP6R2)

TUP:	102501313(PPP6R2)

GVR:	103591319(PPP6R2)

CFA:	481191(PPP6R2)

CLUD:

112665517(PPP6R2)

VVP:	112935848(PPP6R2)

VLG:	121491405(PPP6R2)

NPO:	129511503(PPP6R2)

AML:	100474955(PPP6R2)

UMR:	103674003(PPP6R2)

UAH:	113241609(PPP6R2)

UAR:	123803801(PPP6R2)

ELK:

111157448

LLV:

125107915

MPUF:

101686735(PPP6R2)

MNP:	132019079(PPP6R2)

MLK:	131839660(PPP6R2)

NVS:	122892464(PPP6R2)

ORO:	101385932(PPP6R2)

EJU:	114218411(PPP6R2)

ZCA:	113923076(PPP6R2)

MLX:	117997737(PPP6R2)

NSU:	110577977(PPP6R2)

LWW:	102729037(PPP6R2)

FCA:	101084465(PPP6R2)

PYU:	121040114(PPP6R2)

PCOO:

112863381(PPP6R2)

PBG:	122472993(PPP6R2)

PVIV:

125169514(PPP6R2)

LRUF:

124502151

PTG:	102961458(PPP6R2)

PPAD:

109265772(PPP6R2)

PUC:

125919744

AJU:

106987619

HHV:	120233501(PPP6R2)

BTA:	510764(PPP6R2)

BOM:	102270714(PPP6R2)

BBUB:

102396914(PPP6R2)

BBIS:

104988093

CHX:	102188397(PPP6R2)

OAS:	101116982(PPP6R2)

BTAX:

128049034(PPP6R2)

ODA:	120857801(PPP6R2)

CCAD:

122423848(PPP6R2)

MBEZ:

129537225(PPP6R2)

SSC:	100517282(PPP6R2)

CFR:	102523269(PPP6R2)

CBAI:

105070810(PPP6R2)

CDK:	105090352(PPP6R2)

VPC:	102524714(PPP6R2)

BACU:

103010139(PPP6R2)

BMUS:

118902492(PPP6R2) 118905372

LVE:	103082669(PPP6R2)

OOR:	101281686(PPP6R2)

DLE:	111186438(PPP6R2)

PCAD:

102981014(PPP6R2)

PSIU:

116761289(PPP6R2) 116763191

NASI:

112394630(PPP6R2) 112413764

ECB:	100055355(PPP6R2)

EPZ:	103564760(PPP6R2)

EAI:	106846009(PPP6R2)

MYB:	102256593(PPP6R2)

MYD:	102763336(PPP6R2)

MMYO:

118657392(PPP6R2)

MLF:	102441712(PPP6R2)

PKL:	118714745(PPP6R2)

EFUS:

103298653(PPP6R2)

MNA:	107536064(PPP6R2)

DRO:	112321928(PPP6R2)

SHON:

118988826(PPP6R2)

AJM:	119060578(PPP6R2)

PDIC:

114513504(PPP6R2)

PHAS:

123816083(PPP6R2)

MMF:	118641177(PPP6R2)

PPAM:

129068303(PPP6R2)

HAI:	109396620(PPP6R2)

RFQ:	117028418(PPP6R2)

PALE:

102881569(PPP6R2)

PGIG:

120602811(PPP6R2)

PVP:	105308292(PPP6R2)

RAY:	107500250(PPP6R2)

MJV:	108395601(PPP6R2)

TOD:	119248161(PPP6R2)

SARA:

101546117(PPP6R2)

SETR:

126006207(PPP6R2)

LAV:	100654668(PPP6R2)

TMU:

101348107

ETF:	101654163(PPP6R2)

DNM:	101420077(PPP6R2)

MDO:	100011292(PPP6R2)

GAS:	123249527(PPP6R2)

SHR:	100929755(PPP6R2)

AFZ:

127538829

PCW:	110205908(PPP6R2)

OAA:	100086153(PPP6R2)

GGA:	430580(PPP6R2)

PCOC:

116236432(PPP6R2)

MGP:	100540570(PPP6R2)

CJO:	107307955(PPP6R2)

TPAI:

128079657(PPP6R2)

LMUT:

125683942(PPP6R2)

NMEL:

110392183(PPP6R2)

APLA:

101799955(PPP6R2)

ACYG:

106048861(PPP6R2)

CATA:

118259619(PPP6R2)

AFUL:

116486157(PPP6R2)

TGU:	115492565(PPP6R2)

LSR:	110479246(PPP6R2)

SCAN:

103824815(PPP6R2)

PMOA:

120500107(PPP6R2)

OTC:	121336435(PPP6R2)

PRUF:

121355092(PPP6R2)

GFR:	102045109(PPP6R2)

FAB:	101808451(PPP6R2)

OMA:	130248707(PPP6R2)

PHI:	102104134(PPP6R2)

PMAJ:

107199191(PPP6R2)

CCAE:

111923224

CCW:	120411855(PPP6R2)

CBRC:

103619214(PPP6R2)

ETL:	114069537(PPP6R2)

ZAB:

102066453

ACHL:

103804604(PPP6R2)

SVG:	106862025(PPP6R2)

MMEA:

130587320

HRT:	120751826(PPP6R2)

FPG:	101916151(PPP6R2)

FCH:	102058445(PPP6R2)

CLV:	102084397(PPP6R2)

EGZ:	104127897(PPP6R2)

NNI:	104017328(PPP6R2)

PCRI:

104027375(PPP6R2)

PLET:

104628190(PPP6R2)

PCAO:

104041523

ACUN:

113490413(PPP6R2)

TALA:

104359148(PPP6R2)

PADL:

103913584(PPP6R2)

AFOR:

103893348(PPP6R2)

ACHC:

115340962(PPP6R2)

HALD:

104318640(PPP6R2)

HLE:	104830859(PPP6R2)

AGEN:

126044251

GCL:

127019326

CCRI:

104160032(PPP6R2)

CMAC:

104484451(PPP6R2)

BREG:

104633900(PPP6R2)

FGA:	104083924(PPP6R2)

GSTE:

104254039(PPP6R2)

LDI:	104344574(PPP6R2)

MNB:	103771022(PPP6R2)

OHA:	104332097(PPP6R2)

NNT:	104403604(PPP6R2)

SHAB:

115601750(PPP6R2)

DPUB:

104304908(PPP6R2)

PGUU:

104470499(PPP6R2)

CPEA:

104397844(PPP6R2)

CVF:	104287192(PPP6R2)

RTD:	128908954(PPP6R2)

CUCA:

104062245(PPP6R2)

TEO:	104377483(PPP6R2)

AAM:	106487156(PPP6R2)

AROW:

112968666(PPP6R2)

NPD:	112953475(PPP6R2)

TGT:	104580652(PPP6R2)

DNE:	112991016(PPP6R2)

SCAM:

104150350(PPP6R2)

ASN:	102387378(PPP6R2)

AMJ:	106736989(PPP6R2)

CPOO:

109315877(PPP6R2)

GGN:	109292296(PPP6R2)

PSS:	102461536(PPP6R2)

CMY:	102947775(PPP6R2)

CCAY:

125622555(PPP6R2)

DCC:	119853466(PPP6R2)

CPIC:

101944824(PPP6R2)

TST:	117873634(PPP6R2)

CABI:

116818760(PPP6R2)

MRV:	120395627(PPP6R2)

ACS:	103281746(ppp6r2)

ASAO:

132775554(PPP6R2)

PVT:	110084403(PPP6R2)

SUND:

121930325(PPP6R2)

PBI:	103051617(PPP6R2)

PMUR:

107289200(PPP6R2)

CTIG:

120299965(PPP6R2)

TSR:

106542457

PGUT:

117672978(PPP6R2)

APRI:

131201708(PPP6R2)

PTEX:

113450633(PPP6R2)

NSS:	113425650(PPP6R2)

VKO:	123023262(PPP6R2)

PMUA:

114605693(PPP6R2)

PRAF:

128422444(PPP6R2)

ZVI:	118090868(PPP6R2)

HCG:	128327911(PPP6R2)

GJA:	107114085(PPP6R2)

STOW:

125434282(PPP6R2)

EMC:	129335442(PPP6R2)

XLA:	444243(ppp6r2.L)

XTR:	100125053(ppp6r2)

NPR:	108790481(PPP6R2)

RTEM:

120931594(PPP6R2)

BBUF:

120985543(PPP6R2)

BGAR:

122927761(PPP6R2)

MUO:	115478442(PPP6R2)

GSH:	117366542(PPP6R2)

DRE:	560729(ppp6r2a) 570360(ppp6r2b)

SRX:	107705809 107733000 107738817

SANH:

107662845 107686562 107694165 107699058

SGH:	107557302 107564901 107590524 107600605

CCAR:

109064637 109104182 109109421

CAUA:

113048104 113062439 113079194 113100337 113118147

CGIB:

127934373 127956918 127974153 127977244

PTET:

122343509(ppp6r2a) 122363063(ppp6r2b)

LROH:

127163802(ppp6r2a) 127180983(ppp6r2b)

OMC:	131524264(ppp6r2b) 131538690(ppp6r2a)

PPRM:

120464888(ppp6r2b) 120476960(ppp6r2a)

RKG:	130071299(ppp6r2b) 130072233(ppp6r2a)

MAMB:

125245655(ppp6r2a) 125253870(ppp6r2b)

CIDE:

127499380 127510834

MASI:

127416660 127434900 127436757 127456437

TROS:

130547703(ppp6r2a) 130562733(ppp6r2b) 130566189

TDW:	130420291(ppp6r2a) 130435993(ppp6r2b)

MANU:

129418923(ppp6r2b) 129431728(ppp6r2a)

IPU:	108264053(ppp6r2b) 108275031(ppp6r2a)

IFU:	128606373(ppp6r2b) 128617924(ppp6r2a)

PHYP:

113526335 113529669(ppp6r2)

SMEO:

124392783(ppp6r2a) 124395484(ppp6r2b)

TFD:	113654078(ppp6r2a) 113657285(ppp6r2b)

TVC:	132851780(ppp6r2b) 132856578(ppp6r2a)

AMEX:

103025373 103025683

CMAO:

118812072(ppp6r2a) 118818562(ppp6r2b)

EEE:	113570897 113579989

CHAR:

116218246

TRU:	101066797 101067363

TFS:	130519056(ppp6r2a) 130535994(ppp6r2b)

TNG:	GSTEN00012929G001 GSTEN00035564G001

LCO:	104918110 104923754

NCC:	104957412(ppp6r2)

TBEN:

117483059(ppp6r2a) 117491466(ppp6r2b)

CGOB:

115010176 115028175

PGEO:

117439037(ppp6r2a) 117448000(ppp6r2b)

GACU:

117553142(ppp6r2a) 117557648(ppp6r2b)

EMAC:

134879209(ppp6r2b) 134879457(ppp6r2a)

ELY:	117249242(ppp6r2a) 117262121(ppp6r2b)

EFO:	125883148(ppp6r2a) 125888128(ppp6r2b)

PLEP:

121949763(ppp6r2b) 121961136(ppp6r2a)

SLUC:

116045636(ppp6r2b) 116054683(ppp6r2a)

ECRA:

117939983(ppp6r2a) 117949047(ppp6r2b)

ESP:	116677633 116694155(ppp6r2)

PFLV:

114550574 114559762

GAT:	120808657(ppp6r2b) 120812357 120817493(ppp6r2a)

PPUG:

119195511(ppp6r2b) 119210279(ppp6r2a)

AFB:	129108892(ppp6r2b) 129112849(ppp6r2a)

CLUM:

117726531(ppp6r2a) 117732346(ppp6r2b)

PSWI:

130195052(ppp6r2b) 130200928

MSAM:

119893499(ppp6r2b) 119917929(ppp6r2a)

SCHU:

122871647(ppp6r2a) 122875508(ppp6r2b)

CUD:	121505287(ppp6r2a) 121515098(ppp6r2b)

ALAT:

119024104(ppp6r2b) 119032807(ppp6r2a)

MZE:	101464791(ppp6r2) 101480002

ONL:	100707429 100707632

OAU:	116313485(ppp6r2b) 116317363(ppp6r2a)

OLA:	101169006(ppp6r2) 101175152

OML:	112151770(ppp6r2b) 112154555(ppp6r2a)

CSAI:

133424384(ppp6r2a) 133444288(ppp6r2b)

XMA:	102221355 102236071(ppp6r2)

XCO:	114152728(ppp6r2) 114160834

XHE:	116733072(ppp6r2) 116736534

PRET:

103459548 103466679(ppp6r2)

PFOR:

103131613 103133786(ppp6r2)

PLAI:

106937823 106954920(ppp6r2)

PMEI:

106907180(ppp6r2) 106924870

GAF:	122826071(ppp6r2a) 122835528(ppp6r2b)

PPRL:

129354750(ppp6r2a) 129360270(ppp6r2b)

CVG:	107090553(ppp6r2) 107098827

CTUL:

119771693(ppp6r2a) 119772459(ppp6r2b)

GMU:	124859307(ppp6r2b) 124883355

NFU:	107373115 107383303 107388848

KMR:	108230165(ppp6r2b) 108250966

ALIM:

106514293 106525781

NWH:	119416278(ppp6r2b) 119428162

AOCE:

111579281(ppp6r2) 111586364

MCEP:

124999998(ppp6r2a) 125014478(ppp6r2b)

CSEM:

103380074 103382987

POV:	109624053(ppp6r2) 109637495

SSEN:

122766007(ppp6r2a) 122775904(ppp6r2b)

HHIP:

117757403 117762698(ppp6r2b)

HSP:	118101545(ppp6r2a) 118109105(ppp6r2b)

SMAU:

118301248(ppp6r2a) 118314886(ppp6r2b)

LCF:	108875141(ppp6r2b) 108897442(ppp6r2a)

SDU:	111224522 111228503(ppp6r2)

SLAL:

111653358 111665409

XGL:	120793810(ppp6r2b) 120800222(ppp6r2a)

HCQ:	109513625 109531064(ppp6r2)

SSCV:

125971090 125992264

SBIA:

133493694(ppp6r2a) 133502330(ppp6r2b)

PEE:	133397098(ppp6r2a) 133403326(ppp6r2b)

PTAO:

133472042(ppp6r2a) 133478317(ppp6r2b)

BPEC:

110169194(ppp6r2) 110172368

MALB:

109960910(ppp6r2) 109967737

BSPL:

114856730(ppp6r2b) 114862406(ppp6r2a)

SJO:	128358748(ppp6r2b) 128385278(ppp6r2a)

SASA:

106561245(ppp6r2) 106573421 106576237 106609365

STRU:

115152068 115180522 115197248 115198893

OTW:	112216964 112218633(ppp6r2b) 112247335 112252466

OMY:	110490387 110496452(ppp6r2b) 110500095 110521764

OGO:	123994524 124001695 124013914 124035965

ONE:	115107033 115109481 115114970 115133066

OKI:	109866938 109889416 109896292 109910320

OKE:	118365969 118392436 118396774 118401161

SALP:

111949529 111951395 111952728 111962542

SNH:	120031769 120049926 120053964 120060690

CCLU:

121531971 121543545 121548656 121576352

ELS:	105020220 105022203

SFM:	108936475 108942294(ppp6r2)

PKI:	111842438 111846127(ppp6r2)

AANG:

118219131(ppp6r2b) 118231856

LOC:	102698832(ppp6r2)

PSPA:

121318166 121319940

ARUT:

117415872 117419409(ppp6r2a)

PSEX:

120534176(ppp6r2a)

LCM:	102357720(PPP6R2)

AFUN:

MGEN:

NMEA:

CGIG:

VCAN:

PGW:

DPX:	DAPPUDRAFT_310134

DMK:

DPZ:

HAME:

TCF:

PPOI:

TUT:

TSP:

Reference

PMID:20065038

Authors

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP

Title

Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

Journal

Mol Cell Biol 30:1368-81 (2010)
DOI:10.1128/MCB.00741-09

Sequence

[hsa:9701]

Reference

PMID:16769727

Authors

Stefansson B, Brautigan DL

Title

Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.

Journal

J Biol Chem 281:22624-34 (2006)
DOI:10.1074/jbc.M601772200

Sequence

[hsa:9701]

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