KEGG ORTHOLOGY: K15607

ORTHOLOGY: K15607

Entry

K15607                      KO

Symbol

TLX3, HOX11L2

Name

T-cell leukemia homeobox protein 3

Pathway

map05202

Transcriptional misregulation in cancer

Disease

H00002

T-cell acute lymphoblastic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15607  TLX3, HOX11L2; T-cell leukemia homeobox protein 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K15607  TLX3, HOX11L2; T-cell leukemia homeobox protein 3
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain ANTP: NKL
    K15607  TLX3, HOX11L2; T-cell leukemia homeobox protein 3

Genes

HSA:	30012(TLX3)

PTR:	471737(TLX3)

PPS:	100979317(TLX3)

GGO:	101140896(TLX3)

PON:	100459384(TLX3)

PPYG:

129037258(TLX3)

NLE:	100603915(TLX3)

HMH:	116470498(TLX3)

SSYN:

129485684(TLX3)

MCC:	701703(TLX3)

MCF:	102139514(TLX3)

MTHB:

126956977

MNI:	105480858(TLX3)

CSAB:

103244965(TLX3)

CATY:

105581643(TLX3)

PANU:

101022319(TLX3)

TGE:	112626588(TLX3)

MLEU:

105544978(TLX3)

RRO:	104670119(TLX3)

RBB:	108513594(TLX3)

TFN:	117064542(TLX3)

PTEH:

111547104(TLX3)

CANG:

105515841(TLX3)

CJC:	100385533(TLX3)

SBQ:	101046973(TLX3)

CIMI:

108317347(TLX3)

ANAN:

105723164(TLX3)

MMUR:

105867184(TLX3)

LCAT:

123638872(TLX3)

PCOQ:

105814651(TLX3)

OGA:	100948666(TLX3)

MMU:	27140(Tlx3)

MCAL:

110305939(Tlx3)

MPAH:

110332044(Tlx3)

RNO:	497881(Tlx3)

MCOC:

116079026(Tlx3)

ANU:	117711387(Tlx3)

ASYL:

127695312(Tlx3)

MUN:	110549556(Tlx3)

CGE:

113836634

MAUA:

101830430(Tlx3)

PROB:

127219439(Tlx3)

PLEU:

114683473(Tlx3)

MORG:

121464050(Tlx3)

MFOT:

126494900

AAMP:

119813544(Tlx3)

NGI:	103748182(Tlx3)

HGL:	101702946(Tlx3)

CPOC:

100724310(Tlx3)

CCAN:

109696983(Tlx3)

DSP:	122101872(Tlx3)

PLOP:

125341986(Tlx3)

NCAR:

124987388

MMMA:

107147962(Tlx3)

ITI:	101954939(Tlx3)

OCU:

100340221

OPI:	101534064(TLX3)

TUP:	102497377(TLX3)

GVR:	103594348(TLX3)

CFA:	489123(TLX3)

CLUD:

112651811(TLX3)

VVP:	112928535(TLX3)

VLG:	121486097(TLX3)

NPO:	129509333(TLX3)

AML:	100464754(TLX3)

UMR:

121102748

UAH:	113263896(TLX3)

UAR:	123788635(TLX3)

ELK:

111141192

LLV:

125100112

MPUF:

101673208(TLX3)

MNP:	132028416(TLX3)

MLK:	131831907(TLX3)

NVS:	122901866(TLX3)

ORO:	101380435(TLX3)

EJU:	114208564(TLX3)

ZCA:	113929901(TLX3)

MLX:	118015726(TLX3)

NSU:	110588016(TLX3)

LWW:	102748966(TLX3)

FCA:	101098771(TLX3)

PYU:	121010958(TLX3)

PCOO:

112860516(TLX3)

PBG:	122492419(TLX3)

PVIV:

125156309(TLX3)

LRUF:

124506894

LGF:	123610720(TLX3)

AJU:

113592679

PPAD:

109267490(TLX3)

PUC:

125935153

PLEZ:

122201431(TLX3)

HHV:	120234067(TLX3)

BTA:	618473(TLX3)

BOM:	102288032(TLX3)

BIU:	109574798(TLX3)

BBUB:

102409810(TLX3)

CHX:	108638391(TLX3)

OAS:	101106882(TLX3)

BTAX:

128066194(TLX3)

CSUM:

138094662(TLX3)

ODA:	120879684(TLX3)

CCAD:

122454461(TLX3)

MREE:

136146742(TLX3)

OVR:	110122721(TLX3)

MBEZ:

129553021(TLX3)

SSC:	100525967(TLX3)

CFR:	102524333(TLX3)

CDK:	105089405(TLX3)

BACU:

103008026(TLX3)

BMUS:

118892946(TLX3)

LVE:	103070952(TLX3)

OOR:	101275762(TLX3)

LALB:

132518587(TLX3)

DLE:	111185545(TLX3)

PCAD:

102992577(TLX3)

PSIU:

116751914(TLX3)

NASI:

112405134(TLX3)

ECB:	100059154(TLX3)

EPZ:	103559695(TLX3)

EAI:	106837395(TLX3)

MMYO:

118657563(TLX3)

MLF:	102440745(TLX3)

MDT:	132235956(TLX3)

MYUM:

139011583(TLX3)

PKL:	118711117(TLX3)

EFUS:

103291556(TLX3)

DRO:	112319501(TLX3)

SHON:

118994918(TLX3)

AJM:	119036199(TLX3)

PDIC:

114510059(TLX3)

PHAS:

123812503(TLX3)

MMF:	118616261(TLX3)

PPAM:

129066347(TLX3)

HAI:	109379380(TLX3)

RFQ:	117016716(TLX3)

PALE:

102893059(TLX3)

PGIG:

120614853(TLX3)

PVP:	105299296(TLX3)

RAY:	107511015(TLX3)

MJV:	108387760(TLX3)

TOD:	119236987(TLX3)

SARA:

101549736(TLX3)

SFUM:

130041089(TLX3)

SETR:

126012236(TLX3)

LAV:	100663846(TLX3)

TMU:

101355666

ETF:	101658723(TLX3)

DNM:	101426821(TLX3)

MDO:	100026415(TLX3)

GAS:	123235541(TLX3)

SHR:	100922859(TLX3)

AFZ:

127546801

PCW:	110212397(TLX3)

TVP:	118844738(TLX3)

PBRV:

138172514(TLX3)

OAA:	114806584(TLX3)

TACU:

119919703(TLX3)

GGA:	107054494(TLX3)

PCOC:

116231890(TLX3)

CJO:	107320303(TLX3)

TPAI:

128081565(TLX3)

LMUT:

125700299(TLX3)

NMEL:

110405496(TLX3)

APLA:

113845175(TLX3)

ACYG:

136791906(TLX3)

CATA:

118256211(TLX3)

AFUL:

116495012(TLX3)

TGU:	100222619(TLX3)

LSR:	110475700(TLX3)

SCAN:

103823788

PMOA:

120497679(TLX3)

OTC:	121343466(TLX3)

PRUF:

121355197(TLX3)

ATRC:

139597903(TLX3)

FAB:	101813371(TLX3)

OMA:	130258598(TLX3)

PHI:	102102969(TLX3)

PMAJ:

107198542(TLX3)

CCW:	120410744(TLX3)

ACOE:

138118136(TLX3)

ETL:	114068197(TLX3)

ZLE:	135453740(TLX3)

SVG:	106861505(TLX3)

MMEA:

130581571(TLX3)

HRT:	120759305(TLX3)

SATI:

136367276(TLX3)

CCIC:

134049673(TLX3)

FPG:	101919066(TLX3)

SHAB:

115615963(TLX3)

TALA:

116961510(TLX3)

ACHC:

115334145(TLX3)

AGEN:

126050931

HHAR:

128134503(TLX3)

GCL:

127022018

PPUS:

135185151(TLX3)

CBOY:

140656887(TLX3)

CUCA:

128853637(TLX3)

RTD:	128916204(TLX3)

CRID:

134522063(TLX3)

AROW:

112963862(TLX3)

NPD:	112944303(TLX3)

CPOO:

109309844(TLX3)

GGN:	109290150(TLX3)

PSS:	102444115(TLX3)

CMY:	102931949(TLX3)

CCAY:

125641215(TLX3)

DCC:	119860308(TLX3)

CPIC:

101935034(TLX3)

TST:	117882287(TLX3)

CABI:

116818106(TLX3)

MRV:	120370619(TLX3)

ACS:	100555708(tlx3)

ASAO:

132762011(TLX3)

PVT:	110078974(TLX3)

SUND:

121929452(TLX3) 121931748(TLX2)

PBI:	103053917(TLX3)

PMUR:

107287463(TLX3)

CTIG:

120301803(TLX3)

TSR:	106541134(TLX3)

PGUT:

117674150(TLX3)

APRI:

131197235(TLX3)

PTEX:

113442660(TLX3)

NSS:	113412670(TLX3)

VKO:	123030411(TLX3)

PMUA:

114593313(TLX3)

PRAF:

128410036(TLX3)

ZVI:	118082512(TLX3)

HCG:	128342769(TLX3)

GJA:	107112553(TLX3)

STOW:

125434576(TLX3)

EMC:	129336919(TLX2) 129341163(TLX3)

XLA:	108710909(tlx3.L) 373831(tlx3.S)

XTR:	548656(tlx3)

NPR:	108800461(TLX3)

RTEM:

120932360(TLX3)

BBUF:

120987003(TLX3)

BGAR:

122926420(TLX3)

PWL:	138245604(TLX3)

MUO:	115476678(TLX3)

GSH:	117351527(TLX3)

DRE:	100008066 266965(tlx3b)

SRX:	107720597 107729327 107731355 107742409

SANH:

107654648 107676002 107677998 107704633

SGH:	107552047 107552334 107586149 107596345

CCAR:

109059655 109066560 109072494 109073237

CAUA:

113054195 113070793 113109744 113113815

CGIB:

127966133 127971837 128021230 128027731

PTET:

122352585(tlx3b) 122357282

LROH:

127171618(tlx3b) 127175888

OMC:	131548336(tlx3b) 131553032

PPRM:

120465376 120482005(tlx3b)

RKG:	130082914(tlx3b) 130100306

MAMB:

125259900(tlx3b) 125266844

CIDE:

127494880 127520796

CERY:

137018623 137029707(tlx3b)

MASI:

127413196 127418102 127432714 127433164

TROS:

130545718(tlx3b) 130563478

TDW:	130411876(tlx3b) 130437998

MANU:

129422746 129447062(tlx3b)

PDAB:

135760643 135779870(tlx3b)

IPU:	108274503 108276618(tlx3b)

IFU:	128618622 128620810(tlx3b)

PHYP:

113524155 113529554

SMEO:

124392305 124393075(tlx3b)

TFD:	113650257(tlx3b) 113660224

TVC:	132857082 132862917(tlx3b)

CGAR:

128505669(tlx3b) 128512015

NGRA:

132872963(tlx3b) 132874247

TRN:	134332648(tlx3b)

AMEX:

103024668(tlx3b) 103036459

CMAO:

118811281 118824842(tlx3b)

EEE:	113577161 113588733

CHAR:

105902397(tlx3b) 105903664

SPIL:

134068336 134079578(tlx3b)

TRU:	101061880(tlx3)

TFS:

130531366

TNG:	GSTEN00024580G001

NCC:

104948897

TBEN:

117485530

CGOB:

115014878(tlx3)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116696828(tlx3)

PFLV:

114562386(tlx3)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137792139(tlx3b)

CVE:	137875502(tlx3b)

MSAM:

119888215

SCHU:

122880565

CUD:

121515913

SPUL:

138598707(tlx3b)

LMIX:

132981917

ALAT:

119007146

ASTR:

137603117(tlx3b)

MZE:	101477247(tlx3)

ONL:	100689744(tlx3)

OAU:

116319188

OLA:	101161249(tlx3)

OML:

112153419

CSAI:

133447010

XMA:	102237207(tlx3)

XCO:	114139393(tlx3)

XHE:	116714463(tlx3)

PRET:

103471341(tlx3)

PFOR:

103147452

PLAI:

106942022(tlx3)

PMEI:

106926406

GAF:

122836639

PPRL:

129363027

CVG:	107096702(tlx3)

CTUL:

119796524

GMU:

124860424

NFU:	107376571(tlx3)

KMR:

108243070

ALIM:

106516717(tlx3)

NWH:

EJA:

BFRE:

MCEP:

CSEM:

POV:	109627444(tlx3)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111232415(tlx3)

SLAL:

111662805

XGL:

120785387

HCQ:	109524464(tlx3)

SSCV:

125988950(tlx3b)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140354606(tlx3b)

MALB:

109957455(tlx3)

BSPL:

114863914

SJO:

128362587

SSCO:

133986207

GMH:	115547235 115552789(tlx3)

SASA:

106563176 106603212 106604867 106611906

STRU:

115154622(tlx3) 115173868 115204211 115205361

OTW:	112220794 112230579 112231384 112236181

OMY:	110488649 110504853 110509918(tlx3b) 118966777

OGO:	123993283 123994056 124007538 124011221

ONE:	115119364 115130560 115136428 115147029

OKI:	109865059 109872582 109873736 109904941

OKE:	118374638 118376390 118385653 118390305

OMM:	135527034 135544353 135545185 135549165

OCLA:

139366184 139388511 139391104 139418485

SALP:

111950323 111965424 112072316 112076878

SNH:	120020935 120047074 120056582 120062127

CCLU:

121541786 121544169 121579457 121580327

ELS:	105024610 105025223

OEP:	134032698 134039750(tlx3b)

SFM:	108925283 108934437

PKI:	111838668 111859785

AANG:

118236654(tlx3b)

AROT:

135264278(tlx3b)

CCOG:

133133613(tlx3b)

LOC:

102685936

PSPA:

121296958 121323978

ARUT:

117413021 117973683

PSEX:

120542977(tlx3b)

LCM:	102351781(TLX3)

CMK:

RTP:

CPLA:

HOC:

LERI:

129701412(tlx3b)

BFO:

118413302

BBEL:

109462947

CIN:	778781(tlx)

SPU:

576329

APLC:

110973894

AFIL:

140145899

SKO:	100303489(tlx)

PFLL:

139120319

DME:	Dmel_CG7937(C15)

DER:

6553403

DSE:

6614340

DSI:	Dsimw501_GD19430(Dsim_GD19430)

DYA:	Dyak_GE11155 Dyak_GE25740

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI26997

DAZ:

108609343

DNV:

108649180

DHE:

111602643

DVI:	6634928(C15)

CCAT:

BOD:

BDR:

AOQ:

ALUD:

TDA:	119684468 119684872

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135960123(C15)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002170 CpipJ_CPIJ002171 CpipJ_CPIJ004114

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139103915(C15)

TLN:	139817119(C15)

HST:

DQU:

CFO:

FEX:

PMEC:

138937778(C15)

LHU:	105667716(C15)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124222011(C15)

NFB:

NLO:

NVG:

AROA:

TCA:	663858(c15)

TMOL:

DPA:

ESIM:

EFOR:

SOY:	115883459 115885858

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_215543

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137925800(C15)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

CSTB:

CFEL:

CCRN:

API:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM439310

FOC:

113211017

ZNE:

110841425

CSEC:

111875519

PAME:

138694427(C15)

SGRE:

126354361

BROR:

134538909

IEL:

124153610

HAMR:

139688082(C15)

FCD:

110851526

DMK:

116922482

AFRA:

136024980

PJA:	122250600 122257977

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135225674 135225683

MRJ:	136839509 136839512

PORN:

139749134 139749135

LSM:	121113889 121132227

TCF:

PPOI:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136975477 136981392

PTEP:

107441150 107451627

ABRU:

129960667 129967149

UDV:	129219119 129221972

SDM:	118181115 118202919

LPOL:

106478488

NAI:	NECAME_10446

TSP:

Tsp_05079

HRO:	HELRODRAFT_192586

LGI:	LOTGIDRAFT_163574

PVUL:

126815124

PCAN:

112565143

BGT:

106064705

GAE:	121383854 121384289

HRF:	124142055 124142065

HRJ:	124272603 124272609

HASI:

HCRA:

CRG:

CANU:

CVN:

MYI:	110455371 110455431

PMAX:

MCAF:

MMER:

RPHI:

LJP:

LAK:

LLON:

EPA:

ATEN:

ADF:

AMIL:

SPIS:

RES:

Reference

PMID:16804919

Authors

Su X, Drabkin H, Clappier E, Morgado E, Busson M, Romana S, Soulier J, Berger R, Bernard OA, Lavau C

Title

Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3.

Journal

Genes Chromosomes Cancer 45:846-55 (2006)
DOI:10.1002/gcc.20348

LinkDB

DBGET integrated database retrieval system