KEGG   ORTHOLOGY: K15943
Entry
K15943                      KO                                     
Symbol
snoaL, dnrD, dauD, aknH
Name
nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase [EC:5.5.1.26 5.5.1.23]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Reaction
R06676  auraviketone lyase (decyclizing)
R06681  aklaviketone lyase (ring-opening)
R09328  nogalaviketone lyase (ring-opening)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15943  snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15943  snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
Enzymes [BR:ko01000]
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.23  aklanonic acid methyl ester cyclase
     K15943  snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
    5.5.1.26  nogalonic acid methyl ester cyclase
     K15943  snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K15943  snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
Genes
SPRI: SPRI_0207 SPRI_7146
STIR: DDW44_27900
SKA: CP970_39840
SGAL: CP966_29100
SCIN: CP977_27950
STSU: B7R87_22025
SCHA: CP983_03560 CP983_03585
SCOE: CP976_32890
SPEU: CGZ69_24290
SXN: IAG42_36860
SDD: D9753_08650
SJN: RI060_18395
SHAU: K9S39_40665
SKG: KJK29_16195
TALX: FOF52_07395
PMAD: BAY61_07675
MAU: Micau_3999
MIL: ML5_4422
MFEU: H1D33_25685
AG: AAA99000(dnrD) AAB16937(dauD) AAF01813(snoaL) AAF70112(aknH)
 » show all
Reference
PMID:10639368
  Authors
Torkkell S, Kunnari T, Palmu K, Hakala J, Mantsala P, Ylihonko K
  Title
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.
  Journal
Antimicrob Agents Chemother 44:396-9 (2000)
DOI:10.1128/AAC.44.2.396-399.2000
  Sequence
[ag:AAF01813]
Reference
PMID:7601857
  Authors
Madduri K, Hutchinson CR
  Title
Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius.
  Journal
J Bacteriol 177:3879-84 (1995)
DOI:10.1128/JB.177.13.3879-3884.1995
  Sequence
[ag:AAA99000]
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