KEGG   ORTHOLOGY: K15950
Entry
K15950            Tight     KO                                     
Symbol
dnrF, rdmE
Name
aklavinone 12-hydroxylase [EC:1.14.13.180]
Pathway
map01057  Biosynthesis of type II polyketide products
map01110  Biosynthesis of secondary metabolites
Reaction
R06683  aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15950  dnrF, rdmE; aklavinone 12-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.180  aklavinone 12-hydroxylase
     K15950  dnrF, rdmE; aklavinone 12-hydroxylase
Genes
SPEU: CGZ69_24430
SJN: RI060_18375
SKG: KJK29_16175
AG: AAA83424(rdmE) AAC43342(dnrF)
Reference
PMID:10082933
  Authors
Niemi J, Wang Y, Airas K, Ylihonko K, Hakala J, Mantsala P
  Title
Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.
  Journal
Biochim Biophys Acta 1430:57-64 (1999)
DOI:10.1016/S0167-4838(98)00265-9
  Sequence
[ag:AAA83424]
Reference
PMID:7773378
  Authors
Filippini S, Solinas MM, Breme U, Schluter MB, Gabellini D, Biamonti G, Colombo AL, Garofano L
  Title
Streptomyces peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression.
  Journal
Microbiology 141 ( Pt 4):1007-16 (1995)
DOI:10.1099/13500872-141-4-1007
  Sequence
[ag:AAC43342]
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