KEGG   ORTHOLOGY: K15966
Entry
K15966            Tight     KO                                     
Symbol
mtmOIV
Name
monooxygenase [EC:1.14.13.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Reaction
R09353  premithramycin-B,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15966  mtmOIV; monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15966  mtmOIV; monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15966  mtmOIV; monooxygenase
Genes
AG: CAK50794(mtmOIV)
Reference
PMID:16351075
  Authors
Gibson M, Nur-e-alam M, Lipata F, Oliveira MA, Rohr J
  Title
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.
  Journal
J Am Chem Soc 127:17594-5 (2005)
DOI:10.1021/ja055750t
Reference
PMID:12813091
  Authors
Rodriguez D, Quiros LM, Brana AF, Salas JA
  Title
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.
  Journal
J Bacteriol 185:3962-5 (2003)
DOI:10.1128/JB.185.13.3962-3965.2003
  Sequence
[ag:CAK50794]
LinkDB

KEGG   REACTION: R09353
Entry
R09353                      Reaction                               
Name
premithramycin-B,NADPH:oxygen oxidoreductase
Definition
Premithramycin B + NADPH + H+ + Oxygen <=> Mithramycin DK + NADP+ + CO2
Equation
C12388 + C00005 + C00080 + C00007 <=> C18711 + C00006 + C00011
Comment
Baeyer-Villiger monooxygenase
Reaction class
RC00001  C00005_C00006
RC02490  C12388_C18711
Enzyme
1.14.13.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R09353  Premithramycin B + NADPH + H+ + Oxygen <=> Mithramycin DK + NADP+ + CO2
Orthology
K15966  monooxygenase [EC:1.14.13.-]
LinkDB

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