KEGG   ORTHOLOGY: K15969
Entry
K15969            Tight     KO                                     
Symbol
tcmH
Name
tetracenomycin F1 monooxygenase [EC:1.13.12.21]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Reaction
R06700  tetracenomycin-F1:oxygen C5-monooxygenase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15969  tcmH; tetracenomycin F1 monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15969  tcmH; tetracenomycin F1 monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.21  tetracenomycin-F1 monooxygenase
     K15969  tcmH; tetracenomycin F1 monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15969  tcmH; tetracenomycin F1 monooxygenase
Genes
SGU: SGLAU_26340(tcmH)
Reference
PMID:8244926
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
  Journal
J Bacteriol 175:7571-80 (1993)
DOI:10.1128/JB.175.23.7571-7580.1993
  Sequence
[sgu:SGLAU_26340]
Reference
PMID:8329392
  Authors
Shen B, Hutchinson CR
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019
LinkDB

KEGG   ENZYME: 1.13.12.21
Entry
EC 1.13.12.21               Enzyme                                 
Name
tetracenomycin-F1 monooxygenase;
tcmH (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
tetracenomycin-F1:oxygen C5-monooxygenase
Reaction(IUBMB)
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN:R06700]
Reaction(KEGG)
R06700
Substrate
tetracenomycin F1 [CPD:C12367];
O2 [CPD:C00007]
Product
tetracenomycin D3 [CPD:C12368];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 1.13.12.21 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15969  tetracenomycin F1 monooxygenase
Genes
SGU: SGLAU_26340(tcmH)
Reference
1  [PMID:8329392]
  Authors
Shen B, Hutchinson CR
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.21
IUBMB Enzyme Nomenclature: 1.13.12.21
ExPASy - ENZYME nomenclature database: 1.13.12.21
BRENDA, the Enzyme Database: 1.13.12.21
LinkDB

KEGG   REACTION: R06700
Entry
R06700                      Reaction                               
Name
tetracenomycin-F1:oxygen C5-monooxygenase
Definition
Tetracenomycin F1 + Oxygen <=> Tetracenomycin D3 + H2O
Equation
C12367 + C00007 <=> C12368 + C00001
Reaction class
RC01658  C12367_C12368
Enzyme
1.13.12.21
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.21
     R06700  Tetracenomycin F1 + Oxygen <=> Tetracenomycin D3 + H2O
Orthology
K15969  tetracenomycin F1 monooxygenase [EC:1.13.12.21]
LinkDB

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