KEGG   ORTHOLOGY: K16035
Entry
K16035                      KO                                     
Symbol
asm21
Name
7-O-carbamoyltransferase [EC:2.1.3.-]
Pathway
map01051  Biosynthesis of ansamycins
map01052  Type I polyketide structures
map01110  Biosynthesis of secondary metabolites
Reaction
R09853  carbamoyl-phosphate:20-O-methyl-19-chloroproansamitocin carbamoyltransferase
R09858  carbamoyl-phosphate:ansamitocinoside-P-3 carbamoyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16035  asm21; 7-O-carbamoyltransferase
   01051 Biosynthesis of ansamycins
    K16035  asm21; 7-O-carbamoyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16035  asm21; 7-O-carbamoyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K16035  asm21; 7-O-carbamoyltransferase
Genes
XSK: AB0856_003118
SCB: SCAB_84021
SVL: Strvi_5872
SMAL: SMALA_0860
SAUO: BV401_08115
SSOI: I1A49_07805
SRK: FGW37_30920
AORI: SD37_10855
APRE: CNX65_16245
AMI: Amir_3193 Amir_3283
Reference
  Authors
Li Y, Zhao P, Kang Q, Ma J, Bai L, Deng Z
  Title
Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.
  Journal
Chem Biol 18:1571-80 (2011)
DOI:10.1016/j.chembiol.2011.11.007
Reference
  Authors
Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG
  Title
The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
  Journal
J Am Chem Soc 125:14236-7 (2003)
DOI:10.1021/ja038166y
Reference
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199
  Sequence
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