KEGG   ORTHOLOGY: K16084
Entry
K16084                      KO                                     
Symbol
CYP76M7_8
Name
ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase [EC:1.14.14.112 1.14.14.123]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09866  ent-cassa-12,15-diene,[reduced NADPH---hemoprotein reductase]:oxygen 11-oxidoreductase
R11658  ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin D forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K16084  CYP76M7_8; ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K16084  CYP76M7_8; ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.112  ent-cassa-12,15-diene 11-hydroxylase
     K16084  CYP76M7_8; ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
    1.14.14.123  oryzalexin D synthase
     K16084  CYP76M7_8; ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP76 family
   K16084  CYP76M7_8; ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
Other DBs
GO: 0036202
Genes
OSA: 4329722(CYP76M8) 4329723 4341447(CYP76M7)
OGL: 127763670 127764059
Reference
PMID:22215681 (CYP76M7 CYP76M8)
  Authors
Wang Q, Hillwig ML, Okada K, Yamazaki K, Wu Y, Swaminathan S, Yamane H, Peters RJ
  Title
Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster.
  Journal
J Biol Chem 287:6159-68 (2012)
DOI:10.1074/jbc.M111.305599
  Sequence
[osa:4341447 4329722]
Reference
PMID:23795884 (CYP76M8)
  Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
  Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
  Journal
Biochem J 454:209-16 (2013)
DOI:10.1042/BJ20130574
  Sequence
[osa:4329722]
LinkDB

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