KEGG   ORTHOLOGY: K16306
Entry
K16306                      KO                                     
Symbol
K16306
Name
fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00030  Pentose phosphate pathway
map00051  Fructose and mannose metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   00030 Pentose phosphate pathway
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   00051 Fructose and mannose metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.10  2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Other DBs
RN: R01068 R01070 R02568 R08568
COG: COG1830
GO: 0004332
Genes
KPP: A79E_4023
PAKH: B0X70_03095
PLUI: CE143_03080
PTW: TUM18999_11980
DOV: DSCO28_33870(fbaA_1)
DMM: dnm_078980(aroA')
DEK: DSLASN_18980(aroA'_1)
MRM: A7982_01287
HTQ: FRZ44_21680
HADH: FRZ61_25400
CSCI: HDCHBGLK_02271(lsrF)
KME: H0A61_00395(griI)
MHEV: MHEL_37860
SRW: TUE45_01349(lsrF)
MJA: MJ_0400
MESG: MLAUSG7_1335(aroA)
MESA: MLASG1_0944(aroA)
MMP: MMP0686
MMD: GYY_02835
MMAD: MMJJ_02920(griI)
MAE: Maeo_0316
MVO: Mvol_0365
MTH: MTH_579
MMG: MTBMA_c09600(fbaB)
METC: MTCT_0503
MWO: MWSIV6_0939(aroA')
METE: tca_00548(griI)
MST: Msp_0091
MRU: mru_0997
MSI: Msm_0056
MEB: Abm4_0656
MMIL: sm9_1016
MEYE: TL18_05340
MOL: YLM1_0540
METH: MBMB1_1070
MFC: BRM9_1272
MCUB: MCBB_0939(aroA')
MFV: Mfer_0600
MKA: MK1409(fbaB)
AFU: AF_0108
FPL: Ferp_0600
GAC: GACE_1261
GAH: GAH_01502
MAC: MA_0439 MA_4591(deoC)
MBG: BN140_2035(fbaA1) BN140_2036(fbaA3)
MEZ: Mtc_1383(aroF) Mtc_1667
RCI: RRC153(aroF)
HAL: VNG_0309C
HSL: OE_1472F(fba2)
HHB: Hhub_1454
HALH: HTSR_1439(fba2)
HHSR: HSR6_1511(fba2)
HSU: HLASF_0623(fba1)
HSF: HLASA_0619(fba1)
HARA: AArcS_2621
HMA: rrnAC1881(deoC2)
HHI: HAH_2396(fbaB2)
NPH: NP_3160A(fba2)
NMO: Nmlp_1197(fba2)
HUT: Huta_1178
HTI: HTIA_1098
HMU: Hmuk_3036
HALL: LC1Hm_2379
HWA: HQ_1156A(fba2)
HWC: Hqrw_1193(fba2)
HVO: HVO_0790(fba2)
HME: HFX_0749(fbaB)
HLA: Hlac_1274
HTU: Htur_0853
NMG: Nmag_2815
NAT: NJ7G_4134
SALI: L593_00075
MELU: MTLP_01120
MEAR: Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARC: AR505_0508
NMR: Nmar_0553
NID: NPIRD3C_1721(aroA)
NIN: NADRNF5_1625(aroA)
NCT: NMSP_1118(aroA'_2)
NGA: Ngar_c16210(aroGFH)
NVN: NVIE_005850(aroGFH)
NEV: NTE_01960
TAA: NMY3_02544(griI)
NFN: NFRAN_0128(aroA)
NCV: NCAV_0390(aroGFH)
NBV: T478_0480
NDV: NDEV_0554(aroA)
CCAI: NAS2_0559
BARB: AOA66_0830(aroA')
LOKI: Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
Reference
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
LinkDB

KEGG   ENZYME: 2.2.1.10
Entry
EC 2.2.1.10                 Enzyme                                 
Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
ADH synthase;
ADHS;
MJ0400 (gene name)
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
Sysname
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Reaction(IUBMB)
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate [RN:R08568]
Reaction(KEGG)
R08568
Substrate
L-aspartate 4-semialdehyde [CPD:C00441];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848]
Product
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
2,3-dioxopropyl phosphate [CPD:C16849]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.10 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Genes
KPPA79E_4023
PAKHB0X70_03095
PLUICE143_03080
PTWTUM18999_11980
DOVDSCO28_33870(fbaA_1)
DMMdnm_078980(aroA')
DEKDSLASN_18980(aroA'_1)
MRMA7982_01287
HTQFRZ44_21680
HADHFRZ61_25400
BMETBMMGA3_07340
PTJJRJ22_24810
CSCIHDCHBGLK_02271(lsrF)
KMEH0A61_00395(griI)
MHEVMHEL_37860
NIEKV110_32290
RKOJWS14_15760 JWS14_20865
RGOKYT97_13020
GOILK459_04835
SRWTUE45_01349(lsrF)
PSICJ4E96_11100
PSUBPelsub_P0311 Pelsub_P1007
MINFMESINF_1405
MJAMJ_0400
MFEMefer_1187
MVUMetvu_1437
MFSMFS40622_1668
MIFMetin_0016
MJHJH146_1314
MESGMLAUSG7_1335(aroA)
MESAMLASG1_0944(aroA)
MIGMetig_0643
MMPMMP0686
MMQMmarC5_0890
MMXMmarC6_0201
MMZMmarC7_1710
MMDGYY_02835
MMAKMMKA1_07380
MMAOMMOS7_07320
MMADMMJJ_02920(griI)
MAEMaeo_0316
MVNMevan_1506
MVOMvol_0365
MOKMetok_1495
METFCFE53_05110
MTHMTH_579
MMGMTBMA_c09600(fbaB)
METCMTCT_0503
MWOMWSIV6_0939(aroA')
METEtca_00548(griI)
METZMETMT2_0849
METKFVF72_08665
MTHMFZP57_04495
METJFZP68_04960
MSTMsp_0091
METBAW729_06715
MRUmru_0997
MSIMsm_0056
MEBAbm4_0656
MMILsm9_1016
MEYETL18_05340
MOLYLM1_0540
MAROMarbSA_04640
MELMetbo_1361
MEWMSWAN_0907
METHMBMB1_1070
MFCBRM9_1272
MFIDSM1535_1956
MCUBMCBB_0939(aroA')
MSUBBK009_02850
METNBK008_10575
METTCIT01_09455
METOCIT02_02135
MEMEHYG87_09830
MFVMfer_0600
MKAMK1409(fbaB)
AFUAF_0108
AFGAFULGI_00001050
APOArcpr_0817
AVEArcve_1168
ASTAsulf_00941
FPLFerp_0600
GACGACE_1261
GAHGAH_01502
MBAMbar_A0753 Mbar_A0920
MBYMSBRM_0075 MSBRM_0291
MBWMSBRW_0078 MSBRW_0247
MBARMSBR2_2087 MSBR2_2305
MBAKMSBR3_2087 MSBR3_2364
MACMA_0439 MA_4591(deoC)
MMAMM_1271 MM_1627
MMAZMmTuc01_1317 MmTuc01_1701
MMJMSMAS_0045 MSMAS_3044
MMACMSMAC_0045 MSMAC_1391
MVCMSVAZ_0309 MSVAZ_3439
MEKMSKOL_0292 MSKOL_3399
MLSMSLAZ_0044 MSLAZ_0176
METMMSMTP_0060 MSMTP_2943
MEFMSWH1_0053 MSWH1_0299
MEQMSWHS_0056 MSWHS_0301
MSJMSSAC_0062 MSSAC_0390
MSZMSSIH_0055 MSSIH_0359
MSWMSSIT_0055 MSSIT_0365
MTHRMSTHT_1780 MSTHT_2145
MTHEMSTHC_1138 MSTHC_1506
MHORMSHOH_0050 MSHOH_3760
MFZAOB57_005170 AOB57_008125
MBUMbur_0917 Mbur_2001
MMETMCMEM_0229 MCMEM_1419
MELOJ7W08_05825 J7W08_11215
MMHMmah_0241 Mmah_0691
MHAZBHR79_02305 BHR79_10150
MEVMetev_1692 Metev_1714
MZHMzhil_0254 Mzhil_0268
MPYMpsy_1418 Mpsy_1446
MZIHWN40_01580 HWN40_01705
MHZMetho_0254 Metho_0268
MTPMthe_0532 Mthe_0617
MCJMCON_1478 MCON_3321
MHIMhar_1906 Mhar_2111
MHUMhun_1035 Mhun_1036
MRTJKHC33_11765 KHC33_11770
MLAMlab_0600 Mlab_1654
MEMMemar_1302 Memar_1303
MBGBN140_2035(fbaA1) BN140_2036(fbaA3)
MEMAMMAB1_2640 MMAB1_2641
MCHKMchiMG62_14880 MchiMG62_14890
MPIMpet_2705 Mpet_2706
MBNMboo_1557 Mboo_1558
MFOMetfor_1589 Metfor_1590
MPLMpal_2610 Mpal_2611
MPDMCP_1367 MCP_1669
MEZMtc_1383(aroF) Mtc_1667
RCIRRC153(aroF)
HALVNG_0309C
HSLOE_1472F(fba2)
HDLHALDL1_05725
HHBHhub_1454
HAGSJT689_02635
HABOJRZ79_01140
HNOLT974_02305
HLULT972_11245
HANRLJ422_01350
HJEHacjB3_14310
HALHHTSR_1439(fba2)
HHSRHSR6_1511(fba2)
HSUHLASF_0623(fba1)
HSFHLASA_0619(fba1)
SALRFQU85_02205
HALREFA46_006155
HARAAArcS_2621
HAADMW046_10360
HALXM0R89_11070
HMArrnAC1881(deoC2)
HHIHAH_2396(fbaB2)
HHNHISP_12200
HABSG26_04510
HTABVU17_11665
HALJG9465_07475
HSINKDQ40_01440
NPHNP_3160A(fba2)
NMONmlp_1197(fba2)
NHOHWV23_11585
NSALHWV07_13660
HUTHuta_1178
HTIHTIA_1098
HALAHrd1104_09430
HMUHmuk_3036
HALZE5139_02445
HALLLC1Hm_2379
HAZPGBQ70_02445
HALIBV210_04645
HSNDV733_05035
HDSHSR122_0656
HRRHZS55_09305
HPELHZS54_13385
HLTI7X12_04925
HARCHARCEL1_00665
HDOMUK72_03645
HWAHQ_1156A(fba2)
HWCHqrw_1193(fba2)
HVOHVO_0790(fba2)
HMEHFX_0749(fbaB)
HGIABY42_03765
HALEG3A49_03975
HBOHbor_24270
HAQDU484_08625
HAJDU500_08665
HAERDU502_05965
HRAEI982_07830
HLMDV707_12100
HALMFCF25_10565
HLAHlac_1274
HALPDOS48_06125
HALBEKH57_03855
HEZZEO776_07625
HALQHrr1229_015385
HSSJ7656_08775
HSAIHPS36_14190
HAZZKI388_05335
SRUBC2R22_04735
HAEhalTADL_0575
HALNB4589_008625
HALGHUG10_01095
HALUHUG12_16500
HMPK6T50_14120
HREK6T36_14065
HRMK6T25_02715
HACBHbl1158_05910
HDFAArcSl_0487
HAHHalar_3168
HTUHtur_0853
HDABB347_01155
HJTDVR14_06585
HALYHYG82_17225
HSALJMJ58_04710
HLOJ0X27_10770
HAKZJ0X25_11090
NMGNmag_2815
HXAHalxa_4013
NATNJ7G_4134
NPENatpe_3297
NVRFEJ81_15780
NPLFGF80_14890
NAYHYG81_12485
NGENatgr_0761
HRUHalru_2303
NOUNatoc_0637
SALIL593_00075
SAIMK0C01_01385
HLRHALLA_07800
HLCCHINAEXTREME00240
NAJB1756_17155
NAGAArcMg_1455
NANAArc1_2141
NBGDV706_03245
NASGCU68_10270
MELUMTLP_01120
MEAMMU439_07195
TARTALC_00560 TALC_00670
MAXMMALV_05100
MERMMINT_14400
MEARMpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARCAR505_0508
SACDHS1genome_2052
THBN186_00460
TCBTCARB_0208 TCARB_1172
THFMA03_02210 MA03_05420
THELIG193_03385
NMRNmar_0553
NIRNSED_02805
NKRNKOR_02865
NIDNPIRD3C_1721(aroA)
NINNADRNF5_1625(aroA)
NIWNisw_02100
NCLC5F47_02845
NOXC5F49_03025
NUEC5F50_04220
NIPNsoK4_05575
NCTNMSP_1118(aroA'_2)
NICDSQ20_03075
CSYCENSYa_0200
NGANgar_c16210(aroGFH)
NVNNVIE_005850(aroGFH)
NEVNTE_01960
TAANMY3_02544(griI)
NFNNFRAN_0128(aroA)
NCVNCAV_0390(aroGFH)
CSUCSUB_C0867 CSUB_C0895
NBVT478_0480
TAHSU86_003320
NIUDSQ19_02830
NDVNDEV_0554(aroA)
CCAINAS2_0559
BARBAOA66_0830(aroA')
LOKILokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
Reference
1  [PMID:15182204]
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
3  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
  Sequence
[mja:MJ_0400]
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.10
IUBMB Enzyme Nomenclature: 2.2.1.10
ExPASy - ENZYME nomenclature database: 2.2.1.10
BRENDA, the Enzyme Database: 2.2.1.10
LinkDB

KEGG   REACTION: R08568
Entry
R08568                      Reaction                               
Name
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Definition
L-Aspartate 4-semialdehyde + 6-Deoxy-5-ketofructose 1-phosphate <=> 2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + Hydroxypyruvaldehyde phosphate
Equation
Comment
possibly two-step reaction (aldehyde-lyase x2)
Reaction class
RC00721  C00441_C16850
RC02301  C16848_C16849
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
Reference
1  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
Other DBs
RHEA: 25955
LinkDB

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