KEGG   ORTHOLOGY: K16379
Entry
K16379                      KO                                     
Symbol
fkbD, rapJ
Name
cytochrome P450 C-9 hydroxylase
Pathway
map01052  Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16379  fkbD, rapJ; cytochrome P450 C-9 hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16379  fkbD, rapJ; cytochrome P450 C-9 hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K16379  fkbD, rapJ; cytochrome P450 C-9 hydroxylase
Genes
SRC: M271_40650
SMAL: SMALA_8312 SMALA_8313
SSOI: I1A49_45300 I1A49_45305
SQZ: FQU76_32175
SKA: CP970_02335
STSU: B7R87_01860
SLUO: PS467_39430
ACTN: L083_2968(rapJ)
AG: AAC44359(fkbD) AAF86397(fkbD) ADU56326(fkbD) CAA60469(rapJ)
Reference
PMID:7644502
  Authors
Schwecke T, Aparicio JF, Molnar I, Konig A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, et al.
  Title
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
  Journal
Proc Natl Acad Sci U S A 92:7839-43 (1995)
DOI:10.1073/pnas.92.17.7839
Reference
PMID:8635730 (rapJ)
  Authors
Molnar I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, Konig A, Staunton J, Leadlay PF
  Title
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
  Journal
Gene 169:1-7 (1996)
DOI:10.1016/0378-1119(95)00799-7
  Sequence
[ag:CAA60469]
Reference
PMID:10863099 (fkbD)
  Authors
Wu K, Chung L, Revill WP, Katz L, Reeves CD
  Title
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
  Journal
Gene 251:81-90 (2000)
DOI:10.1016/S0378-1119(00)00171-2
  Sequence
[ag:AAF86397]
Reference
PMID:8752344 (fkbD)
  Authors
Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR
  Title
Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
  Journal
J Bacteriol 178:5243-8 (1996)
DOI:10.1128/JB.178.17.5243-5248.1996
  Sequence
[ag:AAC44359]
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