KEGG   ORTHOLOGY: K16383
Entry
K16383                      KO                                     
Symbol
amphB, nysB
Name
polyene macrolide polyketide synthase, A-type KR domains
Pathway
map01052  Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16383  amphB, nysB; polyene macrolide polyketide synthase, A-type KR domains
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16383  amphB, nysB; polyene macrolide polyketide synthase, A-type KR domains
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Polyene macrolide PKS
     K16383  amphB, nysB; polyene macrolide polyketide synthase, A-type KR domains
Genes
STRE: GZL_00791
SNR: SNOUR_03765
SALU: DC74_7925
SYUN: MOV08_03265
PSEH: XF36_05055
PECQ: AD017_25885
PHH: AFB00_29730(selB)
AG: AAF71775(nysB) AAK73513(amphB)
Reference
PMID:11451671 (amphB)
  Authors
Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M
  Title
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.
  Journal
Chem Biol 8:713-23 (2001)
DOI:10.1016/S1074-5521(01)00046-1
  Sequence
[ag:AAK73513]
Reference
PMID:10873841 (nysB)
  Authors
Brautaset T, Sekurova ON, Sletta H, Ellingsen TE, StrLm AR, Valla S, Zotchev SB
  Title
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.
  Journal
Chem Biol 7:395-403 (2000)
DOI:10.1016/S1074-5521(00)00120-4
  Sequence
[ag:AAF71775]
Reference
PMID:20696392
  Authors
Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT
  Title
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.
  Journal
Structure 18:913-22 (2010)
DOI:10.1016/j.str.2010.04.015
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