KEGG   ORTHOLOGY: K16450
Entry
K16450                      KO                                     
Symbol
mlsA2
Name
mycolactone core lactone polyketide synthase MlsA2
Pathway
map01052  Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16450  mlsA2; mycolactone core lactone polyketide synthase MlsA2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16450  mlsA2; mycolactone core lactone polyketide synthase MlsA2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Mycolactone PKS
     K16450  mlsA2; mycolactone core lactone polyketide synthase MlsA2
Genes
MUL: MUP039c(mlsA2)
MLI: MULP_064(mlsA2)
Reference
PMID:14736915
  Authors
Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST
  Title
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
  Journal
Proc Natl Acad Sci U S A 101:1345-9 (2004)
DOI:10.1073/pnas.0305877101
  Sequence
[mul:MUP039c]
Reference
PMID:18840298
  Authors
Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP
  Title
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.
  Journal
BMC Genomics 9:462 (2008)
DOI:10.1186/1471-2164-9-462
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