KEGG   ORTHOLOGY: K16651
Entry
K16651                      KO                                     
Symbol
pduX
Name
L-threonine kinase [EC:2.7.1.177]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K16651  pduX; L-threonine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.177  L-threonine kinase
     K16651  pduX; L-threonine kinase
Other DBs
RN: R06531
COG: COG4542
Genes
STY: STY2263(pduX)
STT: t0816(pduX)
SEX: STBHUCCB_8710
SENT: TY21A_04145
STM: STM2058(pduX)
SEO: STM14_2547(pduX)
SEV: STMMW_20881
SEY: SL1344_2034(pduX)
SEM: STMDT12_C20800
SEJ: STMUK_2088(pduX)
SEB: STM474_2143(pduX)
SEF: UMN798_2224(pduX)
SENR: STMDT2_20311(pduX)
SEND: DT104_21151(pduX)
SENI: CY43_11105
SPT: SPA0813(pduX)
SEK: SSPA0760
SEI: SPC_1656(pduX)
SEC: SCH_2067(pduX)
SHB: SU5_02652
SENS: Q786_10160
SED: SeD_A2394
SEG: SG2087(pduX)
SEL: SPUL_0842(pduX)
SEGA: SPUCDC_0842(pduX)
SET: SEN2056(pduX)
SENA: AU38_10375
SENO: AU37_10385
SENV: AU39_10385
SENQ: AU40_11630
SENL: IY59_10670
SEEP: I137_03795
SENE: IA1_10270
ENF: AKI40_1785(pduX)
KPN: KPN_03223(pduX)
KPU: KP1_4492(pduX)
KPP: A79E_0887
KPR: KPR_1810(pduX)
KPJ: N559_1016
KPX: PMK1_00704(pduX)
KPNU: LI86_05020
KPNK: BN49_0885(pduX)
KVA: Kvar_0847
KPE: KPK_0892(pduX)
KOX: KOX_01545
KOE: A225_4774
CRO: ROD_21441(pduX)
CKO: CKO_00778
CAMA: F384_10500
KAS: KATP_08810(pduX)
METY: MRY16398_18390(pduX)
PSGC: G163CM_06120(pduX)
EBF: D782_1619
YEN: YE2750(pduX) YE4039(pduX)
YEE: YE5303_31831(pduX) YE5303_38731(pduX)
YFR: AW19_699
YKR: CH54_963
YRO: CH64_1336
PLU: plu2966
PAY: PAU_01636(pduX)
XBO: XBJ1_0855
XBV: XBW1_1555
XNE: XNC1_1145
XNM: XNC2_1124
MMK: MU9_1018
ETR: ETAE_2006
ETD: ETAF_1814
ETE: ETEE_4061(pduX)
GAI: IMCC3135_05635(pduX)
TAU: Tola_1706
BTM: MC28_E122
LMO: lmo1170
LMOC: LMOSLCC5850_1159(pduX)
LMOE: BN418_1373
LMOB: BN419_1371
LMOD: LMON_1163
LMOW: AX10_14355
LMOM: IJ09_04485
LMP: MUO_06045
LMOL: LMOL312_1157(pduX)
LMOX: AX24_03220
LMQ: LMM7_1176(pduX)
LML: lmo4a_1153(pduX)
LMS: LMLG_1094
LMW: LMOSLCC2755_1162(pduX)
LMX: LMOSLCC2372_1165(pduX)
LMZ: LMOSLCC2482_1209(pduX)
LMON: LMOSLCC2376_1121(pduX)
LMOS: LMOSLCC7179_1137(pduX)
LMOO: LMOSLCC2378_1175(pduX)
LMOY: LMOSLCC2479_1166(pduX)
LMOT: LMOSLCC2540_1148(pduX)
LMOA: LMOATCC19117_1170(pduX)
LMOK: CQ02_06015
LIN: lin1134
LWE: lwe1128
LSG: lse_1048(pduX)
LIV: LIV_1102
SSA: SSA_0511(pduX)
SMEN: SAMEA4412692_0330(pduX)
CAC: CA_C1371
CAE: SMB_G1394
CAY: CEA_G1385
CTC: CTC_00786
CBO: CBO0953(pduX)
CBA: CLB_0995
CBH: CLC_1009
CBY: CLM_1104
CBL: CLK_0391
CBB: CLD_3607
CBI: CLJ_B1004
CBF: CLI_1043
CBM: CBF_1012
CKL: CKL_0717
CKR: CKR_0639
CPAS: Clopa_1225
CPAT: CLPA_c12730(pduX)
CPAE: CPAST_c12730(pduX)
CSQ: CSCA_5077
CACE: CACET_c00560(pduX)
CTYK: CTK_C09530
AMT: Amet_0068
PDC: CDIF630_03739(pduX)
CST: CLOST_0986(pduX)
PHX: KGNDJEFE_00479(pduX)
TEB: T8CH_0255(pduX)
DSY: DSY4058
DHD: Dhaf_1308
DRM: Dred_2702
AACX: DEACI_2584
HMO: HM1_2403
ELM: ELI_0756
TKI: TKV_c19670(pduX)
CHY: CHY_0772
MTA: Moth_1103
MTHO: MOTHE_c10630(pduX)
MTHZ: MOTHA_c11520(pduX)
TPZ: Tph_c05150(pduX)
TOC: Toce_1423
NCD: ACONDI_00699(pduX)
KME: H0A61_01981(pduX)
VPR: Vpar_0909
MED: MELS_1829
PUF: UFO1_2208
PFT: JBW_02349
MANA: MAMMFC1_03994(pduX)
STED: SPTER_16900(pduX)
TAI: Taci_0066
TLI: Tlie_0163
ALAM: RT761_00796(pduX)
 » show all
Reference
  Authors
Fan C, Fromm HJ, Bobik TA
  Title
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
  Journal
J Biol Chem 284:20240-8 (2009)
DOI:10.1074/jbc.M109.027425
  Sequence
[stm:STM2058]
LinkDB

KEGG   ENZYME: 2.7.1.177
Entry
EC 2.7.1.177                Enzyme                                 
Name
L-threonine kinase;
PduX
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-threonine O3-phosphotransferase
Reaction(IUBMB)
ATP + L-threonine = ADP + O-phospho-L-threonine [RN:R06531]
Reaction(KEGG)
R06531
Substrate
ATP [CPD:C00002];
L-threonine [CPD:C00188]
Product
ADP [CPD:C00008];
O-phospho-L-threonine [CPD:C12147]
Comment
The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.
History
EC 2.7.1.177 created 2012
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
Orthology
K16651  L-threonine kinase
Genes
STYSTY2263(pduX)
STTt0816(pduX)
SEXSTBHUCCB_8710
SENTTY21A_04145
STMSTM2058(pduX)
SEOSTM14_2547(pduX)
SEVSTMMW_20881
SEYSL1344_2034(pduX)
SEMSTMDT12_C20800
SEJSTMUK_2088(pduX)
SEBSTM474_2143(pduX)
SEFUMN798_2224(pduX)
SETUSTU288_06680
SETCCFSAN001921_06495
SENRSTMDT2_20311(pduX)
SENDDT104_21151(pduX)
SENICY43_11105
SEENSE451236_16500
SPTSPA0813(pduX)
SEKSSPA0760
SPQSPAB_01046
SEISPC_1656(pduX)
SECSCH_2067(pduX)
SEHSeHA_C2281
SHBSU5_02652
SENHCFSAN002069_21530
SEEHSEEH1578_19570
SEESNSL254_A2235
SENNSN31241_31590
SEWSeSA_A2228
SEASeAg_B2181
SENSQ786_10160
SEDSeD_A2394
SEGSG2087(pduX)
SELSPUL_0842(pduX)
SEGASPUCDC_0842(pduX)
SETSEN2056(pduX)
SENAAU38_10375
SENOAU37_10385
SENVAU39_10385
SENQAU40_11630
SENLIY59_10670
SENJCFSAN001992_01145
SEECCFSAN002050_17250
SEEBSEEB0189_009175
SEEPI137_03795
SENBBN855_21430
SENEIA1_10270
SENCSEET0819_17435
SESSARI_00829
SALZEOS98_08720
ESHC1N69_07935
ENRH650_05865
ENFAKI40_1785(pduX)
KPNKPN_03223(pduX)
KPUKP1_4492(pduX)
KPMKPHS_42860
KPPA79E_0887
KPHKPNIH24_07360
KPZKPNIH27_20770
KPVKPNIH29_21540
KPWKPNIH30_21560
KPYKPNIH31_20825
KPGKPNIH32_22420
KPCKPNIH10_21355
KPQKPR0928_20845
KPTVK055_4302
KPOKPN2242_19065
KPRKPR_1810(pduX)
KPJN559_1016
KPID364_16360
KPAKPNJ1_01021
KPSKPNJ2_01052
KPXPMK1_00704(pduX)
KPBFH42_12075
KPNEKU54_005010
KPNULI86_05020
KPNKBN49_0885(pduX)
KVAKvar_0847
KPEKPK_0892(pduX)
KPKA593_06245
KVDKR75_03695
KVQSP68_10240
KOXKOX_01545
KOEA225_4774
KOYJ415_08150
KOMHR38_27680
KOKKONIH1_23985
KOCAB185_12405
KQUAVR78_25865
KQVB8P98_04940
KLLBJF97_23815
KLWDA718_05375
KARLGL98_04520
KGRJJJ10_05395
CROROD_21441(pduX)
CKOCKO_00778
CFDCFNIH1_21285
CBRAA6J81_01025
CWECO701_07940
CYOCD187_09125
CPOTFOB25_20435
CFQC2U38_15405
CSEDJY391_08700
CAMAF384_10500
CAFAL524_12180
CIFAL515_09960
CFARCI104_16285
CIRC2U53_26095
CIEAN232_13905
CPARCUC49_05335
CTELGBC03_14195
CITZE4Z61_02765
CARSE1B03_16815
EBTEBL_c14750
PGELG71_20660
ESCEntcl_1739
KLEAO703_13250
KSAC813_00150
KORAWR26_09165
KRDA3780_14810
KPSEIP581_14425
KIENCTC12125_04859
KASKATP_08810(pduX)
BUFD8682_20820
BAGEBADSM9389_15260
METYMRY16398_18390(pduX)
YREHEC60_23150
KINAB182_08045
PDZHHA33_11170
PSGCG163CM_06120(pduX)
EBFD782_1619
EBCC2U52_18630
EBUCUC76_20195
YENYE2750(pduX) YE4039(pduX)
YEPYE105_C1535 YE105_C3759
YEYY11_16371 Y11_31561
YELLC20_00186 LC20_02014
YEWCH47_2099 CH47_3692
YETCH48_1491 CH48_3131
YEFFORC2_0155 FORC2_2731
YEEYE5303_31831(pduX) YE5303_38731(pduX)
YALAT01_1094 AT01_4013
YFRAW19_699
YINCH53_309 CH53_3347
YKRCH54_963
YROCH64_1336
YAKACZ76_01765
YMADA391_08040
YHID5F51_11610 D5F51_21340
YCAF0T03_14080 F0T03_21025
YMOHRD69_13055
BGJAWC36_11470
BRBEH207_06450
BNGEH206_15130
BIZHC231_16080
PLUplu2966
PLUMA4R40_14825
PAYPAU_01636(pduX)
PTTVY86_16855
PAKHB0X70_15185
PLUICE143_15180
XBOXBJ1_0855
XBVXBW1_1555
XNEXNC1_1145
XNMXNC2_1124
XBUHGO23_10425
MMKMU9_1018
EICNT01EI_2195
ETRETAE_2006
ETDETAF_1814
ETEETEE_4061(pduX)
ETCETAC_09175
EDWQY76_10250
EDLAAZ33_10195
EHOA9798_07130
HAVAT03_05625 AT03_08670
HPARAL518_16430
OPODSM2777_13880
VTUIX91_24675
VEUIXK98_24740
VZIG5S32_07770
GAIIMCC3135_05635(pduX)
TAUTola_1706
BTMMC28_E122
BTNBTF1_32006
BWDCT694_33810
BTROFJR70_30735
MVTI6J10_02965
LMOlmo1170
LMNLM5578_1243
LMYLM5923_1196
LMTLMRG_00613
LMOCLMOSLCC5850_1159(pduX)
LMOEBN418_1373
LMOBBN419_1371
LMODLMON_1163
LMOWAX10_14355
LMOQLM6179_1477
LMRLMR479A_1191
LMOMIJ09_04485
LMFLMOf2365_1178
LMCLm4b_01175
LMOGBN389_11890
LMPMUO_06045
LMOLLMOL312_1157(pduX)
LMOJLM220_17107
LMOZLM1816_08278
LMOXAX24_03220
LMHLMHCC_1480
LMQLMM7_1176(pduX)
LMLlmo4a_1153(pduX)
LMGLMKG_01764
LMSLMLG_1094
LMJLMOG_00559
LMWLMOSLCC2755_1162(pduX)
LMXLMOSLCC2372_1165(pduX)
LMZLMOSLCC2482_1209(pduX)
LMONLMOSLCC2376_1121(pduX)
LMOSLMOSLCC7179_1137(pduX)
LMOOLMOSLCC2378_1175(pduX)
LMOYLMOSLCC2479_1166(pduX)
LMOTLMOSLCC2540_1148(pduX)
LMOALMOATCC19117_1170(pduX)
LMOKCQ02_06015
LMVY193_09885
LINlin1134
LWElwe1128
LSGlse_1048(pduX)
LIVLIV_1102
LIIJL52_05845
LIWAX25_05950
LIAJL58_05970
LIOJL53_06500
LMARLAX80_005430
SSASSA_0511(pduX)
SIPN597_05170
SMENSAMEA4412692_0330(pduX)
EAVEH197_13935
ERAFJ9537_06315
VCPH9L18_11620
VHYG7082_09040
ABAECL176_08765
CACCA_C1371
CAESMB_G1394
CAYCEA_G1385
CTCCTC_00786
CTETBN906_00826
CBOCBO0953(pduX)
CBACLB_0995
CBHCLC_1009
CBYCLM_1104
CBLCLK_0391
CBBCLD_3607
CBICLJ_B1004
CBFCLI_1043
CBMCBF_1012
CBJH04402_01022
CKLCKL_0717
CKRCKR_0639
CLJCLJU_c31830
CPASClopa_1225
CPATCLPA_c12730(pduX)
CPAECPAST_c12730(pduX)
CAHCAETHG_1111
CSQCSCA_5077
CLDCLSPO_c09520
CACECACET_c00560(pduX)
CCKCcar_15380
CTYKCTK_C09530
CFMBJL90_05860
CDRKB9W14_19425
CCOHSAMEA4530647_0646
CFERD4Z93_11015
CLOSDMR38_15940
AMTAmet_0068
GFEGferi_24220
CRSFQB35_05195
CPRFK7H06_10805
PBIFKXZ80_14525
CDFCD630_34310
PDCCDIF630_03739(pduX)
CDCCD196_3207
CDLCDR20291_3253
PDFCD630DERM_34310
EACEAL2_808p00980
CSTCLOST_0986(pduX)
PSORRSJ16_16285
ROCHF520_12005
PHXKGNDJEFE_00479(pduX)
TEMJW646_05960
TEBT8CH_0255(pduX)
DSYDSY4058
DHDDhaf_1308
DDHDesde_1240
DDLDesdi_1031
DMTDESME_03945
DORDesor_2797
DAIDesaci_2446
DMIDesmer_2199
DCADesca_0591
DRMDred_2702
DRUDesru_0911
DFGB0537_13895
TFRBR63_04680
AACXDEACI_2584
TJRTherJR_1311
HMOHM1_2403
HCVFTV88_0710
ELMELI_0756
EMTCPZ25_016720
ELIMB2M23_11480
AWOAwo_c30510
TKITKV_c19670(pduX)
CHYCHY_0772
MTAMoth_1103
MTHOMOTHE_c10630(pduX)
MTHZMOTHA_c11520(pduX)
TPZTph_c05150(pduX)
MASMahau_0759
TEPTepRe1_1002
TAETepiRe1_1099
TOCToce_1423
NCDACONDI_00699(pduX)
HASHalsa_2192
HPKHprae_1518
HALSD7D81_15695
IFNGM661_12830
AARAcear_0846
HHLHalha_1700
KMEH0A61_01981(pduX)
VPRVpar_0909
VATB7L28_04410
VRM44547418_00926
VDNNCTC11831_01037
VNKVEIT17_09200
MEDMELS_1829
MHWACT01_09715
MEGDKB62_00150
MMAXLCQ47_01760
DHODia5BBH33_09490
SRISELR_20710
SELEADJ74_00245
SELOAXE86_10020
SELTBCS37_04990
MFUNGXM21_03750
PUFUFO1_2208
PFTJBW_02349
MANAMAMMFC1_03994(pduX)
STEDSPTER_16900(pduX)
TAITaci_0066
TLITlie_0163
ALAMRT761_00796(pduX)
 » show all
Reference
1  [PMID:18308727]
  Authors
Fan C, Bobik TA.
  Title
The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis.
  Journal
J Biol Chem 283:11322-9 (2008)
DOI:10.1074/jbc.M800287200
  Sequence
[stm:STM2058]
Reference
2  [PMID:19509296]
  Authors
Fan C, Fromm HJ, Bobik TA
  Title
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
  Journal
J Biol Chem 284:20240-8 (2009)
DOI:10.1074/jbc.M109.027425
  Sequence
[stm:STM2058]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.177
IUBMB Enzyme Nomenclature: 2.7.1.177
ExPASy - ENZYME nomenclature database: 2.7.1.177
BRENDA, the Enzyme Database: 2.7.1.177
LinkDB

KEGG   REACTION: R06531
Entry
R06531                      Reaction                               
Name
ATP:L-threonine O-phosphotransferase
Definition
L-Threonine + ATP <=> L-Threonine O-3-phosphate + ADP
Equation
Comment
L-threonine kinase, pduX
Reaction class
RC00002  C00002_C00008
RC00428  C00188_C12147
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
Orthology
K16651  L-threonine kinase [EC:2.7.1.177]
Other DBs
RHEA: 33710
LinkDB

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