KEGG ORTHOLOGY: K16823

ORTHOLOGY: K16823

Entry

K16823                      KO

Symbol

TP53BP2, ASPP2

Name

apoptosis-stimulating of p53 protein 2

Pathway

map04390

Hippo signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K16823  TP53BP2, ASPP2; apoptosis-stimulating of p53 protein 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K16823  TP53BP2, ASPP2; apoptosis-stimulating of p53 protein 2
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K16823  TP53BP2, ASPP2; apoptosis-stimulating of p53 protein 2

Genes

HSA:	7159(TP53BP2)

PTR:	457766(TP53BP2)

PPS:	100989224(TP53BP2)

GGO:	101147536(TP53BP2)

PON:	129047250(TP53BP2)

PPYG:

129014361(TP53BP2)

NLE:	100589440(TP53BP2)

HMH:	116457886(TP53BP2)

SSYN:

129458151(TP53BP2)

MCC:	705383(TP53BP2)

MCF:	102123065(TP53BP2)

MTHB:

126937260

MNI:	105478208(TP53BP2)

CSAB:

103230022(TP53BP2)

CATY:

105576961(TP53BP2)

PANU:

101023677(TP53BP2)

TGE:	112632615(TP53BP2)

MLEU:

105554490(TP53BP2)

RRO:	104677282(TP53BP2)

RBB:	108528247(TP53BP2)

TFN:	117075200(TP53BP2)

PTEH:

111537093(TP53BP2)

CANG:

105502826(TP53BP2)

CJC:	100404852(TP53BP2)

SBQ:	101035278(TP53BP2)

CIMI:

108302704(TP53BP2)

ANAN:

105722302(TP53BP2)

CSYR:

103272578(TP53BP2)

MMUR:

105863765(TP53BP2)

LCAT:

123627506(TP53BP2)

PCOQ:

105810142(TP53BP2)

OGA:	100946404(TP53BP2)

MMU:	209456(Trp53bp2)

MCAL:

110294927(Tp53bp2)

MPAH:

110321776(Tp53bp2)

RNO:	305025(Tp53bp2)

MCOC:

116068089(Tp53bp2)

ANU:	117721612(Tp53bp2)

ASYL:

127697283(Tp53bp2)

MUN:	110546665(Tp53bp2)

CGE:	100770953(Tp53bp2)

MAUA:

101833947(Tp53bp2)

PROB:

127223718(Tp53bp2)

PLEU:

114684419(Tp53bp2)

PMAV:

102903135(Tp53bp2)

MORG:

121435897(Tp53bp2)

MFOT:

126502110

AAMP:

119827717(Tp53bp2)

NGI:	103726265(Tp53bp2)

HGL:	101720764(Tp53bp2)

CPOC:

100732221(Tp53bp2)

CCAN:

109677048(Tp53bp2)

DORD:

105984971(Tp53bp2)

DSP:	122109440(Tp53bp2)

DMER:

138827296 138827446

PLOP:

125360102(Tp53bp2)

NCAR:

124961747

MMMA:

107140515(Tp53bp2)

ITI:	101957044(Tp53bp2)

OCU:

100349267

OPI:	101532430(TP53BP2)

OCZ:	121160061(TP53BP2)

TUP:	102482562(TP53BP2)

GVR:	103607536(TP53BP2)

CFA:	490397(TP53BP2)

CLUD:

112648847(TP53BP2)

VVP:	112923579(TP53BP2)

VLG:	121485747(TP53BP2)

NPO:	129509081(TP53BP2)

AML:	100476406(TP53BP2)

UMR:	103667267(TP53BP2)

UAH:	113262900(TP53BP2)

UAR:	123791955(TP53BP2)

ELK:

111150707

LLV:

125086234

MPUF:

101675543(TP53BP2)

MNP:	132025534(TP53BP2)

MLK:	131814738(TP53BP2)

NVS:	122918703(TP53BP2)

ORO:	101364840(TP53BP2)

EJU:	114215536(TP53BP2)

ZCA:	113932504(TP53BP2)

MLX:	118012994(TP53BP2)

NSU:	110571385(TP53BP2)

LWW:

102743142

FCA:	101083477(TP53BP2)

PYU:	121015187(TP53BP2)

PCOO:

112863176(TP53BP2)

PBG:	122475953(TP53BP2)

PVIV:

125159603(TP53BP2)

LRUF:

124510320

LGF:	123585311(TP53BP2)

AJU:

106983174

PTG:	102972442(TP53BP2)

PPAD:

109258889(TP53BP2)

PUC:

125925061

PLEZ:

122212403(TP53BP2)

HHV:	120234137(TP53BP2)

BTA:	514474(TP53BP2)

BOM:	102271080(TP53BP2)

BIU:	109570369(TP53BP2)

BBUB:

102414562(TP53BP2)

BBIS:

104997874(TP53BP2)

CHX:	102183989(TP53BP2)

OAS:	101108587(TP53BP2)

BTAX:

128061426(TP53BP2)

CSUM:

138090378(TP53BP2)

ODA:	120880359(TP53BP2)

CCAD:

122452393(TP53BP2)

MREE:

136170010(TP53BP2)

OVR:	110128638(TP53BP2)

MBEZ:

129551653(TP53BP2)

SSC:	100519863(TP53BP2)

CFR:	102521585(TP53BP2)

CBAI:

105083947(TP53BP2)

CDK:	105099825(TP53BP2)

VPC:	102531179(TP53BP2)

BACU:

103010522(TP53BP2)

BMUS:

118898786(TP53BP2)

LVE:	103077630(TP53BP2)

OOR:	101270040(TP53BP2)

LALB:

132507810(TP53BP2)

GMF:	115859439(TP53BP2)

DDP:	132414900(TP53BP2)

DLE:	111177506(TP53BP2)

PCAD:

102973637(TP53BP2)

PSIU:

116740331(TP53BP2)

PPHC:

136125657(TP53BP2)

NASI:

112403144(TP53BP2)

ECB:	100055278(TP53BP2)

EPZ:	103563905(TP53BP2)

EAI:	106829556(TP53BP2)

MYB:	102240531(TP53BP2)

MYD:	102769501(TP53BP2)

MMYO:

118678941(TP53BP2)

MLF:	102435911(TP53BP2)

MDT:	132222450(TP53BP2)

MYUM:

138999148(TP53BP2)

PKL:	118727618(TP53BP2)

EFUS:

103293457(TP53BP2)

MNA:	107543610(TP53BP2)

DRO:	112318813(TP53BP2)

SHON:

119003127(TP53BP2)

AJM:	119036515(TP53BP2)

PDIC:

114512399(TP53BP2)

PHAS:

123832244(TP53BP2)

MMF:	118640615(TP53BP2)

PPAM:

129072994(TP53BP2)

HAI:	109381178(TP53BP2)

RFQ:	117018534(TP53BP2)

PALE:

102897452(TP53BP2)

PGIG:

120619137(TP53BP2)

PVP:	105292617(TP53BP2)

RAY:	107498968(TP53BP2)

MJV:	108400833(TP53BP2)

TOD:	119244504(TP53BP2)

SARA:

101557869(TP53BP2)

SFUM:

130040419(TP53BP2)

SETR:

126013359(TP53BP2)

LAV:	100676038(TP53BP2)

TMU:

101354332

ETF:	101649255(TP53BP2)

DNM:	101425893(TP53BP2)

MDO:	100025256(TP53BP2)

GAS:	123246004(TP53BP2)

SHR:	100920563(TP53BP2)

AFZ:

127559524

PCW:	110205535(TP53BP2)

TVP:	118847511(TP53BP2)

PBRV:

138141762(TP53BP2)

MLAO:

141513182(TP53BP2)

OAA:	100081599(TP53BP2)

TACU:

119940720(TP53BP2)

GGA:	421329(TP53BP2)

PCOC:

116230892(TP53BP2)

MGP:	100546024(TP53BP2)

CJO:	107311032(TP53BP2)

TPAI:

128076175(TP53BP2)

LMUT:

125690012(TP53BP2)

NMEL:

110395701(TP53BP2)

APLA:

101799236(TP53BP2)

ACYG:

106031549(TP53BP2)

CATA:

118252980(TP53BP2)

AFUL:

116487637(TP53BP2)

TGU:	100221962(TP53BP2)

LSR:	110478020(TP53BP2)

SCAN:

103819277(TP53BP2)

PMOA:

120505915(TP53BP2)

OTC:	121346914(TP53BP2)

PRUF:

121357078(TP53BP2)

ATRC:

139587700(TP53BP2)

GFR:	102042696(TP53BP2)

FAB:	101809048(TP53BP2)

OMA:	130250772(TP53BP2)

PHI:	102111264(TP53BP2)

PMAJ:

107202198(TP53BP2)

CCAE:

111926248(TP53BP2)

CCW:	104685554(TP53BP2)

CBRC:

103612697(TP53BP2)

ACOE:

138107700(TP53BP2)

ETL:	114073708(TP53BP2)

ZAB:	102072660(TP53BP2)

ZLE:	135446044(TP53BP2)

ACHL:

103802946(TP53BP2)

SVG:	106853911(TP53BP2)

MMEA:

130583037(TP53BP2)

HRT:	120750693(TP53BP2)

SATI:

136359541(TP53BP2)

CFAI:

136286529(TP53BP2)

CCIC:

134042191(TP53BP2)

FPG:	101915972(TP53BP2)

FCH:	102046211(TP53BP2)

CCRI:

104159171(TP53BP2)

NNT:	104408712(TP53BP2)

SHAB:

115613809(TP53BP2)

ACUN:

113477956(TP53BP2)

SURA:

141941308(TP53BP2)

TALA:

104365795(TP53BP2)

ACHC:

115349961(TP53BP2)

HALD:

104317977(TP53BP2)

HLE:	104838131(TP53BP2)

AGEN:

126052619

HHAR:

128149889(TP53BP2)

GCL:

127015288

CSTI:

104550210(TP53BP2)

LDI:	104350928(TP53BP2)

MNB:	103769081(TP53BP2)

DPUB:

104300887(TP53BP2)

PPUS:

135186652(TP53BP2)

AVIT:

104275825(TP53BP2)

BRHI:

104489250(TP53BP2)

EGZ:	104124702(TP53BP2)

NNI:	104019282(TP53BP2)

PCRI:

104025093(TP53BP2)

PCAO:

104045726(TP53BP2)

PADL:

103925022(TP53BP2)

AFOR:

103894450(TP53BP2)

FGA:	104078455(TP53BP2)

CBOR:

142080921(TP53BP2)

GSTE:

104255470(TP53BP2)

CBOY:

140649583(TP53BP2)

MAME:

142407236(TP53BP2)

CLV:	102089213(TP53BP2)

CNIC:

135987447(TP53BP2)

MUI:	104544142(TP53BP2)

PGUU:

104471955(TP53BP2)

PLET:

104625385(TP53BP2)

EHS:	104514070(TP53BP2)

CMAC:

104483675(TP53BP2)

CUCA:

104067030(TP53BP2)

TEO:	104373941(TP53BP2)

BREG:

104629829(TP53BP2)

GAME:

129204224(TP53BP2)

OHA:	104331969(TP53BP2)

ACAR:

104532654(TP53BP2)

CPEA:

104386199(TP53BP2)

CVF:	104294662(TP53BP2)

RTD:	128906889(TP53BP2)

CRID:

134512659(TP53BP2)

LMIC:

141740394(TP53BP2)

AAM:	106482700(TP53BP2)

AROW:

112963430(TP53BP2)

NPD:	112954817(TP53BP2)

TGT:	104570278(TP53BP2)

DNE:	112980020(TP53BP2)

SCAM:

104151688(TP53BP2)

ASN:	102373092(TP53BP2)

AMJ:	102560202(TP53BP2)

CPOO:

109319763(TP53BP2)

GGN:	109296889(TP53BP2)

PSS:	102458316(TP53BP2)

CIZ:	142011068(TP53BP2)

CMY:	102936774(TP53BP2)

CCAY:

125633668(TP53BP2)

DCC:	119852739(TP53BP2)

CPIC:

101940266(TP53BP2)

TST:	117874494(TP53BP2)

CABI:

116825594(TP53BP2)

MRV:	120400952(TP53BP2)

ACS:	100553755(tp53bp2)

ASAO:

132761384(TP53BP2)

PVT:	110075405(TP53BP2)

SUND:

121917683 121917684

PBI:	103057175(TP53BP2)

PMUR:

107290033(TP53BP2)

CTIG:

120307213(TP53BP2)

TSR:	106549640(TP53BP2)

PGUT:

117671749(TP53BP2)

PCAE:

139320871(TP53BP2)

APRI:

131189345(TP53BP2)

PTEX:

113433239(TP53BP2)

NSS:	113421708(TP53BP2)

VKO:	123024617(TP53BP2)

PMUA:

114594631(TP53BP2)

PRAF:

128411076(TP53BP2)

ZVI:	118083209(TP53BP2)

HCG:	128350203(TP53BP2)

GJA:	107121626(TP53BP2)

STOW:

125436790(TP53BP2)

EMC:	129330018(TP53BP2)

XLA:	414498(tp53bp2.S) 446947(tp53bp2.L)

XTR:	548790(tp53bp2)

NPR:	108787070(TP53BP2)

RTEM:

120937866(TP53BP2)

ACAT:

141140826(TP53BP2)

PADS:

140329555(TP53BP2)

BBUF:

120999609(TP53BP2)

BGAR:

122933983(TP53BP2)

DTC:	141060113(TP53BP2)

PWL:	138295490(TP53BP2)

MUO:	115465479(TP53BP2)

GSH:	117357808(TP53BP2)

DRE:	407983(tp53bp2a) 568138(tp53bp2b)

SRX:	107717669 107742808 107753719(tp53bp2)

SANH:

107667887 107699141(tp53bp2) 107704550 107705014

SGH:	107558217 107571640 107582030 107602677

CCAR:

109045620 109065151 109066297(tp53bp2b) 109066301

CAUA:

113039856 113057427 113065023 113113109

CGIB:

127942699 127970280 127987898 128026541

PTET:

122327632(tp53bp2b) 122356434(tp53bp2a)

LROH:

127153355(tp53bp2b) 127175129(tp53bp2a)

GRF:	141326508(tp53bp2a) 141338143 141338268(tp53bp2b)

OMC:	131530123(tp53bp2b) 131552137(tp53bp2a)

PPRM:

120492296(tp53bp2a) 120495332(tp53bp2b)

RKG:	130079596(tp53bp2a) 130103423(tp53bp2b)

MAMB:

125253700(tp53bp2b) 125277543(tp53bp2a)

CIDE:

127520421 127525104

CERY:

137020824(tp53bp2a) 137029047(tp53bp2b)

MASI:

127413605 127438353 127438934

TROS:

130548653(tp53bp2b) 130559573(tp53bp2a)

TDW:	130430376(tp53bp2b) 130431711(tp53bp2a)

MANU:

129454350(tp53bp2b)

PDAB:

135732510(tp53bp2a) 135741046(tp53bp2b)

IPU:	108259391(tp53bp2b) 108260890(tp53bp2a)

IFU:	128602881(tp53bp2b) 128604200(tp53bp2a)

PHYP:

113544335(tp53bp2) 113547645

SMEO:

124379878(tp53bp2b) 124381350(tp53bp2a)

TFD:	113656996(tp53bp2b) 113660727(tp53bp2a)

TVC:	132838544(tp53bp2b) 132841813(tp53bp2a)

CGAR:

128508402(tp53bp2a) 128519005(tp53bp2b)

NGRA:

132875275(tp53bp2b) 132883368(tp53bp2a)

TRN:	134303940(tp53bp2b) 134326060(tp53bp2a)

AMEX:

103027134(tp53bp2a) 103038717(tp53bp2b)

CMAO:

118804649(tp53bp2b) 118816736(tp53bp2a)

EEE:	113568325(tp53bp2) 113588503

CHAR:

105891487 105910060

SPIL:

134064337(tp53bp2a) 134082705(tp53bp2b)

ASAD:

121684731(tp53bp2a) 121719401(tp53bp2b)

TRU:	101064572 101075443(tp53bp2)

TFS:	130527397 130533822

TNG:	GSTEN00008306G001 GSTEN00016473G001

LCO:	104927312 104930256

NCC:

104943175

TBEN:

117481724 117499650(tp53bp2a)

CGOB:

115020013(tp53bp2) 115025572

PGEO:

117450067 117459677(tp53bp2a)

GACU:

117538208(tp53bp2a) 117553397

EMAC:

134858739(tp53bp2a) 134864071

ELY:	117248225(tp53bp2a) 117255642

EFO:	125886157 125903395

PLEP:

121954361(tp53bp2a)

SLUC:

116050924 116054325(tp53bp2a)

ECRA:

117960094(tp53bp2a)

ESP:	116704861(tp53bp2)

PFLV:

114564872 114572206(tp53bp2)

GAT:	120820221(tp53bp2a) 120825286

PPUG:

119214188(tp53bp2a) 119217870

AFB:

129092299

CLUM:

117744169 117748470

PSWI:

130190121 130206982(tp53bp2a)

CANA:

137779782(tp53bp2a) 137792872

CVE:	137880564 137884782

MSAM:

119914507 119917017(tp53bp2a)

SCHU:

122873035 122884197(tp53bp2a)

CUD:	121508697 121510825(tp53bp2a)

SPUL:

138588449(tp53bp2a) 138594492

LMIX:

132975339(tp53bp2a) 132995649

HTC:	141795359(tp53bp2a) 141809170

ALAT:

119023555(tp53bp2b) 119033077

ASTR:

137603487(tp53bp2a)

MZE:	101475253 101482513 112429992

ONL:	100710954(tp53bp2) 102079784

OAU:	116316581(tp53bp2a) 116321227

OLA:	101156674(tp53bp2) 101168840

OML:	112157097 112161492

CSAI:

133447394 133463239(tp53bp2a)

XMA:	102225709(tp53bp2) 102237977

XCO:	114138124(tp53bp2) 114144247

XHE:	116713306(tp53bp2) 116720513

PRET:

103470863 103476865(tp53bp2)

PFOR:

103146655 103147729(tp53bp2)

PLAI:

106959617(tp53bp2) 106962697

PMEI:

106918082(tp53bp2) 106932388

GAF:	122829071 122843040

PPRL:

129359757(tp53bp2a)

CVG:	107095822(tp53bp2) 107104525

CTUL:

119788555

GMU:	124859177(tp53bp2a)

NFU:	107375719(tp53bp2) 107382372

KMR:	108244844(tp53bp2a) 108249788

ALIM:

106532027(tp53bp2) 106533578

NWH:	119412390(tp53bp2a) 119422546

AOCE:

111564379(tp53bp2a) 111571195

EJA:	138195329(tp53bp2a) 138209242

BFRE:

138617581(tp53bp2a) 138634594

MCEP:

125003533 125018802(tp53bp2a)

CSEM:

103383378 103387204(tp53bp2)

POV:	109634521(tp53bp2) 109642395

SSEN:

122770724 122781736

SSOE:

131467041 131473938

HHIP:

117763579 117775214(tp53bp2a)

HSP:	118118995(tp53bp2a) 118123617(tp53bp2b)

PPLT:

128437401 128453041

SMAU:

118283752(tp53bp2a) 118312786

LCF:

108880387

SDU:	111232977 111235334(tp53bp2)

SLAL:

111651194 111654653(tp53bp2)

XGL:	120796611(tp53bp2a) 120799787

HCQ:	109509927(tp53bp2)

SSCV:

125978441

SBIA:

133506728 133509696(tp53bp2a)

PEE:	133403906 133409624(tp53bp2a)

PTAO:

133476969 133485629(tp53bp2a)

BPEC:

110159147(tp53bp2)

ENY:

140351682

MALB:

109961975(tp53bp2) 109971814

BSPL:

114857266 114870396

SJO:	128372758(tp53bp2a) 128377902(tp53bp2b)

SSCO:

133991743(tp53bp2a) 133999214

TTY:	137180384 137197064(tp53bp2a)

GMH:	115540073 115559950(tp53bp2)

SASA:

106564779 106576990 106584892 106607150

STRU:

115153209 115178292 115193780 115208476

OTW:	112230411(tp53bp2b) 112253013(tp53bp2a) 112254456 112266200

OMY:	110486087 110493802 110502460 110528719(tp53bp2a)

OGO:	124003298(tp53bp2b) 124038250 124041264

ONE:	115103485 115113228 115135119 115142679

OKI:	109865632 109889933 109890487 109899715

OKE:	118369700(tp53bp2a) 118389091(tp53bp2b) 118400256

OMM:	135511014(tp53bp2a) 135512329 135521352 135539460

OCLA:

139370588 139381243 139411561 139423527

SALP:

111951812 111960799 111978691 111982257

SNH:	120017644 120032768 120046688 120065002

SFON:

129836336 129839118 129839580 129857260

CCLU:

121553584 121570634 121572345 123483401

ELS:	105010670(tp53bp2) 105028765

OEP:	134008494(tp53bp2b) 134022110(tp53bp2a)

SFM:	108927113(tp53bp2)

PKI:	111835720 111853779

AANG:

118217955 118221105

AROT:

135244419 135245149

CCOG:

133117897 133121765

LOC:	102688734(tp53bp2)

PSPA:

121315721 121316812(tp53bp2a)

ARUT:

117403279 117411322(tp53bp2a)

PSEX:

120516288

LCM:	102358097(TP53BP2)

CMK:

RTP:

CPLA:

CPUN:

HOC:

LERI:

HAKA:

BFO:

BCOO:

EPA:

ADF:

HMG:

Reference

PMID:11684014

Authors

Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L, Crook T, Lu X

Title

ASPP proteins specifically stimulate the apoptotic function of p53.

Journal

Mol Cell 8:781-94 (2001)
DOI:10.1016/S1097-2765(01)00367-7

Sequence

[hsa:7159]

Reference

PMID:17211478

Authors

Sullivan A, Lu X

Title

ASPP: a new family of oncogenes and tumour suppressor genes.

Journal

Br J Cancer 96:196-200 (2007)
DOI:10.1038/sj.bjc.6603525

LinkDB

DBGET integrated database retrieval system