KEGG   ORTHOLOGY: K17475
Entry
K17475                      KO                                     
Symbol
FTMC, CYP5076C
Name
tryprostatin B 6-hydroxylase [EC:1.14.14.118]
Pathway
map00404  Staurosporine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Reaction
R10321  tryprostatin B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K17475  FTMC, CYP5076C; tryprostatin B 6-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17475  FTMC, CYP5076C; tryprostatin B 6-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.118  tryprostatin B 6-hydroxylase
     K17475  FTMC, CYP5076C; tryprostatin B 6-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP5076 family
   K17475  FTMC, CYP5076C; tryprostatin B 6-hydroxylase
Other DBs
COG: COG2124
Genes
TATV: 25784084(TrAtP1_008909)
TASP: 36610641(TrAFT101_002547)
AFM: AFUA_8G00190
NFI: NFIA_093700
APUU: APUU_22030A
Reference
PMID:19226505
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence
[afm:AFUA_8G00190]
LinkDB

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