KEGG   ORTHOLOGY: K17486
Entry
K17486                      KO                                     
Symbol
dmdA
Name
dimethylsulfoniopropionate demethylase [EC:2.1.1.269]
Pathway
map00920  Sulfur metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K17486  dmdA; dimethylsulfoniopropionate demethylase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.269  dimethylsulfoniopropionate demethylase
     K17486  dmdA; dimethylsulfoniopropionate demethylase
Other DBs
RN: R10333
Genes
GAI: IMCC3135_15030(dmdA)
HOE: IMCC20628_01219
LABR: CHH27_18755(dmdA)
LABP: FJ695_04260
SIL: SPO1913(dmdA)
SIT: TM1040_1444
RUA: D1823_05765
RUT: FIU92_07260(dmdA)
JAN: Jann_2379
RDE: RD1_2288
DSH: Dshi_2320(gcvT1)
OTM: OSB_12930(dmdA)
LMD: METH_10405(dmdA)
LAQU: R2C4_07615
MALG: MALG_05026
SULZ: C1J03_10680(dmdA)
SULI: C1J05_10880(dmdA)
SULD: B5M07_09030(dmdA)
SINL: DSM14862_01560(dmdA)
TOM: BWR18_06790(dmdA)
RMM: ROSMUCSMR3_03150(dmdA)
RID: RIdsm_03278(dmdA_2)
ROH: FIU89_12640(dmdA1)
THAA: CFI11_12685(dmdA)
MARU: FIU81_11530(dmdA)
RMB: K529_006360(dmdA)
 » show all
Reference
  Authors
Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN
  Title
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.
  Journal
Protein Sci 21:289-98 (2012)
DOI:10.1002/pro.2015
  Sequence
LinkDB

KEGG   ENZYME: 2.1.1.269
Entry
EC 2.1.1.269                Enzyme                                 
Name
dimethylsulfoniopropionate demethylase;
dmdA (gene name);
dimethylsulfoniopropionate-dependent demethylase A
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase
Reaction(IUBMB)
S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate [RN:R10333]
Reaction(KEGG)
R10333
Substrate
S,S-dimethyl-beta-propiothetin [CPD:C04022];
tetrahydrofolate [CPD:C00101]
Product
3-(methylsulfanyl)propanoate [CPD:C08276];
5-methyltetrahydrofolate [CPD:C00440]
Comment
The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2].
History
EC 2.1.1.269 created 2013
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K17486  dimethylsulfoniopropionate demethylase
Genes
GAIIMCC3135_15030(dmdA)
HOEIMCC20628_01219
LABRCHH27_18755(dmdA)
LABPFJ695_04260
SILSPO1913(dmdA)
SITTM1040_1444
RUAD1823_05765
RUTFIU92_07260(dmdA)
JANJann_2379
RDERD1_2288
RLIRLO149_c022350
RPONG3256_07845
DSHDshi_2320(gcvT1)
PGAPGA1_262p01830
OATOAN307_c32590
OAROA238_c20430
OTMOSB_12930(dmdA)
OCTFTO60_06890
LMDMETH_10405(dmdA)
LEJETW24_11110
LAQUR2C4_07615
REDroselon_02762
MALGMALG_05026
SULZC1J03_10680(dmdA)
SULIC1J05_10880(dmdA)
SULDB5M07_09030(dmdA)
SMEDJNX03_05055
SINLDSM14862_01560(dmdA)
TOMBWR18_06790(dmdA)
RMMROSMUCSMR3_03150(dmdA)
ROKRAK1035_2045
RIDRIdsm_03278(dmdA_2)
ROMEI983_06395
ROHFIU89_12640(dmdA1)
AHTANTHELSMS3_04733
THAACFI11_12685(dmdA)
MARUFIU81_11530(dmdA)
RMBK529_006360(dmdA)
BOOE2K80_07960
PAEDG5B38_17915
CACTHZ995_14240
GCEKYE46_10740
PUBSAR11_0246
PEGE5R92_05090
APCHIMB59_00001390
APMHIMB5_00000090
APBSAR116_0074
 » show all
Reference
1  [PMID:9396840]
  Authors
Jansen M, Hansen TA
  Title
Tetrahydrofolate serves as a methyl acceptor in the demethylation of dimethylsulfoniopropionate in cell extracts of sulfate-reducing bacteria.
  Journal
Arch Microbiol 169:84-7 (1998)
DOI:10.1007/s002030050545
Reference
2  [PMID:18849431]
  Authors
Reisch CR, Moran MA, Whitman WB
  Title
Dimethylsulfoniopropionate-dependent demethylase (DmdA) from Pelagibacter ubique  and Silicibacter pomeroyi.
  Journal
J Bacteriol 190:8018-24 (2008)
DOI:10.1128/JB.00770-08
  Sequence
[pub:SAR11_0246] [sil:SPO1913]
Reference
3  [PMID:22162093]
  Authors
Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN
  Title
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.
  Journal
Protein Sci 21:289-98 (2012)
DOI:10.1002/pro.2015
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.269
IUBMB Enzyme Nomenclature: 2.1.1.269
ExPASy - ENZYME nomenclature database: 2.1.1.269
BRENDA, the Enzyme Database: 2.1.1.269
LinkDB

KEGG   REACTION: R10333
Entry
R10333                      Reaction                               
Name
S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase
Definition
S,S-Dimethyl-beta-propiothetin + Tetrahydrofolate <=> 3-(Methylthio)propanoate + 5-Methyltetrahydrofolate
Equation
Reaction class
RC00113  C00101_C00440
RC00347  C04022_C08276
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
Orthology
K17486  dimethylsulfoniopropionate demethylase [EC:2.1.1.269]
Other DBs
RHEA: 35470
LinkDB

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