KEGG ORTHOLOGY: K17505

ORTHOLOGY: K17505

Entry

K17505                      KO

Symbol

PPM1K, PP2CM

Name

protein phosphatase 1K [EC:3.1.3.16]

Disease

H00172

Maple syrup urine disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K17505  PPM1K, PP2CM; protein phosphatase 1K
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K17505  PPM1K, PP2CM; protein phosphatase 1K
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
   PPM1 phosphatases (PP2C)
    K17505  PPM1K, PP2CM; protein phosphatase 1K

Other DBs

GO:

0004722

Genes

HSA:	152926(PPM1K)

PTR:	461368(PPM1K)

PPS:	100995592(PPM1K)

GGO:	101141730(PPM1K)

PON:	100174714(PPM1K)

PPYG:

129035153(PPM1K)

NLE:	100583724(PPM1K)

HMH:	116461029(PPM1K)

SSYN:

129492139(PPM1K)

MCC:	702398(PPM1K)

MCF:	102141701(PPM1K)

MTHB:

126954700

MNI:	105479642(PPM1K)

CSAB:

103235953(PPM1K)

CATY:

105576749(PPM1K)

PANU:

101018194(PPM1K)

TGE:	112625270(PPM1K)

MLEU:

105547224(PPM1K)

RRO:	104664609(PPM1K)

RBB:	108544703(PPM1K)

TFN:	117085333(PPM1K)

PTEH:

111530859(PPM1K)

CANG:

105518732(PPM1K)

CJC:	100410897(PPM1K)

SBQ:	101028998(PPM1K)

CIMI:

108315663(PPM1K)

ANAN:

105707016(PPM1K)

MMUR:

105876375(PPM1K)

LCAT:

123627317(PPM1K)

PCOQ:

105812719(PPM1K)

OGA:	100956906(PPM1K)

MMU:	243382(Ppm1k)

MCAL:

110296755(Ppm1k)

MPAH:

110316680(Ppm1k)

RNO:	312381(Ppm1k)

MCOC:

116098987(Ppm1k)

ANU:	117707080(Ppm1k)

MUN:	110564240(Ppm1k)

CGE:	100763686(Ppm1k)

MAUA:

101828026(Ppm1k)

PROB:

127235564(Ppm1k)

PLEU:

114710928(Ppm1k)

MORG:

121439742 121439768

MFOT:

126494429

AAMP:

119806680(Ppm1k)

NGI:	103743378(Ppm1k)

HGL:	101723582(Ppm1k)

CPOC:

100723717(Ppm1k)

CCAN:

109700851(Ppm1k)

DORD:

105995913(Ppm1k)

DSP:	122097860(Ppm1k)

PLOP:

125364894(Ppm1k)

NCAR:

124995007

MMMA:

107141311(Ppm1k)

OCU:

100340852

OPI:	101527987(PPM1K)

TUP:	102484960(PPM1K)

GVR:	103591742(PPM1K)

CFA:	478473(PPM1K)

CLUD:

112645549(PPM1K)

VVP:	112919656(PPM1K)

VLG:	121492740(PPM1K)

NPO:	129501822(PPM1K)

AML:	100475039(PPM1K)

UMR:	103677888(PPM1K)

UAH:	113263160(PPM1K)

UAR:	123788343(PPM1K)

ELK:

111154614

LLV:

125093157

MPUF:

101670139(PPM1K)

MNP:	132001291(PPM1K)

MLK:	131830681(PPM1K)

NVS:	122889424(PPM1K)

ORO:	101385323(PPM1K)

EJU:	114220141(PPM1K)

ZCA:	113924601(PPM1K)

MLX:	118010346(PPM1K)

NSU:	110591431(PPM1K)

LWW:	102748288(PPM1K)

FCA:	101093770(PPM1K)

PYU:	121032799(PPM1K)

PCOO:

112858648(PPM1K)

PBG:	122478670(PPM1K)

PVIV:

125164337(PPM1K)

LRUF:

124520708

PTG:	102951148(PPM1K)

PPAD:

109276116(PPM1K)

PUC:

125922920

AJU:

106976215

HHV:	120221186(PPM1K)

BTA:	540329(PPM1K)

BOM:	102273142(PPM1K)

BIU:	109560347(PPM1K)

BBUB:

102405526(PPM1K)

BBIS:

105003176(PPM1K)

CHX:	102173647(PPM1K)

OAS:	101119821(PPM1K)

BTAX:

128050004(PPM1K)

ODA:	120861954(PPM1K)

CCAD:

122422130(PPM1K)

MBEZ:

129561603(PPM1K)

SSC:	110262190(PPM1K)

CFR:	102523789(PPM1K)

CBAI:

105077703(PPM1K)

CDK:	105091569(PPM1K)

VPC:	102534947(PPM1K)

BACU:

103003216(PPM1K)

BMUS:

118895788(PPM1K)

LVE:	103077336(PPM1K)

OOR:	101290439(PPM1K)

DLE:	111179055(PPM1K)

PCAD:

102976190(PPM1K)

PSIU:

116754098(PPM1K)

NASI:

112393758(PPM1K)

ECB:	100063504(PPM1K)

EPZ:	103553206(PPM1K)

EAI:	106831955(PPM1K)

MYB:	102242115(PPM1K)

MYD:	102760340(PPM1K)

MMYO:

118671319(PPM1K)

MLF:	102418723(PPM1K)

MDT:	132216485(PPM1K)

PKL:	118729070(PPM1K)

EFUS:

103287864(PPM1K)

MNA:	107529727(PPM1K)

DRO:	112317807(PPM1K)

SHON:

118987062(PPM1K)

AJM:	119040112(PPM1K)

PDIC:

114493022(PPM1K)

PHAS:

123806854(PPM1K)

MMF:	118631494(PPM1K)

PPAM:

129085363(PPM1K)

HAI:	109377044(PPM1K)

RFQ:	117022151(PPM1K)

PALE:

102891125(PPM1K)

PGIG:

120588308(PPM1K)

PVP:	105289567(PPM1K)

RAY:	107518927(PPM1K)

MJV:	108385385(PPM1K)

TOD:	119260478(PPM1K)

SARA:

101544979(PPM1K)

SETR:

126032057(PPM1K)

LAV:	100669396(PPM1K)

TMU:

101340270

ETF:	101657397(PPM1K)

DNM:	101447453(PPM1K)

MDO:	100024867(PPM1K)

GAS:	123251310(PPM1K)

SHR:	100917274(PPM1K)

AFZ:

127539668

PCW:	110209693(PPM1K)

TVP:	118853909(PPM1K)

OAA:	114812952(PPM1K)

GGA:	422614(PPM1K)

PCOC:

116231126(PPM1K)

MGP:

100546141

CJO:	107313458(PPM1K)

TPAI:

128080598(PPM1K)

LMUT:

125692372(PPM1K)

NMEL:

110397931(PPM1K)

APLA:

101793256(PPM1K)

ACYG:

106048171(PPM1K)

CATA:

118244499(PPM1K)

AFUL:

116489248(PPM1K)

TGU:	100227426(PPM1K)

LSR:	110476482(PPM1K)

SCAN:

103826082(PPM1K)

PMOA:

120497225(PPM1K)

OTC:	121339880(PPM1K)

PRUF:

121360196(PPM1K)

GFR:	102038274(PPM1K)

FAB:	101818110(PPM1K)

OMA:	130252302(PPM1K)

PHI:	102111088(PPM1K)

PMAJ:

107203364(PPM1K)

CCAE:

111928851(PPM1K)

CCW:	104697245(PPM1K)

CBRC:

103622346(PPM1K)

ETL:	114057747(PPM1K)

ZAB:	102067362(PPM1K)

ZLE:	135446841(PPM1K)

ACHL:

103807772(PPM1K)

SVG:	106854834(PPM1K)

MMEA:

130575354(PPM1K)

HRT:	120752510(PPM1K)

SATI:

136360641(PPM1K)

FPG:	101924666(PPM1K)

FCH:	102057478(PPM1K)

CCRI:

104160428(PPM1K)

NNT:	104413017(PPM1K)

SHAB:

115610335(PPM1K)

ACUN:

113479629(PPM1K)

TALA:

104364700(PPM1K)

ACHC:

115345407(PPM1K)

HALD:

104312043

HLE:	104837209(PPM1K)

AGEN:

126044875

GCL:

127015445

CSTI:

104559486

LDI:	104348967(PPM1K)

MNB:	103770352(PPM1K)

DPUB:

104297118(PPM1K)

AVIT:

104268626(PPM1K)

BRHI:

104501436(PPM1K)

EGZ:	104127337(PPM1K)

NNI:	104021558(PPM1K)

PCRI:

104035965(PPM1K)

PCAO:

104042274(PPM1K)

PADL:

103919901(PPM1K)

AFOR:

103899729(PPM1K)

FGA:	104079334(PPM1K)

GSTE:

104251352(PPM1K)

CLV:	102096560(PPM1K)

MUI:	104542782(PPM1K)

PLET:

104627039(PPM1K)

EHS:	104505656(PPM1K)

CMAC:

104487149(PPM1K)

CUCA:

104058077(PPM1K)

TEO:	104376694(PPM1K)

BREG:

104632305(PPM1K)

OHA:	104337012(PPM1K)

ACAR:

104523508(PPM1K)

CPEA:

104398793(PPM1K)

CVF:	104291500(PPM1K)

RTD:	128910079(PPM1K)

AAM:	106494827(PPM1K)

AROW:

112970696(PPM1K)

NPD:	112951892(PPM1K)

TGT:	104572858(PPM1K)

DNE:	112985028(PPM1K)

SCAM:

104145170(PPM1K)

ASN:	102385412(PPM1K)

AMJ:	106737213(PPM1K)

CPOO:

109322126(PPM1K)

GGN:	109303920(PPM1K)

PSS:	102462861(PPM1K)

CMY:	102935696(PPM1K)

CCAY:

125635452(PPM1K)

DCC:	119854452(PPM1K)

CPIC:

101952046(PPM1K)

TST:	117878234(PPM1K)

CABI:

116836561(PPM1K)

MRV:	120406228(PPM1K)

ACS:	100562753(ppm1k)

ASAO:

132777012(PPM1K)

PVT:	110080511(PPM1K)

SUND:

121931489(PPM1K)

PMUR:

107290996(PPM1K)

CTIG:

120316040(PPM1K)

TSR:	106546819(PPM1K)

PGUT:

117678944(PPM1K)

APRI:

131203053(PPM1K)

PTEX:

113434860(PPM1K)

NSS:	113415306(PPM1K)

VKO:	123022564(PPM1K)

PMUA:

114603977(PPM1K)

PRAF:

128421381(PPM1K)

ZVI:	118083606(PPM1K)

HCG:	128327150(PPM1K)

GJA:	107110103(PPM1K)

STOW:

125440097(PPM1K)

EMC:	129336655(PPM1K)

XLA:	108711004(ppm1k.L) 432182(ppm1k.S)

XTR:	100487567(ppm1k)

NPR:	108784688(PPM1K)

RTEM:

120915334(PPM1K)

BBUF:

120989775(PPM1K)

BGAR:

122944721(PPM1K)

MUO:	115461097(PPM1K) 115470181

GSH:	117358824 117367066(PPM1K) 117368188

DRE:	503713(ppm1kb) 562087(ppm1ka)

SRX:	107706815 107729359 107748092 107752423

SANH:

107675910 107684283

SGH:	107550166 107583174 107594437

CCAR:

109062677 109066336 109085968

CAUA:

113041226 113044038 113044117 113044126 113072518

CGIB:

127949302 128011826 128017560

PTET:

122332791(ppm1ka) 122345765(ppm1kb)

LROH:

127154614(ppm1ka) 127167182(ppm1kb)

OMC:	131532659(ppm1ka) 131544643(ppm1kb)

PPRM:

120471138(ppm1ka) 120491073(ppm1kb)

RKG:	130083770(ppm1ka) 130087302(ppm1kb)

MAMB:

125260311(ppm1ka) 125271942(ppm1kb)

CIDE:

127504667 127508586

CERY:

137008862(ppm1ka) 137032750(ppm1kb)

MASI:

127418802 127420477 127444036 127445410

TROS:

130544968(ppm1ka) 130553565(ppm1kb)

TDW:	130408958(ppm1kb) 130409273(ppm1ka)

MANU:

129430716(ppm1ka) 129444119(ppm1kb)

IPU:	108262962(ppm1kb)

IFU:	128606038(ppm1kb) 128619780(ppm1ka)

PHYP:

113539821

SMEO:

124398704(ppm1ka) 124401816(ppm1kb)

TFD:	113642449(ppm1kb) 113655431(ppm1ka)

TVC:	132847610(ppm1kb) 132862678(ppm1ka)

TRN:	134315205(ppm1kb) 134333677(ppm1ka)

AMEX:

103044547(ppm1kb)

CMAO:

118810869(ppm1k) 118823033(si:ch211-149b19.3)

EEE:

113591983

CHAR:

105892600(ppm1kb)

TRU:	101067181(ppm1k)

TFS:	130527112(ppm1kb)

TNG:	GSTEN00020878G001

LCO:	104931319(ppm1k) 104932263

TBEN:

117469823 117482308(ppm1k)

CGOB:

115011271(ppm1k) 115023549

PGEO:

117440905 117449141(ppm1k)

GACU:

117549343 117556231(ppm1k)

EMAC:

134864695(ppm1kb) 134876192(ppm1ka)

ELY:	117245906 117255408(ppm1k)

EFO:	125883399(ppm1ka) 125885612(ppm1kb)

PLEP:

121942089(ppm1kb) 121962108(ppm1ka)

SLUC:

116034241(ppm1k) 116061827

ECRA:

117935184(si:ch211-149b19.3) 117961185(ppm1k)

ESP:

116703888

PFLV:

114545763 114569542(ppm1k)

GAT:	120821726(ppm1ka) 120824951(ppm1kb)

PPUG:

119218237(ppm1k) 119222986(si:ch211-149b19.3)

AFB:	129093405(ppm1ka) 129096421(ppm1kb)

CLUM:

117730489(ppm1k) 117747555(si:ch211-149b19.3)

PSWI:

130190773(ppm1kb)

MSAM:

119889541 119898884(ppm1k) 119913001

SCHU:

122870186 122873732(ppm1kb)

CUD:	121504702(ppm1ka) 121508360(ppm1kb)

ALAT:

119025034(ppm1k) 119026863

ASTR:

137590257(ppm1ka) 137600601(ppm1kb)

MZE:	101464406 101478110(ppm1k)

ONL:	100700412 100701392(ppm1k)

OAU:	116319344 116330002(ppm1kb)

OLA:	101167241 101174726

OML:	112137193(ppm1k) 112156484(si:ch211-149b19.3)

CSAI:

133420659(ppm1ka) 133440666(ppm1kb)

XMA:	102220408(ppm1k) 102229702

XCO:	114145634(ppm1k) 114156951

XHE:	116720206(ppm1k) 116733415

PRET:

103471014(ppm1k)

PFOR:

103144812(ppm1k) 103151629

PLAI:

106950625(ppm1k) 106962942

PMEI:

106928648(ppm1k) 106932816

GAF:	122821017(ppm1ka) 122829210(ppm1kb)

PPRL:

129351078(ppm1kb)

CVG:

107082778

CTUL:

119771658 119773883(ppm1k)

GMU:	124868522(ppm1kb) 124880270

NFU:	107376848 107389354(ppm1k)

KMR:	108231009(ppm1k) 108251600

ALIM:

106517082(ppm1k) 106527320

NWH:	119410367 119423242(ppm1kb)

AOCE:

111582665(ppm1k) 111588619

MCEP:

125004118(ppm1kb) 125004643(ppm1ka)

CSEM:

103383314(ppm1k)

POV:	109638378(ppm1k) 109645856

SSEN:

122767204(ppm1ka) 122770621(ppm1kb)

HHIP:

117752138(si:ch211-149b19.3) 117767518(ppm1k)

HSP:	118102719 118120433(ppm1kb)

PPLT:

128436590(ppm1kb)

SMAU:

118284712 118313001(ppm1kb)

LCF:	108873401(ppm1kb) 108886841(ppm1ka)

SDU:	111233347 111240119(ppm1k)

SLAL:

111671192(ppm1k) 111673182

XGL:	120797274 120800702(ppm1kb)

HCQ:	109511173(ppm1k)

SSCV:

125968864

SBIA:

133506564(ppm1kb)

PEE:	133403687(ppm1kb)

PTAO:

133476885(ppm1kb)

BPEC:

110153836(ppm1k)

MALB:

109951894 109955491(ppm1k)

BSPL:

114858585(ppm1kb) 114868740(ppm1ka)

SJO:	128370659(ppm1kb) 128384098(ppm1ka)

SASA:

106578195 106602316 106610284(PPM1K)

STRU:

115191760 115194727 115202267

OTW:	112261272(ppm1kb) 121847384

OMY:	110497358 110516113 110531332

OGO:	124008440(ppm1ka) 124012146(ppm1kb)

ONE:	115123457(ppm1k)

OKI:	109876595 109881158

OKE:	118377469 118381376(ppm1ka)

SALP:

112074027(ppm1k)

SNH:	120034922 120034927 120040276

CCLU:

121535977 121554587 123489298

ELS:	105020965(ppm1k) 105031515

SFM:	108924564(ppm1k)

PKI:

111837387

AANG:

118227877(ppm1k) 118231996

LOC:	102696178(ppm1k) 102696837

PSPA:

121297152 121320892 121321674 121326117

ARUT:

117409203 117414904 117417638 117421394(ppm1k)

PSEX:

120514705 120527086(ppm1kb)

LCM:	102347504(PPM1K)

CMK:	103188748 121851504(ppm1kb) 121852001

RTP:	109935908(ppm1kb)

CPLA:

122539479(ppm1kb) 122561014

HOC:	132826193 132833338(ppm1kb)

LERI:

129700914(ppm1kb) 129704210

PMRN:

116940252 116951082

LRJ:	133350632 133354324

BFO:

BBEL:

SPU:

LPIC:

ARUN:

AJC:

DPX:	DAPPUDRAFT_45296

DMK:

116932422

DPZ:

124350692

PJA:	122243630 122245283

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

DFR:

CVS:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_136567

PVUL:

PCAN:

BGT:

GAE:

HRF:

CRG:

CANU:

CVN:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LLON:

NVE:

ATEN:

SPIS:

XEN:

HMG:

HSY:

RES:

EHI:	EHI_164420(54.t00015)

» show all

Reference

PMID:17374715

Authors

Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y

Title

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.

Journal

Genes Dev 21:784-96 (2007)
DOI:10.1101/gad.1499107

Sequence

[hsa:152926] [mmu:243382]

LinkDB

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