KEGG   ORTHOLOGY: K17643
Entry
K17643                      KO                                     
Symbol
HYPC
Name
noranthrone monooxygenase [EC:1.13.12.20]
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Reaction
R10224  norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17643  HYPC; noranthrone monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.20  noranthrone monooxygenase
     K17643  HYPC; noranthrone monooxygenase
Genes
PAN: PODANSg8557
PBEL: QC761_207280
PPSD: QC762_207280
AOR: AO090026000010
AFV: AFLA_006310
APUU: APUU_20051A
FFU: CLAFUR5_14273
Reference
PMID:20348292
  Authors
Ehrlich KC, Li P, Scharfenstein L, Chang PK
  Title
HypC, the anthrone oxidase involved in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 76:3374-7 (2010)
DOI:10.1128/AEM.02495-09
  Sequence
[afv:AFLA_006310]
LinkDB

KEGG   ENZYME: 1.13.12.20
Entry
EC 1.13.12.20               Enzyme                                 
Name
noranthrone monooxygenase;
norsolorinate anthrone oxidase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming)
Reaction(IUBMB)
norsolorinic acid anthrone + O2 = norsolorinic acid + H2O [RN:R10224]
Reaction(KEGG)
R10224
Substrate
norsolorinic acid anthrone [CPD:C20453];
O2 [CPD:C00007]
Product
norsolorinic acid [CPD:C20452];
H2O [CPD:C00001]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.13.12.20 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17643  noranthrone monooxygenase
Genes
PAN: PODANSg8557
PBEL: QC761_207280
PPSD: QC762_207280
AOR: AO090026000010
AFV: AFLA_006310
APUU: APUU_20051A
FFU: CLAFUR5_14273
Reference
1  [PMID:20348292]
  Authors
Ehrlich KC, Li P, Scharfenstein L, Chang PK
  Title
HypC, the anthrone oxidase involved in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 76:3374-7 (2010)
DOI:10.1128/AEM.02495-09
  Sequence
[afv:AFLA_006310]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.20
IUBMB Enzyme Nomenclature: 1.13.12.20
ExPASy - ENZYME nomenclature database: 1.13.12.20
BRENDA, the Enzyme Database: 1.13.12.20
LinkDB

KEGG   REACTION: R10224
Entry
R10224                      Reaction                               
Name
norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming)
Definition
Norsolorinic acid anthrone + Oxygen <=> Norsolorinic acid + H2O
Equation
C20453 + C00007 <=> C20452 + C00001
Reaction class
RC01658  C20452_C20453
Enzyme
1.13.12.20
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.20
     R10224  Norsolorinic acid anthrone + Oxygen <=> Norsolorinic acid + H2O
Orthology
K17643  noranthrone monooxygenase [EC:1.13.12.20]
Other DBs
RHEA: 35194
LinkDB

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