KEGG   ORTHOLOGY: K17851
Entry
K17851                      KO                                     
Symbol
dpd
Name
D-proline dehydrogenase [EC:1.5.99.13]
Pathway
map00330  Arginine and proline metabolism
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Reaction
R09496  D-proline:acceptor oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K17851  dpd; D-proline dehydrogenase
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K17851  dpd; D-proline dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.99  With unknown physiological acceptors
    1.5.99.13  D-proline dehydrogenase
     K17851  dpd; D-proline dehydrogenase
Genes
PAI: PAE2095
PIS: Pisl_1862
PCL: Pcal_0182
PAS: Pars_2012
PYR: P186_0365
POG: Pogu_0110
TNE: Tneu_1260
PYW: PYWP30_01320
TTN: TTX_1315(dadA) TTX_1450
TUZ: TUZN_0089
Reference
  Authors
Satomura T, Kawakami R, Sakuraba H, Ohshima T
  Title
Dye-linked D-proline dehydrogenase from hyperthermophilic archaeon Pyrobaculum islandicum is a novel FAD-dependent amino acid dehydrogenase.
  Journal
J Biol Chem 277:12861-7 (2002)
DOI:10.1074/jbc.M112272200
  Sequence
[pis:Pisl_1862]
LinkDB

KEGG   ENZYME: 1.5.99.13
Entry
EC 1.5.99.13                Enzyme                                 
Name
D-proline dehydrogenase;
D-Pro DH;
D-Pro dehydrogenase;
dye-linked D-proline dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
Sysname
D-proline:acceptor oxidoreductase
Reaction(IUBMB)
D-proline + acceptor = 1-pyrroline-2-carboxylate + reduced acceptor [RN:R09496]
Reaction(KEGG)
R09496
Substrate
D-proline [CPD:C00763];
acceptor [CPD:C00028]
Product
1-pyrroline-2-carboxylate [CPD:C03564];
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FAD). The enzyme prefers D-proline and acts on other D-amino acids with lower efficiency.
History
EC 1.5.99.13 created 2010, modified 2011
Pathway
ec00330  Arginine and proline metabolism
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K17851  D-proline dehydrogenase
Genes
PAIPAE2095
PISPisl_1862
PCLPcal_0182
PASPars_2012
PYRP186_0365
POGPogu_0110
TNETneu_1260
PYWPYWP30_01320
TTNTTX_1315(dadA) TTX_1450
TUZTUZN_0089
Reference
1  [PMID:18558115]
  Authors
Tani Y, Tanaka K, Yabutani T, Mishima Y, Sakuraba H, Ohshima T, Motonaka J
  Title
Development of a D-amino acids electrochemical sensor based on immobilization of  thermostable D-proline dehydrogenase within agar gel membrane.
  Journal
Anal Chim Acta 619:215-20 (2008)
DOI:10.1016/j.aca.2008.04.063
  Sequence
[pis:Pisl_1862]
Reference
2  [PMID:11823469]
  Authors
Satomura T, Kawakami R, Sakuraba H, Ohshima T
  Title
Dye-linked D-proline dehydrogenase from hyperthermophilic archaeon Pyrobaculum islandicum is a novel FAD-dependent amino acid dehydrogenase.
  Journal
J Biol Chem 277:12861-7 (2002)
DOI:10.1074/jbc.M112272200
  Sequence
[pis:Pisl_1862]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.13
IUBMB Enzyme Nomenclature: 1.5.99.13
ExPASy - ENZYME nomenclature database: 1.5.99.13
BRENDA, the Enzyme Database: 1.5.99.13
LinkDB

KEGG   REACTION: R09496
Entry
R09496                      Reaction                               
Name
D-proline:acceptor oxidoreductase
Definition
D-Proline + Acceptor <=> 1-Pyrroline-2-carboxylate + Reduced acceptor
Equation
Reaction class
RC00135  C00763_C03564
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.99  With unknown physiological acceptors
    1.5.99.13
     R09496  D-Proline + Acceptor <=> 1-Pyrroline-2-carboxylate + Reduced acceptor
Orthology
K17851  D-proline dehydrogenase [EC:1.5.99.13]
Other DBs
RHEA: 27309
LinkDB

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