KEGG ORTHOLOGY: K18060

ORTHOLOGY: K18060

Entry

K18060                      KO

Symbol

MTPAP

Name

poly(A) RNA polymerase, mitochondrial [EC:2.7.7.19]

Disease

H01351

Spastic ataxia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K18060  MTPAP; poly(A) RNA polymerase, mitochondrial
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.19  polynucleotide adenylyltransferase
     K18060  MTPAP; poly(A) RNA polymerase, mitochondrial
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    K18060  MTPAP; poly(A) RNA polymerase, mitochondrial

Other DBs

GO:

0004652

Genes

HSA:	55149(MTPAP)

PTR:	450875(MTPAP)

PPS:	100978933(MTPAP)

GGO:	101132238(MTPAP)

PON:	100452869(MTPAP)

PPYG:

129044913(MTPAP)

NLE:	100607961(MTPAP)

HMH:	116462081(MTPAP)

SSYN:

129480775(MTPAP)

MCC:	694491(MTPAP)

MCF:	101867197(MTPAP)

MTHB:

126963357

MNI:	105479955(MTPAP)

CSAB:

103238075(MTPAP)

CATY:

105596978(MTPAP)

PANU:

101024350(MTPAP)

TGE:	112632118(MTPAP)

MLEU:

105537671(MTPAP)

RRO:	104657275(MTPAP)

RBB:	108528091(MTPAP)

TFN:	117082167(MTPAP)

PTEH:

111546641(MTPAP)

CANG:

105521960(MTPAP)

CJC:	100415242(MTPAP)

SBQ:	101047307(MTPAP)

CIMI:

108309226

ANAN:

105709661 105712530(MTPAP)

CSYR:

103276429(MTPAP)

MMUR:

105884787(MTPAP)

LCAT:

123624801

PCOQ:

105818748(MTPAP)

OGA:	100953333(MTPAP)

MMU:	67440(Mtpap)

MCAL:

110284686(Mtpap)

MPAH:

110333422(Mtpap)

RNO:	307050(Mtpap)

MCOC:

116086797(Mtpap)

ANU:	117714259(Mtpap)

ASYL:

127664827(Mtpap)

MUN:	110558398(Mtpap)

CGE:	100759832 100765719

MAUA:

101833365

PROB:

127237399(Mtpap)

MORG:

121440765

MFOT:

126507797

AAMP:

119816690

NGI:	103747992(Mtpap)

HGL:	101711487(Mtpap)

CPOC:

100725565(Mtpap)

CCAN:

109695914

DORD:

105984537(Mtpap)

DSP:

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

TUP:	102493426(MTPAP)

GVR:	103601712(MTPAP)

CFA:	477963(MTPAP)

CLUD:

112670384

VVP:	112921581(MTPAP)

VLG:

121497257

NPO:	129515574(MTPAP)

AML:	100481592(MTPAP)

UMR:

103656497

UAH:	113244247(MTPAP)

UAR:

123802258

ELK:

111158638

LLV:

125106699

MPUF:

101670359(MTPAP)

MNP:	132020057(MTPAP)

MLK:	131838104(MTPAP)

NVS:

122891111

ORO:	101385484(MTPAP)

EJU:	114222422(MTPAP)

ZCA:

113922849

MLX:	117998439(MTPAP)

NSU:

110577261

LWW:	102739589(MTPAP)

FCA:

101090875

PYU:

121014661

PCOO:

112867560(MTPAP)

PBG:

122473704

PVIV:

125170250(MTPAP)

LRUF:

124501409

LGF:

123589897

AJU:

106977306

PTG:	102961534(MTPAP)

PPAD:

109276337(MTPAP)

PUC:

125918662

PLEZ:

122224014

HHV:

120221614

BTA:	511412(MTPAP)

BOM:	102279981(MTPAP)

BIU:	109568006(MTPAP)

BBUB:

102400269

BBIS:

105003065(MTPAP)

CHX:	102188233(MTPAP)

OAS:	101116849(MTPAP)

BTAX:

128058487(MTPAP)

CSUM:

138091561(MTPAP)

ODA:

120869010

CCAD:

122448225

MREE:

136159245(MTPAP)

OVR:	110151981(MTPAP)

MBEZ:

129558677(MTPAP)

SSC:	100517235(MTPAP)

CFR:	102518085(MTPAP)

CBAI:

105071850(MTPAP)

CDK:	105096295(MTPAP)

VPC:	102534051(MTPAP)

BACU:

103011480(MTPAP)

BMUS:

118890279

LVE:	103070174(MTPAP)

OOR:	101269330(MTPAP)

LALB:

132527529(MTPAP)

DLE:	111178132(MTPAP)

PCAD:

102988210(MTPAP)

PSIU:

116749547(MTPAP)

NASI:

112402919(MTPAP)

ECB:	100055113(MTPAP)

EPZ:	103564066(MTPAP)

EAI:

106837967

MYB:	102248063(MTPAP)

MYD:	102775168(MTPAP)

MMYO:

118677045

MLF:	102429072(MTPAP)

MDT:	132242792(MTPAP)

MYUM:

139019683(MTPAP)

PKL:

118727622

EFUS:

103294007(MTPAP)

MNA:	107524413(MTPAP)

DRO:	112316806(MTPAP)

SHON:

118995178

AJM:	119063913(MTPAP)

PDIC:

114492849

PHAS:

123831165

MMF:

118616909

PPAM:

129085684(MTPAP)

HAI:	109389091(MTPAP)

RFQ:	117022559(MTPAP)

PALE:

102897242(MTPAP)

PGIG:

120584103

PVP:	105298315(MTPAP)

RAY:

107518932

MJV:

108392182

TOD:	119244637(MTPAP)

SARA:

101550752(MTPAP)

SFUM:

130041990(MTPAP)

SETR:

126014143(MTPAP)

LAV:	100666256(MTPAP)

TMU:

101343377

ETF:

101657393

DNM:	101422973(MTPAP)

MDO:	100024357(MTPAP)

GAS:

123250723

SHR:	100921011(MTPAP)

AFZ:

127539277

PCW:	110211267(MTPAP)

TVP:

118851698

PBRV:

138159978(MTPAP)

OAA:

100076255

TACU:

119936185

GGA:	420478(MTPAP)

PCOC:

116244418(MTPAP)

MGP:	100540017 104911363

CJO:	107308935(MTPAP)

TPAI:

128085854(MTPAP)

LMUT:

125695885

NMEL:

110393428(MTPAP)

APLA:

101791575

ACYG:

106042645(MTPAP)

CATA:

118247390(MTPAP)

AFUL:

116485902(MTPAP)

TGU:	100218145(MTPAP)

LSR:	110477305(MTPAP)

SCAN:

103813079(MTPAP)

PMOA:

120502447

OTC:

121338152

PRUF:

121364647

ATRC:

139590868(MTPAP)

GFR:	102039483(MTPAP)

FAB:	101819218(MTPAP)

OMA:	130249617(MTPAP)

PHI:	102103118(MTPAP)

PMAJ:

107215512(MTPAP)

CCAE:

111924098(MTPAP)

CCW:

104686531

CBRC:

103620666(MTPAP)

ACOE:

138106258(MTPAP)

ETL:	114060303(MTPAP)

ZAB:	102070407(MTPAP)

ZLE:	135443627(MTPAP)

ACHL:

103802901(MTPAP)

SVG:	106855579(MTPAP)

MMEA:

130578236(MTPAP)

HRT:	120755291(MTPAP)

SATI:

136359161(MTPAP)

CCIC:

134044733(MTPAP)

FPG:	101916689(MTPAP)

FCH:	102058961(MTPAP)

CCRI:

104169455(MTPAP)

NNT:	104400081(MTPAP)

SHAB:

115609496(MTPAP)

ACUN:

113476457(MTPAP)

TALA:

104367976

ACHC:

115339241

HALD:

104316912(MTPAP)

HLE:	104828939(MTPAP)

AGEN:

126037672

HHAR:

128149764(MTPAP)

GCL:

127013736

CSTI:

104557343(MTPAP)

LDI:	104348754(MTPAP)

MNB:	103780061(MTPAP)

DPUB:

104298533(MTPAP)

PPUS:

135185726(MTPAP)

AVIT:

104268158(MTPAP)

BRHI:

104490894(MTPAP)

EGZ:

104133601

NNI:	104022276(MTPAP)

PCRI:

104028368(MTPAP)

PCAO:

104050851(MTPAP)

PADL:

103918241(MTPAP)

AFOR:

103895566(MTPAP)

FGA:	104078098(MTPAP)

GSTE:

104257040(MTPAP)

CBOY:

140648484(MTPAP)

CLV:	102086904(MTPAP)

MUI:	104538415(MTPAP)

PGUU:

104465543(MTPAP)

PLET:

104627063(MTPAP)

EHS:	104504431(MTPAP)

CMAC:

104487539(MTPAP)

CUCA:

104066671(MTPAP)

TEO:	104381818(MTPAP)

BREG:

104630002(MTPAP)

OHA:	104339041(MTPAP)

CPEA:

104397104(MTPAP)

CVF:	104295356(MTPAP)

RTD:	128905350(MTPAP)

CRID:

134511105(MTPAP)

AAM:	106490022(MTPAP)

AROW:

112963206(MTPAP)

NPD:	112955456(MTPAP)

TGT:	104570215(MTPAP)

DNE:	112984022(MTPAP)

SCAM:

104147236(MTPAP)

ASN:	102367945(MTPAP)

AMJ:	102566233(MTPAP)

CPOO:

109307413(MTPAP)

GGN:	109291284(MTPAP)

PSS:	102458152(MTPAP)

CMY:

CCAY:

DCC:

CPIC:

TST:	117872091(MTPAP)

CABI:

116815633(MTPAP)

MRV:

120397004

ACS:	100562685(mtpap)

ASAO:

132778940(MTPAP)

PVT:	110082912(MTPAP)

SUND:

121934950

PBI:	103064114(MTPAP)

PMUR:

107282829(MTPAP)

CTIG:

120317303

TSR:	106550998(MTPAP)

PGUT:

117655301(MTPAP)

APRI:

131198323(MTPAP)

PTEX:

113442466(MTPAP)

NSS:	113415003(MTPAP)

VKO:

123020872

PMUA:

114607587(MTPAP)

PRAF:

128424106(MTPAP)

ZVI:	118092068(MTPAP)

HCG:	128331991(MTPAP)

GJA:	107107776(MTPAP)

STOW:

125441142

EMC:	129337984(MTPAP)

XLA:	108718472(mtpap.L)

XTR:	100492805(mtpap)

NPR:	108788844(MTPAP)

RTEM:

120940044

BBUF:

121002735

BGAR:

122939162

PWL:	138261831(MTPAP)

MUO:	115467469(MTPAP)

GSH:	117354263(MTPAP)

DRE:	563801(mtpap)

SRX:	107738987(mtpap) 107749380

SANH:

107657477 107682997 107686374

SGH:	107549401(mtpap) 107577288 107584406

CCAR:

CAUA:

CGIB:

PTET:

LROH:

127174073(mtpap)

OMC:	131551609(mtpap)

PPRM:

120471575

RKG:	130088672(mtpap)

MAMB:

125255241

CIDE:

127523391

CERY:

137007794(mtpap)

MASI:

127423206 127426818

TROS:

130569529(mtpap)

TDW:	130439347(mtpap)

MANU:

129420944(mtpap)

PDAB:

135720299(mtpap) 135752088

IPU:

108274186

IFU:	128616617(mtpap)

PHYP:

113527105(mtpap)

SMEO:

124388914

TFD:

113662602

TVC:	132864020(mtpap)

CGAR:

128540883(mtpap)

NGRA:

132898466(mtpap)

TRN:	134321848(mtpap)

AMEX:

103037561

CMAO:

118809320

EEE:	113588620(mtpap)

CHAR:

105897218

SPIL:

134066370(mtpap)

TRU:	101070480(mtpap) 115248133

TFS:	130514182(mtpap)

TNG:	GSTEN00016561G001

LCO:	104928819(mtpap)

NCC:	104953910(mtpap)

TBEN:

117500006(mtpap)

CGOB:

115025449(mtpap)

PGEO:

117460499(mtpap)

GACU:

117549957(mtpap)

EMAC:

134884046(mtpap)

ELY:	117264335(mtpap)

EFO:

125881576

PLEP:

121960920

SLUC:

116048929

ECRA:

117937730(mtpap)

ESP:	116671910(mtpap)

PFLV:

114549206(mtpap)

GAT:

120811622

PPUG:

119198772(mtpap)

AFB:	129110713(mtpap)

PSWI:

130206388(mtpap)

CANA:

137788809(mtpap)

CVE:	137871960(mtpap)

MSAM:

119906509

SCHU:

122866694

CUD:

121527713

SPUL:

138596052(mtpap)

LMIX:

132993970(mtpap)

ALAT:

119008522

ASTR:

137587904(mtpap)

MZE:	101483945(mtpap)

ONL:	100704807(mtpap)

OAU:

116327504

OLA:	101160027(mtpap)

OML:

112151367

CSAI:

133423050(mtpap)

XMA:	102235772(mtpap)

XCO:	114137120(mtpap)

XHE:	116711853(mtpap)

PRET:

103482390(mtpap)

GAF:

122824155

PPRL:

129364960(mtpap)

CVG:	107085277(mtpap)

CTUL:

119793568

GMU:

124858526

NFU:	107377429(mtpap)

KMR:

108247127

ALIM:

106524836(mtpap)

AOCE:

111571048(mtpap)

EJA:	138199310(mtpap)

BFRE:

138620662(mtpap)

MCEP:

124996066

CSEM:

103376863(mtpap)

POV:	109629873(mtpap)

SSEN:

122778021

SSOE:

131467220(mtpap)

HHIP:

117753978(mtpap)

HSP:

118098886

PPLT:

128426151(mtpap)

SMAU:

118291166

LCF:

108898339

SDU:	111228230(mtpap)

SLAL:

111669239(mtpap)

XGL:

120790060

HCQ:	109514088 109514241(mtpap)

SSCV:

125985668(mtpap)

SBIA:

133492975(mtpap)

PEE:	133396434(mtpap)

PTAO:

133470339(mtpap)

BPEC:

110165527(mtpap)

ENY:	140364771(mtpap)

MALB:

109974519(mtpap)

BSPL:

114854156(mtpap)

SJO:	128382477(mtpap)

SSCO:

134002327(mtpap)

GMH:	115537292(mtpap)

SASA:

106578552

STRU:

115153844

OTW:	112215596(mtpap)

OMY:	110535551(mtpap)

OGO:

124016987

ONE:	115105103(mtpap)

OKI:	109908730(mtpap)

OKE:	118361567(mtpap)

OMM:	135522632(mtpap)

OCLA:

SALP:

SNH:

CCLU:

ELS:	105019415(mtpap)

OEP:	134035217(mtpap)

SFM:	108927786(mtpap)

PKI:	111850108(mtpap)

AANG:

118224585(mtpap)

AROT:

135253295(mtpap)

CCOG:

133126179(mtpap)

LOC:	102683121(mtpap)

PSPA:

121311588 121314103

ARUT:

117394583 117399620

PSEX:

120529756

LCM:	102367247(MTPAP)

CMK:

103186419

CPLA:

122550071

HOC:	132816134(mtpap)

LERI:

129715123(mtpap)

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG11418(MTPAP)

DER:

6555575

DSI:	Dsimw501_GD28714(Dsim_GD28714)

DYA:	Dyak_GE16534

DSR:	110178845 110191855

DPO:	4815894 6897541

DPE:	113567429 6596690 6604218

DMN:	108153237 108156892

DWI:

6644673

DGR:

6565156

DMO:	Dmoj_GI15633

DAZ:

108619902

DNV:	108656123 108660112

DHE:	111592386 111601919

DVI:	6631763(MTPAP)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135956414(MTPAP)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002001

CPII:

120418607

CBRI:

134836894

CNS:	116336990 116349862 116349863 116349864 116349899

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139108979(Mtpap)

TLN:	139823398(Mtpap)

HST:

105189521

DQU:

106742998

CFO:

105253772

FEX:	115237823 115237824

PMEC:

138938194(Mtpap)

LHU:	105678820(MTPAP)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124216268(MTPAP)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

136413805(MTPAP)

EFOR:

136339682(MTPAP)

SOY:

AGRG:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:	111420926(MTPA)

BMOR:

101737642

BMAN:

114240188

MSEX:

115446156

DPL:	KGM_203580 KGM_203581

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:	100168288 100573076

DNX:

107163353

AGS:

114131921

RMD:	113551614 113558712

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111045293 120356574

MQU:

128992080

PHU:	Phum_PHUM400420

FOC:	113201859 113208227

TPAL:

117643655 117646029

ZNE:

110840580

CSEC:

111870656

PAME:

138715052(MTPAP)

SGRE:

BROR:

IEL:

HAMR:

FCD:	110844889 110851327 110861160

DPX:	DAPPUDRAFT_11736

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:	124490346 124495471

CSCU:

111627023

CVS:

136981171

PTEP:

107438998 107454591 107454879

ABRU:

129962097 129981186

UDV:	129216180 129216682

SDM:	118188253 118191706 118194522

LPOL:

106466974

PMEO:

129601432

HRO:	HELRODRAFT_181404 HELRODRAFT_181405 HELRODRAFT_190956

LGI:	LOTGIDRAFT_236893

PVUL:

PCAN:

LSAX:

HRF:

HRJ:

HASI:

HCRA:

MYI:

PMAX:

RPHI:

OBI:

OSN:

LJP:

LAK:

OVI:	T265_10687

LLON:

135497924

EIV:	EIN_388090

» show all

Reference

PMID:21292163

Authors

Bai Y, Srivastava SK, Chang JH, Manley JL, Tong L

Title

Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase.

Journal

Mol Cell 41:311-20 (2011)
DOI:10.1016/j.molcel.2011.01.013

Sequence

[hsa:55149]

Reference

PMID:20970105

Authors

Crosby AH, Patel H, Chioza BA, Proukakis C, Gurtz K, Patton MA, Sharifi R, Harlalka G, Simpson MA, Dick K, Reed JA, Al-Memar A, Chrzanowska-Lightowlers ZM, Cross HE, Lightowlers RN

Title

Defective mitochondrial mRNA maturation is associated with spastic ataxia.

Journal

Am J Hum Genet 87:655-60 (2010)
DOI:10.1016/j.ajhg.2010.09.013

LinkDB

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