KEGG   ORTHOLOGY: K18073
Entry
K18073                      KO                                     
Symbol
parR
Name
two-component system, OmpR family, response regulator ParR
Pathway
map01501  beta-Lactam resistance
map01503  Cationic antimicrobial peptide (CAMP) resistance
map02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18073  parR; two-component system, OmpR family, response regulator ParR
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18073  parR; two-component system, OmpR family, response regulator ParR
   01503 Cationic antimicrobial peptide (CAMP) resistance
    K18073  parR; two-component system, OmpR family, response regulator ParR
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K18073  parR; two-component system, OmpR family, response regulator ParR
   01504 Antimicrobial resistance genes
    K18073  parR; two-component system, OmpR family, response regulator ParR
Two-component system [BR:ko02022]
 OmpR family
  ParS-ParR (polymyxin-adaptive resistance)
   K18073  parR; two-component system, OmpR family, response regulator ParR
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18073  parR; two-component system, OmpR family, response regulator ParR
Other DBs
COG: COG0745
GO: 0000156
Genes
SMT: Smal_3142
BUJ: BurJV3_3176
SMZ: SMD_3332
STEN: CCR98_16360
STEM: CLM74_16685
STES: MG068_16220
SINC: DAIF1_32800(rstA_2)
SPAQ: STNY_R33600
SGEN: RKE57_16395
PAE: PA1799(parR)
PAEV: N297_1853
PAEI: N296_1853
PAU: PA14_41260
PAP: PSPA7_3498
PAG: PLES_35291
PAF: PAM18_3245
PNC: NCGM2_2709
PAEB: NCGM1900_4701
PDK: PADK2_16670
PSG: G655_16160
PRP: M062_09410
PAEP: PA1S_16970
PAER: PA1R_gp5422
PAEM: U769_16685
PAEL: T223_18025
PAES: SCV20265_3605
PAEU: BN889_01933
PAEG: AI22_17020
PAEC: M802_1851
PAEO: M801_1852
PPAA: B7D75_16015
PFL: PFL_2637
PPRC: PFLCHA0_c27040(rstA1)
PPRO: PPC_2686
PFE: PSF113_2429(rstA2)
PFN: HZ99_01205
PFO: Pfl01_2734(mtrA) Pfl01_3391
PFS: PFLU_3484
PFC: PflA506_2547
PFB: VO64_0595
PMAN: OU5_0719
PTV: AA957_27690
PVR: PverR02_17255
PAZO: AYR47_23885
POI: BOP93_13985
PRX: HRH33_15110
PKR: AYO71_18700
PTOL: I7845_12910
PFW: PF1751_v1c29130
PFF: PFLUOLIPICF721620
PFX: A7318_12010
PBA: PSEBR_a3304
PSK: U771_18590
PCH: EY04_12100
PCZ: PCL1606_35450
PCP: JM49_15250 JM49_17765
PCHP: C4K32_2589 C4K32_3156
PSEM: TO66_12905
PSOS: POS17_2644
PFK: PFAS1_27185
PANR: A7J50_3187
PYM: AK972_2783
PKE: DLD99_17110
PGY: AWU82_09755
PATA: JWU58_11560
PDW: BV82_1798
PZE: HU754_018315
PMOE: HV782_012055
PSEP: C4K39_2656
PPII: QL104_17585
PVW: HU752_021370
PTRT: HU722_0016465
PSAM: HU731_001115
PTZ: HU718_012215
PSHH: HU773_012010
PASG: KSS96_13680
PMUY: KSS95_18780
PTW: TUM18999_20210(parR)
PZA: HU749_017755
PIE: HU724_017090
PGF: J0G10_12650
PPEG: KUA23_16555
PSII: NF676_16000
PFIT: KJY40_17745
PNB: NK667_13860
PSOA: PSm6_01720(parR)
PKJ: Q1W70_20620
PHYG: JTY93_10850
PHOM: KJF94_12585
PCUC: PSH97_12600
PPAE: LDL65_26695
PSPI: PS2015_1083
SPSH: FM037_07985
COV: EKO29_17765
THAT: H3N35_24165
TACT: SG35_025140
PFLI: CTT31_22245
PMAZ: R5H13_22285
MEIN: methR_P2151
JEU: BJP62_16575
CHIC: N8I74_07780
MAER: DAI18_00075
CCUP: BKK81_28580
CUP: BKK80_27795
CUU: BKK79_33710
AXY: AXYL_03324
AXO: NH44784_045741
AXN: AX27061_2751
AXX: ERS451415_02731(rstA_1)
ADT: APT56_14650
AIS: BUW96_06505
ASW: CVS48_11400
ACHR: C2U31_20705 C2U31_27190
ACHB: DVB37_23425
ACHO: H4P35_14660
AMUI: PE062_11395
APES: FOC84_28805
AAEG: RA224_16520
KIA: G8A07_04875
LVS: LOKVESSMR4R_03115(cssR)
SECH: B18_20855
 » show all
Reference
PMID:21149619
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
  Sequence
[pae:PA1799]
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:19258280
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08
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