KEGG   ORTHOLOGY: K18110
Entry
K18110                      KO                                     
Symbol
tpc1
Name
avermitilol synthase [EC:4.2.3.96]
Pathway
map00909  Sesquiterpenoid and triterpenoid biosynthesis
Reaction
R09896  (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, avermitilol-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K18110  tpc1; avermitilol synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.96  avermitilol synthase
     K18110  tpc1; avermitilol synthase
Genes
SMA: SAVERM_76(ams)
STRM: M444_02785
SGRS: V9K83_30630
SVN: CP980_01435
SNF: JYK04_00062(tpc1_1)
SMOB: J7W19_05280
SXT: KPP03845_100097(tpc1)
SGK: PET44_01335
SPRF: K4G22_05865
KCH: O1G21_07810
STRH: GXP74_03530
 » show all
Reference
PMID:20536237
  Authors
Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.
  Journal
J Am Chem Soc 132:8850-1 (2010)
DOI:10.1021/ja103087w
  Sequence
[sma:SAVERM_76]
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