KEGG   ORTHOLOGY: K18113
Entry
K18113            Tight     KO                                     
Symbol
MDS
Name
miltiradiene synthase / copalyl diphosphate synthase [EC:4.2.3.131 5.5.1.12]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06298  (+)-copalyl-diphosphate lyase (decyclizing)
R10585  (+)-copaly-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K18113  MDS; miltiradiene synthase / copalyl diphosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.131  miltiradiene synthase
     K18113  MDS; miltiradiene synthase / copalyl diphosphate synthase
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.12  copalyl diphosphate synthase
     K18113  MDS; miltiradiene synthase / copalyl diphosphate synthase
Other DBs
GO: 0050559
Genes
SMO: SELMODRAFT_450918
Reference
PMID:22027823
  Authors
Sugai Y, Ueno Y, Hayashi K, Oogami S, Toyomasu T, Matsumoto S, Natsume M, Nozaki H, Kawaide H
  Title
Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii.
  Journal
J Biol Chem 286:42840-7 (2011)
DOI:10.1074/jbc.M111.302703
  Sequence
[smo:SELMODRAFT_450918]
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