KEGG ORTHOLOGY: K18129

ORTHOLOGY: K18129

Entry

K18129                      KO

Symbol

mexZ

Name

TetR/AcrR family transcriptional regulator, mexXY operon repressor

Pathway

map01501

beta-Lactam resistance

Module

M00643

Multidrug resistance, efflux pump MexXY-OprM

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
Transcription factors [BR:ko03000]
Prokaryotic type
  Helix-turn-helix
   TetR/AcrR family
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
Antimicrobial resistance genes [BR:ko01504]
Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexXY-OprM
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor

Other DBs

COG:

COG1309

Genes

PAE:

PA2020

PAEV:

N297_2084

PAEI:

N296_2084

PAU:	PA14_38380(amrR)

PAF:	PAM18_3024

PNC:	NCGM2_2995(amrR)

PAEB:

NCGM1900_4466(amrR)

PDK:	PADK2_15545

PSG:	G655_15000

PAEP:

PAEM:

PAES:

PAEU:

PAEG:

PAEC:

PAEO:

PPAA:

CVI:

CVC:	BKX93_02735

CHRO:

CXB49_09970

CHRI:

DK842_19515

CHRB:

DK843_02445

CRZ:	D1345_20310

CHRM:

FYK34_05815

CHAE:

CH06BL_41870

IFL:	C1H71_12875

DEE:	HQN60_05595

BMV:	BMASAVP1_A1663

BML:	BMA10229_A0318

BMN:	BMA10247_0842

BMAL:

BMAE:

BMAQ:

BMAI:

BMAZ:

BMAB:

BPS:	BPSL1805(amrR)

BPM:	BURPS1710b_2056(amrR)

BPL:	BURPS1106A_1902(amrR)

BPD:	BURPS668_1888(amrR)

BPR:	GBP346_A1926

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_I1763(amrR)

BPQ:	BPC006_I1956

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_I2446(amrR)

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BUU:	WS70_08025

BSAV:

WS86_09915

BHG:	I6G56_10240

BUD:	AQ610_10120

BVI:	Bcep1808_1573

BVE:

AK36_2272

BUR:	Bcep18194_A4766

BCM:	Bcenmc03_1597

BCH:	Bcen2424_1621

BCEN:

BCEW:

BCEO:

BAM:

BAC:	BamMC406_1542

BMJ:	BMULJ_01627(acrR)

BMU:

BMK:

BMUL:

BCT:

BCED:

BCEP:

BDL:

BPYR:

BCON:

BUB:

BDF:	WI26_07735

BLAT:

BTEI:

BSEM:

BPSL:

BMEC:

BSTG:

BSTL:

BANN:

BARI:

BAEN:

BUK:

BUL:

BURK:

AXY:	AXYL_01447(amrR)

AXO:	NH44784_006231

AXN:	AX27061_1363

AXX:	ERS451415_01360(ttgR_2)

ADT:	APT56_06335

AIS:	BUW96_19170

ACHR:

C2U31_12305(axyZ)

APES:

FOC84_05455(axyZ)

AAEG:

RA224_25695(axyZ)

JAB:	VN23_21150

NEU:

NE1114

MFA:

Mfla_1362

MMB:

Mmol_0004

MEI:	Msip34_2719

MEP:

MPQ_2660

MEU:	ACJ67_10275

SECH:

MAUB:

THAO:

TALX:

AGL:

Reference

PMID:21149619

Authors

Muller C, Plesiat P, Jeannot K

Title

A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.

Journal

Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10

Reference

PMID:19258280

Authors

Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C

Title

Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Journal

Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08

Reference

PMID:10582892

Authors

Westbrock-Wadman S, Sherman DR, Hickey MJ, Coulter SN, Zhu YQ, Warrener P, Nguyen LY, Shawar RM, Folger KR, Stover CK

Title

Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.

Journal

Antimicrob Agents Chemother 43:2975-83 (1999)
DOI:10.1128/AAC.43.12.2975

Sequence

[pae:PA2020]

LinkDB

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