KEGG ORTHOLOGY: K18167

ORTHOLOGY: K18167

Entry

K18167                      KO

Symbol

SDHAF1

Name

succinate dehydrogenase assembly factor 1

Disease

H02005

Mitochondrial complex II deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K18167  SDHAF1; succinate dehydrogenase assembly factor 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-II assembly factors
    K18167  SDHAF1; succinate dehydrogenase assembly factor 1

Genes

HSA:	644096(SDHAF1)

PTR:	468843(SDHAF1)

PPS:	100973415(SDHAF1)

GGO:	101127630(SDHAF1)

PON:	129051822(SDHAF1)

PPYG:

129019534(SDHAF1)

NLE:	100585815(SDHAF1)

HMH:	116478932(SDHAF1)

SSYN:

129461000(SDHAF1)

MCC:	711822(SDHAF1)

MCF:	102126494(SDHAF1)

MTHB:

126942123

MNI:	105495488(SDHAF1)

CSAB:

103234550(SDHAF1)

CATY:

105578204(SDHAF1)

PANU:

101018065(SDHAF1)

TGE:	112613240(SDHAF1)

RRO:	104666672(SDHAF1)

RBB:	108513061(SDHAF1)

TFN:	117092387(SDHAF1)

PTEH:

111530971(SDHAF1)

CANG:

105516712(SDHAF1)

CJC:	100394357(SDHAF1)

SBQ:	101027792(SDHAF1)

CIMI:

108287929(SDHAF1)

ANAN:

105707848(SDHAF1)

CSYR:

103276228(SDHAF1)

MMUR:

105876898(SDHAF1)

LCAT:

123624445(SDHAF1)

PCOQ:

105816216(SDHAF1)

OGA:	100954428(SDHAF1)

MMU:	68332(Sdhaf1)

MCAL:

110297723(Sdhaf1)

MPAH:

110335574(Sdhaf1)

RNO:	499125(Sdhaf1)

MCOC:

116100439(Sdhaf1)

ANU:	117714918(Sdhaf1)

ASYL:

127671709(Sdhaf1)

MUN:	110551681(Sdhaf1)

CGE:	103161641(Sdhaf1) 113837367

MAUA:

101832616(Sdhaf1)

PROB:

127238364(Sdhaf1)

PLEU:

114681671(Sdhaf1)

MORG:

121449665(Sdhaf1)

MFOT:

126486763

AAMP:

119821104 119821181(Sdhaf1)

NGI:	103729951(Sdhaf1)

HGL:	101708716(Sdhaf1)

CPOC:

101787954(Sdhaf1)

CCAN:

109689330(Sdhaf1)

DORD:

105993111(Sdhaf1)

DSP:	122097515(Sdhaf1)

PLOP:

125338740(Sdhaf1)

NCAR:

124966424

MMMA:

107151823(Sdhaf1)

ITI:	101962651(Sdhaf1)

OCU:

100348442

OPI:	101516695(SDHAF1)

TUP:	102479898(SDHAF1)

GVR:	103592809(SDHAF1)

CFA:	100684432 484567(SDHAF1)

CLUD:

112643616(SDHAF1) 112668592

VVP:	112928545(SDHAF1)

VLG:	121485733(SDHAF1)

NPO:	129500858(SDHAF1)

AML:	100465841(SDHAF1)

UMR:	103682529(SDHAF1)

UAH:	113244838(SDHAF1)

UAR:	123793909(SDHAF1)

ELK:

111161504

LLV:

125088461

MPUF:

101676453(SDHAF1)

MNP:	132005454(SDHAF1)

MLK:	131817759(SDHAF1)

NVS:	122913828(SDHAF1)

ORO:	101377843(SDHAF1)

EJU:	114224411(SDHAF1)

ZCA:	113935650(SDHAF1)

MLX:	118022870(SDHAF1)

NSU:	110590154(SDHAF1)

LWW:	102736395(SDHAF1)

FCA:	101084590(SDHAF1)

PYU:	121011533(SDHAF1)

PCOO:

112851051(SDHAF1)

PBG:	122495054(SDHAF1)

PVIV:

125153608(SDHAF1)

LRUF:

124511201

LGF:	123578291(SDHAF1)

AJU:

106974709

PPAD:

109251495(SDHAF1)

PUC:

125915908

PLEZ:

122208257(SDHAF1)

HHV:	120243499(SDHAF1)

BTA:	784051(SDHAF1)

BOM:	102280357(SDHAF1)

BIU:	109572396(SDHAF1)

BBUB:

102405216(SDHAF1)

BBIS:

104995267(SDHAF1)

CHX:	106503113(SDHAF1)

OAS:	101105595(SDHAF1)

BTAX:

128063590(SDHAF1)

CSUM:

138096720(SDHAF1)

ODA:	120872579(SDHAF1)

CCAD:

122421459(SDHAF1)

MREE:

136161271(SDHAF1)

OVR:	110123657(SDHAF1)

MBEZ:

129546135(SDHAF1)

SSC:	100521971(SDHAF1)

CFR:	102509675(SDHAF1)

CBAI:

105065064(SDHAF1)

CDK:	105088068(SDHAF1)

VPC:	102525346(SDHAF1)

BACU:

102998827(SDHAF1)

BMUS:

118884897(SDHAF1)

LVE:	103078075(SDHAF1)

OOR:	101286668(SDHAF1)

LALB:

132509232(SDHAF1)

DLE:	111181215 111181216

PCAD:

102991526(SDHAF1)

PSIU:

116744639(SDHAF1)

NASI:

112392303(SDHAF1)

ECB:	100060247(SDHAF1)

EPZ:	103566803(SDHAF1)

EAI:	106829267(SDHAF1)

MYD:	102763980(SDHAF1)

MMYO:

118674611(SDHAF1)

MLF:	102417211(SDHAF1)

MDT:	132216967(SDHAF1)

MYUM:

138997023(SDHAF1)

PKL:	118720449(SDHAF1)

EFUS:

103284783(SDHAF1)

MNA:	107543448(SDHAF1)

DRO:	112320163(SDHAF1)

SHON:

118982544(SDHAF1)

AJM:	119044192(SDHAF1)

PDIC:

114511563(SDHAF1)

PHAS:

123823809(SDHAF1)

MMF:	118638654(SDHAF1)

PPAM:

129083204(SDHAF1)

RFQ:	117034987(SDHAF1)

PALE:

102894293(SDHAF1)

PGIG:

120592483(SDHAF1)

PVP:	105306665(SDHAF1)

RAY:	107497667(SDHAF1)

MJV:	108384605(SDHAF1)

TOD:	119250239(SDHAF1)

SARA:

101540342(SDHAF1)

SFUM:

130044004(SDHAF1)

SETR:

126027680(SDHAF1)

LAV:	100664045(SDHAF1)

TMU:

101344430

ETF:	101659266(SDHAF1)

DNM:	101420121(SDHAF1)

MDO:	100016789(SDHAF1)

GAS:	123243039(SDHAF1)

AFZ:

127556060

PCW:	110201966(SDHAF1)

TVP:	118839065(SDHAF1)

PBRV:

138154151(SDHAF1)

OAA:	100088385(SDHAF1)

TACU:

119946045(SDHAF1)

GGA:	107049539(SDHAF1)

NMEL:

110391623(SDHAF1)

AFUL:

116501546(SDHAF1)

AAM:	106488003(SDHAF1)

AROW:

112965245(SDHAF1)

ASN:	102372582 106722709(SDHAF1)

AMJ:

106737623

PSS:	102443681(SDHAF1)

CMY:	102943590(SDHAF1)

CCAY:

125628154(SDHAF1)

DCC:	119847247(SDHAF1)

CPIC:

101935694(SDHAF1) 101944410

TST:	117889230(SDHAF1)

CABI:

116822364(SDHAF1)

MRV:	120388695(SDHAF1)

ACS:	100562778 103280984(sdhaf1)

ASAO:

132780473(SDHAF1)

PVT:	110075778(SDHAF1)

SUND:

121915705(SDHAF1)

PMUR:

107291972(SDHAF1)

CTIG:

120299837(SDHAF1)

TSR:	106555760(SDHAF1)

PGUT:

117677790(SDHAF1)

APRI:

131204483(SDHAF1)

PTEX:

113446059(SDHAF1)

NSS:	113426684(SDHAF1)

VKO:	123026180(SDHAF1)

PMUA:

114603118(SDHAF1)

PRAF:

128420189(SDHAF1)

ZVI:	118087063(SDHAF1)

HCG:	128333103(SDHAF1)

GJA:	107121223 107121233(SDHAF1)

STOW:

125434948(SDHAF1)

EMC:	129343640(SDHAF1)

XLA:

108707270

XTR:	101732873(sdhaf1)

NPR:	108787675(SDHAF1)

RTEM:

120929466(SDHAF1)

BBUF:

120992424(SDHAF1)

BGAR:

122936080(SDHAF1)

PWL:	138284583(SDHAF1)

MUO:	115463060(SDHAF1)

GSH:	117357276(SDHAF1)

DRE:	606612(sdhaf1)

CCAR:

109059306(sdhaf1)

CAUA:

113038667(sdhaf1)

CGIB:

127985948

PTET:

122326653(sdhaf1)

OMC:	131529545(sdhaf1)

RKG:	130096461(sdhaf1)

MAMB:

125252503(sdhaf1)

CIDE:

127504076

CERY:

137012581(sdhaf1)

MASI:

127428511 127430739

MANU:

129424070(sdhaf1)

PDAB:

135776253(sdhaf1)

PHYP:

113543294(sdhaf1)

SMEO:

124398028(sdhaf1)

CGAR:

128508027(sdhaf1)

NGRA:

132895367(sdhaf1)

TRN:	134330428(sdhaf1)

AMEX:

103042070(sdhaf1)

CMAO:

118820624(sdhaf1)

TNG:	GSTEN00010758G001

LCO:	104936531(sdhaf1)

NCC:	104955604(sdhaf1)

TBEN:

117472864(sdhaf1)

CGOB:

115013963(sdhaf1)

PGEO:

117452675(sdhaf1)

GACU:

117535029(sdhaf1)

ELY:	117252341(sdhaf1)

EFO:	125890189(sdhaf1)

PLEP:

121940072(sdhaf1)

SLUC:

116056891(sdhaf1)

ECRA:

117945147(sdhaf1)

ESP:	116689994(sdhaf1)

PFLV:

114555181(sdhaf1)

GAT:	120830757(sdhaf1)

PPUG:

119224757(sdhaf1)

AFB:	129101663(sdhaf1)

CLUM:

117736051(sdhaf1)

PSWI:

130196930(sdhaf1)

CANA:

137804874(sdhaf1)

CVE:	137866859(sdhaf1)

CUD:	121506674 121510200

SPUL:

138610795(sdhaf1)

LMIX:

132974883(sdhaf1)

ALAT:

119019176(sdhaf1)

ASTR:

137592181(sdhaf1)

MZE:	101475131(sdhaf1)

ONL:	100702128(sdhaf1)

OAU:	116315337(sdhaf1)

OLA:	101160535(sdhaf1)

CSAI:

133451197(sdhaf1)

XMA:	102233528(sdhaf1)

XCO:	114145252(sdhaf1)

XHE:	116730069(sdhaf1)

PRET:

103470763(sdhaf1)

PFOR:

103129642(sdhaf1)

PLAI:

106937863(sdhaf1)

PMEI:

106908606(sdhaf1)

GAF:	122828578(sdhaf1)

PPRL:

129366168(sdhaf1)

CVG:	107103146(sdhaf1)

CTUL:

119791481(sdhaf1)

GMU:	124877852(sdhaf1)

NFU:	107386150(sdhaf1)

KMR:	108245857(sdhaf1)

ALIM:

106527795(sdhaf1)

NWH:	119413114(sdhaf1)

EJA:	138194730(sdhaf1)

BFRE:

138637094(sdhaf1)

CSEM:

103398017 107988206

POV:	109645776(sdhaf1)

SSEN:

122769839(sdhaf1)

SSOE:

131464009(sdhaf1)

HHIP:

117768373(sdhaf1)

HSP:	118114765(sdhaf1)

PPLT:

128438908(sdhaf1)

SMAU:

118314371(sdhaf1)

LCF:

108875370

SDU:	111236952(sdhaf1)

SLAL:

111661227(sdhaf1)

XGL:	120805395(sdhaf1)

HCQ:	109525334(sdhaf1)

SSCV:

125993841(sdhaf1)

PEE:	133399645(sdhaf1)

PTAO:

133475693(sdhaf1)

ENY:	140346533(sdhaf1)

MALB:

109957398(sdhaf1)

BSPL:

114861463(sdhaf1)

SJO:	128364362(sdhaf1)

SSCO:

133979561(sdhaf1)

GMH:	115545621(sdhaf1)

SASA:

100196578(sdhaf1)

STRU:

115154503(sdhaf1)

OTW:	112250218 112257698

OMY:	110533801(sdhaf1)

OGO:	124000262(sdhaf1)

OKI:

109872904

OMM:	135548446(sdhaf1)

SALP:

111951136(sdhaf1)

SNH:	120056557(sdhaf1)

ELS:	105026981(sdhaf1)

OEP:	134039598(sdhaf1)

SFM:	108932479(sdhaf1)

PKI:	111844892(sdhaf1)

AANG:

118235166(sdhaf1)

AROT:

135263945(sdhaf1)

CCOG:

133134040(sdhaf1)

LOC:	102687131(sdhaf1)

PSPA:

121303782(sdhaf1)

ARUT:

117416138(sdhaf1)

PSEX:

120538687(sdhaf1)

LCM:	102351782(SDHAF1)

RTP:	109925058(sdhaf1)

CPLA:

122542944(sdhaf1)

HOC:	132836728(sdhaf1)

LERI:

129714226(sdhaf1)

PMRN:

116947683(SDHAF1)

LRJ:	133341493(SDHAF1)

LPIC:

129265352

DPX:	DAPPUDRAFT_200722

PTRU:

123520548

EAF:

111696071

HRO:	HELRODRAFT_66878

ATH:

AT2G39725

ALY:

9317739

CRB:

17889034

CSAT:

104782425 104782431 104785457 104792804

EUS:	EUTSA_v10017481mg

BRP:

103865739

BNA:	106381752 106447460 125608346

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10023082mg

PVY:

MINC:

TCC:

GRA:

GHI:	107895066 107918589

GAB:

108468950

HSYR:

120124954 120128974 120216416

DZI:

EGR:

RARG:

GMX:

GSJ:

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:

AIP:

AHF:	112719923 112793426

LANG:

109352563 109352668

PCIN:

129313746

QSA:	O6P43_007032

FVE:

101313120

AANS:

126794696

RCN:	112170706 112176975 112177000 112179654

PPER:

18766230 18766728 18768369

PMUM:

103342709

PAVI:

110747368 110749421 110764636 110770789

PDUL:

117637067 117637747 117638827

MDM:

MSYL:

PXB:

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PNZ:	133679650 133701019

JRE:	109010293 109020183

CILL:

122297177

CAVE:

132182622

AGLU:

133861356

QSU:	112034458 136066798

QLO:	115959320 115983884

TWL:

120011065

VRI:	117906007 117910509

SLY:

SPEN:

SOT:

SSTN:

CANN:

LBB:

NTA:	107826963 107828618

NSY:

104231667

NTO:

104084505

NAU:	109216945 109216946 109223368

ITR:	116007987 116022806

SIND:

OEU:

EGT:

SMIL:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:	108206983 108220431

RVL:

AEW:

DLT:

BVG:

SOE:	110802744 130459933

CQI:

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

BDI:

ATS:

TDC:	119284581 119291587

TAES:

123084752 123089244 123100313

TUA:

125527537

LPER:

127308265

LRD:	124685925 124686416

SBI:

8058772

ZMA:	100280711 100280884 103638067 113174990

SVS:	117834606 117860969

PVIR:

PHAI:

PAUA:

PDA:

ZOF:

DCT:	110108390 114578650 114578671

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_9260 SELMODRAFT_9265

PPP:

112281053

VCN:	VOLCADRAFT_79757

CVR:	CHLNCDRAFT_134067

OTA:	OT_ostta04g03130

MIS:	MICPUN_58518

MPP:	MICPUCDRAFT_11868 MICPUCDRAFT_56602

SCE:	YDR379C-A(SDH6)

SEUB:

DI49_0556

SPAO:

SPAR_D05690

AGO:	AGOS_ACR206C

ERC:

Ecym_4637

KLA:	KLLA0_E02619g

LTH:	KLTH0F15576g

VPO:	Kpol_1062p13

ZRO:	ZYRO0G04422g

CGR:	2886347(GVI51_A02915)

NCS:	NCAS_0A11820(NCAS0A11820)

NDI:	NDAI_0A04460(NDAI0A04460)

TPF:	TPHA_0E01610(TPHA0E01610)

TBL:	TBLA_0A06430(TBLA0A06430)

TGB:	HG536_0F02610

TDL:	TDEL_0D02470(TDEL0D02470)

KAF:	KAFR_0E03740(KAFR0E03740)

KNG:	KNAG_0C04800(KNAG0C04800)

ZMK:	HG535_0C04370

SLUD:

SCDLUD_003242

DHA:	DEHA2D18128g

PIC:	PICST_34302

PGU:	PGUG_05228

SPAA:

SPAPADRAFT_72684

LEL:	PVL30_004075

LBG:	92210203(LODBEIA_P50070)

CAL:	CAALFM_C401990WA

CTP:	CTRG_00240

COT:	CORT_0E01380

CDU:	CD36_41880

CLU:	CLUG_03077

CLUS:

A9F13_12g00968

ASAU:

88174472(PUMCH_003408)

PPA:	PAS_chr1-3_0158

PKZ:	C5L36_0C08110

YLI:	2909076(YALI2_C01152g)

NCR:

NCU07507

NTE:	NEUTE1DRAFT104468(NEUTE1DRAFT_104468)

SMP:	10804934(SMAC4_08049)

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2077668

MTM:	MYCTH_2295791

RTHE:

98123288(VTJ83DRAFT_2380)

MGR:

PPEI:

PGRI:

SSCK:

FPU:	FPSE_00432

FPOA:

FPOAC1_001353

FVR:	FVEG_14828

FOX:	FOXG_17812

FFC:	NCS54_00061500

FKR:	NCS57_00059600

TRE:	TRIREDRAFT_108481

TRR:	M419DRAFT_81253

TATV:

25784200(TrAtP1_003463)

TASP:

36617204(TrAFT101_007136)

MAW:	90962122(J3458_003550)

AMUS:

LMH87_011654

PLJ:	90643196(PLICBS_007049)

PTKZ:

JDV02_001683

VDA:	VDAG_04515

CLUP:

CLUP02_05266

CDET:

87939155(CDEST_02652)

SAPO:

SAPIO_CDS0788

BFU:	BCIN_01g05990(Bcsdh6)

MBE:

MBM_04817

TRG:	TRUGW13939_09786

CIM:	CIMG_07273

PBL:	PAAG_00870

PBN:	PADG_11690

AJE:	HCAG_04109

BGH:	BDBG_01729

PNO:	SNOG_03890

BZE:	COCCADRAFT_96709

BSC:	COCSADRAFT_173266

BOR:	COCMIDRAFT_107603

AALT:

CC77DRAFT_856758

ZTR:	MYCGRDRAFT_31653

PFJ:	MYCFIDRAFT_26785

FFU:	CLAFUR5_00322

BCOM:

BAUCODRAFT_64663

SPO:	2543362(sdh6)

SOM:	SOMG_00388(sdh6)

CNE:

CNF02085

CNG:	CNAG_07991

CDEU:

CNBG_9695

CDEC:

89990707(IAS62_003935)

CDEP:

91087301(L203_103090)

KMG:	30167805(I203_100045)

KDJ:	28971841(I303_106600)

KBI:	30204446(I302_101364)

TASA:

A1Q1_05854

CCAC:

CcaHIS019_0409760(CcaverHIS019_0409760)

TVS:	TRAVEDRAFT_122462

DSQ:	DICSQDRAFT_55520

PCO:	PHACADRAFT_153914

SHS:	STEHIDRAFT_58727

HIR:	HETIRDRAFT_51560

ADL:	AURDEDRAFT_48652

GTR:	GLOTRDRAFT_76958

LBC:	LACBIDRAFT_309148

ABP:	AGABI1DRAFT128366(AGABI1DRAFT_128366)

ABV:	AGABI2DRAFT223864(AGABI2DRAFT_223864)

MPR:	MPER_07245

MRR:	Moror_14035

E1B28_012424

SCM:	SCHCO_02615120(SCHCODRAFT_02615120)

CPUT:

CONPUDRAFT_123766

SLA:	SERLADRAFT_439305

WSE:	WALSEDRAFT_17021

UMA:	UMAG_04300

PFP:	PFL1_03481

SGRA:

EX895_002047

MRT:

MRET_2508

PGR:	PGTG_02579

PTRC:

PtA15_10A61

PSTR:

Pst134EA_018981

DDI:	DDB_G0289475

DPP:	DICPUDRAFT_13673

DFA:	DFA_10311 DFA_10547

ACAN:

ACA1_069030

PTM:	GSPATT00013969001 GSPATT00033245001

FCY:	FRACYDRAFT_234851

NGD:	NGA_2031810 NGA_2031820

PIF:	PITG_04372

PSOJ:

PHYSODRAFT_319036

SPAR:

SPRG_07453

TBR:	Tb10.389.0620

TBG:	TbgDal_X15560

TCR:	509805.120

» show all

Reference

PMID:19465911

Authors

Ghezzi D, Goffrini P, Uziel G, Horvath R, Klopstock T, Lochmuller H, D'Adamo P, Gasparini P, Strom TM, Prokisch H, Invernizzi F, Ferrero I, Zeviani M

Title

SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy.

Journal

Nat Genet 41:654-6 (2009)
DOI:10.1038/ng.378

Sequence

[hsa:644096]

LinkDB

DBGET integrated database retrieval system