KEGG ORTHOLOGY: K18177

ORTHOLOGY: K18177

Entry

K18177                      KO

Symbol

COA4

Name

cytochrome c oxidase assembly factor 4

Pathway

map04714

Thermogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K18177  COA4; cytochrome c oxidase assembly factor 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K18177  COA4; cytochrome c oxidase assembly factor 4
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    K18177  COA4; cytochrome c oxidase assembly factor 4

Genes

HSA:	51287(COA4)

PTR:	451415(COA4)

PPS:	100974206 103785089

GGO:

101138531

PON:

100456167

PPYG:

129008550

NLE:	100580419 100607369 100607393

HMH:	116470306 116476668 116478088

SSYN:

129457478 129460753 129484617

MCC:	718275(CHCHD8)

MCF:

102134966

MTHB:

126935281

MNI:

105468725

CSAB:

103248021(COA4)

CATY:

105578762

PANU:

101016257 116269725 116269727

TGE:

112606599

MLEU:

105551053

RRO:	104655726 104665131

RBB:	108526108 108537641

TFN:

117081530

PTEH:

111540864

CANG:

105519608

CJC:	100388355 100402035(CHCHD8) 118148445

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	68185(Coa4)

MCAL:

110298785

MPAH:

110335264

RNO:	499214(Coa4)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

TUP:	102477784 102480502 102494699

GVR:

103610400

CFA:	100685149(CHCHD8)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

NSU:

LWW:

FCA:	101096761(COA4)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	100296470(COA4)

BOM:	102283861(COA4)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138093151(COA4)

ODA:

120876795

CCAD:

122449740

MREE:

136174247(COA4)

OVR:	110143195(COA4)

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100629588(COA4)

EPZ:	103564426(COA4)

EAI:

MYB:

MYD:

MMYO:

MLF:	102422803 102437434

MDT:	132213802 132229514 132240815

MYUM:

139017329(COA4)

PKL:

EFUS:

MNA:

DRO:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

TACU:

GGA:	101747545(COA4)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106042369(COA4)

CATA:

118260252

AFUL:

116501002

TGU:

100219445

LSR:	110481487(COA4)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139585267(COA4)

FAB:

OMA:

PHI:

PMAJ:

CCW:

ACOE:

138116923(COA4)

ZAB:

ZLE:

SVG:

MMEA:

HRT:

SATI:

136375331(COA4)

CCIC:

FPG:

FCH:

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

HHAR:

GCL:

DPUB:

PPUS:

EGZ:

NNI:

PCRI:

AFOR:

CBOY:

140646653(COA4)

MUI:

EHS:

OHA:

ACAR:

CVF:

RTD:

CRID:

AROW:

NPD:

DNE:

SCAM:

ASN:

AMJ:	102567892(COA4)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:

NPR:

RTEM:

BBUF:

BGAR:

PWL:	138249762(COA4)

MUO:

115468370

GSH:

117362439

DRE:	796017(coa4)

SRX:	107728898 107743475

SANH:

107686185

SGH:

107589877

CCAR:

109087800

CAUA:

113054675 113072752 113096268

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137029572(coa4)

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

TRU:

TFS:

LCO:

TBEN:

CGOB:

115019131 115019175 115019414

PGEO:

117458139(coa4)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:	129114023 129114041 129114927

CLUM:

117742739

PSWI:

130190410

CANA:

137802884(coa4)

CVE:	137876449(coa4) 137876451 137876453

MSAM:

119895989

SCHU:

122888135 122888535

CUD:

121518485

SPUL:

138598060(coa4)

LMIX:

132988005

ALAT:

119030740

ASTR:

137606328(coa4)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138196314(coa4)

BFRE:

138633695(coa4)

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125982438(coa4)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140360288(coa4)

MALB:

BSPL:

SJO:

SSCO:

GMH:

SASA:

100195877(chch8) 106563642

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:

OKE:

OMM:

OCLA:

SALP:

SNH:	120021140 120056416

CCLU:

121580124

ELS:

105028494

OEP:

134013793

SFM:	108922190 114910437

PKI:

111852184

AANG:

118235064

AROT:

135264111

CCOG:

133108366 133126581 133131495 133133745 133135175 133138440 133141227

LOC:

PSPA:

ARUT:

PSEX:

LCM:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BBEL:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG44194(CG44194)

DER:

6552580

DSE:

116801384

DSI:	Dsimw501_GD20527(Dsim_GD20527)

DYA:	Dyak_GE24473

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI25774

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CPII:

CBRI:

CNS:

BCOO:

LLL:

BTER:

BAFF:

BPAS:

FVI:

CCAL:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

PMEC:

PGC:

OBO:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

MDL:

CGLO:

FAS:

AGIF:

CINS:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

ESIM:

EFOR:

AGRG:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

PHU:	Phum_PHUM395720

TPAL:

PTRU:

TUT:

DPTE:

UDV:

LPOL:

LOA:	LOAG_05855

TSP:

Tsp_02643

HRO:	HELRODRAFT_128607

GAE:

121371664

HRJ:	124255428 124280085

MYI:

110456483

PMAX:

117327883

RPHI:

132718989

LAK:	106155972 106170431

SMM:	Smp_033510

EGL:

EPA:

PDAM:

SPIS:

XEN:

HSY:

RES:

AQU:

ATH:

ALY:

CRB:

CSAT:

EUS:	EUTSA_v10015193mg

BRP:

103856349

BNA:	106385123 106443188

BOE:

106333408

RSZ:	108845968 130494500

THJ:

104802735

CPAP:

110819962

CIT:

102628677

CIC:	CICLE_v10006319mg

PVY:

116145489

TCC:

18603385

GRA:

105778088

GHI:	107897658 107915078

GAB:

HSYR:

DZI:

EGR:

RARG:

GMX:	100778194 100818254

GSJ:	114375461 114387366

PVU:

VRA:

VAR:

VUN:

VUM:	124829097 124847584 124847586

CCAJ:

109793335

APRC:

113847955

MTR:	11441942 11443361

TPRA:

PSAT:

VVO:

LJA:

ADU:	107482692 107489260

AIP:

107638543

AHF:	112741116 112795814

LANG:

109330042

PCIN:

129310008

QSA:	O6P43_003481

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:

NSY:

NTO:

NAU:	109212405 109226657

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130771442 130771814

DLT:

BVG:

SOE:

CQI:

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OGL:

BDI:

ATS:

TDC:	119278767 119343181

TAES:

123055147 123132446 123181965

TUA:

125517992

LPER:

127314628

LRD:	124706556 124707829

ZMA:

MFLO:

PAUA:

PDA:

EGU:

ZOF:

DCT:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

CVR:	CHLNCDRAFT_143287

GSL:	Gasu_40830

SCE:	YLR218C(COA4)

SPAO:

SPAR_L02490

AGO:	AGOS_ADR089C

KLA:	KLLA0_F05137g

KMX:	KLMA_60509(COA4)

LTH:	KLTH0H02112g

VPO:	Kpol_1019p29

ZRO:	ZYRO0F05830g

CGR:	2889474(GVI51_J08811)

NCS:	NCAS_0E03760(NCAS0E03760)

NDI:	NDAI_0A02870(NDAI0A02870)

TPF:	TPHA_0A03090(TPHA0A03090)

TBL:	TBLA_0F02150(TBLA0F02150)

TGB:	HG536_0B04880

TDL:	TDEL_0C02350(TDEL0C02350)

KAF:	KAFR_0L01330(KAFR0L01330)

KNG:	KNAG_0B02780(KNAG0B02780)

ZMK:	HG535_0E04800

SLUD:

SCDLUD_000273

DHA:	DEHA2D15598g

PIC:	PICST_9984

PGU:	PGUG_00576

SPAA:

SPAPADRAFT_61831

LBG:	92207390(LODBEIA_P21940)

CAL:	CAALFM_C301780CA

CTP:	CTRG_02137

COT:	CORT_0D06600

CDU:	CD36_81670

CTEN:

18246682(COA4)

CLU:	CLUG_02008

CLUS:

A9F13_02g02882

ASAU:

88173616(PUMCH_002551)

PKZ:	C5L36_0B07700

BBRX:

BRETT_005190

OPA:	HPODL_02588

NCR:

NCU12100

NTE:	NEUTE1DRAFT148691(NEUTE1DRAFT_148691)

SMP:	10807356(SMAC4_00726)

PAN:	PODANSg2870

PBEL:

PPSD:

PPSP:

PPSA:

MTM:	MYCTH_2315637

RTHE:

98126610(VTJ83DRAFT_5373)

MGR:

MGG_17456

SSCK:

SPSK_02796

FPOA:

FPOAC1_004401

FVR:	FVEG_15042

FOX:	FOXG_18566

FFC:	NCS54_00370000

TATV:

25777981(TrAtP1_008470)

TASP:

36607814(TrAFT101_002932)

AMUS:

LMH87_011120

PTKZ:

JDV02_008648

VAL:	VDBG_09199

VDA:	VDAG_07356

CFJ:	CFIO01_12602

CDET:

87947866(CDEST_11366)

SAPO:

SAPIO_CDS6265

BFU:	BCIN_01g05660(Bccoa4)

PSCO:

LY89DRAFT_695255

ACT:	ACLA_081350

AFV:	AFLA_008107

ALUC:

AKAW2_70525S

ACHE:

ACHE_40685S

APUU:

APUU_11145A

PCS:	N7525_004423

PDP:	PDIP_65140

TMF:	EYB26_004781

CIM:	CIMG_07857

PBL:	PAAG_06512

BGH:	BDBG_06962

PNO:	SNOG_08428

PTRR:

6346850(PtrM4_146610)

BZE:	COCCADRAFT_84326

BOR:	COCMIDRAFT_90275

AALT:

CC77DRAFT_997378

ADAC:

96080345(ACET3X_000023)

ARAB:

EKO05_0005123

ZTR:	MYCGRDRAFT_35885

PFJ:	MYCFIDRAFT_125149

FFU:	CLAFUR5_10751

CBET:

CB0940_06453

SPO:	2538864(coa4)

SOM:	SOMG_04539(coa4)

RIE:	OCT59_008194

SRE:	PTSG_10176

ACAN:

ACA1_399810

PYO:	PY17X_0806500

PCB:	PCHAS_0804100

PBE:	PBANKA_0803800

PKN:	PKNH_0104700

PVX:	PVX_087851

PCY:	PCYB_011360

TET:	TTHERM_00695770

PIF:	PITG_18974

PSOJ:

PHYSODRAFT_535424

SPAR:

SPRG_03355

» show all

Reference

PMID:20624914

Authors

Bestwick M, Jeong MY, Khalimonchuk O, Kim H, Winge DR

Title

Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family.

Journal

Mol Cell Biol 30:4480-91 (2010)
DOI:10.1128/MCB.00228-10

Sequence

[sce:YLR218C]

Reference

PMID:11085516

Authors

Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM

Title

Effects of estrogen on global gene expression: identification of novel targets of estrogen action.

Journal

Cancer Res 60:5977-83 (2000)

Sequence

[hsa:51287]

LinkDB

DBGET integrated database retrieval system