KEGG ORTHOLOGY: K18179

ORTHOLOGY: K18179

Entry

K18179                      KO

Symbol

COA6

Name

cytochrome c oxidase assembly factor 6

Pathway

map04714

Thermogenesis

Disease

H01200

Fatal infantile cardioencephalomyopathy

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K18179  COA6; cytochrome c oxidase assembly factor 6
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K18179  COA6; cytochrome c oxidase assembly factor 6
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    K18179  COA6; cytochrome c oxidase assembly factor 6

Genes

HSA:	388753(COA6)

PTR:	742750(COA6)

PPS:

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:

MTHB:

MNI:

CSAB:

103230782(COA6)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100413641(C19H1orf31) 100894981

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:	100953179 105886576

MMU:	67892(Coa6)

MCAL:

110300579

MPAH:

110337690

RNO:	102556031(Coa6)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103726254 103745119

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

TUP:

GVR:

CFA:	607627(COA6)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:	110586026 110592673

LWW:	102735357 102735370

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	104972669 768072(COA6)

BOM:	102286498(COA6)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138087632(COA6)

ODA:	120860507 120865431

CCAD:

122446637

MREE:

136158058(COA6)

OVR:	110132658(COA6)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:	105747993 117197327

LALB:

DLE:

PCAD:

NASI:

ECB:	100629695(COA6)

EPZ:	103560239(COA6)

EAI:

MYD:

MMYO:

MDT:

MYUM:

138999219(COA6)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:	118632075 118640645

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:	119244594 119253456

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138143616(COA6)

OAA:

100089230

TACU:

119940962

GGA:	771652(COA6)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

125180032(COA6)

CATA:

118254760

AFUL:

116487242

TGU:

100223159

LSR:	110468874(COA6)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139592346(COA6)

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

ACOE:

138107233(COA6)

ETL:	114064881 114072298

ZAB:

ZLE:

SVG:

MMEA:

HRT:

SATI:

136359254(COA6)

CCIC:

FPG:

FCH:

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

HHAR:

GCL:

CSTI:

MNB:

DPUB:

PPUS:

BRHI:

PCRI:

AFOR:

FGA:

CLV:

PLET:

CMAC:

CUCA:

CVF:

RTD:

CRID:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

AMJ:	102558907(COA6)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

101941480 101945927 101951139

TST:	117874702 117884203

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	100329134(coa6.L)

XTR:	100135157(coa6)

NPR:

RTEM:

BBUF:

BGAR:

PWL:	138296085(COA6)

MUO:

115480394

GSH:

117366041

DRE:	100150991(coa6)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137023798(coa6)

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

TRU:

TFS:

LCO:

NCC:

TBEN:

CGOB:

PGEO:

117439108(coa6)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137791374(coa6)

CVE:	137877226(coa6)

MSAM:

119918217

SCHU:

122871566

CUD:

121505600

SPUL:

138599215(coa6)

LMIX:

132956697

ALAT:

119032162

ASTR:

137589430(coa6)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138202508(coa6)

BFRE:

138621816(coa6)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125992560(coa6)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140368076(coa6)

MALB:

BSPL:

SJO:

SSCO:

GMH:

SASA:

106576080(C1orf31) 106609214(C1orf31)

STRU:

115180089 115198741

OTW:

112214345

OMY:	100301751(cin) 110490264

OGO:	123994649 124014582

ONE:	115106955 115133166

OKI:	109864327 109896760

OKE:	118366225 118392337

OMM:	135514800 135515988

OCLA:

139378701 139393077

SALP:

111951324 111951463

SNH:	120032222 120049338

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

DME:	Dmel_CG42376(CG42376)

DER:

6555649

DSI:	Dsimw501_GD16495(Dsim_GD16495)

DYA:	Dyak_GE16601

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21427

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ017711

CPII:

CNS:

BCOO:

LLL:

PPAP:

ACER:

ALAB:

AFLR:

FVI:

CCAL:

OBB:

MGEN:

CGIG:

AEC:

ACEP:

PBAR:

DQU:

CFO:

PMEC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

CSOL:

TPRE:

LHT:

LBD:

MDL:

FAS:

AGIF:

CINS:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

AGRG:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

OTU:

BMAN:

MSEX:

NIQ:

VCD:

MCIX:

PMAC:

BPHI:

PRAP:

PBX:

CCRC:

LSIN:

AAGE:

HZE:

SLIU:

OFU:

ONU:

ATRA:

GMW:

CFEL:

CCRN:

AGS:

RMD:

DCI:

CLEC:

NLU:

PHU:	Phum_PHUM284290

FOC:

CSEC:

BROR:

IEL:

DPX:	DAPPUDRAFT_50463

DPZ:

124314298

AFRA:

136028975

PVM:

113823170

PJA:	122250916 122264481

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135204865 135216730

MRJ:	136849102 136856391

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_ZC434.7(coa-6)

CRQ:	GCK72_002348

LOA:	LOAG_05218

HRO:	HELRODRAFT_86725

LGI:	LOTGIDRAFT_185601

PCAN:

BGT:

GAE:

HCRA:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

OBI:

OSN:

SMM:	Smp_131790

NVE:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HSY:

ATH:

ALY:

CRB:

CSAT:

104726368 104735049 104761892 104761895 104783377

EUS:	EUTSA_v10015049mg

BRP:

103856718

BNA:	106385194 106443243 125599337

BOE:

106332649

RSZ:	108845783 130509687

THJ:

104811837

CPAP:

110815609

CIT:

102625714

CIC:	CICLE_v10009941mg

PVY:

MINC:

TCC:

GRA:

GHI:	107906908 107958931

GAB:

HSYR:

DZI:

EGR:

RARG:

GMX:

GSJ:

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:

AIP:

AHF:	112700502 112723419

LANG:

109362214

PCIN:

129310042

QSA:	O6P43_002998 O6P43_022179

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103417954 103431385

MSYL:

126601336 126614000

PXB:	103949093 103955972

PCOX:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:	7465951 7493402

PEU:	105121165 105131926

PALZ:

118034347 118043839

PNZ:	133674163 133689170

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:	101244345 101263329

SPEN:

107005679 107024095

SOT:	102591353 102592534

SSTN:

125850349 125875544

SDUL:

129870556 129893083

CANN:

107840828 107877633

LBB:	132602077 132637015

NTA:	107769447 107783785 107786851 107817148

NSY:	104237767 104241843

NTO:	104092229 104111205

NAU:	109225199 109234509

INI:

109191807

ITR:

116013790

SIND:

105162362

OEU:	111385872 111403763

EGT:

SSPL:

SMIL:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:	131303706 131320321

AEW:	130784621 130784629 130796008

DLT:

127806519

BVG:

104901804

CQI:	110698279 110706472

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119332051 119337451

TAES:

123151659 123158099 123165698

TUA:

125520687

LPER:

127301634

LRD:	124682481 124682483

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PAUA:

PDA:	103714247 120110760

EGU:

105060185

MUS:

135609411

ZOF:	121981404 121987715

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_187186 SELMODRAFT_228084

PPP:	112274009 112295556

VCN:	VOLCADRAFT_104508

MNG:	MNEG_10682

CVR:	CHLNCDRAFT_137711

APRO:

F751_0516

GSL:	Gasu_06230

SCE:	YMR244C-A(COA6)

SEUB:

DI49_4330

SPAO:

SPAR_M03620

AGO:	AGOS_AEL313C

ERC:

Ecym_1497

KLA:	KLLA0_F08767g

KMX:	KLMA_20312(coa6)

LTH:	KLTH0H15532g

VPO:	Kpol_224p3

ZRO:	ZYRO0F12672g

CGR:	2890401(GVI51_K07161)

NCS:	NCAS_0C00710(NCAS0C00710)

NDI:	NDAI_0K00750(NDAI0K00750)

TPF:	TPHA_0G01100(TPHA0G01100)

TBL:	TBLA_0B02760(TBLA0B02760)

TGB:	HG536_0H01060

TDL:	TDEL_0B01030(TDEL0B01030)

KAF:	KAFR_0B03590(KAFR0B03590)

KNG:	KNAG_0J00580(KNAG0J00580)

ZMK:	HG535_0F00740

SLUD:

SCDLUD_000732

DHA:	DEHA2G05896g

PIC:	PICST_39924(CIN2)

PGU:	PGUG_02905

SPAA:

SPAPADRAFT_134291

LEL:	PVL30_002368

LBG:	92207189(LODBEIA_P19930)

CAL:	CAALFM_CR10280WA(CaO19.7603)

CTP:	CTRG_05841

COT:	CORT_0D00690

CDU:	CD36_35245

CTEN:

18250114(PSN45_002755)

CLU:	CLUG_05790

CLUS:

A9F13_05g01628

CAUR:

CJI96_0000607

ASAU:

88175345(PUMCH_004284)

PPA:	PAS_chr1-4_0018

PKZ:	C5L36_0C06960

BNN:	FOA43_001184

BBRX:

BRETT_002327

OPA:	HPODL_03518

YLI:	2912141(YALI2_E00076g)

NCR:

NCU02293

NTE:	NEUTE1DRAFT67507(NEUTE1DRAFT_67507)

SMP:	10801778(SMAC4_08735)

PAN:	PODANSg1802

PPSD:

QC762_509620

PPSP:

QC763_509620

PPSA:

QC764_509620

TTT:	THITE_2117150

MTM:	MYCTH_2308806

CTHR:

CTHT_0016700

RTHE:

98124143(VTJ83DRAFT_3152)

MGR:

MGG_06573

PPEI:

PpBr36_06173

PGRI:

PgNI_01008

TMN:	UCRPA7_5611

SSCK:

SPSK_04610

FGR:	FGSG_10793

FPU:	FPSE_08840

FPOA:

FPOAC1_009515

FVN:	FVRRES_10154

FVR:	FVEG_11464

FOX:	FOXG_12725

FFC:	NCS54_00661600

FKR:	NCS57_00701600

FMU:	J7337_009865

TRE:	TRIREDRAFT_3741

TRR:	M419DRAFT_78253

TATV:

25778912(TrAtP1_008285)

TASP:

36615996(TrAFT101_003101)

MAW:	19245794(J3458_021703)

MAJ:

MAA_04918

MBRN:

26242192(new16)

PCHM:

VFPPC_07752

CMT:

CCM_01362

AMUS:

LMH87_003955

PLJ:	28884010(PLICBS_005287)

PTKZ:

JDV02_004191

VAL:	VDBG_03453

VDA:	VDAG_09934

CFJ:	CFIO01_08801

CLUP:

CLUP02_12939

CHIG:

CH63R_12195

CDET:

87946948(CDEST_10446)

ELA:	UCREL1_9124

PFY:	PFICI_05872

SSL:	SS1G_02629 SS1G_07899

BFU:	BCIN_06g01520 BCIN_15g01070

MBE:

MBM_03062

PSCO:

LY89DRAFT_649772

GLZ:	GLAREA_10101

ANI:	ANIA_05008

AFM:	AFUA_3G09780

ACT:	ACLA_037580

NFI:	NFIA_067520

AOR:	AO090005001272

ANG:	An16g03410

AFV:	AFLA_004089

ALUC:

AKAW2_70291A

ACHE:

ACHE_20923A

APUU:

APUU_30812A

PCS:	N7525_001038

PDP:	PDIP_76280

POU:	POX_b02936

TMF:	EYB26_001021

TRG:	TRUGW13939_03263

CIM:	CIMG_01930

CPW:	9690837(D8B26_001304)

ABE:

ARB_01199

TVE:

TRV_05318

PBL:	PAAG_07921

PBN:	PADG_08152

BGH:	BDBG_02470

PNO:	SNOG_14520

PTE:

PTT_07807

PTRR:

6344508(PtrM4_047110)

BZE:	COCCADRAFT_91269

BSC:	COCSADRAFT_33664

BOR:	COCMIDRAFT_38406

AALT:

CC77DRAFT_1016801

ADAC:

96080864(ACET3X_000542)

ARAB:

EKO05_0009435

ZTR:	MYCGRDRAFT_106110

PFJ:	MYCFIDRAFT_87219

FFU:	CLAFUR5_12565

CBET:

CB0940_05591

BCOM:

BAUCODRAFT_63959

NPA:	UCRNP2_5111

SPO:	14217588(coa6)

SOM:	SOMG_03187(coa6)

CNE:

CNC05150

CNB:

CNBC2020

CNG:	CNAG_02905

CGI:	CGB_C7470W

CDEU:

CNBG_9703

CDEP:

91085004(L203_100790)

KMG:	30165397(I203_101532)

KNE:	92178107(IAR55_000848)

TMS:	TREMEDRAFT_56065

TASA:

A1Q1_06459

CCAC:

CcaHIS019_0703930(CcaverHIS019_0703930)

TVS:	TRAVEDRAFT_150629

DSQ:	DICSQDRAFT_89652

PCO:	PHACADRAFT_89946

SHS:	STEHIDRAFT_128168

HIR:	HETIRDRAFT_450421 HETIRDRAFT_57793

PSQ:	PUNSTDRAFT_108838

FME:	FOMMEDRAFT_17068

GTR:	GLOTRDRAFT_62394

RSX:	RhiXN_02963

LBC:	LACBIDRAFT_296872

CCI:	CC1G_06253

ABP:	AGABI1DRAFT42280(AGABI1DRAFT_42280)

ABV:	AGABI2DRAFT66754(AGABI2DRAFT_66754)

PCUB:

JR316_0006442

MRR:	Moror_12633

E1B28_009735

SCM:	SCHCO_01174606(SCHCODRAFT_01174606)

CPUT:

CONPUDRAFT_26432

SLA:	SERLADRAFT_468999

WSE:	WALSEDRAFT_34022

WIC:	J056_001703

UMA:	UMAG_02034

PFP:	PFL1_00140

SGRA:

EX895_003462

MGL:

MGL_0237

MRT:

MRET_1077

PGR:	PGTG_05754 PGTG_16864

PSTR:

Pst134EA_021143 Pst134EA_031443

MLR:	MELLADRAFT_72078

RIE:	OCT59_027623

MBR:	MONBRDRAFT_3788

SRE:	PTSG_11412

DDI:	DDB_G0269220

DPP:	DICPUDRAFT_75462

DFA:

DFA_06971

ACAN:

ACA1_143600

LMAT:

92512068(LSCM1_01958)

LOI:	92358943(LSCM4_02990)

LEIS:

94178770(GH5_03282)

LENR:

94169705(CUR178_02439)

LEIN:

94186196(JIQ42_02477)

PHET:

94288769(JKF63_02668)

» show all

Reference

PMID:22984289

Authors

Vogtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi RP, Meisinger C

Title

Intermembrane space proteome of yeast mitochondria.

Journal

Mol Cell Proteomics 11:1840-52 (2012)
DOI:10.1074/mcp.M112.021105

Sequence

[sce:YMR244C-A]

Reference

PMID:24549041

Authors

Ghosh A, Trivedi PP, Timbalia SA, Griffin AT, Rahn JJ, Chan SS, Gohil VM

Title

Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency.

Journal

Hum Mol Genet 23:3596-606 (2014)
DOI:10.1093/hmg/ddu069

Sequence

[hsa:388753]

LinkDB

DBGET integrated database retrieval system