KEGG ORTHOLOGY: K18190

ORTHOLOGY: K18190

Entry

K18190                      KO

Symbol

FASTKD2

Name

FAST kinase domain-containing protein 2

Disease

H00891

Combined oxidative phosphorylation deficiency

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K18190  FASTKD2; FAST kinase domain-containing protein 2
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    K18190  FASTKD2; FAST kinase domain-containing protein 2

Genes

HSA:	22868(FASTKD2)

PTR:	470625(FASTKD2)

PPS:	100971833(FASTKD2)

GGO:	101141830(FASTKD2)

PON:	100456209(FASTKD2)

NLE:	100585293(FASTKD2)

HMH:	116810391(FASTKD2)

MCC:	709702(FASTKD2)

MCF:	101925852(FASTKD2)

MTHB:

126932932

MNI:	105468019(FASTKD2)

CSAB:

103217711(FASTKD2)

CATY:

105580093(FASTKD2)

PANU:

101009808(FASTKD2)

TGE:	112636529(FASTKD2)

MLEU:

105549377(FASTKD2)

RRO:	104680226(FASTKD2)

RBB:	108543440(FASTKD2)

TFN:	117094605(FASTKD2)

PTEH:

111547634(FASTKD2)

CANG:

105517362(FASTKD2)

CJC:	100409139(FASTKD2)

SBQ:	101037032(FASTKD2)

CIMI:

108316700(FASTKD2)

CSYR:

103258476(FASTKD2)

MMUR:

105856906

LCAT:

123644079(FASTKD2)

PCOQ:

105823908(FASTKD2)

OGA:	100956356(FASTKD2)

MMU:	75619(Fastkd2)

MCAL:

110291460(Fastkd2)

MPAH:

110321801(Fastkd2)

RNO:	301463(Fastkd2)

MCOC:

116088509(Fastkd2)

ANU:	117705896(Fastkd2)

MUN:	110566904(Fastkd2)

CGE:	100757409(Fastkd2)

MAUA:

101840454(Fastkd2)

PROB:

127226372(Fastkd2)

PLEU:

114705055(Fastkd2)

MORG:

121433456(Fastkd2)

MFOT:

126508846

AAMP:

119821613(Fastkd2)

NGI:	103744438(Fastkd2)

HGL:	101714635(Fastkd2)

CPOC:

100718328(Fastkd2)

CCAN:

109688700(Fastkd2)

DORD:

105982408(Fastkd2)

DSP:	122107446(Fastkd2)

PLOP:

125350360(Fastkd2)

NCAR:

124979974

MMMA:

107138640(Fastkd2)

OCU:	100351224 100355694

OPI:	101534177(FASTKD2)

TUP:	102502444(FASTKD2)

GVR:	103603839(FASTKD2)

CFA:	478884(FASTKD2)

CLUD:

112656325(FASTKD2)

VVP:	112922615(FASTKD2)

VLG:	121480786(FASTKD2)

NPO:	129522907(FASTKD2)

AML:	100463823(FASTKD2)

UMR:	103659796(FASTKD2)

UAH:	113250533(FASTKD2)

UAR:	123798244(FASTKD2)

ELK:

111144463

LLV:

125095408

MPUF:

101671772(FASTKD2)

MNP:	132013490(FASTKD2)

MLK:	131827528(FASTKD2)

NVS:	122902238(FASTKD2)

ORO:	101367275(FASTKD2)

EJU:	114216011(FASTKD2)

ZCA:	113918912 113920124(FASTKD2)

MLX:	118012104(FASTKD2)

NSU:	110591940(FASTKD2)

LWW:

102750600

FCA:	101097009(FASTKD2)

PYU:	121030968(FASTKD2)

PCOO:

112848700(FASTKD2)

PBG:	122481690(FASTKD2)

PVIV:

125173169(FASTKD2)

LRUF:

124516356

PTG:	102972866(FASTKD2)

PPAD:

109265165(FASTKD2)

PUC:

125911268

AJU:

106987168

HHV:	120220410(FASTKD2)

BTA:	528207(FASTKD2)

BOM:	102266499(FASTKD2)

BIU:	109570025(FASTKD2)

BBUB:

102408567(FASTKD2)

BBIS:

105003696(FASTKD2)

CHX:	102184101(FASTKD2)

OAS:	101116708(FASTKD2)

BTAX:

128043177(FASTKD2)

ODA:	120854575(FASTKD2)

CCAD:

122426534(FASTKD2)

MBEZ:

129538155(FASTKD2)

SSC:	100517314(FASTKD2)

CFR:	102509984(FASTKD2)

CBAI:

105072967(FASTKD2)

CDK:	105093566(FASTKD2)

VPC:	102529944(FASTKD2)

BACU:

102999503(FASTKD2)

BMUS:

118898339(FASTKD2)

LVE:	103070530(FASTKD2)

OOR:	101288773(FASTKD2)

DLE:	111171768(FASTKD2)

PCAD:

102978959(FASTKD2)

PSIU:

116756975(FASTKD2)

NASI:

112395273(FASTKD2)

ECB:	100068684(FASTKD2)

EPZ:	103548913(FASTKD2)

EAI:	106828154(FASTKD2)

MYB:	102249056(FASTKD2)

MYD:	102753025(FASTKD2)

MMYO:

118661755(FASTKD2)

MLF:	102425805(FASTKD2)

PKL:	118709548(FASTKD2)

EFUS:

103289367(FASTKD2)

MNA:	107524710(FASTKD2)

DRO:	112307960(FASTKD2)

SHON:

118985188(FASTKD2)

AJM:	119064365(FASTKD2)

PDIC:

114495548(FASTKD2)

PHAS:

123829805(FASTKD2)

MMF:	118625336(FASTKD2)

PPAM:

129080394(FASTKD2)

HAI:	109388308(FASTKD2)

RFQ:	117026106(FASTKD2)

PALE:

102887113(FASTKD2)

PGIG:

120587576(FASTKD2)

PVP:	105298408(FASTKD2)

RAY:	107505174(FASTKD2)

TOD:	119256143(FASTKD2)

SARA:

101545276(FASTKD2)

SETR:

126008915(FASTKD2)

LAV:	100659312(FASTKD2)

TMU:

101344635

ETF:	101646559(FASTKD2)

DNM:	101432540(FASTKD2)

MDO:	100016726(FASTKD2)

GAS:	123242712(FASTKD2)

SHR:	100917680(FASTKD2)

AFZ:

127553183

PCW:	110223288(FASTKD2)

OAA:	100076729(FASTKD2)

GGA:	424096(FASTKD2)

PCOC:

116234003(FASTKD2)

MGP:	104911654(FASTKD2)

CJO:	107316564(FASTKD2)

TPAI:

128077061(FASTKD2)

LMUT:

125696962(FASTKD2)

NMEL:

110400672(FASTKD2)

APLA:

101790590(FASTKD2)

ACYG:

106030075(FASTKD2)

CATA:

118259107(FASTKD2)

AFUL:

116490711(FASTKD2)

TGU:	100218559(FASTKD2)

LSR:	110475015(FASTKD2)

SCAN:

103814720(FASTKD2)

PMOA:

120497971(FASTKD2)

OTC:	121335484(FASTKD2)

PRUF:

121356644(FASTKD2)

GFR:	102032698(FASTKD2)

FAB:	101821931(FASTKD2)

OMA:	130255596(FASTKD2)

PHI:	102109464(FASTKD2)

PMAJ:

107207655(FASTKD2)

CCAE:

111932016(FASTKD2)

CCW:	104693798(FASTKD2)

CBRC:

103616609(FASTKD2)

ETL:	114055742(FASTKD2)

ZAB:	102069691(FASTKD2)

ACHL:

103800919(FASTKD2)

SVG:	106855515(FASTKD2)

MMEA:

130582807(FASTKD2)

HRT:	120755452(FASTKD2)

FPG:	101918342(FASTKD2)

FCH:	102051996(FASTKD2)

CLV:	102093438(FASTKD2)

EGZ:	104125093(FASTKD2)

NNI:	104010264(FASTKD2)

PCRI:

104038786(FASTKD2)

PLET:

104626590(FASTKD2)

EHS:	104503835(FASTKD2)

PCAO:

104053852(FASTKD2)

ACUN:

113482560(FASTKD2)

TALA:

104357070(FASTKD2)

PADL:

103923634(FASTKD2)

AFOR:

103903440(FASTKD2)

ACHC:

115343135(FASTKD2)

HALD:

104323680(FASTKD2)

HLE:	104830280(FASTKD2)

AGEN:

126042180

GCL:

127018395

CCRI:

104163313(FASTKD2)

CSTI:

104550451(FASTKD2)

CMAC:

104473785(FASTKD2)

MUI:	104542748(FASTKD2)

BREG:

104633542(FASTKD2)

GSTE:

104263364(FASTKD2)

LDI:	104350048(FASTKD2)

MNB:	103769172(FASTKD2)

OHA:	104334228(FASTKD2)

NNT:	104408410(FASTKD2)

SHAB:

115607804(FASTKD2)

DPUB:

104298952(FASTKD2)

PGUU:

104467857

ACAR:

104526888(FASTKD2)

CPEA:

104397417(FASTKD2)

AVIT:

104275768(FASTKD2)

CVF:	104291050(FASTKD2)

RTD:	128912811(FASTKD2)

CUCA:

104058311(FASTKD2)

TEO:	104381777(FASTKD2)

BRHI:

104498487(FASTKD2)

AAM:	106492474(FASTKD2)

AROW:

112977221(FASTKD2)

NPD:	112954989(FASTKD2)

TGT:	104565552(FASTKD2)

DNE:	112990087(FASTKD2)

SCAM:

104144019(FASTKD2)

ASN:	102382653(FASTKD2)

AMJ:	102567244(FASTKD2)

CPOO:

109323057(FASTKD2)

GGN:	109302007(FASTKD2)

PSS:	102450032(FASTKD2)

CMY:	102945991(FASTKD2)

CCAY:

125645214(FASTKD2)

DCC:	119863675(FASTKD2)

CPIC:

101937582(FASTKD2)

TST:	117884858(FASTKD2)

CABI:

116816087(FASTKD2)

MRV:	120374442(FASTKD2)

ACS:	100551548(fastkd2)

ASAO:

132779051(FASTKD2)

PVT:	110072403(FASTKD2)

SUND:

121919165(FASTKD2)

PBI:	103051828(FASTKD2)

PMUR:

107289834(FASTKD2)

CTIG:

120312313(FASTKD2)

TSR:	106543417(FASTKD2)

PGUT:

117673921(FASTKD2)

APRI:

131200035(FASTKD2)

PTEX:

113440988(FASTKD2)

NSS:	113415680(FASTKD2)

VKO:	123024338(FASTKD2)

PMUA:

114581783

PRAF:

128400034(FASTKD2)

ZVI:	118096378(FASTKD2)

HCG:	128339214(FASTKD2)

GJA:	107114498(FASTKD2)

STOW:

125441545

EMC:	129323370(FASTKD2)

XLA:	108701469(fastkd2.L)

XTR:	100488261(fastkd2)

NPR:	108802118(FASTKD2)

RTEM:

120943770(FASTKD2)

BBUF:

121008469(FASTKD2)

BGAR:

122945082(FASTKD2)

MUO:	115474383(FASTKD2)

GSH:	117361206(FASTKD2)

DRE:	564382(fastkd2)

SRX:	107706831 107750062

SANH:

107673994

SGH:	107549425 107556283

CCAR:

109044867 109092419(fastkd2)

CAUA:

113044645(fastkd2)

CGIB:

127949718

PTET:

122345968(fastkd2)

LROH:

127172094(fastkd2)

OMC:	131524728(fastkd2)

PPRM:

120460547(fastkd2)

RKG:	130091004(fastkd2)

MAMB:

125272842(fastkd2)

CIDE:

127518494

MASI:

127443501 127445115

TROS:

130552511(fastkd2)

TDW:	130408371(fastkd2)

MANU:

129445047(fastkd2)

IPU:

108258353

IFU:	128601773(fastkd2)

PHYP:

113535427(fastkd2)

SMEO:

124377863(fastkd2)

TFD:	113661920(fastkd2)

TVC:	132839263(fastkd2)

AMEX:

103034825(fastkd2)

CMAO:

118802324(fastkd2)

EEE:	113587234(fastkd2)

CHAR:

105896608(fastkd2)

TRU:	101064313(fastkd2)

TFS:	130522180(fastkd2)

TNG:	GSTEN00027152G001

LCO:	104934535(fastkd2)

NCC:

104945504

TBEN:

117499014 117499043 117499044

CGOB:

115019806(fastkd2)

PGEO:

117459659(fastkd2)

GACU:

117546907(fastkd2)

EMAC:

134861126(fastkd2)

ELY:	117250215(fastkd2)

EFO:	125884943(fastkd2)

PLEP:

121962800(fastkd2)

SLUC:

116044785(fastkd2)

ECRA:

117939422(fastkd2)

ESP:	116674230(fastkd2)

PFLV:

114551059(fastkd2)

GAT:	120821223(fastkd2)

PPUG:

119217097(fastkd2)

AFB:	129111843(fastkd2)

CLUM:

117743646(fastkd2)

PSWI:

130204351(fastkd2)

MSAM:

119902653(fastkd2)

SCHU:

122872171(fastkd2)

CUD:	121506251(fastkd2)

ALAT:

119015615(fastkd2)

MZE:	101482037(fastkd2)

ONL:	100698827(fastkd2)

OAU:	116319225(fastkd2)

OLA:	101163307(fastkd2)

OML:	112160007(fastkd2)

CSAI:

133425041(fastkd2)

XMA:	102235070(fastkd2)

XCO:	114137769(fastkd2)

XHE:	116715848(fastkd2)

PRET:

103475572(fastkd2)

PFOR:

103147124(fastkd2)

PLAI:

106950960(fastkd2)

PMEI:

106905127(fastkd2)

GAF:	122827449(fastkd2)

PPRL:

129378990(fastkd2)

CVG:	107093723(fastkd2)

CTUL:

119779795(fastkd2)

GMU:	124861744(fastkd2)

NFU:	107381098(fastkd2)

KMR:	108246719(fastkd2)

ALIM:

106512136

NWH:	119428938(fastkd2)

AOCE:

111568748(fastkd2)

MCEP:

125000604(fastkd2)

CSEM:

103389878(fastkd2)

POV:	109642983(fastkd2)

SSEN:

122765601(fastkd2)

HHIP:

117777411(fastkd2)

HSP:	118103147(fastkd2)

SMAU:

118301346(fastkd2)

LCF:

108872962

SDU:	111238727(fastkd2)

SLAL:

111644463(fastkd2)

XGL:	120798213(fastkd2)

HCQ:	109520933(fastkd2)

SSCV:

125988592

SBIA:

133492049(fastkd2)

PEE:	133410711(fastkd2)

PTAO:

133489814(fastkd2)

BPEC:

110168981(fastkd2)

MALB:

109955633(fastkd2)

BSPL:

114869972 114869991(fastkd2)

SJO:	128354334(fastkd2)

SASA:

106575095(fastkd2)

STRU:

115179334(fastkd2)

OTW:	112253998(fastkd2)

OMY:	110527568(fastkd2)

OGO:	124008231(fastkd2)

ONE:	115134342(fastkd2)

OKI:	109890698(fastkd2)

OKE:	118370137(fastkd2)

SALP:

111971012(fastkd2)

SNH:	120033704(fastkd2)

CCLU:

121554308

ELS:	105023711(fastkd2)

SFM:	108942580(fastkd2)

PKI:	111858388(fastkd2)

AANG:

118223527(fastkd2)

LOC:	102690283(fastkd2)

PSPA:

121322127 121322599

ARUT:

117426322(fastkd2)

PSEX:

120531951(fastkd2)

LCM:	102347920(FASTKD2)

CMK:	103176850(fastkd2)

RTP:	109910741(fastkd2)

CPLA:

122551404(fastkd2)

HOC:	132817572(fastkd2)

LERI:

129698945(fastkd2)

PMRN:

116948719(FASTKD2)

LRJ:	133345215(FASTKD2)

CIN:

SCLV:

SPU:

APLC:

SKO:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

109413932 115269090 115269202

CQU:	CpipJ_CPIJ013323

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

NMEA:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100116673 100119418 100677888 100677906

CSOL:

TPRE:

MDL:

FAS:

AGIF:

TCA:

DPA:

SOY:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

NLU:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_308140

PVM:

PJA:

PCHN:

HAME:

PCLA:

MNZ:	135207193 135207207

DSV:

RSAN:

TUT:

CSCU:

PTEP:

ABRU:

SDM:

Reference

PMID:18771761

Authors

Ghezzi D, Saada A, D'Adamo P, Fernandez-Vizarra E, Gasparini P, Tiranti V, Elpeleg O, Zeviani M

Title

FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency.

Journal

Am J Hum Genet 83:415-23 (2008)
DOI:10.1016/j.ajhg.2008.08.009

Sequence

[hsa:22868]

LinkDB

DBGET integrated database retrieval system