KEGG ORTHOLOGY: K18207

ORTHOLOGY: K18207

Entry

K18207                      KO

Symbol

POMGNT2, GTDC2

Name

protein O-mannose beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.312]

Pathway

map00515

Mannose type O-glycan biosynthesis

map01100

Metabolic pathways

Module

M00872

O-glycan biosynthesis, mannose type (core M3)

Reaction

R10596

UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-threonyl-[protein] 4-beta-N-acetyl-D-glucosaminyltransferase

R11407

Disease

H00120

Muscular dystrophy-dystroglycanopathy type A

H00593

Limb-girdle muscular dystrophy

H01959

Muscular dystrophy-dystroglycanopathy type C

H02307

Muscular dystrophy-dystroglycanopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K18207  POMGNT2, GTDC2; protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K18207  POMGNT2, GTDC2; protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.312  protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
     K18207  POMGNT2, GTDC2; protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
Glycosyltransferases [BR:ko01003]
Glycan extension
  O-Glycan
   K18207  POMGNT2, GTDC2; protein O-mannose beta-1,4-N-acetylglucosaminyltransferase

Other DBs

CAZy:

GT61

Genes

HSA:	84892(POMGNT2)

PTR:	503649(POMGNT2)

PPS:	100968652(POMGNT2)

GGO:	101154402(POMGNT2)

PON:	100457180(POMGNT2)

PPYG:

129033453(POMGNT2)

NLE:	100592031(POMGNT2)

HMH:	116473592(POMGNT2)

SSYN:

129483540(POMGNT2)

MCC:	717032(POMGNT2)

MCF:	102135133(POMGNT2)

MTHB:

126948513

MNI:	105480291(POMGNT2)

CSAB:

103227475(POMGNT2)

CATY:

105573836(POMGNT2)

PANU:

101000326(POMGNT2)

TGE:	112619700(POMGNT2)

MLEU:

105530512(POMGNT2)

RRO:	104670961(POMGNT2)

RBB:	108532329(POMGNT2)

TFN:	117083971(POMGNT2)

PTEH:

111555566(POMGNT2)

CANG:

105518115(POMGNT2)

CJC:	100387902(POMGNT2)

SBQ:	101039365(POMGNT2)

CIMI:

108299965(POMGNT2)

ANAN:

105729795(POMGNT2)

CSYR:

103273128(POMGNT2)

MMUR:

105874875(POMGNT2)

LCAT:

123623337(POMGNT2)

PCOQ:

105806263(POMGNT2)

OGA:	100944535(POMGNT2)

MMU:	215494(Pomgnt2)

MCAL:

110301603(Pomgnt2)

MPAH:

110327674(Pomgnt2)

RNO:	316091(Pomgnt2)

MCOC:

116072476(Pomgnt2)

ANU:	117693761(Pomgnt2)

MUN:	110554668(Pomgnt2)

CGE:	100770708(Pomgnt2)

MAUA:

101840846(Pomgnt2)

PROB:

127235478(Pomgnt2)

PLEU:

114707640(Pomgnt2)

MORG:

121464461(Pomgnt2)

MFOT:

126501219

AAMP:

119809788(Pomgnt2)

NGI:	103747148(Pomgnt2)

HGL:	101711700(Pomgnt2)

CPOC:

100735127(Pomgnt2)

CCAN:

109695103(Pomgnt2)

DORD:

105996217(Pomgnt2)

DSP:	122100709(Pomgnt2)

PLOP:

125342502(Pomgnt2)

NCAR:

124969452

MMMA:

107145449(Pomgnt2)

OCU:

100341347

OPI:	101531325(POMGNT2)

TUP:	102470610(POMGNT2)

GVR:	103609193(POMGNT2)

CFA:	485621(POMGNT2)

CLUD:

112668679(POMGNT2)

VVP:	112921520(POMGNT2)

VLG:	121478945(POMGNT2)

NPO:	129507196(POMGNT2)

AML:	100483210(POMGNT2)

UMR:	103682052(POMGNT2)

UAH:	113253834(POMGNT2)

UAR:	123778639(POMGNT2)

ELK:

111159113

LLV:

125105552

MPUF:

101680874(POMGNT2)

MNP:	132011724(POMGNT2)

MLK:	131824446(POMGNT2)

NVS:	122909058(POMGNT2)

ORO:	101374856(POMGNT2)

EJU:	114212296(POMGNT2)

ZCA:	113917189(POMGNT2)

MLX:	118002582(POMGNT2)

NSU:	110570800(POMGNT2)

LWW:	102733488(POMGNT2)

FCA:	101093958(POMGNT2)

PYU:	121033536(POMGNT2)

PCOO:

112850319(POMGNT2)

PBG:	122492091(POMGNT2)

PVIV:

125175437(POMGNT2)

LRUF:

124526663

PTG:	102955067(POMGNT2)

PPAD:

109251344(POMGNT2)

PUC:

125922035

AJU:

106966685

HHV:	120243610(POMGNT2)

BTA:	497030(POMGNT2)

BOM:	102278967(POMGNT2)

BIU:	109576335(POMGNT2)

BBUB:

102403309(POMGNT2)

BBIS:

104985317(POMGNT2)

CHX:	102180708(POMGNT2)

OAS:	114112581(POMGNT2)

BTAX:

128048185(POMGNT2)

ODA:	120867724(POMGNT2)

CCAD:

122424540(POMGNT2)

MBEZ:

129548090(POMGNT2)

SSC:	100524525(POMGNT2)

CFR:	102524427(POMGNT2)

CBAI:

105061783(POMGNT2)

CDK:	105084600(POMGNT2)

VPC:	102528411(POMGNT2)

BACU:

103020196

BMUS:

118904460(POMGNT2)

OOR:	101273887(POMGNT2)

DLE:	111164305(POMGNT2)

PCAD:

102990521(POMGNT2)

PSIU:

116762893(POMGNT2)

NASI:

112406925(POMGNT2)

ECB:	100067004(POMGNT2)

EPZ:	103566849(POMGNT2)

EAI:	106843158(POMGNT2)

MYB:	102244479(POMGNT2)

MYD:	102757264(POMGNT2)

MMYO:

118668392(POMGNT2)

MLF:	102438863(POMGNT2)

MDT:	132215765(POMGNT2)

PKL:	118715546(POMGNT2)

EFUS:

103297779(POMGNT2)

MNA:	107524271(POMGNT2)

DRO:	112309655(POMGNT2)

SHON:

118976187(POMGNT2)

AJM:	119051532(POMGNT2)

PDIC:

114502023(POMGNT2)

PHAS:

123830558(POMGNT2)

MMF:	118633191(POMGNT2)

PPAM:

129087623(POMGNT2)

HAI:	109377834(POMGNT2)

RFQ:	117037091(POMGNT2)

PALE:

102883663(POMGNT2)

PGIG:

120582229(POMGNT2)

PVP:	105290309(POMGNT2)

RAY:	107520004(POMGNT2)

MJV:	108383476(POMGNT2)

TOD:	119258809(POMGNT2)

SARA:

101558353(POMGNT2)

SETR:

126020315(POMGNT2)

LAV:	100668532(POMGNT2)

TMU:

101357084

ETF:	101654199(POMGNT2)

DNM:	101445343(POMGNT2)

MDO:	100025375(POMGNT2)

GAS:	123248852(POMGNT2)

SHR:	100917448(POMGNT2)

AFZ:

127564126

PCW:	110213047(POMGNT2)

TVP:	118852394(POMGNT2)

OAA:	100078600(POMGNT2)

GGA:	428446(POMGNT2)

PCOC:

116227144(POMGNT2)

MGP:	100549318(POMGNT2)

CJO:	107309310(POMGNT2)

TPAI:

128086890(POMGNT2)

LMUT:

125696373(POMGNT2)

NMEL:

110394329(POMGNT2)

APLA:

101800017(POMGNT2)

ACYG:

106043324(POMGNT2)

CATA:

118249664(POMGNT2)

AFUL:

116485927(POMGNT2)

TGU:	100220641(POMGNT2)

LSR:	110468216(POMGNT2)

SCAN:

103812956(POMGNT2)

PMOA:

120503320(POMGNT2)

OTC:	121337677(POMGNT2)

PRUF:

121353128(POMGNT2)

GFR:	102034462(POMGNT2)

FAB:	101807065(POMGNT2)

OMA:	130250074(POMGNT2)

PHI:	102114408(POMGNT2)

PMAJ:

107201055(POMGNT2)

CCAE:

111923526(POMGNT2)

CCW:	104689030(POMGNT2)

CBRC:

103615821(POMGNT2)

ETL:	114064424(POMGNT2)

ZAB:	102071811(POMGNT2)

ZLE:	135443894(POMGNT2)

ACHL:

103803427(POMGNT2)

SVG:	106854491(POMGNT2)

MMEA:

130577391(POMGNT2)

HRT:	120761493(POMGNT2)

SATI:

136362141(POMGNT2)

FPG:	101913052(POMGNT2)

FCH:	102054650(POMGNT2)

CCRI:

104159426(POMGNT2)

NNT:	104403025(POMGNT2)

SHAB:

115618400(POMGNT2)

ACUN:

113477085(POMGNT2)

TALA:

104361453(POMGNT2)

ACHC:

115339553(POMGNT2)

HALD:

104318048(POMGNT2)

HLE:	104828616(POMGNT2)

AGEN:

126045796

GCL:

127012834

CSTI:

104556201(POMGNT2)

LDI:	104351382(POMGNT2)

MNB:	103771778(POMGNT2)

DPUB:

104298265(POMGNT2)

AVIT:

104269607(POMGNT2)

BRHI:

104494938(POMGNT2)

EGZ:	104127495(POMGNT2)

NNI:	104018482(POMGNT2)

PCRI:

104037116(POMGNT2)

PCAO:

104046723(POMGNT2)

PADL:

103917061(POMGNT2)

AFOR:

103902502(POMGNT2)

FGA:	104080409(POMGNT2)

GSTE:

104253235(POMGNT2)

CLV:	102097604(POMGNT2)

MUI:	104546557(POMGNT2)

PGUU:

104469959(POMGNT2)

PLET:

104620293(POMGNT2)

EHS:	104508050(POMGNT2)

CMAC:

104480332(POMGNT2)

CUCA:

104068815(POMGNT2)

TEO:	104382447(POMGNT2)

BREG:

104642196(POMGNT2)

OHA:	104332640(POMGNT2)

ACAR:

104531205(POMGNT2)

CPEA:

104397524(POMGNT2)

CVF:	104288061(POMGNT2)

RTD:	128905606(POMGNT2)

AAM:	106491175(POMGNT2)

AROW:

112967156(POMGNT2)

NPD:	112952610(POMGNT2)

TGT:	104567488(POMGNT2)

DNE:	112982406(POMGNT2)

SCAM:

104152517(POMGNT2)

ASN:	102376391(POMGNT2)

AMJ:	102567043(POMGNT2)

CPOO:

109311085(POMGNT2)

GGN:	109291724(POMGNT2)

PSS:	102454469(POMGNT2)

CMY:	102934275(POMGNT2)

CCAY:

125631666(POMGNT2)

DCC:	119850583(POMGNT2)

CPIC:

101953826(POMGNT2)

TST:	117872430(POMGNT2)

CABI:

116827007(POMGNT2)

MRV:	120399661(POMGNT2)

ACS:	100557956(pomgnt2)

ASAO:

132778652(POMGNT2)

PVT:	110082156(POMGNT2)

SUND:

121932383(POMGNT2)

PBI:	103067706(POMGNT2)

PMUR:

107294214(POMGNT2)

CTIG:

120305010(POMGNT2)

TSR:	106545483(POMGNT2)

PGUT:

117656062 132708884

APRI:

131196785(POMGNT2)

PTEX:

113447531(POMGNT2)

NSS:	113423203(POMGNT2)

VKO:	123017684(POMGNT2)

PMUA:

114607367 114607441(POMGNT2)

PRAF:

128423859 128424079(POMGNT2)

ZVI:	118092344(POMGNT2) 118092360

HCG:	128328707(POMGNT2)

GJA:	107111512(POMGNT2)

STOW:

125441281(POMGNT2)

EMC:	129337815(POMGNT2)

XLA:	444520(pomgnt2.L)

XTR:	496628(pomgnt2)

NPR:	108792069(POMGNT2)

RTEM:

120940297(POMGNT2)

BBUF:

121002118(POMGNT2)

BGAR:

122938750(POMGNT2)

MUO:	115472082(POMGNT2)

GSH:	117353766(POMGNT2)

DRE:	497644(pomgnt2)

SRX:	107732433 107751881

SANH:

107657577 107704096

SGH:	107551215 107601673

CCAR:

109076321

CAUA:

113116181

CGIB:

127975034 128030866

PTET:

122360637(pomgnt2)

LROH:

127178843(pomgnt2)

OMC:	131522584(pomgnt2)

PPRM:

120495143(pomgnt2)

RKG:	130089847(pomgnt2)

MAMB:

125243727(pomgnt2)

CIDE:

127497773

CERY:

137024755(pomgnt2)

MASI:

127452564 127454265

TROS:

130558627(pomgnt2)

TDW:	130432975(pomgnt2)

MANU:

129448743(pomgnt2)

IPU:

108268718

IFU:	128611198(pomgnt2)

PHYP:

113533743(pomgnt2)

SMEO:

124383758(pomgnt2)

TFD:	113644175(pomgnt2)

TVC:	132845830(pomgnt2)

TRN:	134310594(pomgnt2)

AMEX:

103031510(pomgnt2)

CMAO:

118818315(pomgnt2)

EEE:	113580583(pomgnt2)

CHAR:

105910516(pomgnt2)

TRU:	777951(pomgnt2)

TFS:	130532710(pomgnt2)

TNG:	GSTEN00012312G001

LCO:	104923101(pomgnt2)

NCC:	104955198(pomgnt2)

TBEN:

117470798(pomgnt2)

PGEO:

117461441(pomgnt2)

GACU:

117553921(pomgnt2)

EMAC:

134861373(pomgnt2)

ELY:	117264371(pomgnt2)

EFO:	125892852(pomgnt2)

PLEP:

121946143(pomgnt2)

SLUC:

116066635(pomgnt2)

ECRA:

117946590(pomgnt2)

ESP:	116691585(pomgnt2)

PFLV:

114557049(pomgnt2)

GAT:	120810019(pomgnt2)

PPUG:

119197677(pomgnt2)

AFB:	129109608(pomgnt2)

CLUM:

117728303(pomgnt2)

PSWI:

130206522(pomgnt2)

MSAM:

119898116(pomgnt2)

SCHU:

122881856(pomgnt2)

CUD:	121513885(pomgnt2)

ALAT:

119006150(pomgnt2)

ASTR:

137602055(pomgnt2)

MZE:	101467114(pomgnt2)

ONL:	100709211(pomgnt2)

OAU:	116312151(pomgnt2)

OLA:	101172435(pomgnt2)

OML:	112152176(pomgnt2)

CSAI:

133440812 133440849

XMA:	102225885(pomgnt2)

XCO:	114144724(pomgnt2)

XHE:	116717158(pomgnt2)

PRET:

103465884(pomgnt2)

PFOR:

103136957(pomgnt2)

PLAI:

106953448(pomgnt2)

PMEI:

106917527(pomgnt2)

GAF:	122831788(pomgnt2)

PPRL:

129367419(pomgnt2)

CVG:	107080768(pomgnt2)

CTUL:

119776915(pomgnt2)

GMU:	124866022(pomgnt2)

NFU:	107396256(pomgnt2)

KMR:	108229753(pomgnt2)

ALIM:

106519275(pomgnt2)

NWH:	119410273(pomgnt2)

AOCE:

111573758(pomgnt2)

MCEP:

125016956(pomgnt2)

CSEM:

103388754(pomgnt2)

POV:	109631931(pomgnt2)

SSEN:

122767628 122775255(pomgnt2)

HHIP:

117776224(pomgnt2)

HSP:	118114080(pomgnt2)

PPLT:

128449994(pomgnt2)

SMAU:

118310819(pomgnt2)

LCF:

108876318

SDU:	111225902(pomgnt2)

SLAL:

111652527(pomgnt2)

XGL:	120784519(pomgnt2)

HCQ:	109531057(pomgnt2)

SSCV:

125975187

SBIA:

133500589(pomgnt2)

PEE:	133410754(pomgnt2)

PTAO:

133486675(pomgnt2)

BPEC:

110171853(pomgnt2)

MALB:

109966635(pomgnt2)

BSPL:

114842791(pomgnt2)

SJO:	128366355(pomgnt2)

SASA:

106579937(Glyt) 106605419

STRU:

115176675 115180439

OTW:	112222815 112228390

OMY:	110485998 110512912

OGO:	123996546 124006437

ONE:	115102845 115140959

OKI:	109901904 109901905

OKE:	118364546 118367714

SALP:

111958562 111964975

SNH:	120031705 120047660

CCLU:

121570072 121586247

ELS:	105025919(pomgnt2)

SFM:	108940488(pomgnt2)

PKI:	111840939(pomgnt2)

AANG:

118215506(pomgnt2)

LOC:	102697824(pomgnt2)

PSPA:

121313360 121314802

ARUT:

117394291 117399418

PSEX:

120515731(pomgnt2)

LCM:	102346285(POMGNT2)

CMK:	103187059(pomgnt2)

RTP:	109919835(pomgnt2)

CPLA:

122549243(pomgnt2)

HOC:	132812698(pomgnt2)

LERI:

129696633(pomgnt2)

PMRN:

116944211(POMGNT2)

LRJ:	133350911(POMGNT2)

BFO:

BBEL:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128996819 128997425

PHU:	Phum_PHUM177410

FOC:

TPAL:

CSEC:

IEL:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

MRJ:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_105809

LGI:	LOTGIDRAFT_194055

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_12816

MBR:	MONBRDRAFT_31627

SRE:	PTSG_12894

» show all

Reference

PMID:23929950

Authors

Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP

Title

SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.

Journal

Science 341:896-9 (2013)
DOI:10.1126/science.1239951

Sequence

[hsa:84892]

LinkDB

DBGET integrated database retrieval system