KEGG ORTHOLOGY: K18403

ORTHOLOGY: K18403

Entry

K18403                      KO

Symbol

MSL3

Name

male-specific lethal 3

Disease

H00658

X-linked syndromic intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K18403  MSL3; male-specific lethal 3
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HAT complexes
    MSL complex
     K18403  MSL3; male-specific lethal 3

Genes

HSA:	10943(MSL3) 151507(MSL3B)

PTR:	107973974 465491(MSL3)

PPS:	100975079 100984247(MSL3)

GGO:	101148577(MSL3) 101150533

PON:	100173442(MSL3) 100450672

PPYG:

129024937(MSL3) 129032064

NLE:	100583470(MSL3) 100596485

HMH:	116810037 116811516(MSL3)

SSYN:

129475811(MSL3) 129488608

MCC:	714902 720836(MSL3)

MCF:	102125503(MSL3B) 102134812(MSL3)

MTHB:

126932270 126946665

MNI:	105473881 105478120(MSL3)

CSAB:

103218119 103231592(MSL3)

CATY:

105574723(MSL3) 105578455

PANU:

101012770 101018583(MSL3)

TGE:	112616273(MSL3) 112636225

MLEU:

105539823 105550038(MSL3)

RRO:	104654402(MSL3) 104660342 115892713

RBB:	108522785 108541002

TFN:	117078568(MSL3) 117094358 117096205

PTEH:

111531470(MSL3) 111553770

CANG:

105502932 105518057(MSL3)

CJC:	100387723(MSL3)

SBQ:	101033936(MSL3)

CIMI:

108296224(MSL3) 108310646

ANAN:

105704680 105705372(MSL3)

CSYR:

103272415(MSL3)

MMUR:

105882444(MSL3)

LCAT:

123628094(MSL3) 123634240

ERUF:

138377994(MSL3) 138396840

PCOQ:

105820969(MSL3)

OGA:	100947285 100963312(MSL3)

MMU:	17692(Msl3) 73390(Msl3l2)

MCAL:

110286918(Msl3)

MPAH:

110313883(Msl3) 110326366

RNO:	309790(Msl3l2) 317464(Msl3)

MCOC:

116075497 116101542(Msl3)

ANU:	117694436(Msl3) 117724350

ASYL:

127669549 127674890(Msl3)

MUN:	110542860(Msl3) 110561529

CGE:	100760785(Msl3) 100765805

MAUA:

101824436 101838137(Msl3)

PROB:

127214500(Msl3) 127215116

PLEU:

114692554 114704618(Msl3)

PMAV:

102904138 102924919(Msl3)

MORG:

121439468 121444441(Msl3) 121449484

MFOT:

126487951 126499070

AAMP:

119804806(Msl3) 119821030

CNL:	130867664(Msl3) 130869348

NGI:	103736287 103749972(Msl3)

HGL:	101698996(Msl3)

CPOC:

100713886(Msl3)

CCAN:

109700337(Msl3)

DORD:

105997684(Msl3)

DSP:	122108554(Msl3) 122117174

DMER:

138840498(Msl3)

PLOP:

125343794(Msl3) 125367697

NCAR:

124972575 124975194

MMMA:

107144224(Msl3) 125615815

ITI:	101954477(Msl3)

OPI:	101521445 101535986

OCZ:	121148194 121151830

TUP:	102467727(MSL3) 102470289

GVR:	103589261(MSL3) 103599405

CFA:	491742(MSL3)

CLUD:

112652829(MSL3)

VVP:	112932361(MSL3)

VLG:	121483481(MSL3)

NPO:	129518755(MSL3)

AML:	100470665(MSL3)

UMR:	103668097(MSL3)

UAH:	113240737(MSL3)

UAR:	123797292(MSL3)

ELK:

111157135

LLV:

125092000

MPUF:

101684058(MSL3)

MNP:	132006785(MSL3)

MLK:	131821418(MSL3)

NVS:	122896831(MSL3)

ORO:	101378665(MSL3)

EJU:	114218084(MSL3)

ZCA:	113931310(MSL3)

MLX:	118026706(MSL3)

NSU:	110575129(MSL3)

LWW:	102728465(MSL3)

FCA:	101086287(MSL3)

PYU:	121025182(MSL3)

PCOO:

112871584(MSL3)

PBG:	122477921(MSL3)

PVIV:

125157216(MSL3)

LRUF:

124509345

LGF:	123595115(MSL3)

AJU:

106971048

PTG:	102971509(MSL3)

PPAD:

109248288(MSL3)

PUC:

125931474

HHV:	120233134(MSL3)

BTA:	515220(MSL3)

BOM:	102279811(MSL3)

BIU:	109555309(MSL3)

BBUB:

102409820(MSL3)

BKE:	129639116(MSL3)

BBIS:

105000186 105003849

CHX:	102172250(MSL3)

OAS:	101119018(MSL3)

BTAX:

128043680 128069916(MSL3)

CSUM:

138070888(MSL3)

ODA:	120854548 120882455(MSL3)

CCAD:

122426185 122435069(MSL3)

MREE:

136153738(MSL3)

OVR:

110137370

MBEZ:

129534815(MSL3) 129550437

SSC:	100526025(MSL3)

CFR:	102510344(MSL3) 116667773

CBAI:

105077749(MSL3)

CDK:	105100585(MSL3)

VPC:	102540753(MSL3)

BACU:

103008730(MSL3) 103017954

BMUS:

118882927 118888882(MSL3) 118901022

LVE:	103074464 103084414(MSL3)

OOR:	101283319 101286087(MSL3)

LALB:

132507209 132513363(MSL3)

GMF:	115846466(MSL3)

DDP:	132418872(MSL3)

DLE:	111167217(MSL3)

PCAD:

102976428(MSL3) 102984192

PSIU:

116741650 116747687(MSL3)

PPHC:

136136394 136141979(MSL3)

NASI:

112393012 112409745(MSL3)

ECB:	100054131(MSL3)

EPZ:	103566600(MSL3)

EAI:	106848665(MSL3)

MYB:	102248006(MSL3)

MYD:	102751713(MSL3)

MMYO:

118654163(MSL3)

MLF:	102442857(MSL3)

MDT:	132225083(MSL3)

PKL:	118719936(MSL3)

EFUS:

103299744(MSL3)

MNA:	107539217(MSL3)

DRO:	112313375(MSL3)

SHON:

118984030 118987224(MSL3)

AJM:	119058350(MSL3)

PDIC:

114505022(MSL3)

PHAS:

123830113(MSL3)

MMF:	118636551(MSL3)

PPAM:

129076898(MSL3)

HAI:	109387374(MSL3)

RFQ:	117024920(MSL3)

PALE:

102889819 102895810(MSL3)

PGIG:

120611583(MSL3) 120620361

PVP:	105293979(MSL3)

RAY:	107504070(MSL3) 118606625

MJV:	108409852(MSL3)

TOD:	119246346(MSL3)

SARA:

101554321(MSL3)

SFUM:

130021630 130039304(MSL3)

SETR:

125999109(MSL3) 126001010

LAV:	100669774(MSL3)

TMU:

101349660

ETF:	101664643 101664675(MSL3)

DNM:	101432238(MSL3)

MDO:	100018077(MSL3)

GAS:	123242548(MSL3) 123251083

SHR:	100924126(MSL3)

AFZ:

127553644

PCW:	110222484(MSL3)

TVP:	118839181(MSL3)

PBRV:

138142065(MSL3)

MLAO:

141491470(MSL3)

OAA:	100084693(MSL3)

TACU:

119937556(MSL3)

GGA:	418641(MSL3)

PCOC:

116230757(MSL3)

MGP:	100543910(MSL3)

CJO:	107325860(MSL3)

TPAI:

128071696(MSL3)

LMUT:

125686832(MSL3)

NMEL:

110405355(MSL3)

APLA:

101797348(MSL3)

AACU:

137856978(MSL3)

ACYG:

106042554(MSL3)

CATA:

118245743(MSL3)

AFUL:

116489475(MSL3)

TGU:	100227046(MSL3)

LSR:	110469219(MSL3)

SCAN:

103815804(MSL3)

PMOA:

120504575(MSL3)

OTC:	121342225(MSL3)

PRUF:

121356189(MSL3)

ATRC:

139591671(MSL3)

GFR:	102039880(MSL3)

FAB:	101821164(MSL3)

OMA:	130267010(MSL3)

PHI:	102103528(MSL3)

PMAJ:

107209768(MSL3)

CCAE:

111922810(MSL3)

CCW:	104686333(MSL3)

CBRC:

103617582(MSL3)

ACOE:

138104377(MSL3)

ETL:	114064243(MSL3)

ZAB:	102073380(MSL3)

ZLE:	135445653(MSL3)

ACHL:

103808296(MSL3)

SVG:	106852900(MSL3)

MMEA:

130588737(MSL3)

HRT:	120748844(MSL3)

SATI:

136358049(MSL3)

CFAI:

136285529(MSL3)

CCIC:

134041356(MSL3)

FPG:	101924315(MSL3)

FCH:	102053449(MSL3)

NNT:	104403191(MSL3)

SHAB:

115604389(MSL3)

ACUN:

113481209(MSL3)

SURA:

141939320(MSL3)

TALA:

104366124(MSL3)

ACHC:

115334609(MSL3)

HALD:

104311624(MSL3)

HLE:	104840567(MSL3)

AGEN:

126053054

HHAR:

128135186(MSL3)

BBUT:

142044804(MSL3)

GCL:

127027060

CSTI:

104549378

LDI:	104352554(MSL3)

DPUB:

104297069(MSL3)

PPUS:

135175231(MSL3)

AVIT:

104267138(MSL3)

BRHI:

104492096(MSL3)

EGZ:

104132992

NNI:	104022550(MSL3)

PCRI:

104031870(MSL3)

PCAO:

104039418(MSL3)

PADL:

103924804(MSL3)

AFOR:

103906023(MSL3)

FGA:	104070346(MSL3)

CBOR:

142094286(MSL3)

GSTE:

104251845(MSL3)

CBOY:

140646098(MSL3)

MAME:

142419421(MSL3)

CLV:

102094442

CNIC:

136003119(MSL3)

MUI:	104546373(MSL3)

PGUU:

104468175(MSL3)

PLET:

104626947(MSL3)

EHS:	104510787(MSL3)

CMAC:

104485726(MSL3)

CUCA:

104054888(MSL3)

TEO:	104379779(MSL3)

BREG:

104634922(MSL3)

GAME:

129195781(MSL3)

OHA:	104337538(MSL3)

ACAR:

104518756(MSL3)

CPEA:

104398667(MSL3)

CVF:	104287268(MSL3)

RTD:	128905848(MSL3)

CRID:

134518618(MSL3)

LMIC:

141750774(MSL3)

NARQ:

141463750(MSL3)

AAM:	106491639(MSL3)

AROW:

112964603(MSL3)

NPD:	112954041(MSL3)

TGT:	104564668(MSL3)

DNE:	112993423(MSL3)

SCAM:

104149813(MSL3)

ASN:	102373137(MSL3)

AMJ:	102557729(MSL3)

CPOO:

109306071(MSL3)

GGN:	109302871(MSL3)

PSS:	102455728(MSL3)

CIZ:	142012509(MSL3)

CMY:	102935530(MSL3)

CCAY:

125641163(MSL3)

LKP:	140915242(MSL3)

NDS:	141995441(MSL3)

DCC:	119842032(MSL3)

CPIC:

101933838(MSL3)

TST:	117869924(MSL3)

CABI:

116824462

MRV:	120368819(MSL3)

ACS:	100563920(msl3)

ASAO:

132771667(MSL3)

PVT:	110075452(MSL3)

SUND:

121926259(MSL3)

PBI:	103051557(MSL3) 103051985

PMUR:

107290458(MSL3)

CTIG:

120317581(MSL3)

TSR:	106539521(MSL3)

PGUT:

117676168(MSL3)

PCAE:

139316315(MSL3)

APRI:

131199120(MSL3)

PTEX:

113445194(MSL3)

NSS:	113411699(MSL3)

VKO:	123024469(MSL3)

PMUA:

114596295(MSL3)

PRAF:

128413214(MSL3)

ZVI:	118085382(MSL3)

HCG:	128350302(MSL3)

GJA:	107124267(MSL3)

STOW:

125431134(MSL3)

EMC:	129326523(MSL3)

XLA:	108708948(msl3.S) 494864(msl3.L)

XTR:	549328(msl3)

NPR:	108800043(MSL3)

RTEM:

120926522(MSL3)

ACAT:

141127941(MSL3)

PADS:

140333004(MSL3)

BBUF:

120995642(MSL3)

BGAR:

122932930(MSL3)

DTC:	141053670 141098396(MSL3)

PWL:	138250131(MSL3)

MUO:	115469193(MSL3)

GSH:	117362120(MSL3)

SRX:

107724056

SANH:

107655940

SGH:	107571708(msl3)

CCAR:

109051366

CAUA:

113093750(msl3) 113095296

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

IPU:

IFU:

PHYP:

113537371(msl3)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113578497(msl3)

CHAR:

105902841

SPIL:

134062286

ASAD:

121696962

TRU:	101061861(msl3)

TFS:

130522306

TNG:	GSTEN00027200G001

LCO:	104924092(msl3)

NCC:	104944392(msl3)

TBEN:

117499106

CGOB:

115020102(msl3)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116673927(msl3)

PFLV:

114551194(msl3)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

EARM:

CUD:

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

PKLU:

MZE:	101467588(msl3)

ONL:	100693414(msl3)

OAU:

116328885

OLA:	101160633(msl3)

OML:

112160118

CSAI:

133424858

XMA:	102233149(msl3)

XCO:	114141003(msl3)

XHE:	116716149(msl3)

PRET:

103475945(msl3)

PFOR:

103141442(msl3)

PLAI:

106946169(msl3)

PMEI:

106917008(msl3)

GAF:

122827179

PPRL:

129379043

CVG:	107095462(msl3)

CTUL:

119784269

GMU:

124861773

NFU:	107381068(msl3)

KMR:

108244317

ALIM:

106521331(msl3)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103389711(msl3)

POV:	109638905(msl3)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111222780(msl3)

SLAL:

111646187(msl3)

XGL:

120797947

HCQ:	109515037(msl3)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110173075(msl3)

ENY:

140345140

MALB:

109955757(msl3)

BSPL:

SJO:

SSCO:

TTY:

GMH:	115542036(msl3)

SASA:

100196618(msl3) 106574410

STRU:

115179122 115196086

OTW:	112253739 112266466

OMY:	110495815 110527435

OGO:	124011707 124026267

ONE:	115129743 115133007

OKI:	109890602 109906722

OKE:	118363802 118372294

OMM:	135542596 135543485

OCLA:

139372515 139413000

SALP:

111970891(msl3)

SNH:	120033348 120051307

SFON:

129840236 129859655

CCLU:

121535967

ELS:	105020023(msl3)

OEP:

134007638

SFM:	108920582(msl3) 108928512

PKI:	111846835 111851506(msl3)

AANG:

118214277

AROT:

135240498

CCOG:

133116992

LOC:	102698972(msl3)

PSPA:

121320647 121327840

ARUT:

117405102 117407093

PSEX:

120522882

LCM:	102350209(MSL3)

CMK:

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PMRN:

116943672(MSL3)

LRJ:	133349895(MSL3)

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG8631(msl-3)

DER:

6544769

DSE:

6611098

DSI:	Dsimw501_GD13090(Dsim_GD13090)

DYA:	Dyak_GE20444

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12047

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:	101900008 131800584

SCAC:

106088629

LCQ:

111679404

LSQ:

119604917

CVJ:	135954918(msl-3)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007324

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108730602(msl-3)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139102050(Msl-3)

TLN:	139819394(Msl-3)

TAME:

143899453(Msl-3)

HST:

DQU:

CFO:

FEX:

PMEC:

138935472(Msl-3)

LHU:	105679608(msl-3)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141530823(Msl-3)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217582(msl-3)

NFB:

NLO:

NVG:

AROA:

TCA:	658850 658875

TMOL:

138137241(msl-3)

DPA:

109537420

ESIM:

136417060(msl-3)

EFOR:

136344194(msl-3)

SOY:

115876450

RFG:	143193223(msl-3)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100101215(Msl3)

BMAN:

114243682

MSEX:

115447290

DPL:	KGM_204979

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137920132(msl-3)

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFUM:

141439300(msl-3)

CCRN:

123298122

API:	100159609 100574279

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106689465(msl-3)

NLU:

111055562

LDA:	142327267(msl-3)

HVI:

124360222

MQU:

128991469

PHU:	Phum_PHUM492390

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138702047(msl-3)

BROR:

134543158

IEL:

124162997

HAMR:

139688558(msl-3)

FCD:

110845052

DPX:	DAPPUDRAFT_222047

DMK:

116922938

DPZ:

124340469

AFRA:

136042096

PVM:	113820204(msl-3)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123744872(msl-3)

PTRU:

123499361

ESN:

127009051

MNZ:

135226636

MRJ:	136831373(msl-3)

PORN:

139761036(msl-3)

HAZT:

108666059

OOT:

143021026

EAF:

111705380

LSM:	121120080(msl-3)

PPOI:

119091565

DSV:

119448711

DALB:

135900617(msl-3)

RSAN:

RMP:

VDE:

VJA:

GOE:

CSCU:

CVS:	136981943(msl-3)

PTEP:

ABRU:

UDV:

SDM:

LGI:	LOTGIDRAFT_165646

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106155791 106160499

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_56822

» show all

Reference

PMID:22547026

Authors

Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M

Title

Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.

Journal

Cell Res 22:1078-81 (2012)
DOI:10.1038/cr.2012.72

Sequence

[hsa:10943]

Reference

PMID:7768187

Authors

Gorman M, Franke A, Baker BS

Title

Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila.

Journal

Development 121:463-75 (1995)

Sequence

[dme:Dmel_CG8631]

LinkDB

DBGET integrated database retrieval system