KEGG   ORTHOLOGY: K18562
Entry
K18562                      KO                                     
Symbol
thnQ, cmmQ
Name
2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R10735  OA-6129-A,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)
R13553  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18562  thnQ, cmmQ; 2-oxoglutarate-dependent dioxygenase
Other DBs
COG: COG5285
Genes
NJO: ABXT42_03855
DAG: PSQ19_18825
DRP: PSQ90_01635
DPV: ACE4RL_08025
SPSO: G4G27_23405
STEL: STAQ_05300
PBRU: LZC95_24850
SORG: NQZ70_08937
MTAR: DF168_01250(ectD_7) DF168_01753
AMOB: HG15A2_21170
BGOK: Pr1d_47440(ptlH_2)
SFA: Sfla_0152
STRP: F750_6869
SCT: SCAT_p0836(thnQ)
 » show all
Reference
  Authors
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA
  Title
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.
  Journal
J Am Chem Soc 132:12-3 (2010)
DOI:10.1021/ja907320n
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
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