The enzyme has been characterized from mammals and from the bacterium Streptantibioticus cattleyicolor. In mammals it hydrolyses excess 4'-phosphopantetheine to prevent cell damage. In S. cattleyicolor it participates in the biosynthesis of the beta-lactam antibiotic thienamycin.
Huang L, Khusnutdinova A, Nocek B, Brown G, Xu X, Cui H, Petit P, Flick R, Zallot R, Balmant K, Ziemak MJ, Shanklin J, de Crecy-Lagard V, Fiehn O, Gregory JF 3rd, Joachimiak A, Savchenko A, Yakunin AF, Hanson AD
Title
A family of metal-dependent phosphatases implicated in metabolite damage-control.
