KEGG   ORTHOLOGY: K18582
Entry
K18582                      KO                                     
Symbol
thnM
Name
carbapenam-3-carboxylate synthase [EC:6.3.3.6]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R10556  (2S,5S)-5-carboxymethylproline cyclo-ligase (AMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18582  thnM; carbapenam-3-carboxylate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.6  carbapenam-3-carboxylate synthase
     K18582  thnM; carbapenam-3-carboxylate synthase
Other DBs
COG: COG0367
Genes
SFA: Sfla_0156
STRP: F750_6865
SFIY: F0344_10095
SCT: SCAT_p0832(thnM)
SCY: SCATT_p09030
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA
  Title
Definition of the common and divergent steps in carbapenem beta-lactam antibiotic biosynthesis.
  Journal
Chembiochem 12:2159-65 (2011)
DOI:10.1002/cbic.201100366
LinkDB

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