KEGG ORTHOLOGY: K19008

ORTHOLOGY: K19008

Entry

K19008                      KO

Symbol

SIK1

Name

serine/threonine-protein kinase SIK1 [EC:2.7.11.1]

Pathway

map04922

Glucagon signaling pathway

Disease

H00606

Early infantile epileptic encephalopathy

H01819

Early myoclonic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K19008  SIK1; serine/threonine-protein kinase SIK1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K19008  SIK1; serine/threonine-protein kinase SIK1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K19008  SIK1; serine/threonine-protein kinase SIK1
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  CAMKL family
   K19008  SIK1; serine/threonine-protein kinase SIK1

Genes

HSA:	102724428(SIK) 150094(SIK1)

PTR:	474029(SIK1)

PPS:	100971941(SIK1)

GGO:	101152536(SIK1)

PON:	100461971(SIK1)

PPYG:

129022547(SIK1)

NLE:	100606608 115833161(SIK1)

HMH:	116481988(SIK1)

SSYN:

129483047(SIK1)

MCC:	722303(SIK1)

MCF:	102144132(SIK1)

MTHB:

126950617

MNI:	105472563(SIK1)

CSAB:

103219558(SIK1)

CATY:

105575499(SIK1)

PANU:

101005219(SIK1)

TGE:	112621412(SIK1)

MLEU:

105555550(SIK1)

RRO:	104677993(SIK1)

RBB:	108529607(SIK1)

TFN:	117095852(SIK1)

PTEH:

111526522(SIK1)

CANG:

105520397(SIK1)

CJC:	100415569(SIK1)

SBQ:	101032736(SIK1)

CIMI:

108311210(SIK1)

ANAN:

105711895(SIK1)

CSYR:

103273541(SIK1)

MMUR:

105879113(SIK1)

LCAT:

123630782(SIK1)

PCOQ:

105822918(SIK1)

OGA:	100949494(SIK1)

MMU:	17691(Sik1)

MCAL:

110312717(Sik1)

MPAH:

110338111(Sik1)

RNO:	59329(Sik1)

MCOC:

116075048(Sik1)

ANU:	117724618(Sik1)

ASYL:

127669179(Sik1)

MUN:	110553316(Sik1)

CGE:	100752067(Sik1)

MAUA:

101829517(Sik1)

PROB:

127224168(Sik1)

PLEU:

114686647(Sik1)

MORG:

121435490(Sik1)

MFOT:

126501097

AAMP:

119823319(Sik1)

NGI:	103729341(Sik1)

HGL:	101702040(Sik1)

CPOC:

100724260(Sik1)

CCAN:

109676098(Sik1)

DORD:

105993962(Sik1)

DSP:	122114268(Sik1)

PLOP:

125351422(Sik1)

NCAR:

124992453

MMMA:

107136519(Sik1)

ITI:	101965820(Sik1)

OPI:	101516213(SIK1)

TUP:	102475110(SIK1)

GVR:	103581365(SIK1)

CFA:	487787(SIK1)

CLUD:

112669189(SIK1)

VVP:	112908006(SIK1)

VLG:	121479495(SIK1)

NPO:	129502136(SIK1)

AML:	100470987(SIK1)

UMR:	103680760(SIK1)

UAH:	113253815(SIK1)

UAR:	123777484(SIK1)

ELK:

111155730

LLV:

125093647

MPUF:

101672642(SIK1)

MNP:	132012438(SIK1)

MLK:	131825427(SIK1)

NVS:	122908231(SIK1)

ORO:	101365821(SIK1)

EJU:	114226449(SIK1)

ZCA:	113918322(SIK1)

MLX:	118026967(SIK1)

NSU:	110571043(SIK1)

LWW:

102746144

FCA:	101092782(SIK1)

PYU:	121035889(SIK1)

PCOO:

112849443(SIK1)

PBG:	122491120(SIK1)

PVIV:

125159133(SIK1)

LRUF:

124526566

LGF:	123610508(SIK1)

AJU:

106985647

PTG:	102967055(SIK1)

PPAD:

109256947(SIK1)

PUC:

125920685

PLEZ:

122198372(SIK1)

HHV:	120240646(SIK1)

BTA:	100337254(SIK1)

BOM:	102286910(SIK1)

BBUB:

102389568(SIK1)

BBIS:

104985018(SIK1)

CHX:	102191654(SIK1)

OAS:	101122497(SIK1)

BTAX:

128065280(SIK1)

CSUM:

138087867(SIK1)

ODA:	120883093(SIK1)

CCAD:

122445392(SIK1)

MREE:

136173236(SIK1)

OVR:	110136062(SIK1)

MBEZ:

129548201(SIK1)

SSC:	100621265(SIK1)

CFR:	102520229(SIK1)

CBAI:

105078026(SIK1)

CDK:	105105909(SIK1)

VPC:	102532108(SIK1)

BACU:

103011901(SIK1)

BMUS:

118894367(SIK1)

LVE:	103083657(SIK1)

OOR:	101284469(SIK1)

LALB:

132521365(SIK1)

DLE:	111163824(SIK1)

PCAD:

102988511

PSIU:

116753451(SIK1)

NASI:

112408660(SIK1)

ECB:	100057456(SIK1)

EPZ:	103559034(SIK1)

EAI:	106825306(SIK1)

MYB:	102245026(SIK1)

MYD:	102775412(SIK1)

MMYO:

118676856(SIK1)

MLF:	102423745(SIK1)

MDT:	132229929(SIK1)

MYUM:

139004250(SIK1)

PKL:	118722872(SIK1)

EFUS:

103289788(SIK1)

MNA:	107541258(SIK1)

DRO:	112306180(SIK1)

SHON:

118984868(SIK1)

AJM:	119048794(SIK1)

PDIC:

114490551(SIK1)

PHAS:

123828005(SIK1)

MMF:	118617424(SIK1)

PPAM:

129074872(SIK1)

HAI:	109395202(SIK1)

RFQ:	117011706(SIK1)

PALE:

102881656(SIK1)

PGIG:

120598582(SIK1)

PVP:	105305390(SIK1)

RAY:	107510194(SIK1)

MJV:	108392428(SIK1)

TOD:	119257166(SIK1)

SARA:

101541844(SIK1)

SFUM:

130028530(SIK1)

SETR:

126025630(SIK1)

LAV:	100671882(SIK1)

TMU:

101351359

ETF:	101647360(SIK1)

DNM:	101440998(SIK1)

MDO:	100014612(SIK1)

GAS:	123239610(SIK1)

SHR:	100934593(SIK1)

AFZ:

127553798

PCW:	110199143(SIK1)

TVP:	118839226(SIK1)

PBRV:

138151380(SIK1)

OAA:	100081047(SIK1)

TACU:

119940151(SIK1)

GGA:	395417(SIK1)

PCOC:

116229880(SIK1)

MGP:	100538356(SIK1)

CJO:	107323996(SIK1)

TPAI:

128076490(SIK1)

LMUT:

125698026(SIK1)

NMEL:

110403526(SIK1)

APLA:

101804342(SIK1)

ACYG:

106036117(SIK1)

CATA:

118247809(SIK1)

AFUL:

116501768(SIK1)

TGU:	100220287(SIK1)

LSR:	110475684(SIK1)

SCAN:

103815890(SIK1)

PMOA:

120511794(SIK1)

OTC:	121333426(SIK1)

PRUF:

121364512(SIK1)

ATRC:

139591546(SIK1)

GFR:	102033129(SIK1)

FAB:	101820574(SIK1)

OMA:

130266876

PHI:	102106753(SIK1)

PMAJ:

107211279(SIK1)

CCAE:

111927369(SIK1)

CCW:	104686361(SIK1)

CBRC:

103614912(SIK1)

ACOE:

138113409(SIK1)

ETL:	114073803(SIK1)

ZAB:	102069948(SIK1)

ZLE:	135444421(SIK1)

ACHL:

103797899

SVG:	106853522(SIK1)

MMEA:

130581021(SIK1)

HRT:	120748588(SIK1)

SATI:

136358183(SIK1)

CCIC:

134058108(SIK1)

FPG:	101910498(SIK1)

FCH:	102052202(SIK1)

CCRI:

104163153

NNT:

104410377

SHAB:

115603655(SIK1)

ACUN:

113481337(SIK1)

TALA:

104368775(SIK1)

ACHC:

115343803(SIK1)

HALD:

104325528

HLE:	104839772(SIK1)

AGEN:

126053162

HHAR:

128144942(SIK1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

104305032(SIK1)

PPUS:

135180229(SIK1)

AVIT:

104268165

BRHI:

104494352

EGZ:	104128199(SIK1)

NNI:	104020850(SIK1)

PCRI:

104033479

PCAO:

104052807

PADL:

103920306(SIK1)

AFOR:

103902098(SIK1)

FGA:

104076814

GSTE:

104251538

CLV:	102085138(SIK1)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104059276(SIK1)

TEO:

104377832

BREG:

104633107

OHA:	104327740(SIK1)

ACAR:

104523075

CPEA:

104389222(SIK1)

CVF:	104292061(SIK1)

RTD:	128918309(SIK1)

CRID:

134519924(SIK1)

AAM:	106483676(SIK1)

AROW:

112968445(SIK1)

NPD:	112944702(SIK1)

TGT:

104564814

DNE:	112981981(SIK1)

SCAM:

104147117(SIK1)

ASN:	102382427(SIK1)

AMJ:	102572763(SIK1)

CPOO:

109305872(SIK1)

GGN:	109302909(SIK1)

PSS:	102445547(SIK1)

CMY:	102933508(SIK1)

CCAY:

125643097(SIK1)

DCC:	119845340(SIK1)

CPIC:

101953489(SIK1)

TST:	117868107(SIK1)

CABI:

116830596(SIK1)

MRV:	120369128(SIK1)

ACS:	100555063(sik1)

ASAO:

132771807(SIK1)

PVT:	110074067(SIK1)

SUND:

121925231(SIK1)

PBI:

103048486

PMUR:

107286401(SIK1)

CTIG:

120319536(SIK1)

TSR:

106537783

PGUT:

117669447(SIK1)

APRI:

131199858(SIK1)

PTEX:

113444728(SIK1)

NSS:	113416253(SIK1)

VKO:	123029261(SIK1)

PMUA:

114596130(SIK1)

PRAF:

128413061(SIK1)

ZVI:	118084970(SIK1)

HCG:	128351052(SIK1)

GJA:	107109239(SIK1)

STOW:

125431537(SIK1)

EMC:	129325635(SIK1)

XLA:	108709301(sik1.S)

XTR:	101733315(sik1)

BBUF:

120994291(SIK1)

BGAR:

122922925 122932866

PWL:	138248928(SIK1)

DRE:	553465(sik1)

SRX:	107715911 107721609

SANH:

107688711 107703039

SGH:	107557923 107559505

CCAR:

109054959 109055015 109098088

CAUA:

113044368 113053631 113108933

CGIB:

127949644 127965316 128019460

PTET:

122330219 122332287(sik1) 122348642

LROH:

127170700(sik1) 127171281

OMC:	131542200 131547393(sik1)

PPRM:

120487312(sik1)

RKG:	130085849(sik1) 130087816

MAMB:

125269973(sik1) 125272283

CIDE:

127518822 127519411

CERY:

137032566 137035498(sik1)

MASI:

127447076 127448187

TROS:

130555724(sik1)

TDW:	130427486(sik1)

MANU:

129451751(sik1)

PDAB:

135782582(sik1)

IPU:	108266559(sik1)

IFU:	128602354 128608461

PHYP:

113525847

SMEO:

124377820 124383201

TFD:	113648842 113661260(sik1)

TVC:	132839394 132850455(sik1)

CGAR:

128506749 128524107

NGRA:

132866725 132892096

TRN:	134324508(sik1)

AMEX:

103047200(sik1)

CMAO:

118800935(sik1)

EEE:

113581353

CHAR:

105908677(sik1) 105911651

SPIL:

134071029 134078616(sik1)

TRU:

101070411

TFS:	130528416(sik1)

TNG:	GSTEN00025995G001

LCO:

104932343

NCC:

104955098

TBEN:

117481441(sik1)

CGOB:

115026238

PGEO:

117466879(sik1)

GACU:

117556866(sik1)

EMAC:

134867204(sik1)

ELY:	117251366(sik1)

EFO:	125899486(sik1)

PLEP:

121948743(sik1)

SLUC:

116046680(sik1)

ECRA:

117953345(sik1)

ESP:

116697734

PFLV:

114564579

GAT:	120834356(sik1)

PPUG:

119229066(sik1)

AFB:	129104389(sik1)

CLUM:

117750095(sik1)

PSWI:

130208054(sik1)

CANA:

137803375(sik1)

CVE:	137868266(sik1)

MSAM:

119904241(sik1)

SCHU:

122885468(sik1)

CUD:	121522530(sik1)

SPUL:

138592219(sik1)

LMIX:

132986777(sik1)

ALAT:

119025982(sik1)

ASTR:

137604851(sik1)

MZE:

101480385

ONL:

100698776

OAU:	116316067(sik1)

OLA:

101175275

OML:	112155275(sik1)

CSAI:

133445848(sik1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122839404(sik1)

PPRL:

129361267(sik1)

CVG:

107104211

CTUL:

119786369(sik1)

GMU:	124871488(sik1)

NFU:

107389842

KMR:	108232495(sik1)

ALIM:

106523942

NWH:	119419669(sik1)

AOCE:

111568111(sik1)

EJA:	138200994(sik1)

BFRE:

138629738(sik1)

MCEP:

125017592(sik1)

CSEM:

103391838

POV:

109631479

SSEN:

122764846(sik1)

SSOE:

131452816(sik1)

HHIP:

117754924(sik1)

HSP:	118120093(sik1)

PPLT:

128455753(sik1)

SMAU:

118282530(sik1)

LCF:	108880461(sik1)

SDU:

111218548

SLAL:

111662132

XGL:	120801554(sik1)

HCQ:

109524683

SSCV:

125973760(sik1)

SBIA:

133512316(sik1)

PEE:	133410555(sik1)

PTAO:

133486783(sik1)

BPEC:

110173108

ENY:	140359621(sik1)

MALB:

109965453

BSPL:

114847452(sik1)

SJO:	128368044(sik1)

SSCO:

133992989(sik1)

GMH:

115533008

SASA:

100195685(sn1l2) 106586692

STRU:

115156306 115161218 115180888 115182121

OTW:	112225022 112241856(sik1)

OMY:	110491196 110496974 110502002 110520496

OGO:	124011674 124044169(sik1) 124045282

ONE:	115112901 115124516

OKI:	109869974 109871033 109884156 116359752

OKE:	118374698(sik1) 118376893 118385822

OMM:	135519061 135530375 135547379

OCLA:

139372926 139380665 139399414 139404271

SALP:

111959827 111979415

SNH:	120050873 120050877 120058471 120064174

CCLU:

121536509(sik1) 121571609 121572647

ELS:

105027338

OEP:	134007833 134017479(sik1)

SFM:

108920086

PKI:

111843677

AANG:

118223320(sik1)

AROT:

135250359(sik1)

CCOG:

133123738(sik1)

LOC:

102682732

PSPA:

121327474

ARUT:

117405736

LCM:	102365652(SIK1)

CMK:	103188730(sik1)

RTP:	109925467(sik1)

CPLA:

122555447(sik1)

HOC:	132821229(sik1)

LRJ:

133342070

PPOI:

119108300

HRO:	HELRODRAFT_65239 HELRODRAFT_67067

LGI:	LOTGIDRAFT_126136

HRF:

124148532

HRJ:

124287921

XEN:

124445426

TAD:	TRIADDRAFT_23373

» show all

Reference

PMID:15511237

Authors

Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M

Title

Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.

Journal

Eur J Biochem 271:4307-19 (2004)
DOI:10.1111/j.1432-1033.2004.04372.x

Sequence

[mmu:17691]

LinkDB

DBGET integrated database retrieval system