KEGG ORTHOLOGY: K19077

ORTHOLOGY: K19077

Entry

K19077                      KO

Symbol

graS

Name

two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]

Pathway

map01503

Cationic antimicrobial peptide (CAMP) resistance

map02020

Two-component system

Module

M00725

Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon

M00726

Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF

M00730

Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01503 Cationic antimicrobial peptide (CAMP) resistance
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
   01504 Antimicrobial resistance genes
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
Protein kinases [BR:ko01001]
Histidine kinases
  OmpR family
   K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
Two-component system [BR:ko02022]
OmpR family
  GraS-GraR (cationic antimicrobial peptide transport)
   K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
Antimicrobial resistance genes [BR:ko01504]
Gene sets
  CAMP resistance modules
   Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
   Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS
   Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter
    K19077  graS; two-component system, OmpR family, sensor histidine kinase GraS

Other DBs

COG:

COG0642

GO:

0000155

Genes

SDO:	SD1155_06065

BCL:

ABC0255

SA0615

SAV:

SAV0660

SAW:	SAHV_0657(graS)

SAH:	SaurJH1_0698

SAJ:	SaurJH9_0683

SAM:

SAS:

SAR:

SAC:

SAX:	USA300HOU_0681

SAA:	SAUSA300_0646

SAO:	SAOUHSC_00666

SAE:	NWMN_0629(graS)

SAD:

SAAV_0622

SUU:	M013TW_0647

SUV:	SAVC_02930

SUE:

SAOV_0694

SUJ:	SAA6159_00614(graS)

SUK:	SAA6008_00676(graS)

SUC:

ECTR2_611

SUT:	SAT0131_00730

SUQ:	HMPREF0772_12528(graS)

SUZ:	MS7_0710(graS)

SUD:	ST398NM01_0738

SUX:	SAEMRSA15_05860

SUW:	SATW20_07350(graS)

SUG:

SAPIG0738

SUF:	SARLGA251_05930(graS)

SAUA:

SAAG_01082

SAUE:

RSAU_000636

SAUN:

SAKOR_00655

SAUS:

SA40_0600(graS)

SAUU:

SA957_0615(graS)

SAUG:

SA268_0613(graS)

SAUZ:

SAZ172_0671(graS)

SAUT:

SAI1T1_2005100(graS)

SAUJ:

SAI2T2_1005120(graS)

SAUK:

SAI3T3_1005110(graS)

SAUQ:

SAI4T8_1005100(graS)

SAUV:

SAI7S6_1005110(graS)

SAUW:

SAI5S5_1005070(graS)

SAUX:

SAI6T6_1005080(graS)

SAUY:

SAI8T7_1005110(graS)

SAUF:

X998_0707

SAB:

SAB0609

SUY:	SA2981_0636(bceS)

SAUB:

C248_0744

SAUM:

BN843_6610

SAUC:

CA347_674(graS)

SAUR:

SABB_03565(graS)

SAUI:

AZ30_03450

SAUD:

CH52_02465

SAMS:

NI36_03310

SUH:	SAMSHR1132_06060

SER:

SERP0313

SEP:

SE_0428

SEPP:

SEB_00348

SEPS:

DP17_1730(graS)

SHA:

SH2234

SHH:	ShL2_02083(graS)

SSP:

SSP2061

SCA:

SCA_0303

SLG:	SLGD_02165

SLN:	SLUG_21380(graS)

SSD:	SPSINT_0368

SDT:	SPSE_2087(graS)

SDP:	NCTC12225_02308(graS)

SWA:	A284_10035

SPAS:

STP1_1744(graS)

SXY:	BE24_01050

SXL:	SXYLSMQ121_2038

SXO:	SXYL_02191(graS)

SCAP:

AYP1020_0026(graS_1)

SSCH:

SSCZ:

SEQO:

SSIF:

SLZ:	B5P37_07735

SCOH:

BZ166_02260

SURY:

MUA21_01955

SNL:	BJD96_11560

SKL:	C7J89_12160

SFQ:	C7J90_01425

SHOM:

EGX58_02955

SMUS:

C7J88_08745

SCAR:

DWB96_10935

SARL:

SAP2_21100(graS)

SPIC:

SAMEA4384060_2214(graS)

SSH:	NCTC13712_00624(graS_1)

SSIM:

SAMEA4384339_0602(bceS)

SDB:	CNQ82_12485

SLLO:

ISP08_10425

SSAC:

I6I31_06045(graS)

SPSD:

STAS:

SEDA:

SCAQ:

SDEV:

SROT:

ML435_03105(graS)

STAP:

SHSI:

SGAI:

SSCU:

SFF:	FOB90_09460

SSTE:

SAMEA4384403_0404(graS)

MLEN:

H3V22_06650

MVT:	I6J10_09095

JEH:	EJN90_07140

JAR:	G7057_08080

CARG:

COO:

BPRL:

RTO:

Reference

PMID:17502406

Authors

Meehl M, Herbert S, Gotz F, Cheung A

Title

Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.

Journal

Antimicrob Agents Chemother 51:2679-89 (2007)
DOI:10.1128/AAC.00209-07

Sequence

[sac:SACOL0717]

Reference

PMID:21765893

Authors

Falord M, Mader U, Hiron A, Debarbouille M, Msadek T

Title

Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways.

Journal

PLoS One 6:e21323 (2011)
DOI:10.1371/journal.pone.0021323

Sequence

[sao:SAOUHSC_00666]

LinkDB

DBGET integrated database retrieval system