KEGG   ORTHOLOGY: K19191
Entry
K19191                      KO                                     
Symbol
mabO
Name
4-methylaminobutanoate oxidase (formaldehyde-forming) [EC:1.5.3.19]
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01120  Microbial metabolism in diverse environments
Reaction
R10102  4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K19191  mabO; 4-methylaminobutanoate oxidase (formaldehyde-forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.19  4-methylaminobutanoate oxidase (formaldehyde-forming)
     K19191  mabO; 4-methylaminobutanoate oxidase (formaldehyde-forming)
Genes
MHUM: NNL39_01815
ARX: ARZXY2_4583
ARTT: IG195_19550
PNV: JMY29_20565(abo)
PAYJ: HMI59_01025
AG: CAD47921(mabO)
Reference
PMID:15606755
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur J Biochem 271:4677-84 (2004)
DOI:10.1111/j.1432-1033.2004.04432.x
  Sequence
[ag:CAD47921]
LinkDB

KEGG   ENZYME: 1.5.3.19
Entry
EC 1.5.3.19                 Enzyme                                 
Name
4-methylaminobutanoate oxidase (formaldehyde-forming);
mabO (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 [RN:R10102]
Reaction(KEGG)
R10102
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
formaldehyde [CPD:C00067];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.
History
EC 1.5.3.19 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19191  4-methylaminobutanoate oxidase (formaldehyde-forming)
Genes
MHUM: NNL39_01815
ARX: ARZXY2_4583
ARTT: IG195_19550
PNV: JMY29_20565(abo)
PAYJ: HMI59_01025
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur J Biochem 271:4677-84 (2004)
DOI:10.1111/j.1432-1033.2004.04432.x
  Sequence
[ag:CAD47921]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.19
IUBMB Enzyme Nomenclature: 1.5.3.19
ExPASy - ENZYME nomenclature database: 1.5.3.19
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.19
BRENDA, the Enzyme Database: 1.5.3.19
LinkDB

KEGG   REACTION: R10102
Entry
R10102                      Reaction                               
Name
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming);
4-methylaminobutanoate:oxygen oxidoreductase (demethylating)
Definition
4-Methylaminobutyrate + Oxygen + H2O <=> 4-Aminobutanoate + Formaldehyde + Hydrogen peroxide
Equation
C15987 + C00007 + C00001 <=> C00334 + C00067 + C00027
Reaction class
RC00060  C00334_C15987
RC00557  C00067_C15987
RC02755  C00007_C00027
Enzyme
1.5.3.19
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.19
     R10102  4-Methylaminobutyrate + Oxygen + H2O <=> 4-Aminobutanoate + Formaldehyde + Hydrogen peroxide
Orthology
K19191  4-methylaminobutanoate oxidase (formaldehyde-forming) [EC:1.5.3.19]
Other DBs
RHEA: 33910
LinkDB

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