KEGG ORTHOLOGY: K19752

ORTHOLOGY: K19752

Entry

K19752                      KO

Symbol

DNAAF3, PF22

Name

dynein axonemal assembly factor 3

Disease

H00564

Primary ciliary dyskinesia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19752  DNAAF3, PF22; dynein axonemal assembly factor 3
   04812 Cytoskeleton proteins
    K19752  DNAAF3, PF22; dynein axonemal assembly factor 3
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Dynein assembly factors
   K19752  DNAAF3, PF22; dynein axonemal assembly factor 3
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     Dynein-related proteins
      K19752  DNAAF3, PF22; dynein axonemal assembly factor 3

Genes

HSA:	352909(DNAAF3)

PTR:	735574(DNAAF3)

PPS:	100985698(DNAAF3)

GGO:	101137368(DNAAF3)

PON:	100446190(DNAAF3)

PPYG:

129020047(DNAAF3)

NLE:	100596507(DNAAF3)

HMH:	116479210(DNAAF3)

SSYN:

129460353(DNAAF3)

MCC:	698780(DNAAF3)

MCF:	102145427(DNAAF3)

MTHB:

126943207

MNI:	105496972(DNAAF3)

CSAB:

103235293(DNAAF3)

CATY:

105582743(DNAAF3)

PANU:

101014398(DNAAF3)

TGE:

112611943

MLEU:

105551676(DNAAF3)

RRO:	104674759(DNAAF3)

RBB:	108542534(DNAAF3)

TFN:	117091727(DNAAF3)

PTEH:

111521181(DNAAF3)

CANG:

105504942(DNAAF3)

CJC:	128930411(DNAAF3)

SBQ:	101046724(DNAAF3)

CIMI:

108316610(DNAAF3)

ANAN:

105725972(DNAAF3)

CSYR:

103267497(DNAAF3)

MMUR:

105877195(DNAAF3)

LCAT:

123624690(DNAAF3)

PCOQ:

105809406(DNAAF3)

OGA:	100941012(DNAAF3)

MMU:	436022(Dnaaf3)

MCAL:

110298720(Dnaaf3)

MPAH:

110337023(Dnaaf3)

RNO:	100359753(Dnaaf3)

MCOC:

116101546(Dnaaf3)

ANU:	117701208(Dnaaf3)

ASYL:

127683304(Dnaaf3)

MUN:	110561051(Dnaaf3)

CGE:

113831488

MAUA:

101840964(Dnaaf3)

PROB:

127238802(Dnaaf3)

PLEU:

114689155(Dnaaf3)

MORG:

121449835(Dnaaf3)

MFOT:

126493654 126496054

AAMP:

119821769(Dnaaf3)

NGI:	103744823(Dnaaf3)

HGL:	101711890(Dnaaf3)

CPOC:

100714373(Dnaaf3)

CCAN:

109696263(Dnaaf3)

DORD:

105999535(Dnaaf3)

DSP:	122110729(Dnaaf3)

PLOP:

125368139(Dnaaf3)

NCAR:

124966908

MMMA:

107158857(Dnaaf3)

ITI:	101971003(Dnaaf3)

OPI:	101532975(DNAAF3)

TUP:	102496539(DNAAF3)

GVR:	103594699(DNAAF3)

CFA:	484300(DNAAF3)

CLUD:

112645004(DNAAF3)

VVP:	112909343(DNAAF3)

VLG:	121484901(DNAAF3)

NPO:	129500664(DNAAF3)

AML:	100477166(DNAAF3)

UMR:	103680270(TNNI3)

UAH:	113247381(DNAAF3)

UAR:	123786948(TNNI3)

ELK:

111140064

LLV:

125089164

MPUF:

101676506(DNAAF3)

MNP:	132005521(DNAAF3)

MLK:	131818804(DNAAF3)

NVS:	122912185(DNAAF3)

ORO:	101373835(DNAAF3)

EJU:	114202064(DNAAF3)

ZCA:	113935896(DNAAF3)

MLX:	117997824(DNAAF3)

NSU:	110573687(DNAAF3)

LWW:	102727434(DNAAF3)

FCA:	123378923(DNAAF3)

PYU:	121023340(DNAAF3)

PBG:	122493742(DNAAF3)

PVIV:

125153307(DNAAF3)

LRUF:

124527754

LGF:	123578579(TNNI3)

AJU:

106980917

PTG:	102964033(DNAAF3)

PPAD:

109259917(DNAAF3)

PUC:	125917310 125918194

PLEZ:

122208033(DNAAF3)

HHV:	120239759(DNAAF3)

BTA:	104968460(DNAAF3)

BOM:	102273536(DNAAF3)

BIU:	109572858(DNAAF3)

BBUB:

102413617(DNAAF3)

BBIS:

104995399(DNAAF3)

CHX:	102187159(DNAAF3)

OAS:	105602098(DNAAF3)

BTAX:

128063798(DNAAF3)

CSUM:

138096948(DNAAF3)

ODA:	120871918(DNAAF3)

CCAD:

122420140(DNAAF3)

MREE:

136161753(TNNI3)

OVR:	110134899(DNAAF3)

MBEZ:

129545976(DNAAF3)

CFR:	102515021(DNAAF3)

CBAI:

105074355(DNAAF3)

CDK:	105098737(DNAAF3)

VPC:	102524749(DNAAF3)

BACU:

103008646(DNAAF3)

BMUS:

118885630(DNAAF3)

LVE:	103068401(DNAAF3)

OOR:	101269845(DNAAF3)

LALB:

132509768(DNAAF3)

DLE:	111180990(DNAAF3)

PCAD:

102992089(DNAAF3)

PSIU:

116743789(DNAAF3)

NASI:

112406413(DNAAF3)

ECB:	100055404(DNAAF3)

EPZ:	103562863(DNAAF3)

EAI:	106840923(DNAAF3)

MYB:	102244705(DNAAF3)

MYD:	102759894(DNAAF3)

MMYO:

118655156(DNAAF3)

MDT:	132216297(DNAAF3)

MYUM:

138999495(DNAAF3)

PKL:	118715918(DNAAF3)

EFUS:

103303377(DNAAF3)

MNA:	107541329(DNAAF3)

DRO:	112313758(DNAAF3)

SHON:

118981379(DNAAF3)

AJM:	119059945(DNAAF3)

PDIC:

114511404(DNAAF3)

PHAS:

123813360(DNAAF3)

MMF:	118638763(DNAAF3)

PPAM:

129082520(DNAAF3)

HAI:	109373750(DNAAF3)

RFQ:	117034317(DNAAF3)

PALE:

102889334(DNAAF3)

PGIG:

120598381(DNAAF3)

PVP:	105304921(DNAAF3)

RAY:	107515438(DNAAF3)

MJV:	108396326(DNAAF3)

TOD:	119248735(DNAAF3)

SARA:

101539092(DNAAF3)

SFUM:

130044490(DNAAF3)

SETR:

126027985(DNAAF3)

LAV:	100670413(DNAAF3)

TMU:

101361028

ETF:	101649248(DNAAF3)

DNM:	101415361(DNAAF3)

MDO:	100032905(DNAAF3)

GAS:	123255436 123255800

SHR:	100926748(DNAAF3)

AFZ:

127556699

PCW:	110220012(DNAAF3)

TVP:	118837555(DNAAF3)

PBRV:

138168246(DNAAF3)

OAA:	100091418(DNAAF3)

TACU:

119933146(DNAAF3)

PCOC:

116239622(DNAAF3)

CJO:	107307227(DNAAF3)

NMEL:

110391347

PMOA:

120512654(DNAAF3)

OTC:	121333032(DNAAF3)

ATRC:

139587094(DNAAF3)

ACOE:

138101287(DNAAF3)

ASN:	102377685(DNAAF3)

AMJ:	106736894(DNAAF3)

PSS:	102452734(DNAAF3)

CMY:	102940800(DNAAF3)

CCAY:

125627885(DNAAF3)

DCC:	119847261(DNAAF3)

CPIC:

101934386(DNAAF3)

CABI:

116840040(DNAAF3)

MRV:	120388272(DNAAF3)

ACS:	100561518(dnaaf3)

ASAO:

132779382(DNAAF3)

PVT:	110078591(DNAAF3)

SUND:

121934752(DNAAF3)

PBI:	103062903(DNAAF3)

PMUR:

107282484(DNAAF3)

CTIG:

120304514(DNAAF3)

TSR:	106538687 106538705(DNAAF3)

PGUT:

117669098(DNAAF3)

APRI:

131198714(DNAAF3)

PTEX:

113443605(DNAAF3)

NSS:	113418611(DNAAF3)

VKO:	123032091(DNAAF3)

PMUA:

114582357(DNAAF3)

PRAF:

128399903(DNAAF3)

ZVI:	118095054(DNAAF3)

HCG:	128329774(DNAAF3)

GJA:	107118433(DNAAF3)

STOW:

125445235(DNAAF3)

EMC:	129340153(DNAAF3)

XLA:	734905(dnaaf3.L)

XTR:	100493459(dnaaf3)

NPR:	108796751(DNAAF3)

RTEM:

120915352(DNAAF3)

BBUF:

121001376(DNAAF3)

BGAR:

122928653(DNAAF3)

PWL:	138246289(DNAAF3)

MUO:	115465015(DNAAF3)

GSH:	117367383(DNAAF3)

DRE:	100148431(dnaaf3) 100536527(dnaaf3l)

SRX:

SANH:

SGH:

CCAR:

CAUA:

113092763(dnaaf3)

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

129426145(dnaaf3)

PDAB:

135740589

IPU:

108278765

IFU:

128604532

PHYP:

113533877(dnaaf3)

SMEO:

124384292

TFD:

113652100

TVC:	132846423(dnaaf3)

CGAR:

128520763

NGRA:

132886457

TRN:

134310927

AMEX:

103035356(dnaaf3)

CMAO:

118822431(dnaaf3)

EEE:	113583383(dnaaf3)

CHAR:

105888794

SPIL:

134070135

TRU:	101063043(dnaaf3)

TFS:

130523910

TNG:	GSTEN00028279G001

LCO:	104935906(dnaaf3)

NCC:	104964176(dnaaf3)

TBEN:

117473963

CGOB:

115024522(dnaaf3)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116671250(dnaaf3)

PFLV:

114547929(dnaaf3)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

ONL:	100701606(dnaaf3)

OAU:

116319866

OLA:	101157011(dnaaf3)

OML:

112154615

CSAI:

133419885

XMA:	102228076(dnaaf3)

XCO:	114136483(dnaaf3)

XHE:	116727666(dnaaf3)

PRET:

103481240(dnaaf3)

PFOR:

103132595(dnaaf3)

PLAI:

106937174(dnaaf3)

PMEI:

106910830(dnaaf3)

GAF:

122823595

PPRL:

129377895

CVG:	107097211 107101224

GMU:

124875483

NFU:	107387997(dnaaf3)

KMR:

108237062

ALIM:

106517434(dnaaf3)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

POV:	109626921(dnaaf3)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111219791(dnaaf3)

SLAL:

111658635(dnaaf3)

XGL:

120794590

HCQ:	109523981(dnaaf3)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110159730(dnaaf3)

ENY:

140368620

MALB:

109963636(dnaaf3)

BSPL:

114845558

SJO:

128381128

SSCO:

134003867

GMH:	115531621(dnaaf3)

SASA:

106579171(dnaaf3)

STRU:

115160481(dnaaf3)

OTW:

112223749

OMY:

110491656

OGO:

124048401

ONE:	115106617(dnaaf3)

OKI:	109866025(dnaaf3)

OKE:

118363304

OMM:

135504861

OCLA:

139367519

SALP:

111977422(dnaaf3)

SNH:

120045771

CCLU:

123484350

ELS:	105030667(dnaaf3)

OEP:

134030852

SFM:	108925150(dnaaf3)

PKI:	111837266(dnaaf3)

AANG:

AROT:

CCOG:

PSPA:

PSEX:

LCM:	102354046(DNAAF3)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG17669(Dnaaf3)

DER:

6546930

DSE:

6609802

DSI:	Dsimw501_GD25389(Dsim_GD25389)

DYA:	Dyak_GE13909

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI19384

DAZ:

108615686

DNV:

108654833

DHE:

111602363

DVI:	6624885(Dnaaf3)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119681525 119685491 119686378

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135961746(Dnaaf3)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ011265

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139102247(Dnaaf3)

TLN:	139812607(Dnaaf3)

HST:	105190455 112588851

DQU:

106751778

CFO:

105253838

FEX:

115234730

PMEC:

138932090(Dnaaf3)

LHU:	105675990(Dnaaf3)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124211271(Dnaaf3)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138125539(Dnaaf3)

DPA:

109538748

ESIM:

136409927(Dnaaf3)

EFOR:

136346596(Dnaaf3)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206731

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137930391(Dnaaf3)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106683048(Dnaaf3)

NLU:	111057203 120351766

HVI:

124366269

MQU:

129003433

PHU:	Phum_PHUM579660

TPAL:

117646242

ZNE:

110840178

CSEC:

111862968

PAME:

138700873(Dnaaf3)

BROR:

134536460

IEL:

124159235

HAMR:

139692238(Dnaaf3)

FCD:

PVM:

PCHN:

HAME:

PCLA:

123770355(Dnaaf3)

PTRU:

123520492

MRJ:	136853872(Dnaaf3)

PORN:

139747353(Dnaaf3)

EAF:	111700849 111711768

LSM:	121127608(Dnaaf3)

TCF:

131885535

CSCU:

111639693

CVS:	136986910(Dnaaf3)

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_163037

LGI:	LOTGIDRAFT_227827

PVUL:

PCAN:

LSAX:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_168710

SHX:	MS3_00008671(DNAAF3_1)

OVI:	T265_03788

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130644235 130646229

RES:

135681010

TAD:	TRIADDRAFT_52076

AQU:

100640711

VCN:	VOLCADRAFT_106739

MNG:

MNEG_1549

MIS:	MICPUN_113945(CS051)

MPP:	MICPUCDRAFT_70660(CS051)

MBR:	MONBRDRAFT_25830

SRE:	PTSG_10969

TGO:	TGME49_271315

TET:	TTHERM_00929510

PTM:	GSPATT00018036001

TPS:	THAPS_6875

PIF:	PITG_16795

PSOJ:

PHYSODRAFT_490132

SPAR:

SPRG_04133

TBR:	Tb11.47.0028

TBG:	TbgDal_XI1280

TCR:

511445.90

LMA:	LMJF_27_0590

LIF:	LINJ_27_2600

LMI:	LMXM_27_0590

LMAT:

92513455(LSCM1_03401)

LBZ:	LBRM_27_0700

LPAN:

LPMP_270580

LOI:	92360053(LSCM4_04130)

LEIS:

94179958(GH5_04528)

LENR:

94170763(CUR178_03521)

LEIN:

94187687(JIQ42_04019)

PHET:

94289318(JKF63_03221)

SSAO:

94302154(SS50377_28131)

GTT:	GUITHDRAFT_149705

» show all

Reference

PMID:22387996

Authors

Mitchison HM, Schmidts M, Loges NT, Freshour J, Dritsoula A, Hirst RA, O'Callaghan C, Blau H, Al Dabbagh M, Olbrich H, Beales PL, Yagi T, Mussaffi H, Chung EM, Omran H, Mitchell DR

Title

Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.

Journal

Nat Genet 44:381-9, S1-2 (2012)
DOI:10.1038/ng.1106

Sequence

[hsa:352909]

LinkDB

DBGET integrated database retrieval system