KEGG ORTHOLOGY: K19755

ORTHOLOGY: K19755

Entry

K19755                      KO

Symbol

RSPH1

Name

radial spoke head protein 1

Disease

H00564

Primary ciliary dyskinesia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19755  RSPH1; radial spoke head protein 1
   04812 Cytoskeleton proteins
    K19755  RSPH1; radial spoke head protein 1
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Radial spoke
   K19755  RSPH1; radial spoke head protein 1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Others
     K19755  RSPH1; radial spoke head protein 1

Genes

HSA:	89765(RSPH1)

PTR:	474127(RSPH1)

PPS:	100980100(RSPH1)

GGO:	101143496(RSPH1)

PON:	100454894(RSPH1)

PPYG:

129022415(RSPH1)

NLE:	100595712(RSPH1)

HMH:	116481494(RSPH1)

SSYN:

129483037(RSPH1)

MCC:	714394(RSPH1)

MCF:	102125456(RSPH1)

MTHB:

126951512

MNI:	105472581(RSPH1)

CSAB:

103219414(RSPH1)

CATY:

105575487(RSPH1)

PANU:

101013165(RSPH1)

TGE:	112620560(RSPH1)

MLEU:

105555561(RSPH1)

RRO:	104678005(RSPH1)

RBB:	108517349(RSPH1)

TFN:	117095829(RSPH1)

PTEH:

111526423(RSPH1)

CANG:

105520473(RSPH1)

CJC:	100413167(RSPH1)

SBQ:	101036405(RSPH1)

CIMI:

108311225(RSPH1)

ANAN:

105713321(RSPH1)

CSYR:

103272704(RSPH1)

MMUR:

105879125(RSPH1)

LCAT:

123630771(RSPH1)

PCOQ:

105822904(RSPH1)

OGA:	100964279(RSPH1)

MMU:	22092(Rsph1)

MCAL:

110312706(Rsph1)

MPAH:

110338219(Rsph1)

RNO:	361818(Rsph1)

MCOC:

116074405(Rsph1)

ANU:	117724812(Rsph1)

ASYL:

127669379(Rsph1)

MUN:	110553313(Rsph1)

CGE:	100760788(Rsph1)

MAUA:

101826255(Rsph1)

PROB:

127224176(Rsph1)

PLEU:

114703995(Rsph1)

MORG:

121435551(Rsph1)

MFOT:

126500646

AAMP:

119823604(Rsph1)

NGI:	103729330(Rsph1)

HGL:	101708501(Rsph1)

CPOC:

100733758(Rsph1)

CCAN:

109700593(Rsph1)

DORD:

105993960(Rsph1)

DSP:	122114264(Rsph1)

PLOP:

125351432(Rsph1)

NCAR:

124993485

MMMA:

107136162(Rsph1)

ITI:	101968901(Rsph1)

OCU:

100352130

OPI:	101517432(RSPH1)

TUP:	102495759(RSPH1)

GVR:	103593832(RSPH1)

CFA:	478420(RSPH1)

CLUD:

112669171(RSPH1)

VVP:	112908015(RSPH1)

VLG:	121479524(RSPH1)

NPO:	129502208(RSPH1)

AML:	100472370(RSPH1)

UMR:	103680766(RSPH1)

UAH:	113256786(RSPH1)

UAR:	123777502(RSPH1)

ELK:

111155748

LLV:

125093799

MPUF:

101677326(RSPH1)

MNP:	132012428(RSPH1)

MLK:	131825413(RSPH1)

NVS:	122910281(RSPH1)

ORO:	101362161(RSPH1)

EJU:	114226371(RSPH1)

ZCA:	113916200(RSPH1)

MLX:	118026979(RSPH1)

NSU:	110571051(RSPH1)

LWW:	102731569(RSPH1)

FCA:	101094040(RSPH1)

PYU:	121035901(RSPH1)

PCOO:

112849451(RSPH1)

PBG:	122491136(RSPH1)

PVIV:

125159068(RSPH1)

LRUF:

124527327

LGF:	123610524(RSPH1)

AJU:

106985688

PTG:	102964741(RSPH1)

PPAD:

109256932(RSPH1)

PUC:

125920703

PLEZ:

122230401(RSPH1)

HHV:	120240647(RSPH1)

BTA:	514556(RSPH1)

BOM:	102284279(RSPH1)

BIU:	109560631(RSPH1)

BBUB:

102403038(RSPH1)

BBIS:

104984950(RSPH1)

CHX:	102182915(RSPH1)

OAS:	101105125(RSPH1)

BTAX:

128055170(RSPH1)

CSUM:

138089606(RSPH1)

ODA:	120856728(RSPH1)

CCAD:

122445378(RSPH1)

MREE:

136173388(RSPH1)

OVR:	110125787(RSPH1)

MBEZ:

129548104(RSPH1)

SSC:	110256495(RSPH1)

CFR:	102523031(RSPH1)

CBAI:

105078039(RSPH1)

CDK:	105101656(RSPH1)

VPC:	102533262(RSPH1)

BACU:

102997856(RSPH1)

BMUS:

118894424(RSPH1)

LVE:	103091296(RSPH1)

OOR:	101279690(RSPH1)

LALB:

132520741(RSPH1)

DLE:	111163882(RSPH1)

PCAD:

102973566(RSPH1)

PSIU:

116753317(RSPH1)

NASI:

112408638(RSPH1)

ECB:	100057874(RSPH1)

EPZ:	103560945(RSPH1)

EAI:	106829929(RSPH1)

MYB:	102249623(RSPH1)

MYD:	102770515(RSPH1)

MMYO:

118676871(RSPH1)

MLF:	102427702(RSPH1)

MDT:	132229911(RSPH1)

MYUM:

139004262(RSPH1)

PKL:	118724180(RSPH1)

EFUS:

103289796(RSPH1)

MNA:	107543762(RSPH1)

DRO:	112304247(RSPH1)

SHON:

118984856(RSPH1)

AJM:	119048808(RSPH1)

PDIC:

114491079(RSPH1)

PHAS:

123828088(RSPH1)

MMF:	118617776(RSPH1)

PPAM:

129072732(RSPH1)

HAI:	109395177(RSPH1)

RFQ:	117031328(RSPH1)

PALE:

102883670(RSPH1)

PGIG:

120598656(RSPH1)

PVP:	105300575(RSPH1)

RAY:	107510181(RSPH1)

MJV:	108405601(RSPH1)

TOD:	119257072(RSPH1)

SARA:

101544228(RSPH1)

SFUM:

130028753(RSPH1)

SETR:

126025649(RSPH1)

LAV:	100657288(RSPH1)

TMU:

101348382

ETF:	101649433(RSPH1)

DNM:	101432347(RSPH1)

MDO:	100012142 100027246

GAS:	123239586 123239715

SHR:	100914901 100928106(RSPH1)

AFZ:	127553714 127557897

PCW:	110212846 110214904

TVP:	118839426 118840377(RSPH1)

PBRV:

138149803 138151328(RSPH1)

OAA:	100080686(RSPH1)

TACU:

119940233(RSPH1)

GGA:	418536(RSPH1)

PCOC:

116229893(RSPH1)

MGP:	100549501(RSPH1)

CJO:	107323828(RSPH1)

TPAI:

128076447(RSPH1)

LMUT:

125687859(RSPH1)

NMEL:

110403366(RSPH1)

APLA:

101800088(RSPH1)

ACYG:

106036053(RSPH1)

CATA:

118247799(RSPH1)

AFUL:

116494837(RSPH1)

TGU:	100219325(RSPH1)

LSR:	110475868(RSPH1)

SCAN:

103815886(RSPH1)

PMOA:

120511855(RSPH1)

OTC:	121333537(RSPH1)

PRUF:

121364559(RSPH1)

ATRC:

139591536(RSPH1)

GFR:	102037501(RSPH1)

FAB:	101817371(RSPH1)

OMA:	130260292(RSPH1)

PHI:	102106689(RSPH1)

PMAJ:

107204265(RSPH1)

CCAE:

111945281(RSPH1)

CCW:	104686264(RSPH1)

CBRC:

103614916(RSPH1)

ACOE:

138117708(RSPH1)

ETL:	114066741(RSPH1)

ZAB:	102067374(RSPH1)

ZLE:	135442736(RSPH1)

ACHL:

103797646

SVG:	106853481(RSPH1)

MMEA:

130583383(RSPH1)

HRT:	120749028(RSPH1)

SATI:

136373370(RSPH1)

CCIC:

134058115(RSPH1)

FPG:	101918072(RSPH1)

FCH:	102049586(RSPH1)

CCRI:

104156486(RSPH1)

NNT:	104413777(RSPH1)

SHAB:

115603731(RSPH1)

ACUN:

113478905(RSPH1)

TALA:

104356469(RSPH1)

ACHC:

115344097(RSPH1)

HALD:

104324787(RSPH1)

HLE:	104839838(RSPH1)

AGEN:

126053260

HHAR:

128145290(RSPH1)

GCL:

127028757

CSTI:

104551268(RSPH1)

LDI:	104349614(RSPH1)

MNB:	103777260(RSPH1)

DPUB:

104305038(RSPH1)

PPUS:

135180217(RSPH1)

AVIT:

104277314

BRHI:

104488370(RSPH1)

EGZ:	104128192(RSPH1)

NNI:	104020860(RSPH1)

PCRI:

104025835(RSPH1)

PCAO:

104049724(RSPH1)

PADL:

103920342(RSPH1)

AFOR:

103902095(RSPH1)

FGA:	104074896(RSPH1)

GSTE:

104252263(RSPH1)

CBOY:

140647533(RSPH1)

CLV:	102094648(RSPH1)

MUI:	104538042(RSPH1)

PGUU:

104471780(RSPH1)

PLET:

104624217(RSPH1)

EHS:	104517020(RSPH1)

CMAC:

104482212(RSPH1)

CUCA:

104059272(RSPH1)

TEO:	104370905(RSPH1)

BREG:

104632532(RSPH1)

OHA:	104327747(RSPH1)

ACAR:

104518962(RSPH1)

CPEA:

104389264(RSPH1)

CVF:	104292058(RSPH1)

RTD:	128916381(RSPH1)

CRID:

134524503(RSPH1)

AAM:	106483633(RSPH1)

AROW:

112968435(RSPH1)

NPD:	112944677(RSPH1)

TGT:	104579766(RSPH1)

DNE:	112981953(RSPH1)

SCAM:

104147152(RSPH1)

ASN:	102382257(RSPH1)

AMJ:	102563229(RSPH1)

CPOO:

109305848(RSPH1)

GGN:	109302316(RSPH1)

PSS:	102455452(RSPH1)

CMY:	102943354(RSPH1)

CCAY:

125643324(RSPH1)

DCC:	119849710(RSPH1)

CPIC:

101940952(RSPH1)

TST:	117867949(RSPH1)

CABI:

116815372(RSPH1)

MRV:	120397474(RSPH1)

ACS:	100556768(rsph1)

ASAO:

132771817(RSPH1)

PVT:	110074037(RSPH1)

SUND:

121924711(RSPH1)

PBI:	103048077(RSPH1)

PMUR:

107292801(RSPH1)

CTIG:

120319771(RSPH1)

TSR:	106544308(RSPH1)

PGUT:

117669460(RSPH1)

PTEX:

113444793(RSPH1)

NSS:	113416203(RSPH1)

VKO:	123029523(RSPH1)

PMUA:

114596114(RSPH1)

PRAF:

128413050(RSPH1)

ZVI:	118085192(RSPH1)

HCG:	128349491(RSPH1)

GJA:	107117587(RSPH1)

STOW:

125430492(RSPH1)

EMC:	129325616(RSPH1)

XLA:	496054(rsph1.L)

XTR:	100489385(rsph1)

NPR:	108803125(RSPH1)

RTEM:

BBUF:

BGAR:

DTC:

PWL:	138248943(RSPH1)

MUO:	115470533(RSPH1)

GSH:	117358678(RSPH1)

DRE:	100003444(rsph1)

SRX:	107728239 107749034

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122351395(rsph1)

LROH:

127170551(rsph1)

OMC:	131546987(rsph1)

PPRM:

120487356(rsph1)

RKG:	130086079(rsph1)

MAMB:

125269902(rsph1)

CIDE:

127518811

CERY:

137036307(rsph1)

MASI:

127447820

TROS:

130550059(rsph1)

TDW:	130428021(rsph1)

MANU:

129452374(rsph1)

PDAB:

135782652(rsph1)

IPU:	100528442(rsph1)

IFU:	128608800(rsph1)

PHYP:

113526081(rsph1)

SMEO:

124382865(rsph1)

TFD:	113654351(rsph1)

TVC:	132850653(rsph1)

CGAR:

128524092(rsph1)

NGRA:

132891278(rsph1)

TRN:	134324010(rsph1)

AMEX:

103045259(rsph1)

CMAO:

118810096(rsph1)

EEE:	113579020(rsph1)

CHAR:

105898500(rsph1)

SPIL:

134079246(rsph1)

TRU:	101064816 101065031

TFS:	130534545(rsph1)

TNG:	GSTEN00021734G001

LCO:	104919482(rsph1)

NCC:	104940994(rsph1)

TBEN:

117483651(rsph1)

CGOB:

115024402(rsph1)

PGEO:

117439242(rsph1)

GACU:

117552373(rsph1)

EMAC:

134871099(rsph1)

ELY:	117246827(rsph1) 117247585

EFO:	125880731 125881201(rsph1)

PLEP:

121959363(rsph1)

SLUC:

116067531(rsph1)

ECRA:

117957746

ESP:	116671102 116703417 116705664(rsph1)

PFLV:

114548411(rsph1)

GAT:	120819489(rsph1)

PPUG:

119212448(rsph1)

AFB:	129093712(rsph1)

CLUM:

117748888(rsph1)

PSWI:

130203215(rsph1)

CANA:

137789755(rsph1)

MSAM:

119894652 119916582(rsph1)

SCHU:

122867167(rsph1)

CUD:	121528775(rsph1)

SPUL:

138593657(rsph1)

LMIX:

132955367(rsph1)

ALAT:

119009366(rsph1)

ASTR:

137588766(rsph1) 137605723

MZE:	101477817(rsph1)

ONL:	100710373(rsph1)

OAU:	116330906(rsph1)

OLA:	101161589(rsph1)

OML:	112153873(rsph1)

CSAI:

133419101(rsph1)

XMA:	102225490(rsph1)

XCO:	114151736(rsph1)

XHE:	116726665(rsph1)

PRET:

103481919(rsph1)

PFOR:

103144489(rsph1)

PLAI:

106964993(rsph1)

PMEI:

106924854(rsph1)

GAF:	122823158(rsph1)

PPRL:

129377464(rsph1)

CVG:

107100758

CTUL:

119796652(rsph1)

GMU:	124874811(rsph1)

NFU:

107396716

KMR:	108235854(rsph1)

ALIM:

106534430

AOCE:

111572503(rsph1)

EJA:	138201864(rsph1)

BFRE:

138626829(rsph1)

MCEP:

125022936(rsph1)

CSEM:

103382177(rsph1) 103382386

POV:	109643055(rsph1)

SSEN:

122760969 122760972

SSOE:

131448647 131448648

HHIP:

117752679(rsph1)

HSP:	118100745(rsph1)

PPLT:

128427307(rsph1)

SMAU:

118288014(rsph1)

LCF:

108890901

SDU:	111219538(rsph1)

SLAL:

111667092(rsph1)

XGL:	120794502(rsph1)

HCQ:	109524688(rsph1)

SSCV:

125973748(rsph1)

SBIA:

133512603(rsph1)

PEE:	133410708(rsph1)

PTAO:

133486696(rsph1)

BPEC:

110162198

ENY:	140364931 140368741

MALB:

109952121

BSPL:

114845948(rsph1)

SJO:	128381179(rsph1)

SSCO:

134003821(rsph1)

GMH:	115533169(rsph1)

SASA:

100196125(rsph1)

STRU:

115161365(rsph1)

OTW:	112243351(rsph1)

OMY:	110520632(rsph1)

OGO:	124044267(rsph1)

ONE:	115113645(rsph1)

OKI:	109871017(rsph1)

OKE:	118366696(rsph1)

OMM:	135518944(rsph1)

OCLA:

139405517

SALP:

112068338(rsph1)

SNH:	120058017(rsph1)

CCLU:

121536451(rsph1)

ELS:	105018797(rsph1)

OEP:	134017613(rsph1)

PKI:	111860688(rsph1)

AANG:

118223419(rsph1)

AROT:

135250939(rsph1)

CCOG:

133124261(rsph1)

LOC:	102693171(rsph1)

PSPA:

121320667 121327703

ARUT:

117406368(rsph1)

PSEX:

120523076(rsph1) 120524393

LCM:	102345385(RSPH1)

CMK:	103185178(rsph1)

CPLA:

122554860(rsph1)

HOC:	132820639(rsph1)

LERI:

129703081(rsph1)

BFO:

118408930

BBEL:

109485292

CIN:	100177304(ci-morn40)

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

139129390 139129430 139129548 139129557

DME:	Dmel_CG5458(Rsph1)

DER:

6543092

DSE:

6617810

DSI:	Dsimw501_GD23870(Dsim_GD23870)

DYA:	Dyak_GE18622

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18099

DAZ:

108610240

DNV:

108649831

DHE:

111605529

DVI:	6629101(Rsph1)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119678909 119678910

MDE:

101895788

SCAC:

106089697

LCQ:

111687665

LSQ:	119602448 119615256

CVJ:	135952201(Rsph1)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AMOU:

AMRS:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ005993

CPII:

CBRI:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138133508(Rsph1)

DPA:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212621

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:	107164264 107172076

AGS:

RMD:

ACOO:

DVT:

CLEC:

HHAL:

106679518(Rsph1)

NLU:	111046483 111063542

HVI:	124358152 124374070

MQU:

128987469

PHU:	Phum_PHUM603200

PAME:

138706407

BROR:

134530340

IEL:

124157252

HAMR:

139687210(Rsph1)

PPOI:

CSCU:

CVS:

LPOL:

PMEO:

129586414 129599579 129600917

HRO:	HELRODRAFT_67918

LGI:	LOTGIDRAFT_133598

PVUL:

PCAN:

LSAX:

BGT:

GAE:	121386334 121391523

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_190140

SHX:	MS3_00009410(ACTR3_1)

OVI:	T265_07084

EGL:

EGR_09869

LLON:

135502426

NVE:	5497521 5499569 5504870 5508541 5510994 5514815 5517101 5517132 5517187 5519103

EPA:	110231188 110236687 110244764 110246062 110248631 110253267 110254637

ATEN:

116287966 116298517 116299742 116299908 116300490 116302130

ADF:	107336660 107337987 107338945

AMIL:

114954093 114956078 114961402 114963519 114971145 114976906

MCAZ:

138024212 138024305 138024306 138024357 138030784 138045756

MFOO:

137973342 137973785 137974301 137974391 137982478 138012742

PDAM:

113668657 113668929 113678997 113679669 113686280

SPIS:

111321194 111323982 111328488 111336673 111339882 111340461

DGT:	114516448 114527248 114536345

XEN:	124439327 124449529

HMG:	100201985 100207234

HSY:	130623974 130630545 130636967 130644839 130653706

RES:	135681957 135684957 135694943 135695139 135695140

TAD:	TRIADDRAFT_63914

AQU:

100633047

SMO:	SELMODRAFT_5381 SELMODRAFT_5387

PPP:	112286768 112287255

CRE:	CHLRE_01g005450v5

VCN:	VOLCADRAFT_76002(rsp10)

MNG:	MNEG_11624

MIS:	MICPUN_80926(RSP10)

MPP:	MICPUCDRAFT_70831(RSP4)

MBR:	MONBRDRAFT_32782

SRE:	PTSG_01649

PFA:	PF3D7_0205200

PFH:	PFHG_03632

PREI:

PRSY57_0204300

PGAB:

PGSY75_0205200

PLAG:

39739716(PADL01_0204000)

PYO:	PY17X_0303500

PCB:	PCHAS_0305100

PBE:	PBANKA_0302900

PVV:	PVVCY_0300380

PKN:	PKNH_0415700

PVX:	PVX_003690

PCY:	PCYB_042500

PMAL:

PMUG01_04027200

PBRS:

92369296(MKS88_001207)

PREL:

PRELSG_0416700

PCOT:

PCOAH_00008430

TGO:	TGME49_240800 TGME49_251750

BBES:

BESB_028770 BESB_045490

TET:	TTHERM_000196029 TTHERM_00378600

PTM:	GSPATT00001020001 GSPATT00008838001 GSPATT00021583001 GSPATT00023261001

TBR:	Tb927.7.6910

TBG:	TbgDal_VII8090

TCR:	506789.140 508387.160

LMA:	LMJF_05_1080

LIF:	LINJ_05_1080

LDO:	LDBPK_051080

LMI:	LMXM_05_1080

LMAT:

92517654(LSCM1_07785)

LBZ:	LBRM_05_1080

LPAN:

LPMP_051080

LOI:	92363923(LSCM4_08113)

LEIS:

94183241(GH5_08023)

LENR:

94174835(CUR178_07685)

LEIN:

94191663(JIQ42_08096)

PHET:

94293450(JKF63_07435)

TVA:	4762973(TVAGG3_0214430)

SSAO:

94295478(SS50377_21455)

GTT:	GUITHDRAFT_95857

NLI:	G3M70_15210

» show all

Reference

PMID:23993197

Authors

Kott E, Legendre M, Copin B, Papon JF, Dastot-Le Moal F, Montantin G, Duquesnoy P, Piterboth W, Amram D, Bassinet L, Beucher J, Beydon N, Deneuville E, Houdouin V, Journel H, Just J, Nathan N, Tamalet A, Collot N, Jeanson L, Le Gouez M, Vallette B, Vojtek AM, Epaud R, Coste A, Clement A, Housset B, Louis B, Escudier E, Amselem S

Title

Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects.

Journal

Am J Hum Genet 93:561-70 (2013)
DOI:10.1016/j.ajhg.2013.07.013

Sequence

[hsa:89765]

LinkDB

DBGET integrated database retrieval system