KEGG ORTHOLOGY: K19759

ORTHOLOGY: K19759

Entry

K19759                      KO

Symbol

DNAAF5

Name

dynein axonemal assembly factor 5

Disease

H00564

Primary ciliary dyskinesia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19759  DNAAF5; dynein axonemal assembly factor 5
   04812 Cytoskeleton proteins
    K19759  DNAAF5; dynein axonemal assembly factor 5
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Dynein assembly factors
   K19759  DNAAF5; dynein axonemal assembly factor 5
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     Dynein-related proteins
      K19759  DNAAF5; dynein axonemal assembly factor 5

Genes

HSA:	54919(DNAAF5)

PTR:	107972019(DNAAF5)

PPS:	100993124(DNAAF5)

GGO:	101130392(DNAAF5)

PON:	100442047(DNAAF5)

PPYG:

129040400(DNAAF5)

NLE:	100592617(DNAAF5)

HMH:	116462997(DNAAF5)

SSYN:

129471841(DNAAF5)

MCC:	708567(DNAAF5)

MCF:	102117822(DNAAF5)

MTHB:

126950587

MNI:	105483493(DNAAF5)

CSAB:

103246904(DNAAF5)

CATY:

105571781(DNAAF5)

PANU:

101003934(DNAAF5)

TGE:	112620174(DNAAF5)

MLEU:

105537869(DNAAF5)

RRO:	104664977(DNAAF5)

RBB:	108543548(DNAAF5)

TFN:	117073584(DNAAF5)

PTEH:

111523726(DNAAF5)

CANG:

105522408(DNAAF5)

CJC:	100406400 100411482(DNAAF5)

SBQ:	101039464(HEATR2)

CIMI:

108289005(DNAAF5)

ANAN:

105716768(DNAAF5)

CSYR:

103249482

MMUR:

105868352(DNAAF5)

LCAT:

123632537(DNAAF5)

PCOQ:

105806044(DNAAF5)

OGA:	100943999(DNAAF5)

MMU:	433956(Dnaaf5)

MCAL:

110294610(Dnaaf5)

MPAH:

110313189(Dnaaf5)

RNO:	304332(Dnaaf5)

MCOC:

116068643(Dnaaf5)

ANU:	117697834(Dnaaf5)

ASYL:

127672828(Dnaaf5)

MUN:	110550680(Dnaaf5)

CGE:	100771212(Dnaaf5)

MAUA:

101831959(Dnaaf5)

PROB:

127237319(Dnaaf5)

PLEU:

114682226(Dnaaf5)

MORG:

121446035(Dnaaf5)

MFOT:

126514354

AAMP:

119824873(Dnaaf5)

NGI:	103748697(Dnaaf5)

HGL:	101700354(Dnaaf5)

CPOC:

100713562(Dnaaf5)

CCAN:

109690351(Dnaaf5)

DORD:

105990855(Dnaaf5)

DSP:	122113619(Dnaaf5)

DMER:

138834725(Dnaaf5)

PLOP:

125339506(Dnaaf5)

NCAR:

124970321

MMMA:

107156024(Dnaaf5)

ITI:	101964627(Dnaaf5)

OCU:

127488008

OPI:	101516147(DNAAF5)

TUP:	102488683(DNAAF5)

GVR:	103582733(HEATR2)

CFA:	491598(DNAAF5)

CLUD:

112640156(DNAAF5)

VVP:	112929351(DNAAF5)

VLG:	121487460(DNAAF5)

NPO:	129519592(DNAAF5)

UMR:	103670055(DNAAF5)

UAH:	113248522(DNAAF5)

UAR:	123802504(DNAAF5)

ELK:

111145867

LLV:

125090688

MPUF:

101675507(DNAAF5)

MNP:	132026407(DNAAF5)

MLK:	131819096(DNAAF5)

NVS:	122895392(DNAAF5)

ORO:	101362108(DNAAF5)

EJU:	114199956(DNAAF5)

ZCA:	113932160(DNAAF5)

MLX:	117999265(DNAAF5)

NSU:	110571895(DNAAF5)

LWW:	102743197(DNAAF5)

FCA:	101087542(DNAAF5)

PYU:	121017421(DNAAF5)

PCOO:

112860029(DNAAF5)

PBG:	122471192(DNAAF5)

PVIV:

125154288(DNAAF5)

LRUF:

124519225

LGF:	123589067(DNAAF5)

AJU:

106966525

PTG:	102968105(DNAAF5)

PPAD:

109251095(DNAAF5)

PUC:

125928435

PLEZ:

122209398(DNAAF5)

HHV:	120227992(DNAAF5)

BTA:	100300875(DNAAF5)

BOM:	102271503(DNAAF5)

BBUB:

102408531(DNAAF5)

BBIS:

105002248(DNAAF5)

CHX:	102173439(DNAAF5)

OAS:	101115933(DNAAF5)

BTAX:

128064154(DNAAF5)

CSUM:

138075559(DNAAF5)

ODA:	120882979(DNAAF5)

CCAD:

122432752(DNAAF5)

MREE:

136160243(DNAAF5)

OVR:	110130388(DNAAF5)

MBEZ:

129545812(DNAAF5)

SSC:	100737767(DNAAF5)

CFR:	102524499(DNAAF5)

CBAI:

105077841(DNAAF5)

CDK:	105102055(DNAAF5)

VPC:	102531956(DNAAF5)

BACU:

103005615(DNAAF5)

BMUS:

118881480(DNAAF5)

LVE:	103069975(HEATR2)

OOR:	101288649(DNAAF5)

LALB:

132505433(DNAAF5)

GMF:	115849598(DNAAF5)

DDP:	132438401(DNAAF5)

DLE:	111169361(DNAAF5)

PCAD:

102985543(DNAAF5)

PSIU:

116740521(DNAAF5)

PPHC:

136134605(DNAAF5)

NASI:

112412056(DNAAF5)

ECB:	100054218(DNAAF5)

EPZ:	103555991(DNAAF5)

EAI:	106834785(DNAAF5)

MYB:	102254160(DNAAF5)

MYD:	102760454(DNAAF5)

MMYO:

118658373(DNAAF5)

MLF:	102424279(DNAAF5)

MDT:	132223613 132236069(DNAAF5)

MYUM:

139011556(DNAAF5)

PKL:	118715964(DNAAF5)

EFUS:

103299216(DNAAF5)

MNA:	107537028(DNAAF5)

DRO:	112319533(DNAAF5)

SHON:

118995062(DNAAF5)

AJM:	119043766(DNAAF5)

PDIC:

114509716(DNAAF5)

PHAS:

123809447(DNAAF5)

MMF:	118615240(DNAAF5)

PPAM:

129065152(DNAAF5)

HAI:	109380138(DNAAF5)

RFQ:	117016573(DNAAF5)

PALE:

102894156(DNAAF5)

PGIG:

120615855(DNAAF5)

PVP:

105294591

RAY:	107497392(DNAAF5)

TOD:	119241449(DNAAF5)

SARA:

101544819(DNAAF5)

SFUM:

130036453(DNAAF5)

SETR:

126030379(DNAAF5)

LAV:	100675399(DNAAF5)

TMU:

101356152

ETF:	101657518(DNAAF5)

DNM:	101423955(DNAAF5)

MDO:	100028037(DNAAF5)

GAS:	123234169(DNAAF5) 123244398

SHR:	100927063(DNAAF5)

AFZ:

127564130

PCW:	110201570(DNAAF5)

TVP:	118833923(DNAAF5)

PBRV:

138158712(DNAAF5)

MLAO:

141502713(DNAAF5)

OAA:	100080919(DNAAF5)

TACU:

119942145(DNAAF5)

GGA:	416447(DNAAF5)

PCOC:

116237495(DNAAF5)

MGP:	100546111(DNAAF5)

CJO:	107320562(DNAAF5)

TPAI:

128079032(DNAAF5)

LMUT:

125700588(DNAAF5)

NMEL:

110405991(DNAAF5)

APLA:

101803699(DNAAF5)

ACYG:

106033385(DNAAF5)

CATA:

118249343(DNAAF5)

AFUL:

116495495(DNAAF5)

TGU:	100225063(DNAAF5)

LSR:	110475580(DNAAF5)

SCAN:

103817869(DNAAF5)

PMOA:

120513005(DNAAF5)

OTC:	121334649(DNAAF5)

PRUF:

121350916(DNAAF5)

ATRC:

139598083(DNAAF5)

GFR:	102032766(DNAAF5)

FAB:	101809997(DNAAF5)

OMA:	130259343(DNAAF5)

PHI:	102099759(DNAAF5)

PMAJ:

107210978(DNAAF5)

CCAE:

111936275(DNAAF5)

CCW:	104685040(DNAAF5)

CBRC:

103615595(DNAAF5)

ACOE:

138118756(DNAAF5)

ETL:	114054752(DNAAF5)

ZAB:	102074892(DNAAF5)

ZLE:	135454051(DNAAF5)

SVG:	106849338(DNAAF5)

MMEA:

130583115(DNAAF5)

HRT:	120759892(DNAAF5)

SATI:

136367883(DNAAF5)

CCIC:

134050538(DNAAF5)

FPG:	101914661(DNAAF5)

FCH:	102059688(DNAAF5)

NNT:	104407217(HEATR2)

SHAB:

115606515(DNAAF5)

ACUN:

113485760(DNAAF5)

TALA:

104361648(DNAAF5)

ACHC:

115335637(DNAAF5)

HALD:

104319695(HEATR2)

HLE:	104833536(HEATR2)

AGEN:

126033911

HHAR:

128134552(DNAAF5)

GCL:

127022626

CSTI:

104550477(HEATR2)

LDI:	104342449(HEATR2)

MNB:	103779688(HEATR2)

DPUB:

104307688(HEATR2)

PPUS:

135180362(DNAAF5)

AVIT:

104267199(HEATR2)

BRHI:

104493848(HEATR2)

EGZ:	104128973(DNAAF5)

NNI:	104015208(HEATR2)

PCRI:

104024142(HEATR2)

PCAO:

104048656(HEATR2)

PADL:

103913560(HEATR2)

AFOR:

103904979(DNAAF5)

FGA:	104082348(HEATR2)

GSTE:

104262748(HEATR2)

CBOY:

140658820(DNAAF5)

CLV:	102092539(DNAAF5)

CNIC:

135994322(DNAAF5)

MUI:	104544821(HEATR2)

PGUU:

104472010(HEATR2)

PLET:

104624717(HEATR2)

EHS:	104515197(HEATR2)

CMAC:

104477255(HEATR2)

CUCA:

104066004(DNAAF5)

TEO:	104380899(HEATR2)

BREG:

104629157(HEATR2)

OHA:	104329112(HEATR2)

ACAR:

104529548(DNAAF5)

CPEA:

104393814(HEATR2)

CVF:	104287440(HEATR2)

RTD:	128913744(DNAAF5)

CRID:

134519700(DNAAF5)

AAM:	106491367(DNAAF5)

AROW:

112974231(DNAAF5)

NPD:	112959826(DNAAF5)

TGT:	104577801(HEATR2)

DNE:	112992915(DNAAF5)

SCAM:

104153951(HEATR2)

ASN:	102386293(DNAAF5)

AMJ:	102569111(DNAAF5)

CPOO:

109314753(DNAAF5)

GGN:	109294509(DNAAF5)

PSS:	102453625(DNAAF5)

CMY:	102942625(DNAAF5)

CCAY:

125643788(DNAAF5)

DCC:	119862476(DNAAF5)

CPIC:

101938804(DNAAF5)

TST:	117884129(DNAAF5)

CABI:

116819334(DNAAF5)

MRV:	120373851(DNAAF5)

ACS:	100560200(dnaaf5)

ASAO:

132780029(DNAAF5)

PVT:	110087202(DNAAF5)

SUND:

121914200(DNAAF5)

PBI:	103066440(DNAAF5)

PMUR:

107291887(DNAAF5)

CTIG:

120315714(DNAAF5)

TSR:	106547574(DNAAF5)

PGUT:

117673298(DNAAF5)

PCAE:

139325195(DNAAF5)

APRI:

131185353(DNAAF5)

PTEX:

113438775(DNAAF5)

VKO:	123025148(DNAAF5)

PMUA:

114584241(DNAAF5)

PRAF:

128401502(DNAAF5)

ZVI:	118092955(DNAAF5)

HCG:	128336829(DNAAF5)

GJA:	107115562(DNAAF5)

STOW:

125431434(DNAAF5)

EMC:	129340649(DNAAF5)

XLA:	496065(dnaaf5.S) 779420(dnaaf5.L)

XTR:	100494246(dnaaf5)

NPR:	108796398(DNAAF5)

RTEM:

120943460(DNAAF5)

ACAT:

141148942(DNAAF5)

BBUF:

121008269(DNAAF5)

BGAR:

122938294(DNAAF5)

DTC:	141047797(DNAAF5)

PWL:	138261153(DNAAF5)

MUO:	115476281(DNAAF5)

GSH:	117369326(DNAAF5)

DRE:

100333660

SRX:	107718606 107753762

SANH:

107653459 107661854

SGH:	107563231 107565615

CCAR:

109110811(dnaaf5)

CAUA:

113050972 113067638 113074041

CGIB:

127952812 127953995

PTET:

122341432(dnaaf5)

LROH:

127163335(dnaaf5)

GRF:	141332422(dnaaf5)

OMC:	131536760(dnaaf5)

PPRM:

120473076(dnaaf5)

RKG:	130069254(dnaaf5)

MAMB:

125266855(dnaaf5)

CIDE:

127509698

CERY:

137013120(dnaaf5)

MASI:

127451519

TROS:

130562102(dnaaf5)

TDW:	130426181(dnaaf5)

MANU:

129436582 141351137

PDAB:

135734136(dnaaf5)

IPU:

108258098

IFU:

128622435

PHYP:

113528252(dnaaf5)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

103037578(dnaaf5)

CMAO:

118801287

EEE:	113576782(dnaaf5)

CHAR:

105897419

SPIL:

134076534

TRU:	101077699(dnaaf5)

TFS:

130514672

TNG:	GSTEN00033360G001

LCO:	109138264(dnaaf5)

NCC:	104941535(dnaaf5)

TBEN:

117493664

CGOB:

115011776(dnaaf5)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116702728(dnaaf5)

PFLV:

114570400(dnaaf5)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:	101487102(dnaaf5)

ONL:	100703087(dnaaf5)

OAU:

116321452

OLA:	101155353(dnaaf5)

OML:

112147002

CSAI:

133421803

XMA:	102230044(dnaaf5)

XCO:	114160374(dnaaf5)

XHE:	116736089(dnaaf5)

PRET:

103469314(dnaaf5)

PFOR:

103141008(dnaaf5)

PLAI:

106942670(dnaaf5)

PMEI:

106915781(dnaaf5)

GAF:

122822552

PPRL:

129363943

CVG:	107095208(dnaaf5)

CTUL:

119773170

GMU:	124863580 124863782

NFU:	107376490(dnaaf5)

KMR:

108247638

ALIM:

106518711(dnaaf5)

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103392993(dnaaf5)

POV:	109638678(dnaaf5)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111227108(dnaaf5)

SLAL:

111667499(dnaaf5)

XGL:

120788494

HCQ:	109517744(dnaaf5)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110169231(dnaaf5)

ENY:	140358806 140358807(dnaaf5)

MALB:

109972907(dnaaf5)

BSPL:

114860926

SJO:

128378387

SSCO:

133999569

GMH:	115534554(dnaaf5)

SASA:

106606483

STRU:

115171770 115206415

OTW:

112241083

OMY:	110485270 110487024

OGO:

124000389

OKI:	109876188 116359960

OKE:

118371726

OMM:

135537547

OCLA:

139398193 139402045

SNH:	120042408 120044085

CCLU:

121551168 121551861

ELS:	105021650(dnaaf5)

OEP:

134014502

SFM:	108928821(dnaaf5)

PKI:	111843221(dnaaf5)

AANG:

118217017

AROT:

135243936

CCOG:

133114380

LOC:	102686159(dnaaf5)

PSPA:

121300935

ARUT:

117431313

PSEX:

120542433

LCM:	102353641(DNAAF5)

CMK:

RTP:

CPLA:

HOC:

LERI:

HAKA:

PMRN:

116956904(DNAAF5)

LRJ:	133347838(DNAAF5)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG31320(Dnaaf5)

DER:

6552529

DSE:

6606403

DSI:	Dsimw501_GD20426(Dsim_GD20426)

DYA:	Dyak_GE26455

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24809

DAZ:

108621087

DNV:

108659413

DHE:

111601497

DVI:	6631204(Dnaaf5)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:	101899975 131804422

SCAC:

106089002

LCQ:

111680625

LSQ:

119599614

CVJ:	135957673(Dnaaf5)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ018707

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

MGEN:

CGIG:

SOC:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

PMEC:

PGC:

OBO:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138137951(Dnaaf5)

DPA:

109538251

ESIM:

136417855(Dnaaf5)

EFOR:

136338798(Dnaaf5)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200356

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137932107(Dnaaf5)

PRAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110379273 135118339

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141428880(Dnaaf5)

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106684690(Dnaaf5)

NLU:

111051170

HVI:

124354724

MQU:	128997312 129005162

PHU:	Phum_PHUM422440

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138699867(Dnaaf5)

BROR:

134538121

IEL:

124155347

HAMR:

139688645(Dnaaf5)

FCD:

110848524

DPX:	DAPPUDRAFT_105307

DMK:

116920392

DPZ:

124337791

PVM:	113802703(Dnaaf5)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123769288(Dnaaf5)

CQD:	128690229(Dnaaf5)

PTRU:

123507746

ESN:

126998140

MNZ:

135214272

MRJ:	136854944(Dnaaf5)

PORN:

139748997(Dnaaf5)

HAZT:

108677738

EAF:

111706106

LSM:	121114707(Dnaaf5)

TCF:

DSV:

RSAN:

RMP:

CSCU:

CVS:	136970309(Dnaaf5)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_111152

LGI:	LOTGIDRAFT_210534

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106170815 106178895

SMM:	Smp_045590

OVI:	T265_02407

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_53253

AQU:

100639900

CJF:

131063777

SMO:	SELMODRAFT_424234

PPP:	112273036 112285639

MIS:	MICPUN_57277

MPP:	MICPUCDRAFT_54264

MBR:	MONBRDRAFT_33000

SRE:	PTSG_02038

PIF:	PITG_03337

PSOJ:

PHYSODRAFT_477034

SPAR:

SPRG_19895

TBR:	Tb927.6.1290

TBG:	TbgDal_VI1000

TCR:

509429.80

LMA:	LMJF_33_1620

LIF:	LINJ_33_1720

LDO:	LDBPK_331720

LMI:	LMXM_32_1620

LMAT:

92512753(LSCM1_02664)

LBZ:	LBRM_33_1890

LPAN:

LPMP_331710

LOI:	92358444(LSCM4_02481)

LEIS:

94177887(GH5_02370)

LENR:

94169203(CUR178_01927)

LEIN:

94185691(JIQ42_01961)

PHET:

94288307(JKF63_02188)

NGR:	NAEGRDRAFT_56483

GTT:	GUITHDRAFT_162678

» show all

Reference

PMID:25232951

Authors

Diggle CP, Moore DJ, Mali G, zur Lage P, Ait-Lounis A, Schmidts M, Shoemark A, Garcia Munoz A, Halachev MR, Gautier P, Yeyati PL, Bonthron DT, Carr IM, Hayward B, Markham AF, Hope JE, von Kriegsheim A, Mitchison HM, Jackson IJ, Durand B, Reith W, Sheridan E, Jarman AP, Mill P

Title

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

Journal

PLoS Genet 10:e1004577 (2014)
DOI:10.1371/journal.pgen.1004577

Sequence

[hsa:54919]

LinkDB

DBGET integrated database retrieval system