KEGG ORTHOLOGY: K20082

ORTHOLOGY: K20082

Entry

K20082                      KO

Symbol

staMB

Name

O-methyltransferase StaMB [EC:2.1.1.139]

Pathway

map00404

Staurosporine biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00805

Staurosporine biosynthesis, tryptophan => staurosporine

Reaction

R05757

S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K20082  staMB; O-methyltransferase StaMB
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.139  3'-demethylstaurosporine O-methyltransferase
     K20082  staMB; O-methyltransferase StaMB

Other DBs

GO:

0030793

Genes

DEK:	DSLASN_18360

SSOI:

I1A49_05025

SRN:	A4G23_00556(rebM_1)

SCLF:

SSPO:

SPAD:

SAUH:

SFB:	CP974_02880

SPRA:

STRZ:

STRH:

ACTQ:

SAQ:

MFEU:

AG:	BAC55218(staMB)

» show all

Reference

PMID:16164546

Authors

Salas AP, Zhu L, Sanchez C, Brana AF, Rohr J, Mendez C, Salas JA

Title

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.

Journal

Mol Microbiol 58:17-27 (2005)
DOI:10.1111/j.1365-2958.2005.04777.x

Sequence

[ag:BAC55218]

LinkDB

ENZYME: 2.1.1.139

Entry

EC 2.1.1.139                Enzyme

Name

3'-demethylstaurosporine O-methyltransferase;
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase;
staurosporine synthase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine [RN:R05757]

Reaction(KEGG)

R05757

Substrate

S-adenosyl-L-methionine [CPD:C00019];
3'-demethylstaurosporine [CPD:C07349]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
staurosporine [CPD:C02079]

Comment

Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.

History

EC 2.1.1.139 created 2000

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20082

O-methyltransferase StaMB

Genes

DEK:	DSLASN_18360

SSOI:

I1A49_05025

SRN:	A4G23_00556(rebM_1)

SCLF:

BB341_29640

SSPO:

DDQ41_30660

SPAD:

DVK44_01710

SAUH:

SU9_001560

SFB:	CP974_02880

SPRA:

CP972_04230

STRZ:

OYE22_17000

STRH:

GXP74_22410

ACTQ:

OG417_05145

SAQ:

Sare_2332

MFEU:

H1D33_18670

» show all

Reference

1 [PMID:9727395]

Authors

Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zahner H.

Title

3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine.

Journal

J Antibiot (Tokyo) 51:679-82 (1998)
DOI:10.7164/antibiotics.51.679

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.139

IUBMB Enzyme Nomenclature:

2.1.1.139

ExPASy - ENZYME nomenclature database:

2.1.1.139

BRENDA, the Enzyme Database:

2.1.1.139

CAS:	212906-74-6

LinkDB

REACTION: R05757

Entry

R05757                      Reaction

Name

S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase

Definition

S-Adenosyl-L-methionine + 3'-Demethylstaurosporine <=> S-Adenosyl-L-homocysteine + Staurosporine

Equation

C00019 + C07349 <=> C00021 + C02079

Reaction class

RC00003

C00019_C00021

RC00466

C02079_C07349

Enzyme

2.1.1.139

Pathway

rn00404

Staurosporine biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00805

Staurosporine biosynthesis, tryptophan => staurosporine

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.139
     R05757  S-Adenosyl-L-methionine + 3'-Demethylstaurosporine <=> S-Adenosyl-L-homocysteine + Staurosporine

Orthology

K20082

O-methyltransferase StaMB [EC:2.1.1.139]

Other DBs

RHEA:

11699

LinkDB

DBGET integrated database retrieval system