KEGG ORTHOLOGY: K20278

ORTHOLOGY: K20278

Entry

K20278                      KO

Symbol

INPP5E

Name

inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

map04070

Phosphatidylinositol signaling system

Reaction

R04404

phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase

R09827

1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase

Disease

H00530

Joubert syndrome and related disorders

H02899

Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E
09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.36  phosphoinositide 5-phosphatase
     K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E

Other DBs

GO:

0004439

Genes

HSA:	56623(INPP5E)

PTR:	748603(INPP5E)

PPS:	100973295(INPP5E)

GGO:	101150746(INPP5E)

PON:	100445730(INPP5E)

PPYG:

129044141(INPP5E)

NLE:	100601830(INPP5E)

HMH:	116475869(INPP5E)

SSYN:

129478681(INPP5E)

MCC:	710121(INPP5E)

MCF:	102140416(INPP5E)

MTHB:

126936936

MNI:	105471932(INPP5E)

CSAB:

103239625(INPP5E)

CATY:

105580571(INPP5E)

PANU:

101025577(INPP5E)

TGE:	112608033(INPP5E)

MLEU:

105543313(INPP5E)

RRO:	104669671(INPP5E)

RBB:	108542841(INPP5E)

TFN:	117099154(INPP5E)

PTEH:

111553033(INPP5E)

CANG:

105522809(INPP5E)

CJC:	100399977(INPP5E)

SBQ:	101031749(INPP5E)

CIMI:

108287316(INPP5E)

ANAN:

105712173(INPP5E)

CSYR:

103250618(INPP5E)

MMUR:

105880784(INPP5E)

LCAT:

123646306(INPP5E)

PCOQ:

105818699(INPP5E)

OGA:	100945799(INPP5E)

MMU:	64436(Inpp5e)

MCAL:

110309573(Inpp5e)

MPAH:

110318558(Inpp5e)

RNO:	114089(Inpp5e)

MCOC:

116089849(Inpp5e)

ANU:	117711522(Inpp5e)

ASYL:

127685089(Inpp5e)

MUN:	110550858(Inpp5e)

CGE:	100759837(Inpp5e)

MAUA:

101838360(Inpp5e)

PROB:

127222628(Inpp5e)

PLEU:

114692815(Inpp5e)

MORG:

121462652(Inpp5e)

MFOT:

126509284

AAMP:

119818551(Inpp5e)

NGI:	103741211(Inpp5e)

HGL:	101701719(Inpp5e)

CPOC:

100715053(Inpp5e)

CCAN:

109697436(Inpp5e)

DORD:

105995602(Inpp5e)

DSP:	122108889(Inpp5e)

PLOP:

125353335(Inpp5e)

NCAR:

124964352

MMMA:

107159148(Inpp5e)

ITI:	101962793(Inpp5e) 101967023

TUP:	102481520(INPP5E)

GVR:	103590868(INPP5E)

CFA:	607443(INPP5E)

CLUD:

112677437(INPP5E)

VVP:	112906951(INPP5E)

VLG:	121473082(INPP5E)

NPO:	129507017(INPP5E)

AML:	100468432(INPP5E)

UMR:	103675239(INPP5E)

UAH:	113248636(INPP5E)

UAR:	123796350(INPP5E)

ELK:

111145744

LLV:

125082908

MPUF:

101677772(INPP5E)

MNP:	132024243(INPP5E)

MLK:	131812057(INPP5E)

NVS:	122917126(INPP5E)

ORO:	101386126(INPP5E)

EJU:	114201889(INPP5E)

ZCA:	113934590(INPP5E)

MLX:	118017519(INPP5E)

NSU:	110581267(INPP5E)

LWW:	102745807(INPP5E)

FCA:	101093901(INPP5E)

PYU:	121022861(INPP5E)

PCOO:

112861046(INPP5E)

PBG:	122474623(INPP5E)

PVIV:

125150559(INPP5E)

LRUF:

124522376

LGF:	123592637(INPP5E)

AJU:

106989561

PTG:	102958429(INPP5E)

PPAD:

109258773(INPP5E)

PUC:

125923267

PLEZ:

122204727(INPP5E)

HHV:	120221978(INPP5E)

BTA:	506349(INPP5E)

BOM:	102275943(INPP5E)

BIU:	109566589(INPP5E)

BBUB:

102414022(INPP5E)

BBIS:

104987722(INPP5E)

CHX:	102172073(INPP5E)

OAS:	101115530(INPP5E)

BTAX:

128055349(INPP5E)

CSUM:

138088566(INPP5E)

ODA:	120852148(INPP5E)

CCAD:

122442337(INPP5E)

MREE:

136163629(INPP5E)

OVR:	110134077(INPP5E)

MBEZ:

129539336(INPP5E)

SSC:	110258074(INPP5E)

CFR:	102513772(INPP5E)

CBAI:

105069738(INPP5E)

CDK:	105106024(INPP5E)

VPC:	102537877(INPP5E)

BACU:

103017804(INPP5E)

BMUS:

118896435(INPP5E)

LVE:	103081690(INPP5E)

OOR:	101279115(INPP5E)

LALB:

132523172(INPP5E)

DLE:	111177038(INPP5E)

PCAD:

102982683(INPP5E)

PSIU:

116755628(INPP5E)

NASI:

112411369(INPP5E)

ECB:	100068731(INPP5E)

EPZ:	103565349(INPP5E)

EAI:	106845556(INPP5E)

MYB:	102247617(INPP5E)

MYD:	102762883(INPP5E)

MMYO:

118655242(INPP5E)

MDT:	132212574(INPP5E)

MYUM:

139020620(INPP5E)

PKL:	118707020(INPP5E)

EFUS:

103296127(INPP5E)

MNA:	107535529(INPP5E)

DRO:	112306323(INPP5E)

SHON:

118980148(INPP5E)

AJM:	119036052(INPP5E)

PDIC:

114504271(INPP5E)

PHAS:

123823296(INPP5E)

MMF:	118630207(INPP5E)

PPAM:

129079548(INPP5E)

HAI:	109382414(INPP5E)

RFQ:	117031766(INPP5E)

PALE:

102886022(INPP5E)

PGIG:

120599819(INPP5E)

PVP:	105298576 111745540

RAY:	107514878(INPP5E)

MJV:	108387655(INPP5E)

TOD:	119233049(INPP5E)

SFUM:

130040852(INPP5E)

SETR:

126009245(INPP5E)

LAV:	100670120(INPP5E)

TMU:

101349334

ETF:	101652034(INPP5E)

DNM:	101421828(INPP5E)

MDO:	100020283(INPP5E)

GAS:	123233616(INPP5E)

SHR:	100930476(INPP5E)

AFZ:

127550979

PCW:	110205343(INPP5E)

TVP:	118843553(INPP5E)

PBRV:

138147045(INPP5E)

OAA:	100092732(INPP5E)

TACU:

119927309(INPP5E)

GGA:	417135(INPP5E)

PCOC:

116234330(INPP5E)

MGP:	100546617(INPP5E)

CJO:	107321710(INPP5E)

TPAI:

128073117(INPP5E)

LMUT:

125702465(INPP5E)

NMEL:

110406835(INPP5E)

APLA:

101805278(INPP5E)

ACYG:

106040740(INPP5E)

CATA:

118252111(INPP5E)

AFUL:

116496836(INPP5E)

TGU:	100218296(INPP5E)

LSR:	110477641(INPP5E)

SCAN:

103818950(INPP5E)

PMOA:

120512456(INPP5E)

OTC:	121336945(INPP5E)

PRUF:

121362495(INPP5E)

ATRC:

139603402(INPP5E)

GFR:	102041103(INPP5E)

FAB:	101814688(INPP5E)

OMA:	130260281(INPP5E)

PHI:	102113826(INPP5E)

PMAJ:

107212181(INPP5E)

CCAE:

111937067(INPP5E)

CCW:	104688354(INPP5E)

CBRC:

103623122(INPP5E)

ACOE:

138119606(INPP5E)

ETL:	114059114(INPP5E)

ZAB:	102067094(INPP5E)

ZLE:	135455051(INPP5E)

ACHL:

103806425(INPP5E)

SVG:	106855429(INPP5E)

MMEA:

130582256(INPP5E)

HRT:	120761679(INPP5E)

SATI:

136369806(INPP5E)

CCIC:

134051652(INPP5E)

FPG:	101924984(INPP5E)

FCH:	102047189(INPP5E)

CCRI:

104163200(INPP5E)

NNT:	104410550(INPP5E)

SHAB:

115616951(INPP5E)

ACUN:

113486499(INPP5E)

TALA:

104356069(INPP5E)

ACHC:

115335480(INPP5E)

HALD:

104311754(INPP5E)

HLE:	104833843(INPP5E)

AGEN:

126051989

HHAR:

128154170(INPP5E)

GCL:

127023659

CSTI:

104550869(INPP5E)

LDI:	104347233(INPP5E)

MNB:	103779770(INPP5E)

DPUB:

104306485(INPP5E)

PPUS:

135190015(INPP5E)

AVIT:

104268329(INPP5E)

BRHI:

104498200(INPP5E)

EGZ:	104129345(INPP5E)

NNI:	104023206(INPP5E)

PCRI:

104024777(INPP5E)

PCAO:

104043856(INPP5E)

PADL:

103915254(INPP5E)

AFOR:

103900036(INPP5E)

FGA:	104070482(INPP5E)

GSTE:

104263559(INPP5E)

CLV:	102084313(INPP5E)

MUI:	104534367(INPP5E)

PGUU:

104458919(INPP5E)

PLET:

104621399(INPP5E)

EHS:	104503909(INPP5E)

CMAC:

104483854(INPP5E)

CUCA:

104066841(INPP5E)

TEO:	104370515(INPP5E)

BREG:

104643146(INPP5E)

OHA:	104336597(INPP5E)

ACAR:

104518724(INPP5E)

CPEA:

104389804(INPP5E)

CVF:	104292835(INPP5E)

RTD:	128917730(INPP5E)

CRID:

134523720(INPP5E)

AAM:	106487004(INPP5E)

AROW:

112964282(INPP5E)

NPD:	112956007(INPP5E)

DNE:	112979918(INPP5E)

SCAM:

104138228(INPP5E)

ASN:	102380140(INPP5E)

AMJ:	102566738(INPP5E)

CPOO:

109314015(INPP5E)

GGN:	109293032(INPP5E)

PSS:	102446991(INPP5E)

CMY:	102932373(INPP5E)

CCAY:

125623373(INPP5E)

DCC:	119844062(INPP5E)

CPIC:

101940841(INPP5E)

TST:	117889330(INPP5E)

CABI:

116817507(INPP5E)

MRV:	120387014(INPP5E)

ACS:	100555178(inpp5e)

ASAO:

132763737(INPP5E)

PVT:	110079694(INPP5E)

SUND:

121936915(INPP5E)

PBI:	103053023(INPP5E)

PMUR:

107296233(INPP5E)

CTIG:

120317511(INPP5E)

TSR:	106539503(INPP5E)

PGUT:

117671314(INPP5E)

APRI:

131185927(INPP5E)

PTEX:

113448459(INPP5E)

NSS:	113425306(INPP5E)

VKO:	123035200(INPP5E)

PMUA:

114588931(INPP5E)

PRAF:

128406918(INPP5E)

ZVI:	118083966(INPP5E)

HCG:	128338911(INPP5E)

GJA:	107112993(INPP5E)

STOW:

125441854(INPP5E)

EMC:	129342058(INPP5E)

XLA:

108698190

XTR:	100486470(inpp5e) 101731958 101734556 101734627 101735025 116409534

NPR:	108800235(INPP5E)

RTEM:

120913837(INPP5E)

BBUF:

120977513(INPP5E)

PWL:	138301295(INPP5E)

MUO:	115473026(INPP5E)

GSH:	117367530(INPP5E)

DRE:	606579(inpp5e)

SRX:	107720240 107731045

SANH:

107672555 107699774

SGH:	107552629 107587653

CCAR:

109050713 109078005

CAUA:

113049676 113079462

CGIB:

127958276 127997215

PTET:

122345508(inpp5e)

LROH:

127166138(inpp5e)

OMC:	131540423(inpp5e)

PPRM:

120477458(inpp5e)

RKG:	130071969(inpp5e)

MAMB:

125267552(inpp5e)

CIDE:

127512909

CERY:

137034248(inpp5e)

MASI:

127420999 127439976

TROS:

130547052(inpp5e)

TDW:	130419340(inpp5e)

MANU:

129441006(inpp5e)

PDAB:

135774323(inpp5e)

IPU:	108255662 108259957

IFU:	128603530 128625665(inpp5e)

PHYP:

113537180(inpp5e)

SMEO:

124380684(inpp5e)

TFD:	113637600(inpp5e)

TVC:	132854497(inpp5e)

CGAR:

128509343(inpp5e)

NGRA:

132872315(inpp5e)

TRN:	134335240(inpp5e)

AMEX:

103038809(inpp5e)

CMAO:

118827201(inpp5e)

EEE:	113572910(inpp5e)

CHAR:

105889666(inpp5e)

SPIL:

134059702(inpp5e)

TRU:	101070553(inpp5e)

TFS:	130525928(inpp5e)

LCO:	104923663(inpp5e)

NCC:	104958594(inpp5e)

TBEN:

117472764(inpp5e)

CGOB:

115013091(inpp5e)

PGEO:

117452497(inpp5e)

GACU:

117552074(inpp5e)

EMAC:

134873609(inpp5e)

ELY:	117252041(inpp5e)

EFO:	125890486(inpp5e)

PLEP:

121944480(inpp5e)

SLUC:

116054322(inpp5e)

ECRA:

117944742(inpp5e)

ESP:	116689123(inpp5e)

PFLV:

114556078(inpp5e)

GAT:	120830825(inpp5e)

PPUG:

119225382(inpp5e)

AFB:	129101563(inpp5e)

PSWI:

130196814(inpp5e)

CANA:

137804900(inpp5e)

CVE:	137880018(inpp5e)

MSAM:

119891082(inpp5e)

SCHU:

122876241(inpp5e)

CUD:	121509489(inpp5e)

SPUL:

138610001(inpp5e)

LMIX:

132974391(inpp5e)

ALAT:

119019501(inpp5e)

ASTR:

137592233(inpp5e)

MZE:	101474548(inpp5e)

ONL:	100699689(inpp5e)

OAU:	116326128(inpp5e)

OLA:	101161245(inpp5e)

OML:	112148471(inpp5e)

CSAI:

133451460(inpp5e)

XMA:	102222173(inpp5e)

XCO:	114155114(inpp5e)

XHE:	116730299(inpp5e)

PRET:

103469902(inpp5e)

PFOR:

103141972(inpp5e)

PLAI:

106954294(inpp5e)

PMEI:

106923726(inpp5e)

GAF:	122828470(inpp5e)

PPRL:

129366241(inpp5e)

CVG:	107098098(inpp5e)

CTUL:

119793132(inpp5e)

GMU:	124877960(inpp5e)

NFU:	107386282(inpp5e)

KMR:	108233566(inpp5e)

ALIM:

106510879 106528771(inpp5e)

NWH:	119413826(inpp5e)

AOCE:

111574698(inpp5e)

EJA:	138215802(inpp5e)

BFRE:

138625526(inpp5e)

MCEP:

125011961(inpp5e)

CSEM:

103396951 103397902

POV:	109637072(inpp5e)

SSEN:

122769354(inpp5e)

SSOE:

131464370(inpp5e)

HHIP:

117767361(inpp5e)

HSP:	124852403(inpp5e)

PPLT:

128437837(inpp5e)

SMAU:

118313688(inpp5e)

LCF:	108875310(inpp5e) 108893042

SDU:	111236487(inpp5e)

SLAL:

111648733 111663074

XGL:	120805852(inpp5e)

HCQ:	109525194(inpp5e)

SSCV:

125994032(inpp5e)

SBIA:

133499619(inpp5e)

PEE:	133400118(inpp5e)

PTAO:

133474877(inpp5e)

BPEC:

110153533 110155831

ENY:	140346480(inpp5e)

MALB:

109959114(inpp5e)

BSPL:

114862787(inpp5e)

SJO:	128364688(inpp5e)

SSCO:

133978990(inpp5e)

GMH:	115548478(inpp5e)

SASA:

106580015 106585421

STRU:

115164728 115199907

OTW:	112232800(inpp5e) 112263110

OMY:	110525468(inpp5e) 110535850

OGO:	124033371 124036132

ONE:	115111436 115139858

OKI:	109877644 109895740

OKE:	118358162 118393037

OMM:	135514270 135539405

OCLA:

139389308 139410776

SALP:

111974852 111974853

SNH:	120058012 120063121(inpp5e)

CCLU:

121551593 121584689

ELS:	105014130(inpp5e)

OEP:	134011697(inpp5e)

SFM:	108933635(inpp5e)

PKI:	111841813(inpp5e)

AANG:

118212695(inpp5e)

AROT:

135240036(inpp5e)

CCOG:

133142138(inpp5e)

LOC:	102686497(inpp5e)

PSPA:

121306696(inpp5e)

ARUT:

117396780(inpp5e) 117422113

PSEX:

120535790(inpp5e)

LCM:	102357566(INPP5E)

CMK:	103184698(inpp5e)

RTP:	109938974(inpp5e)

CPLA:

122565010(inpp5e)

HOC:	132825957(inpp5e)

LERI:

129712086(inpp5e)

PMRN:

116955352(INPP5E)

BFO:

BBEL:

CIN:

SCLV:

SPU:	105437790 115929246 592337

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG10426(INPP5E)

DER:

26526949

DSE:

116801125

DSI:	Dsimw501_GD29624(Dsim_GD29624)

DYA:	Dyak_GE27458

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI26989

DAZ:

108614655

DNV:

108652248

DHE:

111598763

DVI:	26531093(INPP5E)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135954582(INPP5E)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002259

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139109221(Inpp5e)

TLN:	139822773(Inpp5e)

HST:

DQU:

CFO:

FEX:

PMEC:

138937897(Inpp5e)

LHU:	105671365(INPP5E)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

NLO:

AROA:

TCA:

TMOL:

138138128(INPP5E)

DPA:

109536797

ESIM:

136408790(INPP5E)

EFOR:

136340398(INPP5E)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203621

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137932270(INPP5E)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110375671 135118513

HZE:

TNL:

SLIU:

ONU:

ATRA:

GMW:

PGW:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106680878(INPP5E)

NLU:

111058351

MQU:

128999975

PHU:	Phum_PHUM327410

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139689999(INPP5E)

FCD:

110842783

DPX:	DAPPUDRAFT_58697

DMK:

DPZ:

AFRA:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123773696(INPP5E)

CQD:	128695587(INPP5E)

PTRU:

123508043

ESN:

126986823

MNZ:

135205792

MRJ:	136826846(INPP5E)

PORN:

139746865(INPP5E)

HAZT:

108667522

EAF:

111707583

LSM:	121121265(INPP5E)

TCF:

PPOI:

DSV:

RSAN:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136975973(INPP5E)

PTEP:

107443026

ABRU:

129981681

SDM:	118194804 118198644

LPOL:

106469965

CEL:	CELE_T25B9.10(inpp-1)

CBR:

CBG_17633

CRQ:	GCK72_014891

LOA:	LOAG_07278

TSP:

Tsp_01811

HRO:	HELRODRAFT_82107

LGI:	LOTGIDRAFT_116088

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_166990

OVI:	T265_05093

LLON:

135501617

NVE:

5515358

ATEN:

116303638

ADF:	107337873 107337874

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_53207

AQU:

100637624

MIS:	MICPUN_57143

MPP:	MICPUCDRAFT_38698

SRE:	PTSG_12561

TET:	TTHERM_000490669

PTM:	GSPATT00020117001

NGD:	NGA_2009720 NGA_2026300

PIF:	PITG_20083

PSOJ:

PHYSODRAFT_501116

SPAR:

SPRG_01861

EHX:	EMIHUDRAFT_237248

GTT:	GUITHDRAFT_152676

» show all

Reference

PMID:10764818

Authors

Kisseleva MV, Wilson MP, Majerus PW

Title

The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.

Journal

J Biol Chem 275:20110-6 (2000)
DOI:10.1074/jbc.M910119199

Sequence

[hsa:56623]

LinkDB

DBGET integrated database retrieval system