KEGG   ORTHOLOGY: K20421
Entry
K20421                      KO                                     

Symbol
ncsB1
Name
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00830  Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.303  2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
     K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
Other DBs
RN: R10963
Genes
CLIA: C3E79_07185
NCY: NOCYR_3137(dnrK)
NNO: NONO_c58190
NTP: CRH09_14165 CRH09_23690 CRH09_25100 CRH09_33960
NOD: FOH10_15005 FOH10_16430
NAH: F5544_21445
RHU: A3Q40_00430(rdmB)
DTM: BJL86_2741
SMA: SAVERM_2382
SSX: SACTE_5196 SACTE_6329
SALU: DC74_6556
SALL: SAZ_34135
SPRI: SPRI_3765
SLE: sle_66100(sle_66100)
KFL: Kfla_6058
NAL: B005_2465(dnrK)
SEN: SACE_4650
AMD: AMED_3230
AMN: RAM_16420
AMM: AMES_3195
AMZ: B737_3195
AOI: AORI_6472
AMYY: YIM_09465(dnrK1) YIM_15125(dnrK2)
PDX: Psed_0831
AMI: Amir_4382
SESP: BN6_04400
ACTI: UA75_06455
ACAD: UA74_06455
AHG: AHOG_06225(dnrK1)
SAQ: Sare_4955
MIL: ML5_4683
SUS: Acid_5654
AG: AAM77984(ncsB1)
 » show all
Reference
  Authors
Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B
  Title
Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
  Journal
J Biol Chem 283:14694-702 (2008)
DOI:10.1074/jbc.M802206200
  Sequence
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