KEGG   ORTHOLOGY: K20433
Entry
K20433                      KO                                     
Symbol
valC
Name
C7-cyclitol 7-kinase [EC:2.7.1.214]
Pathway
map00525  Acarbose and validamycin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Reaction
R11234  ATP:valienone 7-phosphotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20433  valC; C7-cyclitol 7-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.214  C7-cyclitol 7-kinase
     K20433  valC; C7-cyclitol 7-kinase
Other DBs
COG: COG1940
Genes
TVD: SG34_025400
PAEW: KIH87_05095
CJA: CJA_3253
SUR: STAUR_1374(gacM)
SHY: SHJG_0278
SHO: SHJGH_0112
SGU: SGLAU_01045(gacM)
SNQ: CP978_00080
SSPO: DDQ41_30755
SGF: HEP81_06980
KIS: HUT16_33025
STRH: GXP74_26585
 » show all
Reference
PMID:17335096
  Authors
Minagawa K, Zhang Y, Ito T, Bai L, Deng Z, Mahmud T
  Title
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.
  Journal
Chembiochem 8:632-41 (2007)
DOI:10.1002/cbic.200600528
  Sequence
[shy:SHJG_0278]
LinkDB

KEGG   ENZYME: 2.7.1.214
Entry
EC 2.7.1.214                Enzyme                                 
Name
C7-cyclitol 7-kinase;
valC (gene name);
vldC (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:C7-cyclitol 7-phosphotransferase
Reaction(IUBMB)
(1) ATP + valienone = ADP + valienone 7-phosphate [RN:R11234];
(2) ATP + validone = ADP + validone 7-phosphate [RN:R11406]
Reaction(KEGG)
R11234 R11406
Substrate
ATP [CPD:C00002];
valienone [CPD:C17696];
validone [CPD:C21371]
Product
ADP [CPD:C00008];
valienone 7-phosphate [CPD:C17697];
validone 7-phosphate [CPD:C21218]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.7.1.214 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20433  C7-cyclitol 7-kinase
Genes
TVD: SG34_025400
PAEW: KIH87_05095
CJA: CJA_3253
SUR: STAUR_1374(gacM)
SHY: SHJG_0278
SHO: SHJGH_0112
SGU: SGLAU_01045(gacM)
SNQ: CP978_00080
SSPO: DDQ41_30755
SGF: HEP81_06980
KIS: HUT16_33025
STRH: GXP74_26585
 » show all
Reference
1  [PMID:17335096]
  Authors
Minagawa K, Zhang Y, Ito T, Bai L, Deng Z, Mahmud T
  Title
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.
  Journal
Chembiochem 8:632-41 (2007)
DOI:10.1002/cbic.200600528
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.214
IUBMB Enzyme Nomenclature: 2.7.1.214
ExPASy - ENZYME nomenclature database: 2.7.1.214
BRENDA, the Enzyme Database: 2.7.1.214
LinkDB

KEGG   REACTION: R11234
Entry
R11234                      Reaction                               
Name
ATP:valienone 7-phosphotransferase
Definition
Valienone + ATP <=> Valienone 7-phosphate + ADP
Equation
C17696 + C00002 <=> C17697 + C00008
Reaction class
RC00017  C17696_C17697
Enzyme
2.7.1.214
Pathway
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.214
     R11234  Valienone + ATP <=> Valienone 7-phosphate + ADP
Orthology
K20433  C7-cyclitol 7-kinase [EC:2.7.1.214]
Other DBs
RHEA: 49423
LinkDB

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