KEGG   ORTHOLOGY: K20513
Entry
K20513                      KO                                     
Symbol
CYP76AH1
Name
ferruginol synthase [EC:1.14.14.175]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R12652  abieta-8,11,13-triene,[reduced NADPH---hemoprotein reductase]:oxygen 12-oxidoreductase (ferruginol-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K20513  CYP76AH1; ferruginol synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K20513  CYP76AH1; ferruginol synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.175  ferruginol synthase
     K20513  CYP76AH1; ferruginol synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP76 family
   K20513  CYP76AH1; ferruginol synthase
Genes
EGT: 105959240 105975178
SSPL: 121747525 121750147 121753304 121756002 121759934 121761842 121764980 121766433 121766434 121766435 121766436 121766444 121766445 121778538 121780327 121781922 121783193 121783532 121785163 121788348 121788445 121790204 121790205 121790206 121800549 121802016 121802484 121808049
SMIL: 130991308 130991309 130991327 130998360 131000178 131000189 131015108 131015112 131015113 131015954 131020581 131020582
SHIS: 125186032 125188718 125189260 125192328 125192396 125192722 125193130 125193616 125193666 125193680 125194753 125194755 125197002 125197822 125197829 125199011 125200770 125202661 125202663 125202849 125205027 125211802 125212140 125212654 125212704 125212705 125212706 125212708 125212946 125216734 125217682 125218657 125218856 125219752 125219893 125224036
APAN: 127248465 127248517 127248518 127248772 127265187
AG: AGN04215(CYP76AH1) AJQ30186(FS) AJQ30187(FS1)
Reference
PMID:23812755
  Authors
Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang Y, Zhang X, Liu W, Peters RJ, Chen X, Zhao ZK, Huang L
  Title
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.
  Journal
Proc Natl Acad Sci U S A 110:12108-13 (2013)
DOI:10.1073/pnas.1218061110
  Sequence
[ag:AGN04215]
Reference
PMID:26020634
  Authors
Bozic D, Papaefthimiou D, Bruckner K, de Vos RC, Tsoleridis CA, Katsarou D, Papanikolaou A, Pateraki I, Chatzopoulou FM, Dimitriadou E, Kostas S, Manzano D, Scheler U, Ferrer A, Tissier A, Makris AM, Kampranis SC, Kanellis AK
  Title
Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and  Rosmarinus officinalis.
  Journal
PLoS One 10:e0124106 (2015)
DOI:10.1371/journal.pone.0124106
  Sequence
[ag:AJQ30186 AJQ30187]
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